EC: 3.5.4.10

IMP cyclohydrolase (IMP 1,2-hydrolase (decyclizing))

enzyme lambda metabolic reaction experiment
uniprot:P31939 [IMP cyclohydrolase(Enzyme) mutant K66A]

1_(5'_Phosphoribosyl)_5_formamido_4_imidazolecarboxamide -> IMP + H2O		 (( (( (E * Kcat) ) * S) ) / (S + Km)) buffer: 100 mM Tris-HCl
PH: 7.5
Temperature: 22
uniprot:P31939 [IMP cyclohydrolase(Enzyme) mutant Y104A]

1_(5'_Phosphoribosyl)_5_formamido_4_imidazolecarboxamide -> IMP + H2O		 (( (( (E * Kcat) ) * S) ) / (S + Km)) buffer: 100 mM Tris-HCl
PH: 7.5
Temperature: 22
uniprot:P31939 [IMP cyclohydrolase(Enzyme) mutant Y104F]

1_(5'_Phosphoribosyl)_5_formamido_4_imidazolecarboxamide -> H2O + IMP		 (( (( (E * Kcat) ) * S) ) / (S + Km)) buffer: 100 mM Tris-HCl
PH: 7.5
Temperature: 22
uniprot:P31939 [IMP cyclohydrolase(Enzyme) wildtype]

1_(5'_Phosphoribosyl)_5_formamido_4_imidazolecarboxamide -> IMP + H2O		 (( (( (E * Kcat) ) * S) ) / (S + Km)) buffer: 100 mM Tris-HCl
PH: 7.5
Temperature: 22
uniprot:P31939 [IMP cyclohydrolase(Enzyme) mutant D125N]

1_(5'_Phosphoribosyl)_5_formamido_4_imidazolecarboxamide -> IMP + H2O		 (( (( (E * Kcat) ) * S) ) / (S + Km)) buffer: 100 mM Tris-HCl
PH: 7.5
Temperature: 22
uniprot:P31939 [IMP cyclohydrolase(Enzyme) mutant D125E]

1_(5'_Phosphoribosyl)_5_formamido_4_imidazolecarboxamide -> IMP + H2O		 (( (( (E * Kcat) ) * S) ) / (S + Km)) buffer: 100 mM Tris-HCl
PH: 7.5
Temperature: 22
uniprot:P31939 [IMP cyclohydrolase(Enzyme) mutant D125A]

1_(5'_Phosphoribosyl)_5_formamido_4_imidazolecarboxamide -> IMP + H2O		 (( (( (E * Kcat) ) * S) ) / (S + Km)) buffer: 100 mM Tris-HCl
PH: 7.5
Temperature: 22
uniprot:P31939 [IMP cyclohydrolase(Enzyme) mutant K137R]

1_(5'_Phosphoribosyl)_5_formamido_4_imidazolecarboxamide -> H2O + IMP		 (( (( (E * Kcat) ) * S) ) / (S + Km)) buffer: 100 mM Tris-HCl
PH: 7.5
Temperature: 22
uniprot:P31939 [IMP cyclohydrolase(Enzyme) mutant K137A]

1_(5'_Phosphoribosyl)_5_formamido_4_imidazolecarboxamide -> H2O + IMP		 (( (( (E * Kcat) ) * S) ) / (S + Km)) buffer: 100 mM Tris-HCl
PH: 7.5
Temperature: 22

