数据之源，洞见之始

L-lysyl⁴-[histone H3] + 2 S-adenosyl-L-methionine <=> N⁶,N⁶-dimethyl-L-lysyl⁴-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H⁺

= [] + S-adenosyl-L-methionine zwitterion[C15H23N6O5S] + [] + S-adenosyl-L-homocysteine zwitterion[C14H20N6O5S] + H+[H]

DB Links

• EC Number: 2.1.1.370
• Rhea: RHEA:64451

Alias

• [Rhea:RHEA:10025] L-lysyl-[histone] + S-adenosyl-L-methionine => N⁶-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:10026] N⁶-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H⁺ => L-lysyl-[histone] + S-adenosyl-L-methionine
• [Rhea:RHEA:10027] L-lysyl-[histone] + S-adenosyl-L-methionine <=> N⁶-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:13682] a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine => a 5-methyl-2'-deoxycytidine in DNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:13683] a 5-methyl-2'-deoxycytidine in DNA + S-adenosyl-L-homocysteine + H⁺ => a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine
• [Rhea:RHEA:13684] a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine <=> a 5-methyl-2'-deoxycytidine in DNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:14394] N-terminal L-alanyl-[cypemycin] + 2 S-adenosyl-L-methionine => N-terminal N,N-dimethyl-L-alanyl-[cypemycin] + 2 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:14395] N-terminal N,N-dimethyl-L-alanyl-[cypemycin] + 2 S-adenosyl-L-homocysteine + 3 H⁺ => N-terminal L-alanyl-[cypemycin] + 2 S-adenosyl-L-methionine
• [Rhea:RHEA:14396] N-terminal L-alanyl-[cypemycin] + 2 S-adenosyl-L-methionine <=> N-terminal N,N-dimethyl-L-alanyl-[cypemycin] + 2 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:15198] a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine => an N⁶-methyl-2'-deoxyadenosine in DNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:15199] an N⁶-methyl-2'-deoxyadenosine in DNA + S-adenosyl-L-homocysteine + H⁺ => a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine
• [Rhea:RHEA:15200] a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine <=> an N⁶-methyl-2'-deoxyadenosine in DNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:16498] adenosine¹⁶¹⁸ in 23S rRNA + S-adenosyl-L-methionine => N⁶-methyladenosine¹⁶¹⁸ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:16499] N⁶-methyladenosine¹⁶¹⁸ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺ => adenosine¹⁶¹⁸ in 23S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:16500] adenosine¹⁶¹⁸ in 23S rRNA + S-adenosyl-L-methionine <=> N⁶-methyladenosine¹⁶¹⁸ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:16786] an adenosine in tRNA + S-adenosyl-L-methionine => an N⁶-methyladenosine in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:16787] an N⁶-methyladenosine in tRNA + S-adenosyl-L-homocysteine + H⁺ => an adenosine in tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:16788] an adenosine in tRNA + S-adenosyl-L-methionine <=> an N⁶-methyladenosine in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:16858] a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine => an N⁴-methyl-2'-deoxycytidine in DNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:16859] an N⁴-methyl-2'-deoxycytidine in DNA + S-adenosyl-L-homocysteine + H⁺ => a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine
• [Rhea:RHEA:16860] a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine <=> an N⁴-methyl-2'-deoxycytidine in DNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:19370] L-histidyl-[protein] + S-adenosyl-L-methionine => N^τ-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:19371] N^τ-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine + H⁺ => L-histidyl-[protein] + S-adenosyl-L-methionine
• [Rhea:RHEA:19372] L-histidyl-[protein] + S-adenosyl-L-methionine <=> N^τ-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:19570] 5-aminomethyl-2-thiouridine³⁴ in tRNA + S-adenosyl-L-methionine => 5-methylaminomethyl-2-thiouridine³⁴ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:19571] 5-methylaminomethyl-2-thiouridine³⁴ in tRNA + S-adenosyl-L-homocysteine + H⁺ => 5-aminomethyl-2-thiouridine³⁴ in tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:19572] 5-aminomethyl-2-thiouridine³⁴ in tRNA + S-adenosyl-L-methionine <=> 5-methylaminomethyl-2-thiouridine³⁴ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:19618] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine => a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:19619] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine + H⁺ => a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:19620] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:20078] guanosine¹⁸ in tRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine¹⁸ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:20079] 2'-O-methylguanosine¹⁸ in tRNA + S-adenosyl-L-homocysteine + H⁺ => guanosine¹⁸ in tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:20080] guanosine¹⁸ in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine¹⁸ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:20414] glucuronoxylan D-glucuronate + n S-adenosyl-L-methionine => glucuronoxylan 4-O-methyl-D-glucuronate + n S-adenosyl-L-homocysteine + n H⁺
• [Rhea:RHEA:20415] glucuronoxylan 4-O-methyl-D-glucuronate + n S-adenosyl-L-homocysteine + n H⁺ => glucuronoxylan D-glucuronate + n S-adenosyl-L-methionine
• [Rhea:RHEA:20416] glucuronoxylan D-glucuronate + n S-adenosyl-L-methionine <=> glucuronoxylan 4-O-methyl-D-glucuronate + n S-adenosyl-L-homocysteine + n H⁺
• [Rhea:RHEA:21125] cytidine⁷² in tRNA^Thr + S-adenosyl-L-methionine => 5-methylcytidine⁷² in tRNA^Thr + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:21126] 5-methylcytidine⁷² in tRNA^Thr + S-adenosyl-L-homocysteine + H⁺ => cytidine⁷² in tRNA^Thr + S-adenosyl-L-methionine
• [Rhea:RHEA:21127] cytidine⁷² in tRNA^Thr + S-adenosyl-L-methionine <=> 5-methylcytidine⁷² in tRNA^Thr + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:21557] [calmodulin]-L-lysine + S-adenosyl-L-methionine => [calmodulin]-N⁶-methyl-L-lysine + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:21558] [calmodulin]-N⁶-methyl-L-lysine + S-adenosyl-L-homocysteine + H⁺ => [calmodulin]-L-lysine + S-adenosyl-L-methionine
• [Rhea:RHEA:21559] [calmodulin]-L-lysine + S-adenosyl-L-methionine <=> [calmodulin]-N⁶-methyl-L-lysine + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:21697] N⁶-methyl-L-lysyl-[histone] + S-adenosyl-L-methionine => N⁶,N⁶-dimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:21698] N⁶,N⁶-dimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H⁺ => N⁶-methyl-L-lysyl-[histone] + S-adenosyl-L-methionine
• [Rhea:RHEA:21699] N⁶-methyl-L-lysyl-[histone] + S-adenosyl-L-methionine <=> N⁶,N⁶-dimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:21841] N⁶,N⁶-dimethyl-L-lysyl-[histone] + S-adenosyl-L-methionine => N⁶,N⁶,N⁶-trimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:21842] N⁶,N⁶,N⁶-trimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H⁺ => N⁶,N⁶-dimethyl-L-lysyl-[histone] + S-adenosyl-L-methionine
