EC: 2.7.10.2

non-specific protein-tyrosine kinase (ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific))

enzyme lambda metabolic reaction experiment
- [non-specific protein-tyrosine kinase(Enzyme) wildtype]

p_cyclin_cdc2 + ATP -> p_cyclin_cdc2_p + ADP		 (( (cell * k5notP) ) * M) buffer: *
PH: 7
Temperature: 36
uniprot:P06213 [Insulin]

ATP + Protein_tyrosine -> Protein_tyrosine_phosphate + ADP		 (( (( (E * kcat) ) * B) ) / (Km + B)) buffer: 50 mM Hepes, 5 mM MnCl2, 0.1 % Triton X-100
PH: 7
Temperature: 22
uniprot:P06213 [Insulin]

Protein_tyrosine + ATP -> ADP + Protein_tyrosine_phosphate		 (( (( (E * kcat) ) * B) ) / (Km + B)) buffer: 50 mM Hepes, 5 mM MnCl2, 0.1 % Triton X-100
PH: 7
Temperature: 22
uniprot:P06213 [Insulin]

Protein_tyrosine + ATP -> Protein_tyrosine_phosphate + ADP		 (( (( (E * kcat) ) * B) ) / (Km + B)) buffer: 50 mM Hepes, 5 mM MnCl2, 0.1 % Triton X-100
PH: 7
Temperature: 22
uniprot:P06213 [Insulin]

Protein_tyrosine + ATP -> Protein_tyrosine_phosphate + ADP		 (( (( (E * kcat) ) * B) ) / (Km + B)) buffer: 50 mM Hepes, 5 mM MnCl2, 0.1 % Triton X-100
PH: 7
Temperature: 22
uniprot:P06213 [Insulin]

Protein_tyrosine + ATP -> ADP + Protein_tyrosine_phosphate		 (( (( (E * kcat) ) * B) ) / (Km + B)) buffer: 50 mM Hepes, 5 mM MnCl2, 0.1 % Triton X-100
PH: 7
Temperature: 22
uniprot:P06213 [Insulin]

Protein_tyrosine + ATP -> ADP + Protein_tyrosine_phosphate		 (( (( (E * kcat) ) * B) ) / (Km + B)) buffer: 50 mM Hepes, 5 mM MnCl2, 0.1 % Triton X-100
PH: 7
Temperature: 22
uniprot:P06213 [Insulin]

Protein_tyrosine + ATP -> Protein_tyrosine_phosphate + ADP		 (( (( (E * kcat) ) * B) ) / (Km + B)) buffer: 50 mM Hepes, 5 mM MnCl2, 0.1 % Triton X-100
PH: 7
Temperature: 22
uniprot:P06213 [Insulin]

Protein_tyrosine + ATP -> Protein_tyrosine_phosphate + ADP		 (( (( (E * kcat) ) * B) ) / (Km + B)) buffer: 50 mM Hepes, 5 mM MnCl2, 0.1 % Triton X-100
PH: 7
Temperature: 22
uniprot:P06213 [Insulin]

ATP + Protein_tyrosine -> ADP + Protein_tyrosine_phosphate		 (( (( (E * kcat) ) * B) ) / (Km + B)) buffer: 50 mM Hepes, 5 mM MnCl2, 0.1 % Triton X-100
PH: 7
Temperature: 22
uniprot:P06213 [Insulin]

ATP + Protein_tyrosine -> Protein_tyrosine_phosphate + ADP		 (( (( (E * kcat) ) * B) ) / (Km + B)) buffer: 50 mM Hepes, 5 mM MnCl2, 0.1 % Triton X-100
PH: 7
Temperature: 22
uniprot:P06213 [Insulin]

ATP + Protein_tyrosine -> ADP + Protein_tyrosine_phosphate		 (( (( (E * kcat) ) * B) ) / (Km + B)) buffer: 50 mM Hepes, 5 mM MnCl2, 0.1 % Triton X-100
PH: 7
Temperature: 22
uniprot:P06213 [Insulin]

ATP + Protein_tyrosine -> Protein_tyrosine_phosphate + ADP		 (( (( (E * kcat) ) * B) ) / (Km + B)) buffer: 50 mM Hepes, 5 mM MnCl2, 0.1 % Triton X-100
PH: 7
Temperature: 22
uniprot:P06213 [Insulin]

ATP + Protein_tyrosine -> ADP + Protein_tyrosine_phosphate		 (( (( (E * kcat) ) * B) ) / (Km + B)) buffer: 50 mM Hepes, 5 mM MnCl2, 0.1 % Triton X-100
PH: 7
Temperature: 22
uniprot:P06213 [Insulin]

ATP + Protein_tyrosine -> ADP + Protein_tyrosine_phosphate		 (( (( (E * kcat) ) * B) ) / (Km + B)) buffer: 50 mM Hepes, 5 mM MnCl2, 0.1 % Triton X-100
PH: 7
Temperature: 22
uniprot:P06213 [Insulin]

ATP + Protein_tyrosine -> Protein_tyrosine_phosphate + ADP		 (( (( (E * kcat) ) * B) ) / (Km + B)) buffer: 50 mM Hepes, 5 mM MnCl2, 0.1 % Triton X-100
PH: 7
Temperature: 22
- [non-specific protein-tyrosine kinase(Enzyme) wildtype]

((IFNRJ2_activated)(STAT1)) -> STAT1_activated + IFNRJ2_activated		 (( (cytoplasm * kf6) ) * IFNRJ2_activatedSTAT1c) buffer: *
PH: 7
Temperature: 36
- [non-specific protein-tyrosine kinase(Enzyme) wildtype]

IFNRJ2 -> IFNRJ2_activated		 (( (cytoplasm * kf4) ) * IFNRJ2) buffer: *
PH: 7
Temperature: 36
uniprot:Q13882 [non-specific protein-tyrosine kinase(Enzyme) wildtype His-tagged]

ATP + Peptide -> Phosphopeptide + ADP		 (( (Vmax * B) ) / (Km + B)) buffer: 20 mM Tris, 3 mM MnCl2, 1 mM phosphoenolpyruvate, 0.28 mM NADH, 89 units/ml pyruvate kinase, 124 units/ml lactate dehydrogenase
PH: 7.5
Temperature: 30
uniprot:Q13882 [non-specific protein-tyrosine kinase(Enzyme) wildtype His-tagged]

Peptide + ATP -> ADP + Phosphopeptide		 (( (Vmax * B) ) / (Km + B)) buffer: 20 mM Tris, 3 mM MnCl2, 1 mM phosphoenolpyruvate, 0.28 mM NADH, 89 units/ml pyruvate kinase, 124 units/ml lactate dehydrogenase
PH: 7.5
Temperature: 30
uniprot:Q13882 [non-specific protein-tyrosine kinase(Enzyme) wildtype His-tagged]

Peptide + ATP -> ADP + Phosphopeptide		 (( (Vmax * B) ) / (Km + B)) buffer: 20 mM Tris, 3 mM MnCl2, 1 mM phosphoenolpyruvate, 0.28 mM NADH, 89 units/ml pyruvate kinase, 124 units/ml lactate dehydrogenase
PH: 7.5
Temperature: 30
uniprot:Q13882 [Polyproline peptide]

ATP + Peptide -> ADP + Phosphopeptide		 (( (Vmax * L) ) / (Kact + L)) buffer: 20 mM Tris, 3 mM MnCl2, 1 mM phosphoenolpyruvate, 0.28 mM NADH, 89 units/ml pyruvate kinase, 124 units/ml lactate dehydrogenase
PH: 7.5
Temperature: 30
uniprot:Q13882 [non-specific protein-tyrosine kinase(Enzyme) wildtype His-tagged]

ATP + Peptide -> ADP + Phosphopeptide		 (( (Vmax * A) ) / (Km + A)) buffer: 20 mM Tris, 3 mM MnCl2, 1 mM phosphoenolpyruvate, 0.28 mM NADH, 89 units/ml pyruvate kinase, 124 units/ml lactate dehydrogenase
PH: 7.5
Temperature: 30

