BioCyc:RXN-18117

ActVI-ORF1 catalyzes the reduction of |FRAME: CPD1A0-6104| at C-3 via two active amino acids, Glu141 and His129,and NAD(P)H to yield a secondary alcohol |CITS: [7929165]||CITS: [10091691]||CITS: [10805574]||CITS: [15498668]|.It was also discovered that the likely substrate for ActVI-ORF1 is the β-keto acid form of the bicyclic intermediate,thus indicating that the ACP is released prior to this reaction |CITS: [15645472]|.

CPD-19414 + OXYGEN-MOLECULE + FMNH2 --> CPD-19415 + WATER + FMN + PROTON

Medermycin[C24H27NO8] + Oxygen[O2] + Reduced FMN[C17H23N4O9P] = Mederrhodin A[C24H27NO9] + H2O[H2O] + FMN(3-)[C17H18N4O9P] + H+[H]

DB Links

Alias

Metabolites

Substrates
metabolite compartment Structure
Medermycin

Formula: C24H27NO8 		Cytoplasm
Oxygen

Formula: O2 		Cytoplasm
Reduced FMN

Formula: C17H23N4O9P 		Cytoplasm
Products
metabolite compartment Structure
Mederrhodin A

Formula: C24H27NO9		 Cytoplasm
H2O

Formula: H2O		 Cytoplasm
FMN(3-)

Formula: C17H18N4O9P		 Cytoplasm
H+

Formula: H		 Cytoplasm