• [Rhea:RHEA:21843] N⁶,N⁶-dimethyl-L-lysyl-[histone] + S-adenosyl-L-methionine <=> N⁶,N⁶,N⁶-trimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:22745] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine => a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(N⁶,2'-O-dimethyladenosine) in mRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:22746] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(N⁶,2'-O-dimethyladenosine) in mRNA + S-adenosyl-L-homocysteine + H⁺ => a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:22747] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(N⁶,2'-O-dimethyladenosine) in mRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:23549] guanosine⁹⁶⁶ in 16S rRNA + S-adenosyl-L-methionine => N²-methylguanosine⁹⁶⁶ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:23550] N²-methylguanosine⁹⁶⁶ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺ => guanosine⁹⁶⁶ in 16S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:23551] guanosine⁹⁶⁶ in 16S rRNA + S-adenosyl-L-methionine <=> N²-methylguanosine⁹⁶⁶ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:24141] guanosine²²⁵¹ in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine²²⁵¹ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:24142] 2'-O-methylguanosine²²⁵¹ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺ => guanosine²²⁵¹ in 23S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:24143] guanosine²²⁵¹ in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine²²⁵¹ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:24313] L-lysyl-[cytochrome c] + S-adenosyl-L-methionine => N⁶-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:24314] N⁶-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine + H⁺ => L-lysyl-[cytochrome c] + S-adenosyl-L-methionine
• [Rhea:RHEA:24315] L-lysyl-[cytochrome c] + S-adenosyl-L-methionine <=> N⁶-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:26467] a 2-demethylmenaquinone + S-adenosyl-L-methionine => a menaquinone + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:26468] a menaquinone + S-adenosyl-L-homocysteine + H⁺ => a 2-demethylmenaquinone + S-adenosyl-L-methionine
• [Rhea:RHEA:26469] a 2-demethylmenaquinone + S-adenosyl-L-methionine <=> a menaquinone + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:28287] a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine => a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:28288] a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H⁺ => a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine
• [Rhea:RHEA:28289] a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine <=> a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:31412] a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => a 2-methoxy-6-(all-trans-polyprenyl)phenol + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:31413] a 2-methoxy-6-(all-trans-polyprenyl)phenol + S-adenosyl-L-homocysteine + H⁺ => a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine
• [Rhea:RHEA:31414] a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> a 2-methoxy-6-(all-trans-polyprenyl)phenol + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:32768] cytidine⁴ in tRNA^Pro + S-adenosyl-L-methionine => 2'-O-methylcytidine⁴ in tRNA^Pro + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:32769] 2'-O-methylcytidine⁴ in tRNA^Pro + S-adenosyl-L-homocysteine + H⁺ => cytidine⁴ in tRNA^Pro + S-adenosyl-L-methionine
• [Rhea:RHEA:32770] cytidine⁴ in tRNA^Pro + S-adenosyl-L-methionine <=> 2'-O-methylcytidine⁴ in tRNA^Pro + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:36416] 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine => diphthine-[translation elongation factor 2] + 3 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:36417] diphthine-[translation elongation factor 2] + 3 S-adenosyl-L-homocysteine + 3 H⁺ => 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine
• [Rhea:RHEA:36418] 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine <=> diphthine-[translation elongation factor 2] + 3 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:36420] 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine => 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:36421] 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-homocysteine + H⁺ => 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine
• [Rhea:RHEA:36422] 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:36424] 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine => 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:36425] 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-homocysteine + H⁺ => 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine
• [Rhea:RHEA:36426] 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:36428] 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine => diphthine-[translation elongation factor 2] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:36429] diphthine-[translation elongation factor 2] + S-adenosyl-L-homocysteine + H⁺ => 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine
• [Rhea:RHEA:36430] 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> diphthine-[translation elongation factor 2] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:36636] 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine³⁷ in tRNA^Phe + S-adenosyl-L-methionine => 7-[(3S)-3-amino-3-carboxypropyl]wyosine³⁷ in tRNA^Phe + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:36637] 7-[(3S)-3-amino-3-carboxypropyl]wyosine³⁷ in tRNA^Phe + S-adenosyl-L-homocysteine + H⁺ => 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine³⁷ in tRNA^Phe + S-adenosyl-L-methionine
• [Rhea:RHEA:36638] 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine³⁷ in tRNA^Phe + S-adenosyl-L-methionine <=> 7-[(3S)-3-amino-3-carboxypropyl]wyosine³⁷ in tRNA^Phe + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:36900] guanosine³⁷ in tRNA + S-adenosyl-L-methionine => N¹-methylguanosine³⁷ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:36901] N¹-methylguanosine³⁷ in tRNA + S-adenosyl-L-homocysteine + H⁺ => guanosine³⁷ in tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:36902] guanosine³⁷ in tRNA + S-adenosyl-L-methionine <=> N¹-methylguanosine³⁷ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:37064] 2-thio-N⁶-dimethylallyladenosine³⁷ in tRNA + S-adenosyl-L-methionine => 2-methylsulfanyl-N⁶-dimethylallyladenosine³⁷ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:37065] 2-methylsulfanyl-N⁶-dimethylallyladenosine³⁷ in tRNA + S-adenosyl-L-homocysteine + H⁺ => 2-thio-N⁶-dimethylallyladenosine³⁷ in tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:37066] 2-thio-N⁶-dimethylallyladenosine³⁷ in tRNA + S-adenosyl-L-methionine <=> 2-methylsulfanyl-N⁶-dimethylallyladenosine³⁷ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:37080] 2-sulfanyl-N⁶-L-threonylcarbamoyladenosine³⁷ in tRNA + S-adenosyl-L-methionine => 2-methylsulfanyl-N⁶-L-threonylcarbamoyladenosine³⁷ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:37081] 2-methylsulfanyl-N⁶-L-threonylcarbamoyladenosine³⁷ in tRNA + S-adenosyl-L-homocysteine + H⁺ => 2-sulfanyl-N⁶-L-threonylcarbamoyladenosine³⁷ in tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:37082] 2-sulfanyl-N⁶-L-threonylcarbamoyladenosine³⁷ in tRNA + S-adenosyl-L-methionine <=> 2-methylsulfanyl-N⁶-L-threonylcarbamoyladenosine³⁷ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:37084] L-aspartate⁸⁹-[ribosomal protein uS12]-hydrogen + (sulfur carrier)-SH + S-adenosyl-L-methionine => L-aspartate⁸⁹-[ribosomal protein uS12]-methanesulfate + (sulfur carrier)-H + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:37085] L-aspartate⁸⁹-[ribosomal protein uS12]-methanesulfate + (sulfur carrier)-H + S-adenosyl-L-homocysteine + H⁺ => L-aspartate⁸⁹-[ribosomal protein uS12]-hydrogen + (sulfur carrier)-SH + S-adenosyl-L-methionine
