EC: 2.5.1.16

spermidine synthase (S-adenosyl 3-(methylthio)propylamine:putrescine 3-aminopropyltransferase)

enzyme lambda metabolic reaction experiment
- [spermidine synthase(Enzyme) wildtype]

Putrescine + S_Adenosylmethioninamine -> Spermidine + 5'_Deoxy_5'_(methylthio)adenosine		 (( (( (( (cytosol * Vmspds) ) * A) ) * P) ) / (( (( (( (( (Kiaspds * Kpspds) ) * (1 + (D / Kidspds))) ) + (Kpspds * A)) ) + (( (KaSpds * (1 + (D / Kidspds))) ) * P)) ) + (A * P))) buffer: *
PH: 7
Temperature: 36
uniprot:Q8U4G1 [spermidine synthase(Enzyme) wildtype His-tagged]

S_Adenosylmethioninamine + Putrescine -> 5'_Deoxy_5'_(methylthio)adenosine + Spermidine		 (( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 100 mM Tris-HCl
PH: 7.4
Temperature: 70
uniprot:P19623 [spermidine synthase(Enzyme) wildtype]

S_Adenosylmethioninamine + Putrescine -> Spermidine + 5'_Deoxy_5'_(methylthio)adenosine		 (( (Vmax * S) ) / (Km + S)) buffer: 0.1 M potassium phosphate, 5 mM dithiotreitol
PH: 7.4
Temperature: 37
uniprot:P19623 [spermidine synthase(Enzyme) wildtype]

Putrescine + S_Adenosylmethioninamine -> Spermidine + 5'_Deoxy_5'_(methylthio)adenosine		 (( (Vmax * S) ) / (Km + S)) buffer: 0.1 M potassium phosphate, 5 mM dithiotreitol
PH: 7.4
Temperature: 37

Pathways

pathway id name
BioCyc:HUMAN_BSUBPOLYAMSYN-PWY spermidine biosynthesis
BioCyc:META_BSUBPOLYAMSYN-PWY spermidine biosynthesis I
BioCyc:META_POLYAMINSYN3-PWY superpathway of polyamine biosynthesis II
BioCyc:META_PWY-7527 L-methionine salvage cycle III
BioCyc:ECO_POLYAMSYN-PWY superpathway of polyamine biosynthesis I
BioCyc:HPY_BSUBPOLYAMSYN-PWY spermidine biosynthesis I
BioCyc:ANTHRA_BSUBPOLYAMSYN-PWY spermidine biosynthesis I
BioCyc:SYNEL_BSUBPOLYAMSYN-PWY spermidine biosynthesis I
BioCyc:ECOL316407_ARG+POLYAMINE-SYN superpathway of arginine and polyamine biosynthesis
BioCyc:PDIF272563_BSUBPOLYAMSYN-PWY spermidine biosynthesis I
BioCyc:META_PWY0-1303 aminopropylcadaverine biosynthesis
BioCyc:META_POLYAMSYN-PWY superpathway of polyamine biosynthesis I
BioCyc:ECO_ARG+POLYAMINE-SYN superpathway of arginine and polyamine biosynthesis
BioCyc:MTBH37RV_BSUBPOLYAMSYN-PWY spermidine biosynthesis I
BioCyc:ECOL199310_BSUBPOLYAMSYN-PWY spermidine biosynthesis I
BioCyc:HUMAN_PWY-7527 methionine salvage cycle III
BioCyc:ECOO157_BSUBPOLYAMSYN-PWY spermidine biosynthesis I
BioCyc:MOUSE_BSUBPOLYAMSYN-PWY spermidine biosynthesis I
BioCyc:SYNEL_ARGSPECAT-PWY spermine biosynthesis
BioCyc:META_PWY-6834 spermidine biosynthesis III
BioCyc:META_ARG+POLYAMINE-SYN superpathway of arginine and polyamine biosynthesis
BioCyc:ECO_BSUBPOLYAMSYN-PWY spermidine biosynthesis I
BioCyc:ECO_PWY0-1303 aminopropylcadaverine biosynthesis
BioCyc:YEAST_BSUBPOLYAMSYN-PWY spermidine and methylthioadenosine biosynthesis
BioCyc:MTBCDC1551_BSUBPOLYAMSYN-PWY spermidine biosynthesis I
BioCyc:MOUSE_ORNSPNANA-PWY spermine biosynthesis II
BioCyc:BSUB_BSUBPOLYAMSYN-PWY spermidine biosynthesis I
BioCyc:ECOL316407_BSUBPOLYAMSYN-PWY spermidine biosynthesis I
BioCyc:ECOL316407_PWY0-1303 aminopropylcadaverine biosynthesis
BioCyc:ECOL316407_POLYAMSYN-PWY superpathway of polyamine biosynthesis I
PathBank:SMP0000857 S-Adenosyl-L-Methionine Biosynthesis
PathBank:SMP0002053 Aminopropylcadaverine Biosynthesis
PathBank:SMP0002054 Spermidine Biosynthesis I
PathBank:SMP0002097 Spermidine Biosynthesis and Metabolism
Reactome:R-HSA-351202 Metabolism of polyamines
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-351202 Metabolism of polyamines
Reactome:R-SCE-71291 Amino acid and derivative metabolism
Reactome:R-SPO-1430728 Metabolism
Reactome:R-DDI-71291 Amino acid and derivative metabolism
Reactome:R-SCE-1430728 Metabolism
Reactome:R-SCE-351202 Metabolism of polyamines
Reactome:R-SPO-71291 Amino acid and derivative metabolism
Reactome:R-HSA-71291 Amino acid and derivative metabolism
Reactome:R-MMU-71291 Amino acid and derivative metabolism
Reactome:R-DDI-1430728 Metabolism
Reactome:R-DDI-351202 Metabolism of polyamines
Reactome:R-HSA-1430728 Metabolism
Reactome:R-SPO-351202 Metabolism of polyamines
WikiPathways:WP497 Urea cycle and metabolism of amino groups
PathBank:SMP0000177 Cystathionine beta-Synthase Deficiency
PathBank:SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)
PathBank:SMP0120471 Cystathionine beta-Synthase Deficiency
PathBank:SMP0120487 Glycine N-Methyltransferase Deficiency
PathBank:SMP0120519 Methionine Adenosyltransferase Deficiency
PathBank:SMP0120527 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency
PathBank:SMP0000033 Methionine Metabolism
PathBank:SMP0000222 Glycine N-Methyltransferase Deficiency
PathBank:SMP0002307 beta-Alanine Metabolism
PathBank:SMP0063637 Methionine Metabolism
PathBank:SMP0120634 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type
PathBank:SMP0000341 Hypermethioninemia
PathBank:SMP0000221 Methionine Adenosyltransferase Deficiency
PathBank:SMP0063671 Spermidine and Spermine Biosynthesis
PathBank:SMP0120498 Hypermethioninemia
PathBank:SMP0000445 Spermidine and Spermine Biosynthesis
PathBank:SMP0000214 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency
PathBank:SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type