Pathways

pathway id name
BioCyc:HUMAN_PWY66-400 glycolysis
BioCyc:META_ANAGLYCOLYSIS-PWY glycolysis III (from glucose)
BioCyc:MOUSE_GLYCOLYSIS glycolysis I
BioCyc:META_ANAEROFRUCAT-PWY homolactic fermentation
BioCyc:HUMAN_PWY66-407 superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
BioCyc:MOUSE_P341-PWY glycolysis V (Pyrococcus)
BioCyc:MOUSE_ANAGLYCOLYSIS-PWY glycolysis III
Reactome:R-MMU-9639288 Amino acids regulate mTORC1
Reactome:R-HSA-9639288 Amino acids regulate mTORC1
Reactome:R-HSA-9607240 FLT3 Signaling
Reactome:R-DRE-9663891 Selective autophagy
Reactome:R-MMU-9663891 Selective autophagy
Reactome:R-CEL-9663891 Selective autophagy
Reactome:R-DRE-9612973 Autophagy
Reactome:R-RNO-9663891 Selective autophagy
Reactome:R-BTA-9607240 FLT3 Signaling
Reactome:R-MMU-9607240 FLT3 Signaling
Reactome:R-MMU-9612973 Autophagy
Reactome:R-CEL-9612973 Autophagy
Reactome:R-RNO-9639288 Amino acids regulate mTORC1
Reactome:R-RNO-9612973 Autophagy
Reactome:R-SSC-9675108 Nervous system development
Reactome:R-HSA-9664422 FCGR3A-mediated phagocytosis
Reactome:R-HSA-9664323 FCGR3A-mediated IL10 synthesis
Reactome:R-HSA-9669938 Signaling by KIT in disease
Reactome:R-HSA-9670439 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Reactome:R-HSA-9679506 SARS-CoV Infections
Reactome:R-HSA-9679191 Potential therapeutics for SARS
Reactome:R-HSA-9706374 FLT3 signaling through SRC family kinases
Reactome:R-HSA-9694516 SARS-CoV-2 Infection
Reactome:R-CEL-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Reactome:R-RNO-9674555 Signaling by CSF3 (G-CSF)
Reactome:R-HSA-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Reactome:R-HSA-9013420 RHOU GTPase cycle
Reactome:R-HSA-9674555 Signaling by CSF3 (G-CSF)
Reactome:R-MMU-201556 Signaling by ALK
Reactome:R-HSA-9700206 Signaling by ALK in cancer
Reactome:R-HSA-9824439 Bacterial Infection Pathways
Reactome:R-CEL-9675108 Nervous system development
Reactome:R-MMU-9675108 Nervous system development
Reactome:R-HSA-9675108 Nervous system development
Reactome:R-HSA-9664417 Leishmania phagocytosis
Reactome:R-SSC-9705462 Inactivation of CSF3 (G-CSF) signaling
Reactome:R-MMU-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Reactome:R-MMU-9705462 Inactivation of CSF3 (G-CSF) signaling
Reactome:R-HSA-9707564 Cytoprotection by HMOX1
Reactome:R-HSA-9711097 Cellular response to starvation
Reactome:R-HSA-9634597 GPER1 signaling
Reactome:R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses
Reactome:R-RNO-9833482 PKR-mediated signaling
Reactome:R-HSA-9833109 Evasion by RSV of host interferon responses
Reactome:R-HSA-9658195 Leishmania infection
Reactome:R-HSA-9664433 Leishmania parasite growth and survival
Reactome:R-MMU-9706374 FLT3 signaling through SRC family kinases
Reactome:R-HSA-9706369 Negative regulation of FLT3
Reactome:R-GGA-9674555 Signaling by CSF3 (G-CSF)
Reactome:R-RNO-9705462 Inactivation of CSF3 (G-CSF) signaling
Reactome:R-RNO-9711097 Cellular response to starvation
Reactome:R-HSA-9012999 RHO GTPase cycle
Reactome:R-HSA-9705462 Inactivation of CSF3 (G-CSF) signaling
Reactome:R-RNO-201556 Signaling by ALK
Reactome:R-HSA-9725370 Signaling by ALK fusions and activated point mutants
Reactome:R-HSA-201556 Signaling by ALK
Reactome:R-HSA-9755511 KEAP1-NFE2L2 pathway
Reactome:R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells
Reactome:R-HSA-9824446 Viral Infection Pathways
Reactome:R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion
Reactome:R-MMU-9833482 PKR-mediated signaling
Reactome:R-HSA-9842663 Signaling by LTK
Reactome:R-RNO-9675108 Nervous system development
Reactome:R-BTA-9675108 Nervous system development
Reactome:R-DME-9675108 Nervous system development
Reactome:R-HSA-9664407 Parasite infection
Reactome:R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection
Reactome:R-BTA-9706369 Negative regulation of FLT3
Reactome:R-MMU-9706369 Negative regulation of FLT3
Reactome:R-SSC-9674555 Signaling by CSF3 (G-CSF)
Reactome:R-GGA-9705462 Inactivation of CSF3 (G-CSF) signaling
Reactome:R-DME-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Reactome:R-MMU-9711097 Cellular response to starvation
Reactome:R-MMU-9674555 Signaling by CSF3 (G-CSF)
Reactome:R-HSA-9711123 Cellular response to chemical stress
Reactome:R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer
Reactome:R-HSA-9705683 SARS-CoV-2-host interactions
Reactome:R-HSA-9824443 Parasitic Infection Pathways
Reactome:R-HSA-9833482 PKR-mediated signaling
Reactome:R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway
Reactome:R-HSA-9833110 RSV-host interactions
Reactome:R-MMU-9861718 Regulation of pyruvate metabolism
Reactome:R-MMU-9842663 Signaling by LTK
Reactome:R-RNO-9842663 Signaling by LTK
Reactome:R-CEL-9855142 Cellular responses to mechanical stimuli
Reactome:R-CEL-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes
Reactome:R-DME-9855142 Cellular responses to mechanical stimuli
Reactome:R-DME-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes
Reactome:R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes
Reactome:R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Reactome:R-MMU-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes
Reactome:R-MMU-9860931 Response of endothelial cells to shear stress
Reactome:R-RNO-9855142 Cellular responses to mechanical stimuli
Reactome:R-HSA-9909505 Modulation of host responses by IFN-stimulated genes
Reactome:R-HSA-9764265 Regulation of CDH1 Expression and Function
Reactome:R-HSA-9920951 Dengue virus modulates apoptosis
Reactome:R-CEL-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Reactome:R-CEL-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes
Reactome:R-DME-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Reactome:R-DME-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Reactome:R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes
Reactome:R-HSA-9860931 Response of endothelial cells to shear stress
Reactome:R-MMU-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Reactome:R-MMU-9855142 Cellular responses to mechanical stimuli
Reactome:R-RNO-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Reactome:R-BTA-9909505 Modulation of host responses by IFN-stimulated genes
Reactome:R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins
Reactome:R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription
Reactome:R-HSA-9909648 Regulation of PD-L1(CD274) expression
Reactome:R-MMU-9909615 Regulation of PD-L1(CD274) Post-translational modification
Reactome:R-MMU-9931295 PD-L1(CD274) glycosylation and translocation to plasma membrane
Reactome:R-CEL-9860931 Response of endothelial cells to shear stress
Reactome:R-CEL-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Reactome:R-DME-9860931 Response of endothelial cells to shear stress
Reactome:R-DME-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes
Reactome:R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes
Reactome:R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Reactome:R-MMU-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes
Reactome:R-MMU-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Reactome:R-RNO-9860931 Response of endothelial cells to shear stress
Reactome:R-HSA-9764560 Regulation of CDH1 Gene Transcription
Reactome:R-MMU-9909648 Regulation of PD-L1(CD274) expression
Reactome:R-HSA-9839923 Dengue Virus Infection
Reactome:R-HSA-9918476 Assembly and Release of Dengue Virus Virions
Reactome:R-CEL-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes
Reactome:R-DME-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes
Reactome:R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Reactome:R-HSA-9855142 Cellular responses to mechanical stimuli
Reactome:R-MMU-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes
Reactome:R-MMU-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Reactome:R-RNO-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Reactome:R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification
Reactome:R-HSA-9931295 PD-L1(CD274) glycosylation and translocation to plasma membrane
Reactome:R-HSA-9918481 Dengue Virus-Host Interactions
Reactome:R-CEL-186763 Downstream signal transduction
Reactome:R-CEL-525793 Myogenesis
Reactome:R-CEL-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
Reactome:R-BTA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Reactome:R-MMU-8964315 G beta:gamma signalling through BTK
Reactome:R-CEL-186797 Signaling by PDGF
Reactome:R-RNO-9009391 Extra-nuclear estrogen signaling
Reactome:R-HSA-8964315 G beta:gamma signalling through BTK
Reactome:R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Reactome:R-DRE-1295596 Spry regulation of FGF signaling
Reactome:R-MMU-5621480 Dectin-2 family
Reactome:R-HSA-9009391 Extra-nuclear estrogen signaling
Reactome:R-CEL-9009391 Extra-nuclear estrogen signaling
Reactome:R-CEL-3928663 EPHA-mediated growth cone collapse
Reactome:R-CEL-8934903 Receptor Mediated Mitophagy
Reactome:R-DRE-9009391 Extra-nuclear estrogen signaling