• [Rhea:RHEA:37086] L-aspartate⁸⁹-[ribosomal protein uS12]-hydrogen + (sulfur carrier)-SH + S-adenosyl-L-methionine <=> L-aspartate⁸⁹-[ribosomal protein uS12]-methanesulfate + (sulfur carrier)-H + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:37888] small RNA 3'-end nucleotide + S-adenosyl-L-methionine => small RNA 3'-end 2'-O-methylnucleotide + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:37889] small RNA 3'-end 2'-O-methylnucleotide + S-adenosyl-L-homocysteine + H⁺ => small RNA 3'-end nucleotide + S-adenosyl-L-methionine
• [Rhea:RHEA:37890] small RNA 3'-end nucleotide + S-adenosyl-L-methionine <=> small RNA 3'-end 2'-O-methylnucleotide + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42629] uridine⁷⁴⁷ in 23S rRNA + S-adenosyl-L-methionine => 5-methyluridine⁷⁴⁷ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42630] 5-methyluridine⁷⁴⁷ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺ => uridine⁷⁴⁷ in 23S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:42631] uridine⁷⁴⁷ in 23S rRNA + S-adenosyl-L-methionine <=> 5-methyluridine⁷⁴⁷ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42641] a 2-demethylmenaquinol + S-adenosyl-L-methionine => a menaquinol + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42642] a menaquinol + S-adenosyl-L-homocysteine + H⁺ => a 2-demethylmenaquinol + S-adenosyl-L-methionine
• [Rhea:RHEA:42643] a 2-demethylmenaquinol + S-adenosyl-L-methionine <=> a menaquinol + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42653] 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine => diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:42654] diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H⁺ => 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine
• [Rhea:RHEA:42655] 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine <=> diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:42713] uridine⁵⁴ in tRNA + S-adenosyl-L-methionine => 5-methyluridine⁵⁴ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42714] 5-methyluridine⁵⁴ in tRNA + S-adenosyl-L-homocysteine + H⁺ => uridine⁵⁴ in tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:42715] uridine⁵⁴ in tRNA + S-adenosyl-L-methionine <=> 5-methyluridine⁵⁴ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42721] uridine²⁵⁵² in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methyluridine²⁵⁵² in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42722] 2'-O-methyluridine²⁵⁵² in 23S rRNA + S-adenosyl-L-homocysteine + H⁺ => uridine²⁵⁵² in 23S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:42723] uridine²⁵⁵² in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methyluridine²⁵⁵² in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42725] guanosine²⁹²² in 27S pre-rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine²⁹²² in 27S pre-rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42726] 2'-O-methylguanosine²⁹²² in 27S pre-rRNA + S-adenosyl-L-homocysteine + H⁺ => guanosine²⁹²² in 27S pre-rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:42727] guanosine²⁹²² in 27S pre-rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine²⁹²² in 27S pre-rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42729] uridine²⁷⁹¹ in 21S rRNA + S-adenosyl-L-methionine => 2'-O-methyluridine²⁷⁹¹ in 21S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42730] 2'-O-methyluridine²⁷⁹¹ in 21S rRNA + S-adenosyl-L-homocysteine + H⁺ => uridine²⁷⁹¹ in 21S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:42731] uridine²⁷⁹¹ in 21S rRNA + S-adenosyl-L-methionine <=> 2'-O-methyluridine²⁷⁹¹ in 21S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42737] guanosine¹²⁰⁷ in 16S rRNA + S-adenosyl-L-methionine => N²-methylguanosine¹²⁰⁷ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42738] N²-methylguanosine¹²⁰⁷ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺ => guanosine¹²⁰⁷ in 16S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:42739] guanosine¹²⁰⁷ in 16S rRNA + S-adenosyl-L-methionine <=> N²-methylguanosine¹²⁰⁷ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42741] guanosine²⁴⁴⁵ in 23S rRNA + S-adenosyl-L-methionine => N²-methylguanosine²⁴⁴⁵ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42742] N²-methylguanosine²⁴⁴⁵ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺ => guanosine²⁴⁴⁵ in 23S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:42743] guanosine²⁴⁴⁵ in 23S rRNA + S-adenosyl-L-methionine <=> N²-methylguanosine²⁴⁴⁵ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42745] guanosine¹⁸³⁵ in 23S rRNA + S-adenosyl-L-methionine => N²-methylguanosine¹⁸³⁵ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42746] N²-methylguanosine¹⁸³⁵ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺ => guanosine¹⁸³⁵ in 23S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:42747] guanosine¹⁸³⁵ in 23S rRNA + S-adenosyl-L-methionine <=> N²-methylguanosine¹⁸³⁵ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42749] cytidine⁹⁶⁷ in 16S rRNA + S-adenosyl-L-methionine => 5-methylcytidine⁹⁶⁷ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42750] 5-methylcytidine⁹⁶⁷ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺ => cytidine⁹⁶⁷ in 16S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:42751] cytidine⁹⁶⁷ in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine⁹⁶⁷ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42753] pseudouridine¹⁹¹⁵ in 23S rRNA + S-adenosyl-L-methionine => N³-methylpseudouridine¹⁹¹⁵ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42754] N³-methylpseudouridine¹⁹¹⁵ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺ => pseudouridine¹⁹¹⁵ in 23S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:42755] pseudouridine¹⁹¹⁵ in 23S rRNA + S-adenosyl-L-methionine <=> N³-methylpseudouridine¹⁹¹⁵ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42757] cytidine¹⁴⁰⁷ in 16S rRNA + S-adenosyl-L-methionine => 5-methylcytidine¹⁴⁰⁷ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42758] 5-methylcytidine¹⁴⁰⁷ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺ => cytidine¹⁴⁰⁷ in 16S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:42759] cytidine¹⁴⁰⁷ in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine¹⁴⁰⁷ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42777] adenosine¹⁴⁰⁸ in 16S rRNA + S-adenosyl-L-methionine => N¹-methyladenosine¹⁴⁰⁸ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42778] N¹-methyladenosine¹⁴⁰⁸ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺ => adenosine¹⁴⁰⁸ in 16S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:42779] adenosine¹⁴⁰⁸ in 16S rRNA + S-adenosyl-L-methionine <=> N¹-methyladenosine¹⁴⁰⁸ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42785] adenosine²⁰⁸⁵ in 23S rRNA + 2 S-adenosyl-L-methionine => N⁶-dimethyladenosine²⁰⁸⁵ in 23S rRNA + 2 S-adenosyl-L-homocysteine + 2 H⁺
• [Rhea:RHEA:42786] N⁶-dimethyladenosine²⁰⁸⁵ in 23S rRNA + 2 S-adenosyl-L-homocysteine + 2 H⁺ => adenosine²⁰⁸⁵ in 23S rRNA + 2 S-adenosyl-L-methionine
• [Rhea:RHEA:42787] adenosine²⁰⁸⁵ in 23S rRNA + 2 S-adenosyl-L-methionine <=> N⁶-dimethyladenosine²⁰⁸⁵ in 23S rRNA + 2 S-adenosyl-L-homocysteine + 2 H⁺
• [Rhea:RHEA:42789] cytidine²⁴⁹⁸ in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine²⁴⁹⁸ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42790] 2'-O-methylcytidine²⁴⁹⁸ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺ => cytidine²⁴⁹⁸ in 23S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:42791] cytidine²⁴⁹⁸ in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine²⁴⁹⁸ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42897] L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine => N⁵-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42898] N⁵-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine + H⁺ => L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine
