Hydroxyacetone

Hydroxyacetone, also known as acetol or acetone alcohol, belongs to the class of organic compounds known as alpha-hydroxy ketones. These are organic compounds containing a carboxylic acid, and an amine group attached to the alpha carbon atom, relative to the C=O group. Hydroxyacetone exists in all living organisms, ranging from bacteria to humans. Hydroxyacetone is a sweet, caramel, and ethereal tasting compound. hydroxyacetone has been detected, but not quantified in several different foods, such as bog bilberries, cardoons, amaranths, black salsifies, and komatsuna. This could make hydroxyacetone a potential biomarker for the consumption of these foods. Hydroxyacetone is an intermediate in glycine, serine, and threonine metabolism.

ID EC Number Name
KEGG:R02528 1.1.1.- C00546 + C00005 + C00080<=>C05235 + C00006
KEGG:R10717 1.1.1.6 propane-1,2-diol:NAD+ 2-oxidoreductase
KEGG:R10718 1.1.1.- hydroxyacetone:NAD+ 1-oxidoreductase
KEGG:R12150 4.1.99.24 L-tyrosine:D-ribulose-5-phosphate lyase (isonitrile-forming)
KEGG:R12151 4.1.99.25 L-tryptophan:D-ribulose-5-phosphate lyase (isonitrile-forming)
KEGG:R12764 4.4.1.41 (2S)-2,3-dihydroxypropane-1-sulfonate sulfite-lyase
BioCyc:RXN0-4281 1.1.1.21 PROTON + METHYL-GLYOXAL + NADPH --> ACETOL + NADP
BioCyc:RXN-8632 PROPANE-1-2-DIOL + NAD<=>ACETOL + NADH + PROTON
BioCyc:RXN0-5213 1.1.1.- PROTON + METHYL-GLYOXAL + NADH --> ACETOL + NAD
Rhea:RHEA:27987 hydroxyacetone + NADP+ => methylglyoxal + NADPH + H+
Rhea:RHEA:27988 methylglyoxal + NADPH + H+ => hydroxyacetone + NADP+
Rhea:RHEA:27989 hydroxyacetone + NADP+ <=> methylglyoxal + NADPH + H+
Rhea:RHEA:28668 hydroxyacetone + NADH + H+ => (S)-propane-1,2-diol + NAD+
Rhea:RHEA:28669 (S)-propane-1,2-diol + NAD+ => hydroxyacetone + NADH + H+
Rhea:RHEA:28670 hydroxyacetone + NADH + H+ <=> (S)-propane-1,2-diol + NAD+
Rhea:RHEA:35616 hydroxyacetone + NAD+ => methylglyoxal + NADH + H+
Rhea:RHEA:35617 methylglyoxal + NADH + H+ => hydroxyacetone + NAD+
Rhea:RHEA:35618 hydroxyacetone + NAD+ <=> methylglyoxal + NADH + H+
Rhea:RHEA:45733 4.1.99.24 D-ribulose 5-phosphate + L-tyrosine => (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + hydroxyacetone + formaldehyde + phosphate + H2O + H+
Rhea:RHEA:45734 4.1.99.24 (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + hydroxyacetone + formaldehyde + phosphate + H2O + H+ => D-ribulose 5-phosphate + L-tyrosine
Rhea:RHEA:45735 4.1.99.24 D-ribulose 5-phosphate + L-tyrosine <=> (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + hydroxyacetone + formaldehyde + phosphate + H2O + H+
Rhea:RHEA:55789 acetone + NADH + O2 + H+ => hydroxyacetone + NAD+ + H2O
Rhea:RHEA:55790 hydroxyacetone + NAD+ + H2O => acetone + NADH + O2 + H+
Rhea:RHEA:55791 acetone + NADH + O2 + H+ <=> hydroxyacetone + NAD+ + H2O
Rhea:RHEA:56697 4.1.99.25 D-ribulose 5-phosphate + L-tryptophan => (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + hydroxyacetone + formaldehyde + phosphate + H2O + H+
Rhea:RHEA:56698 4.1.99.25 (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + hydroxyacetone + formaldehyde + phosphate + H2O + H+ => D-ribulose 5-phosphate + L-tryptophan
Rhea:RHEA:56699 4.1.99.25 D-ribulose 5-phosphate + L-tryptophan <=> (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + hydroxyacetone + formaldehyde + phosphate + H2O + H+
Rhea:RHEA:68605 4.4.1.41 (2S)-3-sulfopropanediol => hydroxyacetone + sulfite + H+
Rhea:RHEA:68606 4.4.1.41 hydroxyacetone + sulfite + H+ => (2S)-3-sulfopropanediol
Rhea:RHEA:68607 4.4.1.41 (2S)-3-sulfopropanediol <=> hydroxyacetone + sulfite + H+