12(S)-HPETE

12-HPETE is one of the six monohydroperoxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid (Leukotrienes). Reduction of the hydroperoxide yields the more stable hydroxyl fatty acid (+/-)12-HETE. A family of biologically active compounds derived from arachidonic acid by oxidative metabolism through the 5-lipoxygenase pathway. They participate in host defense reactions and pathophysiological conditions such as immediate hypersensitivity and inflammation. They have potent actions on many essential organs and systems, including the cardiovascular, pulmonary, and central nervous system as well as the gastrointestinal tract and the immune system.

ID EC Number Name
KEGG:R01596 1.13.11.31 arachidonate:oxygen 12-oxidoreductase
KEGG:R07039 5.4.4.7 12(S)-HPETE hydroxymutase
KEGG:R07040 5.4.4.7 12(S)-HPETE hydroxymutase
KEGG:R13043 1.11.1.12 glutathione:12(S)-HPETE oxidoreductase
KEGG:R13045 4.2.1.152 12(S)-HPETE hydro-lyase