• [Rhea:RHEA:42899] L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine <=> N⁵-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42901] guanosine⁷⁴⁵ in 23S rRNA + S-adenosyl-L-methionine => N¹-methylguanosine⁷⁴⁵ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42902] N¹-methylguanosine⁷⁴⁵ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺ => guanosine⁷⁴⁵ in 23S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:42903] guanosine⁷⁴⁵ in 23S rRNA + S-adenosyl-L-methionine <=> N¹-methylguanosine⁷⁴⁵ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42905] guanosine⁷⁴⁸ in 23S rRNA + S-adenosyl-L-methionine => N¹-methylguanosine⁷⁴⁸ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42906] N¹-methylguanosine⁷⁴⁸ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺ => guanosine⁷⁴⁸ in 23S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:42907] guanosine⁷⁴⁸ in 23S rRNA + S-adenosyl-L-methionine <=> N¹-methylguanosine⁷⁴⁸ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42909] uridine¹⁹³⁹ in 23S rRNA + S-adenosyl-L-methionine => 5-methyluridine¹⁹³⁹ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42910] 5-methyluridine¹⁹³⁹ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺ => uridine¹⁹³⁹ in 23S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:42911] uridine¹⁹³⁹ in 23S rRNA + S-adenosyl-L-methionine <=> 5-methyluridine¹⁹³⁹ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42913] cytidine¹⁹⁶² in 23S rRNA + S-adenosyl-L-methionine => 5-methylcytidine¹⁹⁶² in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42914] 5-methylcytidine¹⁹⁶² in 23S rRNA + S-adenosyl-L-homocysteine + H⁺ => cytidine¹⁹⁶² in 23S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:42915] cytidine¹⁹⁶² in 23S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine¹⁹⁶² in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42921] uridine¹⁴⁹⁸ in 16S rRNA + S-adenosyl-L-methionine => N³-methyluridine¹⁴⁹⁸ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42922] N³-methyluridine¹⁴⁹⁸ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺ => uridine¹⁴⁹⁸ in 16S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:42923] uridine¹⁴⁹⁸ in 16S rRNA + S-adenosyl-L-methionine <=> N³-methyluridine¹⁴⁹⁸ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42925] cytidine¹⁴⁰² in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine¹⁴⁰² in 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42926] 2'-O-methylcytidine¹⁴⁰² in 16S rRNA + S-adenosyl-L-homocysteine + H⁺ => cytidine¹⁴⁰² in 16S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:42927] cytidine¹⁴⁰² in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine¹⁴⁰² in 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42929] cytidine¹⁴⁰² in 16S rRNA + S-adenosyl-L-methionine => N⁴-methylcytidine¹⁴⁰² in 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42930] N⁴-methylcytidine¹⁴⁰² in 16S rRNA + S-adenosyl-L-homocysteine + H⁺ => cytidine¹⁴⁰² in 16S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:42931] cytidine¹⁴⁰² in 16S rRNA + S-adenosyl-L-methionine <=> N⁴-methylcytidine¹⁴⁰² in 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42933] cytidine³² in tRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine³² in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42934] 2'-O-methylcytidine³² in tRNA + S-adenosyl-L-homocysteine + H⁺ => cytidine³² in tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:42935] cytidine³² in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine³² in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42937] uridine³² in tRNA + S-adenosyl-L-methionine => 2'-O-methyluridine³² in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42938] 2'-O-methyluridine³² in tRNA + S-adenosyl-L-homocysteine + H⁺ => uridine³² in tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:42939] uridine³² in tRNA + S-adenosyl-L-methionine <=> 2'-O-methyluridine³² in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42941] cytidine³⁴ in tRNA precursor + S-adenosyl-L-methionine => 5-methylcytidine³⁴ in tRNA precursor + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42942] 5-methylcytidine³⁴ in tRNA precursor + S-adenosyl-L-homocysteine + H⁺ => cytidine³⁴ in tRNA precursor + S-adenosyl-L-methionine
• [Rhea:RHEA:42943] cytidine³⁴ in tRNA precursor + S-adenosyl-L-methionine <=> 5-methylcytidine³⁴ in tRNA precursor + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42945] cytidine⁴⁰ in tRNA precursor + S-adenosyl-L-methionine => 5-methylcytidine⁴⁰ in tRNA precursor + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42946] 5-methylcytidine⁴⁰ in tRNA precursor + S-adenosyl-L-homocysteine + H⁺ => cytidine⁴⁰ in tRNA precursor + S-adenosyl-L-methionine
• [Rhea:RHEA:42947] cytidine⁴⁰ in tRNA precursor + S-adenosyl-L-methionine <=> 5-methylcytidine⁴⁰ in tRNA precursor + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42949] cytidine⁴⁸ in tRNA + S-adenosyl-L-methionine => 5-methylcytidine⁴⁸ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42950] 5-methylcytidine⁴⁸ in tRNA + S-adenosyl-L-homocysteine + H⁺ => cytidine⁴⁸ in tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:42951] cytidine⁴⁸ in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine⁴⁸ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42953] cytidine⁴⁹ in tRNA + S-adenosyl-L-methionine => 5-methylcytidine⁴⁹ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42954] 5-methylcytidine⁴⁹ in tRNA + S-adenosyl-L-homocysteine + H⁺ => cytidine⁴⁹ in tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:42955] cytidine⁴⁹ in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine⁴⁹ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42957] cytidine³⁸ in tRNA + S-adenosyl-L-methionine => 5-methylcytidine³⁸ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42958] 5-methylcytidine³⁸ in tRNA + S-adenosyl-L-homocysteine + H⁺ => cytidine³⁸ in tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:42959] cytidine³⁸ in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine³⁸ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42969] cytidine⁵⁶ in tRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine⁵⁶ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:42970] 2'-O-methylcytidine⁵⁶ in tRNA + S-adenosyl-L-homocysteine + H⁺ => cytidine⁵⁶ in tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:42971] cytidine⁵⁶ in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine⁵⁶ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43085] cytidine³⁴ in tRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine³⁴ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43086] 2'-O-methylcytidine³⁴ in tRNA + S-adenosyl-L-homocysteine + H⁺ => cytidine³⁴ in tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:43087] cytidine³⁴ in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine³⁴ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43089] 5-carboxymethylaminomethyluridine³⁴ in tRNA^Leu + S-adenosyl-L-methionine => 5-carboxymethylaminomethyl-2'-O-methyluridine³⁴ in tRNA^Leu + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43090] 5-carboxymethylaminomethyl-2'-O-methyluridine³⁴ in tRNA^Leu + S-adenosyl-L-homocysteine + H⁺ => 5-carboxymethylaminomethyluridine³⁴ in tRNA^Leu + S-adenosyl-L-methionine
