7beta-Hydroxycholesterol
7beta-Hydroxycholesterol belongs to the class of organic compounds known as cholesterols and derivatives. Cholesterols and derivatives are compounds containing a 3-hydroxylated cholestane core. Thus, 7beta-hydroxycholesterol is considered to be a sterol lipid molecule. 7beta-Hydroxycholesterol is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. 7beta-Hydroxycholesterol has been identified in atheromatous plaques and in plasma of atherosclerotic patients (PMID: 16604541). 7beta-Hydroxycholesterol induces apoptosis in Caco-2 cells and alters lysosomal membrane integrity. It exhibits a specific enhancement of oxidative stress and of endonuclease G expression (PMID: 17136497).
| ID | EC Number | Name |
|---|---|---|
| Rhea:RHEA:39796 | 7β-hydroxycholesterol(in) + ATP + H2O => 7β-hydroxycholesterol(out) + ADP + phosphate + H+ | |
| Rhea:RHEA:39797 | 7β-hydroxycholesterol(out) + ADP + phosphate + H+ => 7β-hydroxycholesterol(in) + ATP + H2O | |
| Rhea:RHEA:39798 | 7β-hydroxycholesterol(in) + ATP + H2O <=> 7β-hydroxycholesterol(out) + ADP + phosphate + H+ | |
| Rhea:RHEA:68657 | 7-oxocholesterol + NADPH + H+ => 7β-hydroxycholesterol + NADP+ | |
| Rhea:RHEA:68658 | 7β-hydroxycholesterol + NADP+ => 7-oxocholesterol + NADPH + H+ | |
| Rhea:RHEA:68659 | 7-oxocholesterol + NADPH + H+ <=> 7β-hydroxycholesterol + NADP+ |