BioCyc:RXN-12006
Nonenzymatic glycation is an important factor in the pathogenesis of diabetic complications. Key early intermediates in this process are fructosamines, such as [protein]-N6-D-fructosyl-L-lysine. Fructosamine-3-kinase is part of an ATP-dependent system for removing carbohydrates from nonenzymatically glycated proteins. The phosphorylation destablilizes the [protein]-N6-D-fructosyl-L-lysine adduct and leads to its spontaneous decomposition.
Protein-erythrulosamines + ATP<=>Protein-phospho-erythrulosamines + ADP + PROTON
[] + ATP(4-)[C10H12N5O13P3] = [] + ADP(3-)[C10H12N5O10P2] + H+[H]
DB Links
- BioCyc: RXN-12006
- EC Number: 2.7.1.-
Alias
- [BioCyc:RXN-17940] ATP + Pre-tRNA-3-prime-half-molecules --> Pre-tRNA-3-prime-half-molecules-5P + ADP + PROTON
- [BioCyc:2.7.11.27-RXN] Acetyl-CoA-carboxylases + ATP<=>Acetyl-CoA-carboxylase-phosphate + ADP + PROTON
- [BioCyc:2.7.11.24-RXN] ATP + Protein-L-Ser-or-L-Thr-L-Pro --> ADP + Protein-L-Ser-or-L-Thr-P-L-Pro + PROTON
- [BioCyc:RXN-12006] Protein-erythrulosamines + ATP<=>Protein-phospho-erythrulosamines + ADP + PROTON
- [BioCyc:RXN-12003] Protein-ribulosamines + ATP<=>Protein-phospho-ribulosamines + ADP + PROTON
- [BioCyc:RXN-20318] ATP + 2-Amino-4OH-Hexamino-Hydroxybenzoyl-ACP --> 2-Amino-4OH-Hexamino-P-benzoyl-ACP + ADP + PROTON
- [BioCyc:RXN-12004] Protein-psicosamines + ATP<=>Protein-phospho-psicosamines + ADP + PROTON
- [BioCyc:RXN-10038] L-seryl-SEC-tRNAs + ATP<=>O-phospho-L-seryl-tRNASecs + ADP + PROTON
Metabolites
Substrates
| metabolite | compartment | Structure |
|---|---|---|
Formula: |
Cytoplasm | |
| ATP(4-) Formula: C10H12N5O13P3 |
Cytoplasm |
Products
| metabolite | compartment | Structure |
|---|---|---|
Formula: |
Cytoplasm | |
| ADP(3-) Formula: C10H12N5O10P2 |
Cytoplasm | |
| H+ Formula: H |
Cytoplasm |