D-Glucosamine 6-phosphate
Glucosamine 6-phosphate (CAS: 3616-42-0) is normally produced in endothelial cells via de novo glucosamine synthesis by the enzyme fructose-6-phosphate amidotransferase and the modulation of this pathway by hyperglycemia and glutamine. Glutamine-fructose-6-phosphate amidotransferase (GFAT) catalyzes the first committed step in the pathway for biosynthesis of hexosamines in mammals.It is a member of the N-terminal nucleophile class of amidotransferases, GFAT transfers the amino group from the L-glutamine amide to D-fructose 6-phosphate, producing glutamic acid and glucosamine 6-phosphate. As glucosamine inhibits endothelial nitric oxide synthesis it has important implications for impaired endothelium-dependent relaxation and vascular dysfunction in diabetes mellitus (PMID:11270676, 11842094).
| ID | EC Number | Name |
|---|---|---|
| KEGG:R00765 | 3.5.99.6 | D-glucosamine-6-phosphate aminohydrolase (ketol isomerizing); |
| KEGG:R00768 | 2.6.1.16 | L-glutamine:D-fructose-6-phosphate isomerase (deaminating); |
| KEGG:R01961 | 2.7.1.1 | ATP:D-glucosamine 6-phosphotransferase |
| KEGG:R01964 | 2.7.1.1 | ITP:D-glucosamine 6-phosphotransferase |
| KEGG:R01965 | 2.7.1.1 | dATP:D-glucosamine 6-phosphotransferase |
| KEGG:R02058 | 2.3.1.4 | acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase |
| KEGG:R02059 | 3.5.1.25 | N-acetyl-D-glucosamine-6-phosphate amidohydrolase |
| KEGG:R02060 | 5.4.2.10 | D-glucosamine 1-phosphate 1,6-phosphomutase; |
| KEGG:R02631 | 2.7.1.- | protein-N(pi)-phosphohistidine:D-glucosamine 6-phosphotransferase |
| KEGG:R12220 | 5.1.3.42 | D-glucosamine 6-phosphate 4-epimerase |
| KEGG:R12594 | 2.7.1.147 | ADP:D-glucosamine 6-phosphotransferase |
| BioCyc:GLUCOSAMINE-6-P-DEAMIN-RXN | 3.5.99.6 | CPD-13469 + WATER<=>FRUCTOSE-6P + AMMONIUM |