EC: 2.3.1.12

dihydrolipoyllysine-residue acetyltransferase (acetyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-acetyltransferase)

enzyme lambda metabolic reaction experiment
uniprot:Q7M0X6 [dihydrolipoyllysine-residue acetyltransferase(Enzyme) wildtype]

Dihydrolipoamide + Acetyl_CoA -> Coenzyme_A + S_Acetyldihydrolipoamide		 (( (Vmax * A) ) / (Km + A)) buffer: 100 mM Tris, 10 mM Acetyl phosphate, 2 units/ml Phosphotransacetylase, 0.13 mM CoA
PH: 7.4
Temperature: 30
uniprot:Q835M2 [dihydrolipoyllysine-residue acetyltransferase(Enzyme) wildtype E2]

Dihydrolipoamide + Acetyl_CoA -> Coenzyme_A + S_Acetyldihydrolipoamide		 (( (Vmax * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM acetylphosphate, 0.13 mM CoA, 2 U phosphotransacetylase
PH: 7.5
Temperature: 25

Pathways

pathway id name
BioCyc:MTBH37RV_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
BioCyc:MTBH37RV_PWY-5482 pyruvate fermentation to acetate II
BioCyc:MTBCDC1551_GLYCOLYSIS-TCA-GLYOX-BYPASS superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass
BioCyc:ECOL316407_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
BioCyc:META_PWY-5482 pyruvate fermentation to acetate II
BioCyc:ECO_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
BioCyc:MOUSE_PYRUVDEHYD-PWY acetyl-CoA biosynthesis (from pyruvate)
BioCyc:BSUB_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
BioCyc:ECOL316407_ANARESP1-PWY respiration (anaerobic)
BioCyc:CORYNE_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
BioCyc:HUMAN_PWY66-407 superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
BioCyc:HUMAN_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
BioCyc:META_P41-PWY pyruvate fermentation to acetate and lactate I
BioCyc:META_PWY-7218 photosynthetic 3-hydroxybutanoate biosynthesis (engineered)
BioCyc:ECO_GLYCOLYSIS-TCA-GLYOX-BYPASS superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass
BioCyc:ARA_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
BioCyc:MTBCDC1551_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
BioCyc:MTBCDC1551_PWY-5482 pyruvate fermentation to acetate II
BioCyc:MOUSE_PWY-5173 superpathway of acetyl-CoA biosynthesis
BioCyc:ECOL316407_GLYCOLYSIS-TCA-GLYOX-BYPASS superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass
BioCyc:CORYNE_TCA TCA cycle I (prokaryotic)
BioCyc:META_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
BioCyc:META_GLYCOLYSIS-TCA-GLYOX-BYPASS superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass
BioCyc:YEAST_PYRUVDEHYD-PWY pyruvate dehydrogenase complex
BioCyc:CORYNE_TCA-GLYOX-BYPASS superpathway of glyoxylate bypass and TCA
WikiPathways:WP2472 Escherichia coli K-12 peripherome
PathBank:SMP0000807 Glycolysis and Pyruvate Dehydrogenase
PathBank:SMP0002095 Pyruvate Decarboxylation to Acetyl-CoA
PlantCyc:ARA_PWY-5464 superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle
PlantCyc:PLANT_PWY-5173 superpathway of acetyl-CoA biosynthesis
PlantCyc:ARA_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
PlantCyc:PLANT_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
PlantCyc:ARA_PWY-5173 superpathway of acetyl-CoA biosynthesis
PlantCyc:PLANT_PWY-5464 superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle
Reactome:R-HSA-9635486 Infection with Mycobacterium tuberculosis
Reactome:R-HSA-9824439 Bacterial Infection Pathways
Reactome:R-HSA-9861718 Regulation of pyruvate metabolism
Reactome:R-HSA-9857492 Protein lipoylation
Reactome:R-SPO-9861718 Regulation of pyruvate metabolism
Reactome:R-SPO-9857492 Protein lipoylation
Reactome:R-HSA-9861559 PDH complex synthesizes acetyl-CoA from PYR
Reactome:R-MMU-9857492 Protein lipoylation
Reactome:R-SCE-9861559 PDH complex synthesizes acetyl-CoA from PYR
Reactome:R-SPO-9861559 PDH complex synthesizes acetyl-CoA from PYR
Reactome:R-DDI-9861559 PDH complex synthesizes acetyl-CoA from PYR
Reactome:R-MMU-9861559 PDH complex synthesizes acetyl-CoA from PYR
Reactome:R-RNO-9861559 PDH complex synthesizes acetyl-CoA from PYR