Reactome:R-RNO-5621480 Dectin-2 family
Reactome:R-MMU-9009391 Extra-nuclear estrogen signaling
Reactome:R-HSA-9620244 Long-term potentiation
Reactome:R-BTA-597592 Post-translational protein modification
Reactome:R-BTA-5689896 Ovarian tumor domain proteases
Reactome:R-BTA-109582 Hemostasis
Reactome:R-BTA-422475 Axon guidance
Reactome:R-BTA-168256 Immune System
Reactome:R-BTA-389356 CD28 co-stimulation
Reactome:R-BTA-913531 Interferon Signaling
Reactome:R-BTA-1500931 Cell-Cell communication
Reactome:R-BTA-373753 Nephrin family interactions
Reactome:R-BTA-8953897 Cellular responses to stimuli
Reactome:R-BTA-2262752 Cellular responses to stress
Reactome:R-BTA-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-BTA-180292 GAB1 signalosome
Reactome:R-BTA-194138 Signaling by VEGF
Reactome:R-BTA-209543 p75NTR recruits signalling complexes
Reactome:R-CEL-432142 Platelet sensitization by LDL
Reactome:R-CEL-418592 ADP signalling through P2Y purinoceptor 1
Reactome:R-CEL-354192 Integrin signaling
Reactome:R-CEL-2029482 Regulation of actin dynamics for phagocytic cup formation
Reactome:R-CEL-2454202 Fc epsilon receptor (FCERI) signaling
Reactome:R-CEL-1500931 Cell-Cell communication
Reactome:R-CEL-8953897 Cellular responses to stimuli
Reactome:R-CEL-4420097 VEGFA-VEGFR2 Pathway
Reactome:R-CEL-1253288 Downregulation of ERBB4 signaling
Reactome:R-CEL-388396 GPCR downstream signalling
Reactome:R-CEL-9006925 Intracellular signaling by second messengers
Reactome:R-CEL-422475 Axon guidance
Reactome:R-CEL-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Reactome:R-CEL-418885 DCC mediated attractive signaling
Reactome:R-CEL-3928665 EPH-ephrin mediated repulsion of cells
Reactome:R-CEL-8878159 Transcriptional regulation by RUNX3
Reactome:R-CEL-212165 Epigenetic regulation of gene expression
Reactome:R-DRE-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-DRE-5654736 Signaling by FGFR1
Reactome:R-DRE-5654738 Signaling by FGFR2
Reactome:R-DRE-5654732 Negative regulation of FGFR3 signaling
Reactome:R-DRE-186797 Signaling by PDGF
Reactome:R-DRE-1236394 Signaling by ERBB4
Reactome:R-DRE-1253288 Downregulation of ERBB4 signaling
Reactome:R-DRE-372790 Signaling by GPCR
Reactome:R-DRE-8878159 Transcriptional regulation by RUNX3
Reactome:R-DRE-1632852 Macroautophagy
Reactome:R-DRE-1500931 Cell-Cell communication
Reactome:R-DRE-430116 GP1b-IX-V activation signalling
Reactome:R-DRE-5621481 C-type lectin receptors (CLRs)
Reactome:R-DRE-1280215 Cytokine Signaling in Immune system
Reactome:R-DRE-449147 Signaling by Interleukins
Reactome:R-DME-111465 Apoptotic cleavage of cellular proteins
Reactome:R-DME-168256 Immune System
Reactome:R-DME-2029482 Regulation of actin dynamics for phagocytic cup formation
Reactome:R-DME-2454202 Fc epsilon receptor (FCERI) signaling
Reactome:R-DME-9020558 Interleukin-2 signaling
Reactome:R-DME-1266695 Interleukin-7 signaling
Reactome:R-DME-416482 G alpha (12/13) signalling events
Reactome:R-DME-194315 Signaling by Rho GTPases
Reactome:R-DME-5663213 RHO GTPases Activate WASPs and WAVEs
Reactome:R-DME-69481 G2/M Checkpoints
Reactome:R-DME-69278 Cell Cycle, Mitotic
Reactome:R-DME-69656 Cyclin A:Cdk2-associated events at S phase entry
Reactome:R-DME-453274 Mitotic G2-G2/M phases
Reactome:R-DME-1266738 Developmental Biology
Reactome:R-DME-376176 Signaling by ROBO receptors
Reactome:R-DME-5693606 DNA Double Strand Break Response
Reactome:R-DME-983231 Factors involved in megakaryocyte development and platelet production
Reactome:R-DME-432553 Phosphorylation of PER and TIM
Reactome:R-DME-209228 Formation of the activated STAT92E dimer and transport to the nucleus
Reactome:R-DME-1660499 Synthesis of PIPs at the plasma membrane
Reactome:R-GGA-354192 Integrin signaling
Reactome:R-GGA-2029485 Role of phospholipids in phagocytosis
Reactome:R-GGA-2871796 FCERI mediated MAPK activation
Reactome:R-GGA-5621481 C-type lectin receptors (CLRs)
Reactome:R-GGA-1280215 Cytokine Signaling in Immune system
Reactome:R-HSA-422475 Axon guidance
Reactome:R-HSA-418885 DCC mediated attractive signaling
Reactome:R-HSA-376176 Signaling by ROBO receptors
Reactome:R-HSA-2682334 EPH-Ephrin signaling
Reactome:R-HSA-418990 Adherens junctions interactions
Reactome:R-HSA-391160 Signal regulatory protein family interactions
Reactome:R-HSA-354192 Integrin signaling
Reactome:R-HSA-111465 Apoptotic cleavage of cellular proteins
Reactome:R-HSA-5693532 DNA Double-Strand Break Repair
Reactome:R-HSA-5693538 Homology Directed Repair
Reactome:R-HSA-177929 Signaling by EGFR
Reactome:R-HSA-180292 GAB1 signalosome
Reactome:R-HSA-9034015 Signaling by NTRK3 (TRKC)
Reactome:R-HSA-9603381 Activated NTRK3 signals through PI3K
Reactome:R-HSA-1227986 Signaling by ERBB2
Reactome:R-HSA-8863795 Downregulation of ERBB2 signaling
Reactome:R-HSA-8875878 MET promotes cell motility
Reactome:R-HSA-416482 G alpha (12/13) signalling events
Reactome:R-HSA-9006925 Intracellular signaling by second messengers
Reactome:R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs
Reactome:R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases
Reactome:R-HSA-8849470 PTK6 Regulates Cell Cycle
Reactome:R-HSA-8857538 PTK6 promotes HIF1A stabilization
Reactome:R-HSA-9027284 Erythropoietin activates RAS
Reactome:R-HSA-3371571 HSF1-dependent transactivation
Reactome:R-HSA-112315 Transmission across Chemical Synapses
Reactome:R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
Reactome:R-HSA-442755 Activation of NMDA receptors and postsynaptic events
Reactome:R-HSA-69620 Cell Cycle Checkpoints
Reactome:R-HSA-69473 G2/M DNA damage checkpoint
Reactome:R-HSA-69206 G1/S Transition
Reactome:R-HSA-392499 Metabolism of proteins
Reactome:R-HSA-597592 Post-translational protein modification
Reactome:R-HSA-2990846 SUMOylation
Reactome:R-HSA-4755510 SUMOylation of immune response proteins
Reactome:R-HSA-5689896 Ovarian tumor domain proteases
Reactome:R-HSA-1643685 Disease
Reactome:R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer
Reactome:R-HSA-162909 Host Interactions of HIV factors
Reactome:R-HSA-168276 NS1 Mediated Effects on Host Pathways
Reactome:R-HSA-169131 Inhibition of PKR
Reactome:R-HSA-5260271 Diseases of Immune System
Reactome:R-HSA-5602498 MyD88 deficiency (TLR2/4)
Reactome:R-HSA-74160 Gene expression (Transcription)
Reactome:R-HSA-73857 RNA Polymerase II Transcription
Reactome:R-HSA-6804757 Regulation of TP53 Degradation
Reactome:R-HSA-8941326 RUNX2 regulates bone development
Reactome:R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains
Reactome:R-HSA-388841 Costimulation by the CD28 family
Reactome:R-HSA-5690714 CD22 mediated BCR regulation
Reactome:R-HSA-1236975 Antigen processing-Cross presentation
Reactome:R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
Reactome:R-HSA-168638 NOD1/2 Signaling Pathway
Reactome:R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
Reactome:R-HSA-2172127 DAP12 interactions
Reactome:R-HSA-2871809 FCERI mediated Ca+2 mobilization
Reactome:R-HSA-5607764 CLEC7A (Dectin-1) signaling
Reactome:R-HSA-5621480 Dectin-2 family
Reactome:R-HSA-909733 Interferon alpha/beta signaling
Reactome:R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes
Reactome:R-HSA-451927 Interleukin-2 family signaling
Reactome:R-HSA-9020958 Interleukin-21 signaling
Reactome:R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
Reactome:R-HSA-1266695 Interleukin-7 signaling
Reactome:R-HSA-1170546 Prolactin receptor signaling
Reactome:R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements
Reactome:R-MMU-1640170 Cell Cycle
Reactome:R-MMU-69481 G2/M Checkpoints
Reactome:R-MMU-69202 Cyclin E associated events during G1/S transition
Reactome:R-MMU-156711 Polo-like kinase mediated events
Reactome:R-MMU-168256 Immune System
Reactome:R-MMU-202430 Translocation of ZAP-70 to Immunological synapse
Reactome:R-MMU-389356 CD28 co-stimulation
Reactome:R-MMU-389948 PD-1 signaling
Reactome:R-MMU-168249 Innate Immune System
Reactome:R-MMU-2029481 FCGR activation
Reactome:R-MMU-2424491 DAP12 signaling
Reactome:R-MMU-2871837 FCERI mediated NF-kB activation
Reactome:R-MMU-913531 Interferon Signaling
Reactome:R-MMU-449147 Signaling by Interleukins
Reactome:R-MMU-8983432 Interleukin-15 signaling
Reactome:R-MMU-6788467 IL-6-type cytokine receptor ligand interactions
Reactome:R-MMU-9020591 Interleukin-12 signaling
Reactome:R-MMU-1170546 Prolactin receptor signaling
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-556833 Metabolism of lipids
Reactome:R-MMU-1483255 PI Metabolism
Reactome:R-MMU-8953854 Metabolism of RNA
Reactome:R-MMU-76002 Platelet activation, signaling and aggregation
Reactome:R-MMU-418592 ADP signalling through P2Y purinoceptor 1
Reactome:R-MMU-76009 Platelet Aggregation (Plug Formation)
Reactome:R-MMU-399954 Sema3A PAK dependent Axon repulsion
Reactome:R-MMU-5357801 Programmed Cell Death
Reactome:R-MMU-391160 Signal regulatory protein family interactions
Reactome:R-MMU-74160 Gene expression (Transcription)
Reactome:R-MMU-73857 RNA Polymerase II Transcription