• [Rhea:RHEA:43091] 5-carboxymethylaminomethyluridine³⁴ in tRNA^Leu + S-adenosyl-L-methionine <=> 5-carboxymethylaminomethyl-2'-O-methyluridine³⁴ in tRNA^Leu + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43093] uridine²⁴⁷⁹ in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methyluridine²⁴⁷⁹ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43094] 2'-O-methyluridine²⁴⁷⁹ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺ => uridine²⁴⁷⁹ in 23S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:43095] uridine²⁴⁷⁹ in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methyluridine²⁴⁷⁹ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43097] guanosine²⁵³⁵ in 23S rRNA + S-adenosyl-L-methionine => N¹-methylguanosine²⁵³⁵ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43098] N¹-methylguanosine²⁵³⁵ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺ => guanosine²⁵³⁵ in 23S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:43099] guanosine²⁵³⁵ in 23S rRNA + S-adenosyl-L-methionine <=> N¹-methylguanosine²⁵³⁵ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43101] uridine⁴⁴ in tRNA^Ser + S-adenosyl-L-methionine => 2'-O-methyluridine⁴⁴ in tRNA^Ser + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43102] 2'-O-methyluridine⁴⁴ in tRNA^Ser + S-adenosyl-L-homocysteine + H⁺ => uridine⁴⁴ in tRNA^Ser + S-adenosyl-L-methionine
• [Rhea:RHEA:43103] uridine⁴⁴ in tRNA^Ser + S-adenosyl-L-methionine <=> 2'-O-methyluridine⁴⁴ in tRNA^Ser + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43125] guanosine¹⁰ in tRNA + 2 S-adenosyl-L-methionine => N²-dimethylguanosine¹⁰ in tRNA + 2 S-adenosyl-L-homocysteine + 2 H⁺
• [Rhea:RHEA:43126] N²-dimethylguanosine¹⁰ in tRNA + 2 S-adenosyl-L-homocysteine + 2 H⁺ => guanosine¹⁰ in tRNA + 2 S-adenosyl-L-methionine
• [Rhea:RHEA:43127] guanosine¹⁰ in tRNA + 2 S-adenosyl-L-methionine <=> N²-dimethylguanosine¹⁰ in tRNA + 2 S-adenosyl-L-homocysteine + 2 H⁺
• [Rhea:RHEA:43129] guanosine¹⁰ in tRNA + S-adenosyl-L-methionine => N²-methylguanosine¹⁰ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43130] N²-methylguanosine¹⁰ in tRNA + S-adenosyl-L-homocysteine + H⁺ => guanosine¹⁰ in tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:43131] guanosine¹⁰ in tRNA + S-adenosyl-L-methionine <=> N²-methylguanosine¹⁰ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43133] N²-methylguanosine¹⁰ in tRNA + S-adenosyl-L-methionine => N²-dimethylguanosine¹⁰ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43134] N²-dimethylguanosine¹⁰ in tRNA + S-adenosyl-L-homocysteine + H⁺ => N²-methylguanosine¹⁰ in tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:43135] N²-methylguanosine¹⁰ in tRNA + S-adenosyl-L-methionine <=> N²-dimethylguanosine¹⁰ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43141] guanosine²⁶ in tRNA + 2 S-adenosyl-L-methionine => N²-dimethylguanosine²⁶ in tRNA + 2 S-adenosyl-L-homocysteine + 2 H⁺
• [Rhea:RHEA:43142] N²-dimethylguanosine²⁶ in tRNA + 2 S-adenosyl-L-homocysteine + 2 H⁺ => guanosine²⁶ in tRNA + 2 S-adenosyl-L-methionine
• [Rhea:RHEA:43143] guanosine²⁶ in tRNA + 2 S-adenosyl-L-methionine <=> N²-dimethylguanosine²⁶ in tRNA + 2 S-adenosyl-L-homocysteine + 2 H⁺
• [Rhea:RHEA:43145] adenosine²² in tRNA + S-adenosyl-L-methionine => N¹-methyladenosine²² in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43146] N¹-methyladenosine²² in tRNA + S-adenosyl-L-homocysteine + H⁺ => adenosine²² in tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:43147] adenosine²² in tRNA + S-adenosyl-L-methionine <=> N¹-methyladenosine²² in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43149] adenosine⁹ in tRNA + S-adenosyl-L-methionine => N¹-methyladenosine⁹ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43150] N¹-methyladenosine⁹ in tRNA + S-adenosyl-L-homocysteine + H⁺ => adenosine⁹ in tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:43151] adenosine⁹ in tRNA + S-adenosyl-L-methionine <=> N¹-methyladenosine⁹ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43153] adenosine⁵⁸ in tRNA + S-adenosyl-L-methionine => N¹-methyladenosine⁵⁸ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43154] N¹-methyladenosine⁵⁸ in tRNA + S-adenosyl-L-homocysteine + H⁺ => adenosine⁵⁸ in tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:43155] adenosine⁵⁸ in tRNA + S-adenosyl-L-methionine <=> N¹-methyladenosine⁵⁸ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43157] guanosine⁹ in tRNA + S-adenosyl-L-methionine => N¹-methylguanosine⁹ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43158] N¹-methylguanosine⁹ in tRNA + S-adenosyl-L-homocysteine + H⁺ => guanosine⁹ in tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:43159] guanosine⁹ in tRNA + S-adenosyl-L-methionine <=> N¹-methylguanosine⁹ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43161] adenosine³⁷ in tRNA₁^Val + S-adenosyl-L-methionine => N⁶-methyladenosine³⁷ in tRNA₁^Val + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43162] N⁶-methyladenosine³⁷ in tRNA₁^Val + S-adenosyl-L-homocysteine + H⁺ => adenosine³⁷ in tRNA₁^Val + S-adenosyl-L-methionine
• [Rhea:RHEA:43163] adenosine³⁷ in tRNA₁^Val + S-adenosyl-L-methionine <=> N⁶-methyladenosine³⁷ in tRNA₁^Val + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43177] cytidine²⁸⁷⁰ in 25S rRNA + S-adenosyl-L-methionine => 5-methylcytidine²⁸⁷⁰ in 25S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43178] 5-methylcytidine²⁸⁷⁰ in 25S rRNA + S-adenosyl-L-homocysteine + H⁺ => cytidine²⁸⁷⁰ in 25S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:43179] cytidine²⁸⁷⁰ in 25S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine²⁸⁷⁰ in 25S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43181] cytidine²²⁷⁸ in 25S rRNA + S-adenosyl-L-methionine => 5-methylcytidine²²⁷⁸ in 25S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43182] 5-methylcytidine²²⁷⁸ in 25S rRNA + S-adenosyl-L-homocysteine + H⁺ => cytidine²²⁷⁸ in 25S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:43183] cytidine²²⁷⁸ in 25S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine²²⁷⁸ in 25S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43185] uridine²⁸⁴³ in 25S rRNA + S-adenosyl-L-methionine => N³-methyluridine²⁸⁴³ in 25S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43186] N³-methyluridine²⁸⁴³ in 25S rRNA + S-adenosyl-L-homocysteine + H⁺ => uridine²⁸⁴³ in 25S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:43187] uridine²⁸⁴³ in 25S rRNA + S-adenosyl-L-methionine <=> N³-methyluridine²⁸⁴³ in 25S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43189] uridine²⁶³⁴ in 25S rRNA + S-adenosyl-L-methionine => N³-methyluridine²⁶³⁴ in 25S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43190] N³-methyluridine²⁶³⁴ in 25S rRNA + S-adenosyl-L-homocysteine + H⁺ => uridine²⁶³⁴ in 25S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:43191] uridine²⁶³⁴ in 25S rRNA + S-adenosyl-L-methionine <=> N³-methyluridine²⁶³⁴ in 25S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43193] cytidine⁴ in tRNA^Gly(GCC) + S-adenosyl-L-methionine => 2'-O-methylcytidine⁴ in tRNA^Gly(GCC) + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43194] 2'-O-methylcytidine⁴ in tRNA^Gly(GCC) + S-adenosyl-L-homocysteine + H⁺ => cytidine⁴ in tRNA^Gly(GCC) + S-adenosyl-L-methionine
• [Rhea:RHEA:43195] cytidine⁴ in tRNA^Gly(GCC) + S-adenosyl-L-methionine <=> 2'-O-methylcytidine⁴ in tRNA^Gly(GCC) + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43197] adenosine⁴ in tRNA^His + S-adenosyl-L-methionine => 2'-O-methyladenosine⁴ in tRNA^His + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43198] 2'-O-methyladenosine⁴ in tRNA^His + S-adenosyl-L-homocysteine + H⁺ => adenosine⁴ in tRNA^His + S-adenosyl-L-methionine