Pathways

pathway id name
BioCyc:HUMAN_PWY-6124 inosine-5'-phosphate biosynthesis
BioCyc:ECO_PWY-6123 inosine-5'-phosphate biosynthesis I
BioCyc:YEAST_PWY-841 superpathway of purine nucleotides de novo biosynthesis I
BioCyc:YEAST_PWY-6124 inosine-5'-phosphate biosynthesis II
BioCyc:MTBCDC1551_PWY-841 superpathway of purine nucleotides de novo biosynthesis I
BioCyc:CAULO_PWY-6124 inosine-5'-phosphate biosynthesis II
BioCyc:SYNEL_PWY-6124 inosine-5'-phosphate biosynthesis II
BioCyc:PDIF272563_PWY-6123 inosine-5'-phosphate biosynthesis I
BioCyc:BTHE_PWY-841 superpathway of purine nucleotides de novo biosynthesis I
BioCyc:CORYNE_PWY-6123 inosine-5'-phosphate biosynthesis I
BioCyc:GCF_000013425_PWY-6123 inosine-5'-phosphate biosynthesis I
BioCyc:META_PWY-6124 inosine-5'-phosphate biosynthesis II
BioCyc:MTBCDC1551_PWY-6124 inosine-5'-phosphate biosynthesis II
BioCyc:ECOL199310_PWY-6124 inosine-5'-phosphate biosynthesis II
BioCyc:ECOL199310_PWY-841 superpathway of purine nucleotides de novo biosynthesis I
BioCyc:ANTHRA_PWY-841 superpathway of purine nucleotides de novo biosynthesis I
BioCyc:AGRO_PWY-6124 inosine-5'-phosphate biosynthesis II
BioCyc:SYNEL_PWY-6123 inosine-5'-phosphate biosynthesis I
BioCyc:PDIF272563_PWY-6124 inosine-5'-phosphate biosynthesis II
BioCyc:BTHE_PWY-6123 inosine-5'-phosphate biosynthesis I
BioCyc:VCHO_PWY-841 superpathway of purine nucleotides de novo biosynthesis I
BioCyc:ECOL199310_PWY-6123 inosine-5'-phosphate biosynthesis I
BioCyc:CAULO_PWY-6123 inosine-5'-phosphate biosynthesis I
BioCyc:CAULO_PWY-841 superpathway of purine nucleotides de novo biosynthesis I
BioCyc:ANTHRA_PWY-6123 inosine-5'-phosphate biosynthesis I
BioCyc:ANTHRA_PWY-6124 inosine-5'-phosphate biosynthesis II
BioCyc:BSUB_PWY-841 superpathway of purine nucleotides de novo biosynthesis I
BioCyc:BSUB_PWY-6124 inosine-5'-phosphate biosynthesis II
BioCyc:ECOL316407_PWY-6123 inosine-5'-phosphate biosynthesis I
BioCyc:HUMAN_PWY-841 purine nucleotides de novo biosynthesis
BioCyc:META_PWY-841 superpathway of purine nucleotides de novo biosynthesis I
BioCyc:META_PWY-7234 inosine-5'-phosphate biosynthesis III
BioCyc:META_PWY-6123 inosine-5'-phosphate biosynthesis I
BioCyc:VCHO_PWY-6124 inosine-5'-phosphate biosynthesis II
BioCyc:ECOO157_PWY-6123 inosine-5'-phosphate biosynthesis I
BioCyc:ANTHRA_DENOVOPURINE2-PWY superpathway of purine nucleotides de novo biosynthesis II
BioCyc:MOUSE_PWY-6124 inosine-5'-phosphate biosynthesis II
BioCyc:SYNEL_PWY-841 superpathway of purine nucleotides de novo biosynthesis I
BioCyc:SYNEL_DENOVOPURINE2-PWY superpathway of purine nucleotides de novo biosynthesis II
BioCyc:PDIF272563_PWY-841 superpathway of purine nucleotides de novo biosynthesis I
BioCyc:BTHE_PWY-6124 inosine-5'-phosphate biosynthesis II
PathBank:SMP0000927 Purine Nucleotides De Novo Biosynthesis
PathBank:SMP0001750 One Carbon Pool by Folate
PathBank:SMP0002047 Purine Nucleotides De Novo Biosynthesis 2
Reactome:R-HSA-9700206 Signaling by ALK in cancer
Reactome:R-HSA-9725370 Signaling by ALK fusions and activated point mutants
Reactome:R-BTA-1430728 Metabolism
Reactome:R-DDI-8956320 Nucleotide biosynthesis
Reactome:R-GGA-1660598 Metabolism
Reactome:R-HSA-73817 Purine ribonucleoside monophosphate biosynthesis
Reactome:R-HSA-1643685 Disease
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-73817 Purine ribonucleoside monophosphate biosynthesis