Reactome:R-MMU-3700989 Transcriptional Regulation by TP53
Reactome:R-MMU-5633007 Regulation of TP53 Activity
Reactome:R-MMU-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
Reactome:R-MMU-212165 Epigenetic regulation of gene expression
Reactome:R-MMU-5250924 B-WICH complex positively regulates rRNA expression
Reactome:R-MMU-162582 Signaling Pathways
Reactome:R-MMU-190236 Signaling by FGFR
Reactome:R-MMU-5654726 Negative regulation of FGFR1 signaling
Reactome:R-MMU-5654727 Negative regulation of FGFR2 signaling
Reactome:R-MMU-166520 Signaling by NTRKs
Reactome:R-MMU-9006115 Signaling by NTRK2 (TRKB)
Reactome:R-MMU-9032759 NTRK2 activates RAC1
Reactome:R-MMU-9603381 Activated NTRK3 signals through PI3K
Reactome:R-MMU-186797 Signaling by PDGF
Reactome:R-MMU-1250196 SHC1 events in ERBB2 signaling
Reactome:R-MMU-1236394 Signaling by ERBB4
Reactome:R-MMU-1253288 Downregulation of ERBB4 signaling
Reactome:R-MMU-388396 GPCR downstream signalling
Reactome:R-MMU-8939211 ESR-mediated signaling
Reactome:R-MMU-6807070 PTEN Regulation
Reactome:R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs
Reactome:R-MMU-9006927 Signaling by Non-Receptor Tyrosine Kinases
Reactome:R-MMU-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Reactome:R-MMU-8849472 PTK6 Down-Regulation
Reactome:R-MMU-209543 p75NTR recruits signalling complexes
Reactome:R-RNO-69620 Cell Cycle Checkpoints
Reactome:R-RNO-69473 G2/M DNA damage checkpoint
Reactome:R-RNO-69275 G2/M Transition
Reactome:R-RNO-5205647 Mitophagy
Reactome:R-RNO-6804757 Regulation of TP53 Degradation
Reactome:R-RNO-8941858 Regulation of RUNX3 expression and activity
Reactome:R-RNO-3371571 HSF1-dependent transactivation
Reactome:R-RNO-162582 Signaling Pathways
Reactome:R-RNO-190236 Signaling by FGFR
Reactome:R-RNO-5654726 Negative regulation of FGFR1 signaling
Reactome:R-RNO-5654727 Negative regulation of FGFR2 signaling
Reactome:R-RNO-166520 Signaling by NTRKs
Reactome:R-RNO-9034015 Signaling by NTRK3 (TRKC)
Reactome:R-RNO-186763 Downstream signal transduction
Reactome:R-RNO-4420097 VEGFA-VEGFR2 Pathway
Reactome:R-RNO-1433557 Signaling by SCF-KIT
Reactome:R-RNO-6806834 Signaling by MET
Reactome:R-RNO-372790 Signaling by GPCR
Reactome:R-RNO-9006931 Signaling by Nuclear Receptors
Reactome:R-RNO-165159 MTOR signalling
Reactome:R-RNO-199991 Membrane Trafficking
Reactome:R-RNO-109582 Hemostasis
Reactome:R-RNO-432142 Platelet sensitization by LDL
Reactome:R-RNO-392518 Signal amplification
Reactome:R-RNO-456926 Thrombin signalling through proteinase activated receptors (PARs)
Reactome:R-RNO-111465 Apoptotic cleavage of cellular proteins
Reactome:R-RNO-1280218 Adaptive Immune System
Reactome:R-RNO-202433 Generation of second messenger molecules
Reactome:R-RNO-389357 CD28 dependent PI3K/Akt signaling
Reactome:R-RNO-983705 B Cell Activation
Reactome:R-RNO-2029485 Role of phospholipids in phagocytosis
Reactome:R-RNO-2871796 FCERI mediated MAPK activation
Reactome:R-RNO-5621481 C-type lectin receptors (CLRs)
Reactome:R-RNO-1169410 Antiviral mechanism by IFN-stimulated genes
Reactome:R-RNO-451927 Interleukin-2 family signaling
Reactome:R-RNO-9020958 Interleukin-21 signaling
Reactome:R-RNO-6785807 Interleukin-4 and Interleukin-13 signaling
Reactome:R-RNO-1266695 Interleukin-7 signaling
Reactome:R-RNO-9020933 Interleukin-23 signaling
Reactome:R-RNO-1266738 Developmental Biology
Reactome:R-RNO-373752 Netrin-1 signaling
Reactome:R-RNO-3928662 EPHB-mediated forward signaling
Reactome:R-RNO-8866376 Reelin signalling pathway
Reactome:R-SSC-373755 Semaphorin interactions
Reactome:R-SSC-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Reactome:R-SSC-9032500 Activated NTRK2 signals through FYN
Reactome:R-SSC-168256 Immune System
Reactome:R-SSC-389356 CD28 co-stimulation
Reactome:R-SSC-913531 Interferon Signaling
Reactome:R-SSC-449147 Signaling by Interleukins
Reactome:R-SSC-6785807 Interleukin-4 and Interleukin-13 signaling
Reactome:R-SSC-9020933 Interleukin-23 signaling
Reactome:R-BTA-354192 Integrin signaling
Reactome:R-BTA-1266738 Developmental Biology
Reactome:R-BTA-202427 Phosphorylation of CD3 and TCR zeta chains
Reactome:R-BTA-388841 Costimulation by the CD28 family
Reactome:R-BTA-168249 Innate Immune System
Reactome:R-BTA-1280215 Cytokine Signaling in Immune system
Reactome:R-BTA-162582 Signaling Pathways
Reactome:R-BTA-4420097 VEGFA-VEGFR2 Pathway
Reactome:R-BTA-193639 p75NTR signals via NF-kB
Reactome:R-CEL-392518 Signal amplification
Reactome:R-CEL-76009 Platelet Aggregation (Plug Formation)
Reactome:R-CEL-168256 Immune System
Reactome:R-CEL-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
Reactome:R-CEL-373753 Nephrin family interactions
Reactome:R-CEL-177929 Signaling by EGFR
Reactome:R-CEL-194138 Signaling by VEGF
Reactome:R-CEL-1251985 Nuclear signaling by ERBB4
Reactome:R-CEL-8874081 MET activates PTK2 signaling
Reactome:R-CEL-9006931 Signaling by Nuclear Receptors
Reactome:R-CEL-194315 Signaling by Rho GTPases
Reactome:R-CEL-5663213 RHO GTPases Activate WASPs and WAVEs
Reactome:R-CEL-1266738 Developmental Biology
Reactome:R-CEL-373752 Netrin-1 signaling
Reactome:R-CEL-3928664 Ephrin signaling
Reactome:R-CEL-212436 Generic Transcription Pathway
Reactome:R-DRE-162582 Signaling Pathways
Reactome:R-DRE-190236 Signaling by FGFR
Reactome:R-DRE-5654726 Negative regulation of FGFR1 signaling
Reactome:R-DRE-5654741 Signaling by FGFR3
Reactome:R-DRE-5218921 VEGFR2 mediated cell proliferation
Reactome:R-DRE-1251985 Nuclear signaling by ERBB4
Reactome:R-DRE-8874081 MET activates PTK2 signaling
Reactome:R-DRE-354192 Integrin signaling
Reactome:R-DRE-5693606 DNA Double Strand Break Response
Reactome:R-DRE-212436 Generic Transcription Pathway
Reactome:R-DRE-373753 Nephrin family interactions
Reactome:R-DRE-76002 Platelet activation, signaling and aggregation
Reactome:R-DRE-418592 ADP signalling through P2Y purinoceptor 1
Reactome:R-DRE-76009 Platelet Aggregation (Plug Formation)
Reactome:R-DRE-5205647 Mitophagy
Reactome:R-DRE-168256 Immune System
Reactome:R-DRE-877300 Interferon gamma signaling
Reactome:R-DRE-6783783 Interleukin-10 signaling
Reactome:R-DME-75153 Apoptotic execution phase
Reactome:R-DME-168249 Innate Immune System
Reactome:R-DME-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
Reactome:R-DME-2424491 DAP12 signaling
Reactome:R-DME-451927 Interleukin-2 family signaling
Reactome:R-DME-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
Reactome:R-DME-162582 Signaling Pathways
Reactome:R-DME-388396 GPCR downstream signalling
Reactome:R-DME-416476 G alpha (q) signalling events
Reactome:R-DME-6807070 PTEN Regulation
Reactome:R-DME-8953897 Cellular responses to stimuli
Reactome:R-DME-69620 Cell Cycle Checkpoints
Reactome:R-DME-69478 G2/M DNA replication checkpoint
Reactome:R-DME-69242 S Phase
Reactome:R-DME-69273 Cyclin A/B1/B2 associated events during G2/M transition
Reactome:R-DME-428890 Role of ABL in ROBO-SLIT signaling
Reactome:R-DME-73894 DNA Repair
Reactome:R-DME-5693532 DNA Double-Strand Break Repair
Reactome:R-DME-8878171 Transcriptional regulation by RUNX1
Reactome:R-DME-109582 Hemostasis
Reactome:R-DME-209209 Formation of the activated receptor complex
Reactome:R-DME-210688 Dephosphorylation by PTP61F phosphatases
Reactome:R-DME-1430728 Metabolism
Reactome:R-DME-1483257 Phospholipid metabolism
Reactome:R-GGA-76002 Platelet activation, signaling and aggregation
Reactome:R-GGA-76009 Platelet Aggregation (Plug Formation)
Reactome:R-GGA-168249 Innate Immune System
Reactome:R-GGA-2029482 Regulation of actin dynamics for phagocytic cup formation
Reactome:R-GGA-2454202 Fc epsilon receptor (FCERI) signaling
Reactome:R-GGA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
Reactome:R-HSA-1266738 Developmental Biology
Reactome:R-HSA-399956 CRMPs in Sema3A signaling
Reactome:R-HSA-373752 Netrin-1 signaling
Reactome:R-HSA-525793 Myogenesis
Reactome:R-HSA-421270 Cell-cell junction organization
Reactome:R-HSA-76002 Platelet activation, signaling and aggregation
Reactome:R-HSA-76009 Platelet Aggregation (Plug Formation)
Reactome:R-HSA-556833 Metabolism of lipids
Reactome:R-HSA-75153 Apoptotic execution phase
Reactome:R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Reactome:R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-HSA-194138 Signaling by VEGF
Reactome:R-HSA-5218920 VEGFR2 mediated vascular permeability
Reactome:R-HSA-8847993 ERBB2 Activates PTK6 Signaling
Reactome:R-HSA-6806834 Signaling by MET
Reactome:R-HSA-372790 Signaling by GPCR
Reactome:R-HSA-418555 G alpha (s) signalling events
Reactome:R-HSA-9006931 Signaling by Nuclear Receptors
Reactome:R-HSA-8948751 Regulation of PTEN stability and activity
Reactome:R-HSA-195258 RHO GTPase Effectors
Reactome:R-HSA-8849474 PTK6 Activates STAT3
Reactome:R-HSA-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
Reactome:R-HSA-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Reactome:R-HSA-2262752 Cellular responses to stress
Reactome:R-HSA-1640170 Cell Cycle
Reactome:R-HSA-69481 G2/M Checkpoints