• [Rhea:RHEA:43199] adenosine⁴ in tRNA^His + S-adenosyl-L-methionine <=> 2'-O-methyladenosine⁴ in tRNA^His + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43201] cytidine¹⁹²⁰ in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine¹⁹²⁰ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43202] 2'-O-methylcytidine¹⁹²⁰ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺ => cytidine¹⁹²⁰ in 23S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:43203] cytidine¹⁹²⁰ in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine¹⁹²⁰ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43205] cytidine¹⁴⁰⁹ in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine¹⁴⁰⁹ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43206] 2'-O-methylcytidine¹⁴⁰⁹ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺ => cytidine¹⁴⁰⁹ in 16S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:43207] cytidine¹⁴⁰⁹ in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine¹⁴⁰⁹ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43213] adenosine¹⁰⁶⁷ in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methyladenosine¹⁰⁶⁷ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43214] 2'-O-methyladenosine¹⁰⁶⁷ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺ => adenosine¹⁰⁶⁷ in 23S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:43215] adenosine¹⁰⁶⁷ in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methyladenosine¹⁰⁶⁷ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43221] guanosine¹⁵¹⁶ in 16S rRNA + S-adenosyl-L-methionine => N²-methylguanosine¹⁵¹⁶ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43222] N²-methylguanosine¹⁵¹⁶ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺ => guanosine¹⁵¹⁶ in 16S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:43223] guanosine¹⁵¹⁶ in 16S rRNA + S-adenosyl-L-methionine <=> N²-methylguanosine¹⁵¹⁶ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43229] L-glutamine¹⁰⁴-[histone H2A] + S-adenosyl-L-methionine => N⁵-methyl-L-glutamine¹⁰⁴-[histone H2A] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43230] N⁵-methyl-L-glutamine¹⁰⁴-[histone H2A] + S-adenosyl-L-homocysteine + H⁺ => L-glutamine¹⁰⁴-[histone H2A] + S-adenosyl-L-methionine
• [Rhea:RHEA:43231] L-glutamine¹⁰⁴-[histone H2A] + S-adenosyl-L-methionine <=> N⁵-methyl-L-glutamine¹⁰⁴-[histone H2A] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43613] uridine³⁴¹ in tmRNA + S-adenosyl-L-methionine => 5-methyluridine³⁴¹ in tmRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43614] 5-methyluridine³⁴¹ in tmRNA + S-adenosyl-L-homocysteine + H⁺ => uridine³⁴¹ in tmRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:43615] uridine³⁴¹ in tmRNA + S-adenosyl-L-methionine <=> 5-methyluridine³⁴¹ in tmRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43737] adenosine²⁰³⁰ in 23S rRNA + S-adenosyl-L-methionine => N⁶-methyladenosine²⁰³⁰ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43738] N⁶-methyladenosine²⁰³⁰ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺ => adenosine²⁰³⁰ in 23S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:43739] adenosine²⁰³⁰ in 23S rRNA + S-adenosyl-L-methionine <=> N⁶-methyladenosine²⁰³⁰ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43773] guanosine²⁰⁶⁹ in 23S rRNA + S-adenosyl-L-methionine => N²-methylguanosine²⁰⁶⁹ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43774] N²-methylguanosine²⁰⁶⁹ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺ => guanosine²⁰⁶⁹ in 23S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:43775] guanosine²⁰⁶⁹ in 23S rRNA + S-adenosyl-L-methionine <=> N²-methylguanosine²⁰⁶⁹ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43785] adenosine²¹⁴² in 25S rRNA + S-adenosyl-L-methionine => N¹-methyladenosine²¹⁴² in 25S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43786] N¹-methyladenosine²¹⁴² in 25S rRNA + S-adenosyl-L-homocysteine + H⁺ => adenosine²¹⁴² in 25S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:43787] adenosine²¹⁴² in 25S rRNA + S-adenosyl-L-methionine <=> N¹-methyladenosine²¹⁴² in 25S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43793] adenosine⁶⁴⁵ in 25S rRNA + S-adenosyl-L-methionine => N¹-methyladenosine⁶⁴⁵ in 25S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:43794] N¹-methyladenosine⁶⁴⁵ in 25S rRNA + S-adenosyl-L-homocysteine + H⁺ => adenosine⁶⁴⁵ in 25S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:43795] adenosine⁶⁴⁵ in 25S rRNA + S-adenosyl-L-methionine <=> N¹-methyladenosine⁶⁴⁵ in 25S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:44381] a 3-demethylubiquinol + S-adenosyl-L-methionine => a ubiquinol + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:44382] a ubiquinol + S-adenosyl-L-homocysteine + H⁺ => a 3-demethylubiquinol + S-adenosyl-L-methionine
• [Rhea:RHEA:44383] a 3-demethylubiquinol + S-adenosyl-L-methionine <=> a ubiquinol + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:44453] a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine => a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:44454] a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H⁺ => a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine
• [Rhea:RHEA:44455] a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine <=> a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:45021] L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine => N⁵-methyl-L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:45022] N⁵-methyl-L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-homocysteine + H⁺ => L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine
• [Rhea:RHEA:45023] L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine <=> N⁵-methyl-L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:46697] a pseudouridine in rRNA + S-adenosyl-L-methionine => an N¹-methylpseudouridine in rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:46698] an N¹-methylpseudouridine in rRNA + S-adenosyl-L-homocysteine + H⁺ => a pseudouridine in rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:46699] a pseudouridine in rRNA + S-adenosyl-L-methionine <=> an N¹-methylpseudouridine in rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:46713] pseudouridine¹²⁴⁸ in human 18S rRNA + S-adenosyl-L-methionine => N¹-methylpseudouridine¹²⁴⁸ in human 18S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:46714] N¹-methylpseudouridine¹²⁴⁸ in human 18S rRNA + S-adenosyl-L-homocysteine + H⁺ => pseudouridine¹²⁴⁸ in human 18S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:46715] pseudouridine¹²⁴⁸ in human 18S rRNA + S-adenosyl-L-methionine <=> N¹-methylpseudouridine¹²⁴⁸ in human 18S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:46717] pseudouridine⁹¹⁴ in M. jannaschii 16S rRNA + S-adenosyl-L-methionine => N¹-methylpseudouridine⁹¹⁴ in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:46718] N¹-methylpseudouridine⁹¹⁴ in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine + H⁺ => pseudouridine⁹¹⁴ in M. jannaschii 16S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:46719] pseudouridine⁹¹⁴ in M. jannaschii 16S rRNA + S-adenosyl-L-methionine <=> N¹-methylpseudouridine⁹¹⁴ in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:46809] [trehalose-6-phosphate synthase]-L-cysteine + S-adenosyl-L-methionine => [trehalose-6-phosphate synthase]-S-methyl-L-cysteine + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:46810] [trehalose-6-phosphate synthase]-S-methyl-L-cysteine + S-adenosyl-L-homocysteine + H⁺ => [trehalose-6-phosphate synthase]-L-cysteine + S-adenosyl-L-methionine
