(-)-Menthol
Menthol is an alcohol produced from mint oils or prepared synthetically. Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils. It is a waxy, crystalline substance, clear or white in color, which is solid at room temperature and melts slightly above. The main form of menthol occurring in nature is (-)-menthol, which is assigned the (1R,2S,5R) configuration. Menthol has local anesthetic and counterirritant qualities, and it is widely used to relieve minor throat irritation.
| ID | EC Number | Name |
|---|---|---|
| KEGG:R02177 | 1.1.1.207 | (-)-menthol:NADP+ oxidoreductase |
| KEGG:R02178 | 1.14.13.46 | (-)-menthol,NADPH:oxygen oxidoreductase (8-hydroxylating) |
| KEGG:R02179 | 2.4.1.127 | UDPglucose:(-)-menthol O-beta-D-glucosyltransferase |
| KEGG:R08530 | 2.3.1.69 | acetyl-CoA:monoterpenol O-acetyltransferase |
| Rhea:RHEA:11521 | 2.4.1.127 | (−)-menthol + UDP-α-D-glucose => (−)-menthyl β-D-glucoside + UDP + H+ |
| Rhea:RHEA:11522 | 2.4.1.127 | (−)-menthyl β-D-glucoside + UDP + H+ => (−)-menthol + UDP-α-D-glucose |
| Rhea:RHEA:11523 | 2.4.1.127 | (−)-menthol + UDP-α-D-glucose <=> (−)-menthyl β-D-glucoside + UDP + H+ |
| Rhea:RHEA:11649 | 1.14.13.46 | (−)-menthol + NADPH + O2 + H+ => 1,4-menthane-3,8-diol + NADP+ + H2O |
| Rhea:RHEA:11650 | 1.14.13.46 | 1,4-menthane-3,8-diol + NADP+ + H2O => (−)-menthol + NADPH + O2 + H+ |
| Rhea:RHEA:11651 | 1.14.13.46 | (−)-menthol + NADPH + O2 + H+ <=> 1,4-menthane-3,8-diol + NADP+ + H2O |
| Rhea:RHEA:13918 | 1.1.1.207 | (−)-menthol + NADP+ => (1R,4S)-menthone + NADPH + H+ |
| Rhea:RHEA:13919 | 1.1.1.207 | (1R,4S)-menthone + NADPH + H+ => (−)-menthol + NADP+ |
| Rhea:RHEA:13920 | 1.1.1.207 | (−)-menthol + NADP+ <=> (1R,4S)-menthone + NADPH + H+ |
| BioCyc:--MENTHOL-MONOOXYGENASE-RXN | 1.14.13.46 | --MENTHOL + OXYGEN-MOLECULE + NADPH + PROTON --> PARA-MENTHANE-38-DIOL + WATER + NADP |
| BioCyc:2.4.1.127-RXN | 2.4.1.127 | CPD-12575 + --MENTHOL --> CPD-1910 + UDP + PROTON |
| BioCyc:--MENTHOL-DEHYDROGENASE-RXN | 1.1.1.207 | PROTON + CPD-1909 + NADPH --> NADP + --MENTHOL |