Reactome:R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry
Reactome:R-HSA-453274 Mitotic G2-G2/M phases
Reactome:R-HSA-162906 HIV Infection
Reactome:R-HSA-164938 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
Reactome:R-HSA-3214858 RMTs methylate histone arginines
Reactome:R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
Reactome:R-HSA-8939245 RUNX1 regulates transcription of genes involved in BCR signaling
Reactome:R-HSA-212165 Epigenetic regulation of gene expression
Reactome:R-HSA-5250924 B-WICH complex positively regulates rRNA expression
Reactome:R-HSA-202403 TCR signaling
Reactome:R-HSA-202424 Downstream TCR signaling
Reactome:R-HSA-389359 CD28 dependent Vav1 pathway
Reactome:R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome:R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
Reactome:R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Reactome:R-HSA-2029485 Role of phospholipids in phagocytosis
Reactome:R-HSA-2871796 FCERI mediated MAPK activation
Reactome:R-HSA-5621481 C-type lectin receptors (CLRs)
Reactome:R-HSA-913531 Interferon Signaling
Reactome:R-HSA-449147 Signaling by Interleukins
Reactome:R-HSA-8983432 Interleukin-15 signaling
Reactome:R-HSA-6788467 IL-6-type cytokine receptor ligand interactions
Reactome:R-HSA-9020591 Interleukin-12 signaling
Reactome:R-HSA-8984722 Interleukin-35 Signalling
Reactome:R-HSA-982772 Growth hormone receptor signaling
Reactome:R-MMU-69478 G2/M DNA replication checkpoint
Reactome:R-MMU-453279 Mitotic G1 phase and G1/S transition
Reactome:R-MMU-69206 G1/S Transition
Reactome:R-MMU-69656 Cyclin A:Cdk2-associated events at S phase entry
Reactome:R-MMU-453274 Mitotic G2-G2/M phases
Reactome:R-MMU-202427 Phosphorylation of CD3 and TCR zeta chains
Reactome:R-MMU-388841 Costimulation by the CD28 family
Reactome:R-MMU-5690714 CD22 mediated BCR regulation
Reactome:R-MMU-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
Reactome:R-MMU-2172127 DAP12 interactions
Reactome:R-MMU-2871809 FCERI mediated Ca+2 mobilization
Reactome:R-MMU-5607764 CLEC7A (Dectin-1) signaling
Reactome:R-MMU-1280215 Cytokine Signaling in Immune system
Reactome:R-MMU-877300 Interferon gamma signaling
Reactome:R-MMU-8985947 Interleukin-9 signaling
Reactome:R-MMU-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
Reactome:R-MMU-447115 Interleukin-12 family signaling
Reactome:R-MMU-8984722 Interleukin-35 Signalling
Reactome:R-MMU-982772 Growth hormone receptor signaling
Reactome:R-MMU-5693606 DNA Double Strand Break Response
Reactome:R-MMU-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Reactome:R-MMU-5685938 HDR through Single Strand Annealing (SSA)
Reactome:R-MMU-70171 Glycolysis
Reactome:R-MMU-1660499 Synthesis of PIPs at the plasma membrane
Reactome:R-MMU-70268 Pyruvate metabolism
Reactome:R-MMU-450531 Regulation of mRNA stability by proteins that bind AU-rich elements
Reactome:R-MMU-450520 HuR (ELAVL1) binds and stabilizes mRNA
Reactome:R-MMU-418346 Platelet homeostasis
Reactome:R-MMU-75892 Platelet Adhesion to exposed collagen
Reactome:R-MMU-114604 GPVI-mediated activation cascade
Reactome:R-MMU-372708 p130Cas linkage to MAPK signaling for integrins
Reactome:R-MMU-983231 Factors involved in megakaryocyte development and platelet production
Reactome:R-MMU-373755 Semaphorin interactions
Reactome:R-MMU-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Reactome:R-MMU-375165 NCAM signaling for neurite out-growth
Reactome:R-MMU-437239 Recycling pathway of L1
Reactome:R-MMU-2682334 EPH-Ephrin signaling
Reactome:R-MMU-111465 Apoptotic cleavage of cellular proteins
Reactome:R-MMU-3371571 HSF1-dependent transactivation
Reactome:R-MMU-6804757 Regulation of TP53 Degradation
Reactome:R-MMU-5250913 Positive epigenetic regulation of rRNA expression
Reactome:R-MMU-5654743 Signaling by FGFR4
Reactome:R-MMU-5654733 Negative regulation of FGFR4 signaling
Reactome:R-MMU-9032500 Activated NTRK2 signals through FYN
Reactome:R-MMU-5218921 VEGFR2 mediated cell proliferation
Reactome:R-MMU-1227986 Signaling by ERBB2
Reactome:R-MMU-1251985 Nuclear signaling by ERBB4
Reactome:R-MMU-8874081 MET activates PTK2 signaling
Reactome:R-MMU-418594 G alpha (i) signalling events
Reactome:R-MMU-1257604 PI3K/AKT Signaling
Reactome:R-MMU-8948751 Regulation of PTEN stability and activity
Reactome:R-MMU-195258 RHO GTPase Effectors
Reactome:R-MMU-8849470 PTK6 Regulates Cell Cycle
Reactome:R-MMU-8857538 PTK6 promotes HIF1A stabilization
Reactome:R-MMU-193639 p75NTR signals via NF-kB
Reactome:R-MMU-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Reactome:R-MMU-5205647 Mitophagy
Reactome:R-RNO-1640170 Cell Cycle
Reactome:R-RNO-69481 G2/M Checkpoints
Reactome:R-RNO-69202 Cyclin E associated events during G1/S transition
Reactome:R-RNO-156711 Polo-like kinase mediated events
Reactome:R-RNO-8878159 Transcriptional regulation by RUNX3
Reactome:R-RNO-8953897 Cellular responses to stimuli
Reactome:R-RNO-2262752 Cellular responses to stress
Reactome:R-RNO-5654743 Signaling by FGFR4
Reactome:R-RNO-5654733 Negative regulation of FGFR4 signaling
Reactome:R-RNO-9006115 Signaling by NTRK2 (TRKB)
Reactome:R-RNO-9032759 NTRK2 activates RAC1
Reactome:R-RNO-9603381 Activated NTRK3 signals through PI3K
Reactome:R-RNO-186797 Signaling by PDGF
Reactome:R-RNO-1236394 Signaling by ERBB4
Reactome:R-RNO-1253288 Downregulation of ERBB4 signaling
Reactome:R-RNO-388396 GPCR downstream signalling
Reactome:R-RNO-372708 p130Cas linkage to MAPK signaling for integrins
Reactome:R-RNO-8939211 ESR-mediated signaling
Reactome:R-RNO-6807070 PTEN Regulation
Reactome:R-RNO-5653656 Vesicle-mediated transport
Reactome:R-RNO-157858 Gap junction trafficking and regulation
Reactome:R-RNO-191650 Regulation of gap junction activity
Reactome:R-RNO-430116 GP1b-IX-V activation signalling
Reactome:R-RNO-983231 Factors involved in megakaryocyte development and platelet production
Reactome:R-RNO-75153 Apoptotic execution phase
Reactome:R-RNO-168256 Immune System
Reactome:R-RNO-202430 Translocation of ZAP-70 to Immunological synapse
Reactome:R-RNO-389356 CD28 co-stimulation
Reactome:R-RNO-389948 PD-1 signaling
Reactome:R-RNO-168249 Innate Immune System
Reactome:R-RNO-2029482 Regulation of actin dynamics for phagocytic cup formation
Reactome:R-RNO-2454202 Fc epsilon receptor (FCERI) signaling
Reactome:R-RNO-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
Reactome:R-RNO-913531 Interferon Signaling
Reactome:R-RNO-449147 Signaling by Interleukins
Reactome:R-RNO-8983432 Interleukin-15 signaling
Reactome:R-RNO-9020591 Interleukin-12 signaling
Reactome:R-RNO-1170546 Prolactin receptor signaling
Reactome:R-SSC-422475 Axon guidance
Reactome:R-SSC-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-SSC-194138 Signaling by VEGF
Reactome:R-SSC-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Reactome:R-SSC-388841 Costimulation by the CD28 family
Reactome:R-SSC-1280215 Cytokine Signaling in Immune system
Reactome:R-SSC-877300 Interferon gamma signaling
Reactome:R-SSC-9020591 Interleukin-12 signaling
Reactome:R-SSC-1170546 Prolactin receptor signaling
Reactome:R-BTA-392499 Metabolism of proteins
Reactome:R-BTA-5688426 Deubiquitination
Reactome:R-BTA-381119 Unfolded Protein Response (UPR)
Reactome:R-BTA-381042 PERK regulates gene expression
Reactome:R-BTA-75892 Platelet Adhesion to exposed collagen
Reactome:R-BTA-114604 GPVI-mediated activation cascade
Reactome:R-BTA-373755 Semaphorin interactions
Reactome:R-BTA-1280218 Adaptive Immune System
Reactome:R-BTA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Reactome:R-BTA-177929 Signaling by EGFR
Reactome:R-BTA-73887 Death Receptor Signaling
Reactome:R-BTA-193704 p75 NTR receptor-mediated signalling
Reactome:R-CEL-109582 Hemostasis
Reactome:R-CEL-76002 Platelet activation, signaling and aggregation
Reactome:R-CEL-456926 Thrombin signalling through proteinase activated receptors (PARs)
Reactome:R-CEL-5621481 C-type lectin receptors (CLRs)
Reactome:R-CEL-5621575 CD209 (DC-SIGN) signaling
Reactome:R-CEL-1632852 Macroautophagy
Reactome:R-CEL-162582 Signaling Pathways
Reactome:R-CEL-1227986 Signaling by ERBB2
Reactome:R-CEL-1236394 Signaling by ERBB4
Reactome:R-CEL-6806834 Signaling by MET
Reactome:R-CEL-1257604 PI3K/AKT Signaling
Reactome:R-CEL-8948751 Regulation of PTEN stability and activity
Reactome:R-CEL-195258 RHO GTPase Effectors
Reactome:R-CEL-373755 Semaphorin interactions
Reactome:R-CEL-373760 L1CAM interactions
Reactome:R-CEL-2682334 EPH-Ephrin signaling
Reactome:R-CEL-74160 Gene expression (Transcription)
Reactome:R-CEL-8941858 Regulation of RUNX3 expression and activity
Reactome:R-DRE-5653656 Vesicle-mediated transport
Reactome:R-DRE-157858 Gap junction trafficking and regulation
Reactome:R-DRE-191650 Regulation of gap junction activity
Reactome:R-DRE-177929 Signaling by EGFR
Reactome:R-DRE-5654743 Signaling by FGFR4
Reactome:R-DRE-5654733 Negative regulation of FGFR4 signaling
Reactome:R-DRE-186763 Downstream signal transduction
Reactome:R-DRE-4420097 VEGFA-VEGFR2 Pathway
Reactome:R-DRE-6806834 Signaling by MET