• [Rhea:RHEA:46811] [trehalose-6-phosphate synthase]-L-cysteine + S-adenosyl-L-methionine <=> [trehalose-6-phosphate synthase]-S-methyl-L-cysteine + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:47733] cytidine¹⁴⁰⁰ in 16S rRNA + S-adenosyl-L-methionine => 5-methylcytidine¹⁴⁰⁰ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:47734] 5-methylcytidine¹⁴⁰⁰ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺ => cytidine¹⁴⁰⁰ in 16S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:47735] cytidine¹⁴⁰⁰ in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine¹⁴⁰⁰ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:47737] cytidine¹⁴⁰⁴ in 16S rRNA + S-adenosyl-L-methionine => 5-methylcytidine¹⁴⁰⁴ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:47738] 5-methylcytidine¹⁴⁰⁴ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺ => cytidine¹⁴⁰⁴ in 16S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:47739] cytidine¹⁴⁰⁴ in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine¹⁴⁰⁴ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:47757] guanosine¹³⁷⁰ in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine¹³⁷⁰ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:47758] 2'-O-methylguanosine¹³⁷⁰ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺ => guanosine¹³⁷⁰ in 16S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:47759] guanosine¹³⁷⁰ in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine¹³⁷⁰ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:47761] a uridine in 21S rRNA + S-adenosyl-L-methionine => a 2'-O-methyluridine in 21S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:47762] a 2'-O-methyluridine in 21S rRNA + S-adenosyl-L-homocysteine + H⁺ => a uridine in 21S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:47763] a uridine in 21S rRNA + S-adenosyl-L-methionine <=> a 2'-O-methyluridine in 21S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:47765] uridine¹³⁶⁹ in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methyluridine¹³⁶⁹ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:47766] 2'-O-methyluridine¹³⁶⁹ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺ => uridine¹³⁶⁹ in 16S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:47767] uridine¹³⁶⁹ in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methyluridine¹³⁶⁹ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:47769] guanosine²²⁷⁰ in 21S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine²²⁷⁰ in 21S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:47770] 2'-O-methylguanosine²²⁷⁰ in 21S rRNA + S-adenosyl-L-homocysteine + H⁺ => guanosine²²⁷⁰ in 21S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:47771] guanosine²²⁷⁰ in 21S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine²²⁷⁰ in 21S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:47773] a guanosine in 21S rRNA + S-adenosyl-L-methionine => a 2'-O-methylguanosine in 21S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:47774] a 2'-O-methylguanosine in 21S rRNA + S-adenosyl-L-homocysteine + H⁺ => a guanosine in 21S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:47775] a guanosine in 21S rRNA + S-adenosyl-L-methionine <=> a 2'-O-methylguanosine in 21S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:47777] guanosine¹¹⁴⁵ in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine¹¹⁴⁵ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:47778] 2'-O-methylguanosine¹¹⁴⁵ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺ => guanosine¹¹⁴⁵ in 16S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:47779] guanosine¹¹⁴⁵ in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine¹¹⁴⁵ in 16S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:47781] a cytidine in 25S rRNA + S-adenosyl-L-methionine => a 5-methylcytidine in 25S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:47782] a 5-methylcytidine in 25S rRNA + S-adenosyl-L-homocysteine + H⁺ => a cytidine in 25S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:47783] a cytidine in 25S rRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in 25S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:47785] cytidine³⁷⁸² in 28S rRNA + S-adenosyl-L-methionine => 5-methylcytidine³⁷⁸² in 28S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:47786] 5-methylcytidine³⁷⁸² in 28S rRNA + S-adenosyl-L-homocysteine + H⁺ => cytidine³⁷⁸² in 28S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:47787] cytidine³⁷⁸² in 28S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine³⁷⁸² in 28S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:47789] a cytidine in 28S rRNA + S-adenosyl-L-methionine => a 5-methylcytidine in 28S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:47790] a 5-methylcytidine in 28S rRNA + S-adenosyl-L-homocysteine + H⁺ => a cytidine in 28S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:47791] a cytidine in 28S rRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in 28S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:47793] cytidine⁴⁴⁴⁷ in 28S rRNA + S-adenosyl-L-methionine => 5-methylcytidine⁴⁴⁴⁷ in 28S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:47794] 5-methylcytidine⁴⁴⁴⁷ in 28S rRNA + S-adenosyl-L-homocysteine + H⁺ => cytidine⁴⁴⁴⁷ in 28S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:47795] cytidine⁴⁴⁴⁷ in 28S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine⁴⁴⁴⁷ in 28S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:48097] L-arginyl-[protein] + 2 S-adenosyl-L-methionine => N^ω,N^ω-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H⁺
• [Rhea:RHEA:48098] N^ω,N^ω-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H⁺ => L-arginyl-[protein] + 2 S-adenosyl-L-methionine
• [Rhea:RHEA:48099] L-arginyl-[protein] + 2 S-adenosyl-L-methionine <=> N^ω,N^ω-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H⁺
• [Rhea:RHEA:48101] L-arginyl-[protein] + S-adenosyl-L-methionine => N^ω-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:48102] N^ω-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H⁺ => L-arginyl-[protein] + S-adenosyl-L-methionine
• [Rhea:RHEA:48103] L-arginyl-[protein] + S-adenosyl-L-methionine <=> N^ω-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:48105] N^ω-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine => N^ω,N^ω-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:48106] N^ω,N^ω-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H⁺ => N^ω-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine
• [Rhea:RHEA:48107] N^ω-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine <=> N^ω,N^ω-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:48109] L-arginyl-[protein] + 2 S-adenosyl-L-methionine => N^ω,N^ω'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H⁺
• [Rhea:RHEA:48110] N^ω,N^ω'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H⁺ => L-arginyl-[protein] + 2 S-adenosyl-L-methionine
• [Rhea:RHEA:48111] L-arginyl-[protein] + 2 S-adenosyl-L-methionine <=> N^ω,N^ω'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H⁺
• [Rhea:RHEA:48113] N^ω-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine => N^ω,N^ω'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:48114] N^ω,N^ω'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H⁺ => N^ω-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine
