BioCyc:RXN-10024

Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing. Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signaling which, in turn, initiates the expression of particular virulence genes. N-(3-oxohexanoyl)-[acyl-carrier-protein] and hexanoyl-[acyl-carrier protein] are the best substrates. The fatty-acyl substrate is derived from fatty-acid biosynthesis through acyl-[acyl-carrier-protein] rather than from fatty-acid degradation through acyl-CoA. S-adenosyl-L-methionine cannot be replaced by methionine, S-adenosylhomocysteine, homoserine or homoserine lactone.

S-ADENOSYLMETHIONINE + Butanoyl-ACPs<=>ACP + 5-METHYLTHIOADENOSINE + CPD-10784 + PROTON

S-Adenosylmethionine[C15H23N6O5S] + [] = [] + 5'-Methylthioadenosine[C11H15N5O3S] + N-Butyryl-L-homoserine lactone[C8H13NO3] + H+[H]

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Alias

Metabolites

Substrates
metabolite compartment Structure
S-Adenosylmethionine

Formula: C15H23N6O5S 		Cytoplasm


Formula: 		Cytoplasm
Products
metabolite compartment Structure


Formula: 		Cytoplasm
5'-Methylthioadenosine

Formula: C11H15N5O3S		 Cytoplasm
N-Butyryl-L-homoserine lactone

Formula: C8H13NO3		 Cytoplasm
H+

Formula: H		 Cytoplasm