Reactome:R-DRE-418594 G alpha (i) signalling events
Reactome:R-DRE-8939211 ESR-mediated signaling
Reactome:R-DRE-73894 DNA Repair
Reactome:R-DRE-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Reactome:R-DRE-8941858 Regulation of RUNX3 expression and activity
Reactome:R-DRE-109582 Hemostasis
Reactome:R-DRE-392518 Signal amplification
Reactome:R-DRE-456926 Thrombin signalling through proteinase activated receptors (PARs)
Reactome:R-DRE-8934903 Receptor Mediated Mitophagy
Reactome:R-DRE-5621480 Dectin-2 family
Reactome:R-DRE-913531 Interferon Signaling
Reactome:R-DRE-8983432 Interleukin-15 signaling
Reactome:R-DME-5357801 Programmed Cell Death
Reactome:R-DME-8985947 Interleukin-9 signaling
Reactome:R-DME-6785807 Interleukin-4 and Interleukin-13 signaling
Reactome:R-DME-372790 Signaling by GPCR
Reactome:R-DME-9006925 Intracellular signaling by second messengers
Reactome:R-DME-69473 G2/M DNA damage checkpoint
Reactome:R-DME-453279 Mitotic G1 phase and G1/S transition
Reactome:R-DME-69206 G1/S Transition
Reactome:R-DME-156711 Polo-like kinase mediated events
Reactome:R-DME-422475 Axon guidance
Reactome:R-DME-74160 Gene expression (Transcription)
Reactome:R-DME-73857 RNA Polymerase II Transcription
Reactome:R-DME-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
Reactome:R-DME-212165 Epigenetic regulation of gene expression
Reactome:R-DME-5252538 Drosophila signaling pathways
Reactome:R-DME-1483255 PI Metabolism
Reactome:R-GGA-109582 Hemostasis
Reactome:R-GGA-432142 Platelet sensitization by LDL
Reactome:R-GGA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
Reactome:R-GGA-2871809 FCERI mediated Ca+2 mobilization
Reactome:R-GGA-5621480 Dectin-2 family
Reactome:R-HSA-373755 Semaphorin interactions
Reactome:R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Reactome:R-HSA-375165 NCAM signaling for neurite out-growth
Reactome:R-HSA-418886 Netrin mediated repulsion signals
Reactome:R-HSA-1500931 Cell-Cell communication
Reactome:R-HSA-373753 Nephrin family interactions
Reactome:R-HSA-109582 Hemostasis
Reactome:R-HSA-432142 Platelet sensitization by LDL
Reactome:R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
Reactome:R-HSA-1483257 Phospholipid metabolism
Reactome:R-HSA-1483255 PI Metabolism
Reactome:R-HSA-1660499 Synthesis of PIPs at the plasma membrane
Reactome:R-HSA-5357801 Programmed Cell Death
Reactome:R-HSA-5693606 DNA Double Strand Break Response
Reactome:R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Reactome:R-HSA-5685938 HDR through Single Strand Annealing (SSA)
Reactome:R-HSA-186797 Signaling by PDGF
Reactome:R-HSA-1250196 SHC1 events in ERBB2 signaling
Reactome:R-HSA-1251985 Nuclear signaling by ERBB4
Reactome:R-HSA-8874081 MET activates PTK2 signaling
Reactome:R-HSA-418594 G alpha (i) signalling events
Reactome:R-HSA-416476 G alpha (q) signalling events
Reactome:R-HSA-397795 G-protein beta:gamma signalling
Reactome:R-HSA-2586552 Signaling by Leptin
Reactome:R-HSA-1257604 PI3K/AKT Signaling
Reactome:R-HSA-194315 Signaling by Rho GTPases
Reactome:R-HSA-8848021 Signaling by PTK6
Reactome:R-HSA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Reactome:R-HSA-8849472 PTK6 Down-Regulation
Reactome:R-HSA-193639 p75NTR signals via NF-kB
Reactome:R-HSA-9006335 Signaling by Erythropoietin
Reactome:R-HSA-9027277 Erythropoietin activates Phospholipase C gamma (PLCG)
Reactome:R-HSA-112316 Neuronal System
Reactome:R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Reactome:R-HSA-69278 Cell Cycle, Mitotic
Reactome:R-HSA-69202 Cyclin E associated events during G1/S transition
Reactome:R-HSA-69275 G2/M Transition
Reactome:R-HSA-156711 Polo-like kinase mediated events
Reactome:R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
Reactome:R-HSA-5688426 Deubiquitination
Reactome:R-HSA-381119 Unfolded Protein Response (UPR)
Reactome:R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
Reactome:R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis
Reactome:R-HSA-8876384 Listeria monocytogenes entry into host cells
Reactome:R-HSA-5602358 Defects in Toll-like Receptor Cascades
Reactome:R-HSA-4839726 Chromatin organization
Reactome:R-HSA-212436 Generic Transcription Pathway
Reactome:R-HSA-3700989 Transcriptional Regulation by TP53
Reactome:R-HSA-5633007 Regulation of TP53 Activity
Reactome:R-HSA-8878171 Transcriptional regulation by RUNX1
Reactome:R-HSA-8940973 RUNX2 regulates osteoblast differentiation
Reactome:R-HSA-8878159 Transcriptional regulation by RUNX3
Reactome:R-HSA-168256 Immune System
Reactome:R-HSA-202430 Translocation of ZAP-70 to Immunological synapse
Reactome:R-HSA-389356 CD28 co-stimulation
Reactome:R-HSA-389948 PD-1 signaling
Reactome:R-HSA-983169 Class I MHC mediated antigen processing & presentation
Reactome:R-HSA-168249 Innate Immune System
Reactome:R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
Reactome:R-HSA-2029481 FCGR activation
Reactome:R-HSA-2424491 DAP12 signaling
Reactome:R-HSA-2871837 FCERI mediated NF-kB activation
Reactome:R-HSA-912694 Regulation of IFNA/IFNB signaling
Reactome:R-HSA-9020558 Interleukin-2 signaling
Reactome:R-HSA-6783589 Interleukin-6 family signaling
Reactome:R-HSA-6783783 Interleukin-10 signaling
Reactome:R-HSA-9020933 Interleukin-23 signaling
Reactome:R-HSA-8854691 Interleukin-20 family signaling
Reactome:R-HSA-8953854 Metabolism of RNA
Reactome:R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA
Reactome:R-MMU-69620 Cell Cycle Checkpoints
Reactome:R-MMU-69473 G2/M DNA damage checkpoint
Reactome:R-MMU-187577 SCF(Skp2)-mediated degradation of p27/p21
Reactome:R-MMU-69275 G2/M Transition
Reactome:R-MMU-1280218 Adaptive Immune System
Reactome:R-MMU-202433 Generation of second messenger molecules
Reactome:R-MMU-389357 CD28 dependent PI3K/Akt signaling
Reactome:R-MMU-983705 B Cell Activation
Reactome:R-MMU-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Reactome:R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
Reactome:R-MMU-2454202 Fc epsilon receptor (FCERI) signaling
Reactome:R-MMU-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
Reactome:R-MMU-909733 Interferon alpha/beta signaling
Reactome:R-MMU-1169410 Antiviral mechanism by IFN-stimulated genes
Reactome:R-MMU-451927 Interleukin-2 family signaling
Reactome:R-MMU-9020958 Interleukin-21 signaling
Reactome:R-MMU-6785807 Interleukin-4 and Interleukin-13 signaling
Reactome:R-MMU-1266695 Interleukin-7 signaling
Reactome:R-MMU-9020933 Interleukin-23 signaling
Reactome:R-MMU-8854691 Interleukin-20 family signaling
Reactome:R-MMU-73894 DNA Repair
Reactome:R-MMU-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Reactome:R-MMU-71387 Carbohydrate metabolism
Reactome:R-MMU-70326 Glucose metabolism
Reactome:R-MMU-1483257 Phospholipid metabolism
Reactome:R-MMU-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-MMU-430116 GP1b-IX-V activation signalling
Reactome:R-MMU-354192 Integrin signaling
Reactome:R-MMU-1266738 Developmental Biology
Reactome:R-MMU-399956 CRMPs in Sema3A signaling
Reactome:R-MMU-373752 Netrin-1 signaling
Reactome:R-MMU-3928662 EPHB-mediated forward signaling
Reactome:R-MMU-8866376 Reelin signalling pathway
Reactome:R-MMU-109581 Apoptosis
Reactome:R-MMU-1632852 Macroautophagy
Reactome:R-MMU-3371556 Cellular response to heat stress
Reactome:R-MMU-1500931 Cell-Cell communication
Reactome:R-MMU-373753 Nephrin family interactions
Reactome:R-MMU-212436 Generic Transcription Pathway
Reactome:R-MMU-6806003 Regulation of TP53 Expression and Degradation
Reactome:R-MMU-8878159 Transcriptional regulation by RUNX3
Reactome:R-MMU-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-MMU-5654736 Signaling by FGFR1
Reactome:R-MMU-1295596 Spry regulation of FGF signaling
Reactome:R-MMU-5654741 Signaling by FGFR3
Reactome:R-MMU-9034015 Signaling by NTRK3 (TRKC)
Reactome:R-MMU-186763 Downstream signal transduction
Reactome:R-MMU-4420097 VEGFA-VEGFR2 Pathway
Reactome:R-MMU-1433557 Signaling by SCF-KIT
Reactome:R-MMU-8847993 ERBB2 Activates PTK6 Signaling
Reactome:R-MMU-6806834 Signaling by MET
Reactome:R-MMU-372790 Signaling by GPCR
Reactome:R-MMU-416482 G alpha (12/13) signalling events
Reactome:R-MMU-9006931 Signaling by Nuclear Receptors
Reactome:R-MMU-194315 Signaling by Rho GTPases
Reactome:R-MMU-8848021 Signaling by PTK6
Reactome:R-MMU-8849468 PTK6 Regulates Proteins Involved in RNA Processing
Reactome:R-MMU-165159 MTOR signalling
Reactome:R-MMU-73887 Death Receptor Signaling
Reactome:R-MMU-193704 p75 NTR receptor-mediated signalling
Reactome:R-MMU-392499 Metabolism of proteins
Reactome:R-MMU-597592 Post-translational protein modification
Reactome:R-MMU-5689896 Ovarian tumor domain proteases
Reactome:R-MMU-5653656 Vesicle-mediated transport
Reactome:R-MMU-157858 Gap junction trafficking and regulation
Reactome:R-MMU-191650 Regulation of gap junction activity
Reactome:R-MMU-8934903 Receptor Mediated Mitophagy
Reactome:R-RNO-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Reactome:R-RNO-69278 Cell Cycle, Mitotic
Reactome:R-RNO-69242 S Phase