Reactome:R-RNO-73817 Purine ribonucleoside monophosphate biosynthesis
Reactome:R-SPO-1430728 Metabolism
Reactome:R-SPO-15869 Nucleotide metabolism
Reactome:R-BTA-73817 Purine ribonucleoside monophosphate biosynthesis
Reactome:R-DDI-15869 Nucleotide metabolism
Reactome:R-GGA-419470 Nucleotide metabolism
Reactome:R-GGA-419140 De novo synthesis of IMP
Reactome:R-HSA-8956320 Nucleotide biosynthesis
Reactome:R-MMU-8956320 Nucleotide biosynthesis
Reactome:R-RNO-8956320 Nucleotide biosynthesis
Reactome:R-SCE-1430728 Metabolism
Reactome:R-SCE-73817 Purine ribonucleoside monophosphate biosynthesis
Reactome:R-BTA-15869 Nucleotide metabolism
Reactome:R-DDI-73817 Purine ribonucleoside monophosphate biosynthesis
Reactome:R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
Reactome:R-RNO-1430728 Metabolism
Reactome:R-SCE-15869 Nucleotide metabolism
Reactome:R-SPO-8956320 Nucleotide biosynthesis
Reactome:R-BTA-8956320 Nucleotide biosynthesis
Reactome:R-DDI-1430728 Metabolism
Reactome:R-GGA-419474 Purine metabolism
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-15869 Nucleotide metabolism
Reactome:R-MMU-15869 Nucleotide metabolism
Reactome:R-RNO-15869 Nucleotide metabolism
Reactome:R-SCE-8956320 Nucleotide biosynthesis
Reactome:R-SPO-73817 Purine ribonucleoside monophosphate biosynthesis
WikiPathways:WP4792 Purine metabolism
WikiPathways:WP4224 Purine metabolism and related disorders
WikiPathways:WP4259 Disorders of folate metabolism and transport
PathBank:SMP0120448 Adenosine Deaminase Deficiency
PathBank:SMP0120452 AICA-Ribosiduria
PathBank:SMP0120508 Lesch-Nyhan Syndrome (LNS)
PathBank:SMP0120532 Molybdenum Cofactor Deficiency
PathBank:SMP0120536 Purine Nucleoside Phosphorylase Deficiency
PathBank:SMP0120577 Xanthinuria Type I
PathBank:SMP0120601 Mitochondrial DNA Depletion Syndrome
PathBank:SMP0122040 One Carbon Pool by Folate
PathBank:SMP0000167 Adenylosuccinate Lyase Deficiency
PathBank:SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria)
PathBank:SMP0000512 Xanthinuria Type I
PathBank:SMP0000536 Mitochondrial DNA Depletion Syndrome-3
PathBank:SMP0002369 One Carbon Pool by Folate I
PathBank:SMP0063668 Purine Metabolism
PathBank:SMP0120600 Adenine Phosphoribosyltransferase Deficiency (APRT)
PathBank:SMP0121307 Purine Nucleotides De Novo Biosynthesis
PathBank:SMP0122223 Purine Nucleotides De Novo Biosynthesis 2
PathBank:SMP0000050 Purine Metabolism
PathBank:SMP0000144 Adenosine Deaminase Deficiency
PathBank:SMP0000203 Molybdenum Cofactor Deficiency
PathBank:SMP0000428 Mercaptopurine Action Pathway
PathBank:SMP0000535 Adenine Phosphoribosyltransferase Deficiency (APRT)
PathBank:SMP0120449 Adenylosuccinate Lyase Deficiency
PathBank:SMP0120489 Gout or Kelley-Seegmiller Syndrome
PathBank:SMP0120497 Xanthine Dehydrogenase Deficiency (Xanthinuria)
PathBank:SMP0120578 Xanthinuria Type II
PathBank:SMP0120602 Myoadenylate Deaminase Deficiency
PathBank:SMP0000365 Gout or Kelley-Seegmiller Syndrome
PathBank:SMP0000210 Purine Nucleoside Phosphorylase Deficiency
PathBank:SMP0000430 Thioguanine Action Pathway
PathBank:SMP0000513 Xanthinuria Type II
PathBank:SMP0000537 Myoadenylate Deaminase Deficiency
PathBank:SMP0000364 Lesch-Nyhan Syndrome (LNS)
PathBank:SMP0000168 AICA-Ribosiduria
PathBank:SMP0000427 Azathioprine Action Pathway
PathBank:SMP0087239 Purine Metabolism