3-Phospho-D-glyceroyl phosphate
Glyceric acid 1,3-biphosphate (CAS: 1981-49-3), also known as 1,3-bisphosphoglycerate (1,3BPG) or PGAP, is a 3-carbon organic molecule present in most, if not all living creatures. It primarily exists as a metabolic intermediate in glycolysis during respiration. 1,3BPG has been recognized as regulatory signal implicated in the control of metabolism, oxygen affinity of red cells, and other cellular functions. 1,3BPG concentration in erythrocytes changes in a number of pathological conditions, such as inherited phosphoglycerate kinase deficiency in erythrocytes (involved in the synthesis and breakdown of 1,3BPG) (PMID: 3555887). Glyceric acid 1,3-biphosphate is phosphorylated at the number 1 and 3 carbons. The result of this phosphorylation gives 1,3BPG important biological properties such as the ability to phosphorylate ADP to form the energy storage molecule ATP (Wikipedia).
| ID | EC Number | Name |
|---|---|---|
| KEGG:R01061 | 1.2.1.12 | D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating) |
| KEGG:R01063 | 1.2.1.13 | D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase (phosphorylating) |
| KEGG:R01512 | 2.7.2.3 | ATP:3-phospho-D-glycerate 1-phosphotransferase |
| KEGG:R01515 | 3.6.1.7 | 3-phospho-D-glyceroyl phosphate phosphohydrolase |
| KEGG:R01517 | 2.7.2.10 | GTP:3-phospho-D-glycerate 1-phosphotransferase |
| KEGG:R01660 | 2.7.1.106 | 3-phospho-D-glyceroyl-phosphate:alpha-D-glucose-1-phosphate 6-phosphotransferase |
| KEGG:R01662 | 5.4.2.4 | 3-phospho-D-glycerate 1,2-phosphomutase |
| KEGG:R02188 | 2.7.4.17 | 3-phospho-D-glyceroyl-phosphate:polyphosphate phosphotransferase |
| BioCyc:GAPOXNPHOSPHN-RXN | 1.2.1.12 | GAP + Pi + NAD<=>PROTON + DPG + NADH |
| BioCyc:PHOSGLYPHOS-RXN | 2.7.2.3 | G3P + ATP<=>DPG + ADP |
| BioCyc:GLUCOSE-16-BISPHOSPHATE-SYNTHASE-RXN | 2.7.1.106 | GLC-1-P + DPG<=>PROTON + ALPHA-GLUCOSE-16-BISPHOSPHATE + G3P |
| BioCyc:RXN-17274 | Protein-Histidines + DPG<=>Protein-pi-phospho-L-histidines + G3P + PROTON | |
| BioCyc:RXN-16914 | 2.3.1.- | ACP + DPG + WATER --> D-Glyceryl-ACP + 2 Pi |
| BioCyc:BISPHOSPHOGLYCERATE-MUTASE-RXN | 5.4.2.4 | DPG --> PROTON + 23-DIPHOSPHOGLYCERATE |
| BioCyc:GAPDHSYNEC-RXN | 1.2.1.59 | GAP + Pi + NAD-P-OR-NOP<=>DPG + NADH-P-OR-NOP + PROTON |
| BioCyc:2.7.4.17-RXN | 2.7.4.17 | DPG + Long-Chain-Polyphosphate --> G3P + Long-Chain-Polyphosphate |
| BioCyc:PHOSPHOGLYCERATE-KINASE-GTP-RXN | 2.7.2.10 | G3P + GTP<=>DPG + GDP |
| BioCyc:1.2.1.13-RXN | 1.2.1.13 | DPG + NADPH + PROTON --> GAP + Pi + NADP |