Reactome:R-RNO-69273 Cyclin A/B1/B2 associated events during G2/M transition
Reactome:R-RNO-381119 Unfolded Protein Response (UPR)
Reactome:R-RNO-381042 PERK regulates gene expression
Reactome:R-RNO-74160 Gene expression (Transcription)
Reactome:R-RNO-73857 RNA Polymerase II Transcription
Reactome:R-RNO-3700989 Transcriptional Regulation by TP53
Reactome:R-RNO-5633007 Regulation of TP53 Activity
Reactome:R-RNO-391160 Signal regulatory protein family interactions
Reactome:R-RNO-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-RNO-5654736 Signaling by FGFR1
Reactome:R-RNO-1295596 Spry regulation of FGF signaling
Reactome:R-RNO-5654741 Signaling by FGFR3
Reactome:R-RNO-194138 Signaling by VEGF
Reactome:R-RNO-5218920 VEGFR2 mediated vascular permeability
Reactome:R-RNO-8875878 MET promotes cell motility
Reactome:R-RNO-354192 Integrin signaling
Reactome:R-RNO-9006925 Intracellular signaling by second messengers
Reactome:R-RNO-9006335 Signaling by Erythropoietin
Reactome:R-RNO-418346 Platelet homeostasis
Reactome:R-RNO-75892 Platelet Adhesion to exposed collagen
Reactome:R-RNO-114604 GPVI-mediated activation cascade
Reactome:R-RNO-5357801 Programmed Cell Death
Reactome:R-RNO-202403 TCR signaling
Reactome:R-RNO-202424 Downstream TCR signaling
Reactome:R-RNO-389359 CD28 dependent Vav1 pathway
Reactome:R-RNO-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome:R-RNO-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
Reactome:R-RNO-2172127 DAP12 interactions
Reactome:R-RNO-2871809 FCERI mediated Ca+2 mobilization
Reactome:R-RNO-5607764 CLEC7A (Dectin-1) signaling
Reactome:R-RNO-9020558 Interleukin-2 signaling
Reactome:R-RNO-422475 Axon guidance
Reactome:R-RNO-418885 DCC mediated attractive signaling
Reactome:R-RNO-373760 L1CAM interactions
Reactome:R-SSC-1500931 Cell-Cell communication
Reactome:R-SSC-373753 Nephrin family interactions
Reactome:R-SSC-9006115 Signaling by NTRK2 (TRKB)
Reactome:R-SSC-9032759 NTRK2 activates RAC1
Reactome:R-SSC-109582 Hemostasis
Reactome:R-SSC-983231 Factors involved in megakaryocyte development and platelet production
Reactome:R-SSC-1280218 Adaptive Immune System
Reactome:R-BTA-76002 Platelet activation, signaling and aggregation
Reactome:R-BTA-76009 Platelet Aggregation (Plug Formation)
Reactome:R-BTA-8866376 Reelin signalling pathway
Reactome:R-BTA-202403 TCR signaling
Reactome:R-BTA-202424 Downstream TCR signaling
Reactome:R-BTA-389359 CD28 dependent Vav1 pathway
Reactome:R-BTA-168638 NOD1/2 Signaling Pathway
Reactome:R-CEL-418346 Platelet homeostasis
Reactome:R-CEL-430116 GP1b-IX-V activation signalling
Reactome:R-CEL-168249 Innate Immune System
Reactome:R-CEL-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-CEL-8875878 MET promotes cell motility
Reactome:R-CEL-372790 Signaling by GPCR
Reactome:R-CEL-418594 G alpha (i) signalling events
Reactome:R-CEL-8939211 ESR-mediated signaling
Reactome:R-CEL-6807070 PTEN Regulation
Reactome:R-CEL-437239 Recycling pathway of L1
Reactome:R-CEL-5205647 Mitophagy
Reactome:R-CEL-73857 RNA Polymerase II Transcription
Reactome:R-CEL-8878171 Transcriptional regulation by RUNX1
Reactome:R-DRE-199991 Membrane Trafficking
Reactome:R-DRE-5654727 Negative regulation of FGFR2 signaling
Reactome:R-DRE-194138 Signaling by VEGF
Reactome:R-DRE-8875878 MET promotes cell motility
Reactome:R-DRE-388396 GPCR downstream signalling
Reactome:R-DRE-9006931 Signaling by Nuclear Receptors
Reactome:R-DRE-5693532 DNA Double-Strand Break Repair
Reactome:R-DRE-74160 Gene expression (Transcription)
Reactome:R-DRE-73857 RNA Polymerase II Transcription
Reactome:R-DRE-168249 Innate Immune System
Reactome:R-DRE-5621575 CD209 (DC-SIGN) signaling
Reactome:R-DRE-909733 Interferon alpha/beta signaling
Reactome:R-DRE-451927 Interleukin-2 family signaling
Reactome:R-DRE-9020958 Interleukin-21 signaling
Reactome:R-DRE-6785807 Interleukin-4 and Interleukin-13 signaling
Reactome:R-DRE-8854691 Interleukin-20 family signaling
Reactome:R-DME-109581 Apoptosis
Reactome:R-DME-2172127 DAP12 interactions
Reactome:R-DME-2871809 FCERI mediated Ca+2 mobilization
Reactome:R-DME-1280215 Cytokine Signaling in Immune system
Reactome:R-DME-449147 Signaling by Interleukins
Reactome:R-DME-1257604 PI3K/AKT Signaling
Reactome:R-DME-8948751 Regulation of PTEN stability and activity
Reactome:R-DME-195258 RHO GTPase Effectors
Reactome:R-DME-1640170 Cell Cycle
Reactome:R-DME-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Reactome:R-DME-69202 Cyclin E associated events during G1/S transition
Reactome:R-DME-69275 G2/M Transition
Reactome:R-DME-525793 Myogenesis
Reactome:R-DME-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Reactome:R-DME-212436 Generic Transcription Pathway
Reactome:R-DME-432626 Circadian Clock pathway
Reactome:R-DME-209405 JAK/STAT pathway
Reactome:R-DME-556833 Metabolism of lipids
Reactome:R-GGA-162582 Signaling Pathways
Reactome:R-GGA-418346 Platelet homeostasis
Reactome:R-GGA-114604 GPVI-mediated activation cascade
Reactome:R-GGA-168256 Immune System
Reactome:R-HSA-399954 Sema3A PAK dependent Axon repulsion
Reactome:R-HSA-428542 Regulation of commissural axon pathfinding by SLIT and ROBO
Reactome:R-HSA-3928662 EPHB-mediated forward signaling
Reactome:R-HSA-8866376 Reelin signalling pathway
Reactome:R-HSA-446728 Cell junction organization
Reactome:R-HSA-418346 Platelet homeostasis
Reactome:R-HSA-75892 Platelet Adhesion to exposed collagen
Reactome:R-HSA-114604 GPVI-mediated activation cascade
Reactome:R-HSA-372708 p130Cas linkage to MAPK signaling for integrins
Reactome:R-HSA-202733 Cell surface interactions at the vascular wall
Reactome:R-HSA-983231 Factors involved in megakaryocyte development and platelet production
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-109581 Apoptosis
Reactome:R-HSA-73894 DNA Repair
Reactome:R-HSA-162582 Signaling Pathways
Reactome:R-HSA-166520 Signaling by NTRKs
Reactome:R-HSA-186763 Downstream signal transduction
Reactome:R-HSA-4420097 VEGFA-VEGFR2 Pathway
Reactome:R-HSA-1433557 Signaling by SCF-KIT
Reactome:R-HSA-1236394 Signaling by ERBB4
Reactome:R-HSA-1253288 Downregulation of ERBB4 signaling
Reactome:R-HSA-388396 GPCR downstream signalling
Reactome:R-HSA-8939211 ESR-mediated signaling
Reactome:R-HSA-6807070 PTEN Regulation
Reactome:R-HSA-8849473 PTK6 Expression
Reactome:R-HSA-8849468 PTK6 Regulates Proteins Involved in RNA Processing
Reactome:R-HSA-165159 MTOR signalling
Reactome:R-HSA-73887 Death Receptor Signaling
Reactome:R-HSA-193704 p75 NTR receptor-mediated signalling
Reactome:R-HSA-209543 p75NTR recruits signalling complexes
Reactome:R-HSA-9027283 Erythropoietin activates STAT5
Reactome:R-HSA-8953897 Cellular responses to stimuli
Reactome:R-HSA-3371556 Cellular response to heat stress
Reactome:R-HSA-438064 Post NMDA receptor activation events
Reactome:R-HSA-69478 G2/M DNA replication checkpoint
Reactome:R-HSA-453279 Mitotic G1 phase and G1/S transition
Reactome:R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21
Reactome:R-HSA-69242 S Phase
Reactome:R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition
Reactome:R-HSA-381042 PERK regulates gene expression
Reactome:R-HSA-2219528 PI3K/AKT Signaling in Cancer
Reactome:R-HSA-5663205 Infectious disease
Reactome:R-HSA-164944 Nef and signal transduction
Reactome:R-HSA-167590 Nef Mediated CD4 Down-regulation
Reactome:R-HSA-168255 Influenza Infection
Reactome:R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells
Reactome:R-HSA-5603041 IRAK4 deficiency (TLR2/4)
Reactome:R-HSA-3247509 Chromatin modifying enzymes
Reactome:R-HSA-6806003 Regulation of TP53 Expression and Degradation
Reactome:R-HSA-8934593 Regulation of RUNX1 Expression and Activity
Reactome:R-HSA-8878166 Transcriptional regulation by RUNX2
Reactome:R-HSA-8941858 Regulation of RUNX3 expression and activity
Reactome:R-HSA-5250913 Positive epigenetic regulation of rRNA expression
Reactome:R-HSA-1280218 Adaptive Immune System
Reactome:R-HSA-202433 Generation of second messenger molecules
Reactome:R-HSA-389357 CD28 dependent PI3K/Akt signaling
Reactome:R-HSA-983705 B Cell Activation
Reactome:R-HSA-1236974 ER-Phagosome pathway
Reactome:R-HSA-168898 Toll-like Receptor Cascades
Reactome:R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Reactome:R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
Reactome:R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
Reactome:R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
Reactome:R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
Reactome:R-HSA-1280215 Cytokine Signaling in Immune system
Reactome:R-HSA-877300 Interferon gamma signaling
Reactome:R-HSA-8985947 Interleukin-9 signaling
Reactome:R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
Reactome:R-HSA-447115 Interleukin-12 family signaling
Reactome:R-HSA-9020956 Interleukin-27 signaling
Reactome:R-HSA-449836 Other interleukin signaling
Reactome:R-MMU-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Reactome:R-MMU-69278 Cell Cycle, Mitotic
Reactome:R-MMU-69242 S Phase
