D-Arginine
D-Arginine, also known as D-2-amino-5-guanidinovaleric acid or (2R)-2-amino-5-guanidinopentanoate, is a member of the class of compounds known as D-alpha-amino acids. D-alpha-Amino acids are alpha amino acids which have the D-configuration of the alpha-carbon atom. D-Arginine is slightly soluble (in water). D-Arginine can be found in human epidermis and platelet tissues. Within the cell, D-arginine is primarily located in the peroxisome. In humans, D-arginine is involved in D-arginine and D-ornithine metabolism. Arginine (abbreviated as Arg or R) is an alpha-amino acid that is used in the biosynthesis of proteins. It is encoded by the codons CGU, CGC, CGA, CGG, AGA, and AGG. It contains an alpha-amino group, an alpha-carboxylic acid group, and a side chain consisting of a 3-carbon aliphatic straight chain ending in a guanidino group. At physiological pH, the carboxylic acid is deprotonated, the amino group is protonated, and the guanidino group is also protonated to give the guanidinium form (-C-(NH2)2+), making arginine a charged, aliphatic amino acid. It is the precursor for the biosynthesis of nitric oxide. D-Arginine is an essential amino acid that is physiologically active in the L-form.
| ID | EC Number | Name |
|---|---|---|
| KEGG:R00567 | 5.1.1.9 | arginine racemase |
| KEGG:R02458 | 3.5.3.10 | D-arginine amidinohydrolase |
| KEGG:R02923 | 1.4.3.3 | D-arginine:oxygen oxidoreductase (deaminating) |
| KEGG:R02924 | 2.6.1.21 | D-arginine:2-oxoglutarate aminotransferase |
| KEGG:R11016 | 1.4.99.6 | C00792 + C00028<=>C21026 + C00030 |
| KEGG:R11018 | 1.4.99.6 | D-arginine:acceptor oxidoreductase (deaminating) |
| BioCyc:RXN-15849 | CPD-220 + Acceptor --> CPD-17095 + Donor-H2 | |
| BioCyc:RXN-7563 | 1.4.99.6 | CPD-220 + WATER + Acceptor --> CPD-824 + AMMONIUM + Donor-H2 |
| BioCyc:ARGININE-RACEMASE-RXN | 5.1.1.9 | ARG<=>CPD-220 |
| BioCyc:D-ARGINASE-RXN | 3.5.3.10 | WATER + CPD-220<=>UREA + CPD-217 |