Reactome:R-DDI-9857492 Protein lipoylation
Reactome:R-MMU-9861718 Regulation of pyruvate metabolism
Reactome:R-RNO-9857492 Protein lipoylation
Reactome:R-RNO-9861718 Regulation of pyruvate metabolism
Reactome:R-SCE-9857492 Protein lipoylation
Reactome:R-DDI-597592 Post-translational protein modification
Reactome:R-DDI-70268 Pyruvate metabolism
Reactome:R-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex
Reactome:R-HSA-5362517 Signaling by Retinoic Acid
Reactome:R-HSA-392499 Metabolism of proteins
Reactome:R-HSA-597592 Post-translational protein modification
Reactome:R-HSA-1643685 Disease
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-204174 Regulation of pyruvate dehydrogenase (PDH) complex
Reactome:R-MMU-162582 Signaling Pathways
Reactome:R-RNO-204174 Regulation of pyruvate dehydrogenase (PDH) complex
Reactome:R-RNO-597592 Post-translational protein modification
Reactome:R-RNO-162582 Signaling Pathways
Reactome:R-RNO-9006931 Signaling by Nuclear Receptors
Reactome:R-SCE-597592 Post-translational protein modification
Reactome:R-SPO-1430728 Metabolism
Reactome:R-SPO-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-DDI-392499 Metabolism of proteins
Reactome:R-HSA-70268 Pyruvate metabolism
Reactome:R-HSA-9006931 Signaling by Nuclear Receptors
Reactome:R-HSA-1222499 Latent infection - Other responses of Mtb to phagocytosis
Reactome:R-MMU-70268 Pyruvate metabolism
Reactome:R-RNO-70268 Pyruvate metabolism
Reactome:R-RNO-392499 Metabolism of proteins
Reactome:R-SCE-1430728 Metabolism
Reactome:R-SCE-70268 Pyruvate metabolism
Reactome:R-SPO-204174 Regulation of pyruvate dehydrogenase (PDH) complex
Reactome:R-HSA-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-MMU-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-MMU-9006931 Signaling by Nuclear Receptors
Reactome:R-MMU-392499 Metabolism of proteins
Reactome:R-MMU-597592 Post-translational protein modification
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-RNO-5362517 Signaling by Retinoic Acid
Reactome:R-SCE-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-SPO-392499 Metabolism of proteins
Reactome:R-SPO-162582 Signaling Pathways
Reactome:R-SPO-9006931 Signaling by Nuclear Receptors
Reactome:R-DDI-1430728 Metabolism
Reactome:R-DDI-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-162582 Signaling Pathways
Reactome:R-HSA-5663205 Infectious disease
Reactome:R-HSA-1222541 Cell redox homeostasis
Reactome:R-MMU-5362517 Signaling by Retinoic Acid
Reactome:R-SCE-392499 Metabolism of proteins
Reactome:R-SPO-597592 Post-translational protein modification
Reactome:R-SPO-70268 Pyruvate metabolism
Reactome:R-SPO-5362517 Signaling by Retinoic Acid
WikiPathways:WP5220 Metabolic reprogramming in pancreatic cancer
PathBank:SMP0121182 Citrate Cycle
PathBank:SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency)
PathBank:SMP0000548 Mitochondrial Complex II Deficiency
PathBank:SMP0002295 The Oncogenic Action of Fumarate
PathBank:SMP0002358 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria
PathBank:SMP0000196 Leigh Syndrome
PathBank:SMP0000547 Fumarase Deficiency
PathBank:SMP0000551 Pyruvate Dehydrogenase Deficiency (E2)
PathBank:SMP0000559 Pyruvate Kinase Deficiency
PathBank:SMP0002292 The Oncogenic Action of Succinate
PathBank:SMP0087449 Pyruvate Metabolism
PathBank:SMP0000057 Citric Acid Cycle
PathBank:SMP0000212 Pyruvate Dehydrogenase Complex Deficiency
PathBank:SMP0000549 2-Ketoglutarate Dehydrogenase Complex Deficiency
PathBank:SMP0000654 Warburg Effect
PathBank:SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria
PathBank:SMP0087424 Citric Acid Cycle
PathBank:SMP0000060 Pyruvate Metabolism
PathBank:SMP0000546 Congenital Lactic Acidosis
PathBank:SMP0000550 Pyruvate Dehydrogenase Deficiency (E3)
PathBank:SMP0000558 Primary Hyperoxaluria II, PH2
PathBank:SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate
PathBank:SMP0002298 Glutaminolysis and Cancer
PathBank:SMP0002304 TCA Cycle
PathBank:SMP0087527 Warburg Effect