Reactome:R-MMU-69273 Cyclin A/B1/B2 associated events during G2/M transition
Reactome:R-MMU-202403 TCR signaling
Reactome:R-MMU-202424 Downstream TCR signaling
Reactome:R-MMU-389359 CD28 dependent Vav1 pathway
Reactome:R-MMU-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome:R-MMU-168638 NOD1/2 Signaling Pathway
Reactome:R-MMU-2029485 Role of phospholipids in phagocytosis
Reactome:R-MMU-2871796 FCERI mediated MAPK activation
Reactome:R-MMU-5621481 C-type lectin receptors (CLRs)
Reactome:R-MMU-912694 Regulation of IFNA/IFNB signaling
Reactome:R-MMU-9020558 Interleukin-2 signaling
Reactome:R-MMU-6783589 Interleukin-6 family signaling
Reactome:R-MMU-6783783 Interleukin-10 signaling
Reactome:R-MMU-9020956 Interleukin-27 signaling
Reactome:R-MMU-5693532 DNA Double-Strand Break Repair
Reactome:R-MMU-5693538 Homology Directed Repair
Reactome:R-MMU-109582 Hemostasis
Reactome:R-MMU-432142 Platelet sensitization by LDL
Reactome:R-MMU-392518 Signal amplification
Reactome:R-MMU-456926 Thrombin signalling through proteinase activated receptors (PARs)
Reactome:R-MMU-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
Reactome:R-MMU-422475 Axon guidance
Reactome:R-MMU-418885 DCC mediated attractive signaling
Reactome:R-MMU-373760 L1CAM interactions
Reactome:R-MMU-525793 Myogenesis
Reactome:R-MMU-75153 Apoptotic execution phase
Reactome:R-MMU-8953897 Cellular responses to stimuli
Reactome:R-MMU-2262752 Cellular responses to stress
Reactome:R-MMU-8878171 Transcriptional regulation by RUNX1
Reactome:R-MMU-8941858 Regulation of RUNX3 expression and activity
Reactome:R-MMU-177929 Signaling by EGFR
Reactome:R-MMU-180292 GAB1 signalosome
Reactome:R-MMU-5654738 Signaling by FGFR2
Reactome:R-MMU-5654732 Negative regulation of FGFR3 signaling
Reactome:R-MMU-194138 Signaling by VEGF
Reactome:R-MMU-5218920 VEGFR2 mediated vascular permeability
Reactome:R-MMU-8863795 Downregulation of ERBB2 signaling
Reactome:R-MMU-8875878 MET promotes cell motility
Reactome:R-MMU-416476 G alpha (q) signalling events
Reactome:R-MMU-397795 G-protein beta:gamma signalling
Reactome:R-MMU-9006925 Intracellular signaling by second messengers
Reactome:R-MMU-8849474 PTK6 Activates STAT3
Reactome:R-MMU-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
Reactome:R-MMU-9006335 Signaling by Erythropoietin
Reactome:R-MMU-5688426 Deubiquitination
Reactome:R-MMU-381119 Unfolded Protein Response (UPR)
Reactome:R-MMU-381042 PERK regulates gene expression
Reactome:R-MMU-199991 Membrane Trafficking
Reactome:R-RNO-69478 G2/M DNA replication checkpoint
Reactome:R-RNO-453279 Mitotic G1 phase and G1/S transition
Reactome:R-RNO-69206 G1/S Transition
Reactome:R-RNO-69656 Cyclin A:Cdk2-associated events at S phase entry
Reactome:R-RNO-453274 Mitotic G2-G2/M phases
Reactome:R-RNO-8934903 Receptor Mediated Mitophagy
Reactome:R-RNO-212436 Generic Transcription Pathway
Reactome:R-RNO-6806003 Regulation of TP53 Expression and Degradation
Reactome:R-RNO-1500931 Cell-Cell communication
Reactome:R-RNO-373753 Nephrin family interactions
Reactome:R-RNO-1632852 Macroautophagy
Reactome:R-RNO-3371556 Cellular response to heat stress
Reactome:R-RNO-177929 Signaling by EGFR
Reactome:R-RNO-180292 GAB1 signalosome
Reactome:R-RNO-5654738 Signaling by FGFR2
Reactome:R-RNO-5654732 Negative regulation of FGFR3 signaling
Reactome:R-RNO-9032500 Activated NTRK2 signals through FYN
Reactome:R-RNO-5218921 VEGFR2 mediated cell proliferation
Reactome:R-RNO-1251985 Nuclear signaling by ERBB4
Reactome:R-RNO-8874081 MET activates PTK2 signaling
Reactome:R-RNO-418594 G alpha (i) signalling events
Reactome:R-RNO-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
Reactome:R-RNO-1257604 PI3K/AKT Signaling
Reactome:R-RNO-8948751 Regulation of PTEN stability and activity
Reactome:R-RNO-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Reactome:R-RNO-76002 Platelet activation, signaling and aggregation
Reactome:R-RNO-418592 ADP signalling through P2Y purinoceptor 1
Reactome:R-RNO-76009 Platelet Aggregation (Plug Formation)
Reactome:R-RNO-109581 Apoptosis
Reactome:R-RNO-202427 Phosphorylation of CD3 and TCR zeta chains
Reactome:R-RNO-388841 Costimulation by the CD28 family
Reactome:R-RNO-5690714 CD22 mediated BCR regulation
Reactome:R-RNO-2029481 FCGR activation
Reactome:R-RNO-2424491 DAP12 signaling
Reactome:R-RNO-2871837 FCERI mediated NF-kB activation
Reactome:R-RNO-1280215 Cytokine Signaling in Immune system
Reactome:R-RNO-877300 Interferon gamma signaling
Reactome:R-RNO-8985947 Interleukin-9 signaling
Reactome:R-RNO-447115 Interleukin-12 family signaling
Reactome:R-RNO-8984722 Interleukin-35 Signalling
Reactome:R-RNO-982772 Growth hormone receptor signaling
Reactome:R-RNO-373755 Semaphorin interactions
Reactome:R-RNO-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Reactome:R-RNO-375165 NCAM signaling for neurite out-growth
Reactome:R-RNO-437239 Recycling pathway of L1
Reactome:R-RNO-2682334 EPH-Ephrin signaling
Reactome:R-SSC-1266738 Developmental Biology
Reactome:R-SSC-8866376 Reelin signalling pathway
Reactome:R-SSC-162582 Signaling Pathways
Reactome:R-SSC-166520 Signaling by NTRKs
Reactome:R-SSC-4420097 VEGFA-VEGFR2 Pathway
Reactome:R-SSC-1433557 Signaling by SCF-KIT
Reactome:R-SSC-9006335 Signaling by Erythropoietin
Reactome:R-SSC-389359 CD28 dependent Vav1 pathway
Reactome:R-SSC-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
Reactome:R-SSC-447115 Interleukin-12 family signaling
Reactome:R-SSC-8984722 Interleukin-35 Signalling
WikiPathways:WP4861 Endoplasmic reticulum stress response in coronavirus infection
WikiPathways:WP5144 NRP1-triggered signaling pathways in pancreatic cancer
WikiPathways:WP5287 17q12 copy number variation syndrome
WikiPathways:WP5298 Dravet syndrome: Scn1a-A1783V point mutation model
WikiPathways:WP5381 Smith-Magenis and Potocki-Lupski syndrome copy number variation
WikiPathways:WP2643 Nanoparticle-mediated activation of receptor signaling
WikiPathways:WP5200 Dravet syndrome
WikiPathways:WP1971 Integrated cancer pathway
WikiPathways:WP3959 DNA IR-double strand breaks and cellular response via ATM
WikiPathways:WP5098 T-cell activation SARS-CoV-2
WikiPathways:WP5220 Metabolic reprogramming in pancreatic cancer
WikiPathways:WP2263 Androgen receptor network in prostate cancer
WikiPathways:WP5322 CKAP4 signaling pathway map
WikiPathways:WP5158 Urotensin-II-mediated signaling pathway
WikiPathways:WP2526 PDGF pathway
WikiPathways:WP3634 Insulin signaling in adipocytes (normal condition)
WikiPathways:WP4863 Host-pathogen interaction of human coronaviruses - autophagy
WikiPathways:WP5191 Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution
WikiPathways:WP5242 Comprehensive IL-17A signaling
WikiPathways:WP1984 Integrated breast cancer pathway
WikiPathways:WP3635 Insulin signaling in adipocytes (diabetic condition)
PathBank:SMP0031696 Dasatinib Inhibition of BCR-ABL
PathBank:SMP0031700 Ponatinib Inhibition of BCR-ABL
PathBank:SMP0120915 FAS signaling pathway ( CD95 )
PathBank:SMP0120935 T Cell Receptor Signaling Pathway
PathBank:SMP0120939 FAS signaling pathway ( CD95 )
PathBank:SMP0120947 Growth Hormone Signaling Pathway
PathBank:SMP0120955 Toll-Like Receptor Pathway 1
PathBank:SMP0120959 T Cell Receptor Signaling Pathway
PathBank:SMP0120963 FAS signaling pathway ( CD95 )
PathBank:SMP0063810 EGF Signalling Pathway
PathBank:SMP0063899 Toll-Like Receptor Pathway 1
PathBank:SMP0066977 T Cell Receptor Signaling Pathway
PathBank:SMP0067587 Stat3 Signaling Pathway
PathBank:SMP0031694 Imatinib Inhibition of BCR-ABL
PathBank:SMP0031699 Bafetinib Inhibition of BCR-ABL
PathBank:SMP0108010 Leucine Stimulation on Insulin Signaling
PathBank:SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells
PathBank:SMP0069695 FAS signaling pathway ( CD95 )
PathBank:SMP0120926 NF-kB Signaling Pathway
PathBank:SMP0120950 NF-kB Signaling Pathway
PathBank:SMP0120962 EPO Signaling Pathway
PathBank:SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway
PathBank:SMP0100483 TNF/Stress Related Signaling
PathBank:SMP0100498 TNF/Stress Related Signaling
PathBank:SMP0031692 BCR-ABL Action in CML Pathogenesis
PathBank:SMP0031698 Bosutinib Inhibition of BCR-ABL
PathBank:SMP0108142 Insulin Signalling
PathBank:SMP0108186 Fc Epsilon Receptor I Signaling in Mast Cells
PathBank:SMP0069678 EPO Signaling Pathway
PathBank:SMP0069871 BCR Signaling Pathway
PathBank:SMP0120916 BCR Signaling Pathway
PathBank:SMP0120940 BCR Signaling Pathway
PathBank:SMP0120948 EGF Signalling Pathway
PathBank:SMP0120960 Stat3 Signaling Pathway
PathBank:SMP0120964 BCR Signaling Pathway
PathBank:SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells
PathBank:SMP0000654 Warburg Effect
PathBank:SMP0000682 Leucine Stimulation on Insulin Signaling
PathBank:SMP0031697 Nilotinib Inhibition of BCR-ABL
PathBank:SMP0108139 Fc Epsilon Receptor I Signaling in Mast Cells
PathBank:SMP0120925 GnRH Signaling Pathway
PathBank:SMP0063807 Growth Hormone Signaling Pathway
PathBank:SMP0063811 GnRH Signaling Pathway
PathBank:SMP0064625 CXCR4 Signaling Pathway