• [Rhea:RHEA:48115] N^ω-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine <=> N^ω,N^ω'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:48117] L-arginyl-[protein] + S-adenosyl-L-methionine => N⁵-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:48118] N⁵-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H⁺ => L-arginyl-[protein] + S-adenosyl-L-methionine
• [Rhea:RHEA:48119] L-arginyl-[protein] + S-adenosyl-L-methionine <=> N⁵-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:48629] a ribonucleotide in rRNA + S-adenosyl-L-methionine => a 2'-O-methylribonucleotide in rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:48630] a 2'-O-methylribonucleotide in rRNA + S-adenosyl-L-homocysteine + H⁺ => a ribonucleotide in rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:48631] a ribonucleotide in rRNA + S-adenosyl-L-methionine <=> a 2'-O-methylribonucleotide in rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:49133] an adenosine in tRNA + S-adenosyl-L-methionine => an N¹-methyladenosine in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:49134] an N¹-methyladenosine in tRNA + S-adenosyl-L-homocysteine + H⁺ => an adenosine in tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:49135] an adenosine in tRNA + S-adenosyl-L-methionine <=> an N¹-methyladenosine in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:50905] L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine => N⁵-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:50906] N⁵-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H⁺ => L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine
• [Rhea:RHEA:50907] L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine <=> N⁵-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:50957] cytidine³² in tRNA^Ser + S-adenosyl-L-methionine => N³-methylcytidine³² in tRNA^Ser + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:50958] N³-methylcytidine³² in tRNA^Ser + S-adenosyl-L-homocysteine + H⁺ => cytidine³² in tRNA^Ser + S-adenosyl-L-methionine
• [Rhea:RHEA:50959] cytidine³² in tRNA^Ser + S-adenosyl-L-methionine <=> N³-methylcytidine³² in tRNA^Ser + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:50961] cytidine³² in tRNA^Thr + S-adenosyl-L-methionine => N³-methylcytidine³² in tRNA^Thr + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:50962] N³-methylcytidine³² in tRNA^Thr + S-adenosyl-L-homocysteine + H⁺ => cytidine³² in tRNA^Thr + S-adenosyl-L-methionine
• [Rhea:RHEA:50963] cytidine³² in tRNA^Thr + S-adenosyl-L-methionine <=> N³-methylcytidine³² in tRNA^Thr + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:50997] L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-methionine => N⁶,N⁶,N⁶-trimethyl-L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:50998] N⁶,N⁶,N⁶-trimethyl-L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-homocysteine + 3 H⁺ => L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-methionine
• [Rhea:RHEA:50999] L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-methionine <=> N⁶,N⁶,N⁶-trimethyl-L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:51001] [fructose-bisphosphate aldolase]-L-lysine + 3 S-adenosyl-L-methionine => [fructose-bisphosphate aldolase]-N⁶,N⁶,N⁶-trimethyl-L-lysine + 3 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:51002] [fructose-bisphosphate aldolase]-N⁶,N⁶,N⁶-trimethyl-L-lysine + 3 S-adenosyl-L-homocysteine + 3 H⁺ => [fructose-bisphosphate aldolase]-L-lysine + 3 S-adenosyl-L-methionine
• [Rhea:RHEA:51003] [fructose-bisphosphate aldolase]-L-lysine + 3 S-adenosyl-L-methionine <=> [fructose-bisphosphate aldolase]-N⁶,N⁶,N⁶-trimethyl-L-lysine + 3 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:51117] guanosine⁶ in tRNA + S-adenosyl-L-methionine => N²-methylguanosine⁶ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:51118] N²-methylguanosine⁶ in tRNA + S-adenosyl-L-homocysteine + H⁺ => guanosine⁶ in tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:51119] guanosine⁶ in tRNA + S-adenosyl-L-methionine <=> N²-methylguanosine⁶ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:51161] cytidine⁶⁰ in tRNA^Asp + S-adenosyl-L-methionine => 5-methylcytidine⁶⁰ in tRNA^Asp + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:51162] 5-methylcytidine⁶⁰ in tRNA^Asp + S-adenosyl-L-homocysteine + H⁺ => cytidine⁶⁰ in tRNA^Asp + S-adenosyl-L-methionine
• [Rhea:RHEA:51163] cytidine⁶⁰ in tRNA^Asp + S-adenosyl-L-methionine <=> 5-methylcytidine⁶⁰ in tRNA^Asp + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:51165] cytidine⁶¹ in tRNA^Asp + S-adenosyl-L-methionine => 5-methylcytidine⁶¹ in tRNA^Asp + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:51166] 5-methylcytidine⁶¹ in tRNA^Asp + S-adenosyl-L-homocysteine + H⁺ => cytidine⁶¹ in tRNA^Asp + S-adenosyl-L-methionine
• [Rhea:RHEA:51167] cytidine⁶¹ in tRNA^Asp + S-adenosyl-L-methionine <=> 5-methylcytidine⁶¹ in tRNA^Asp + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:51173] cytidine⁶² in tRNA^Asp + S-adenosyl-L-methionine => 5-methylcytidine⁶² in tRNA^Asp + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:51174] 5-methylcytidine⁶² in tRNA^Asp + S-adenosyl-L-homocysteine + H⁺ => cytidine⁶² in tRNA^Asp + S-adenosyl-L-methionine
• [Rhea:RHEA:51175] cytidine⁶² in tRNA^Asp + S-adenosyl-L-methionine <=> 5-methylcytidine⁶² in tRNA^Asp + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:51177] cytidine⁴⁸ in tRNA^Asp + S-adenosyl-L-methionine => 5-methylcytidine⁴⁸ in tRNA^Asp + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:51178] 5-methylcytidine⁴⁸ in tRNA^Asp + S-adenosyl-L-homocysteine + H⁺ => cytidine⁴⁸ in tRNA^Asp + S-adenosyl-L-methionine
• [Rhea:RHEA:51179] cytidine⁴⁸ in tRNA^Asp + S-adenosyl-L-methionine <=> 5-methylcytidine⁴⁸ in tRNA^Asp + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:51181] cytidine⁴⁹ in tRNA^Asp + S-adenosyl-L-methionine => 5-methylcytidine⁴⁹ in tRNA^Asp + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:51182] 5-methylcytidine⁴⁹ in tRNA^Asp + S-adenosyl-L-homocysteine + H⁺ => cytidine⁴⁹ in tRNA^Asp + S-adenosyl-L-methionine
• [Rhea:RHEA:51183] cytidine⁴⁹ in tRNA^Asp + S-adenosyl-L-methionine <=> 5-methylcytidine⁴⁹ in tRNA^Asp + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:51737] L-lysyl-[protein] + S-adenosyl-L-methionine => N⁶-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:51738] N⁶-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺ => L-lysyl-[protein] + S-adenosyl-L-methionine
• [Rhea:RHEA:51739] L-lysyl-[protein] + S-adenosyl-L-methionine <=> N⁶-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:52809] adenosine in U6 snRNA + S-adenosyl-L-methionine => N⁶-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:52810] N⁶-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine + H⁺ => adenosine in U6 snRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:52811] adenosine in U6 snRNA + S-adenosyl-L-methionine <=> N⁶-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:53045] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-ribonucleotide in mRNA + S-adenosyl-L-methionine => a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:53046] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + S-adenosyl-L-homocysteine + H⁺ => a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-ribonucleotide in mRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:53047] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-ribonucleotide in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:53057] 4-demethylwyosine³⁷ in tRNA^Phe + S-adenosyl-L-methionine => isowyosine³⁷ in tRNA^Phe + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:53058] isowyosine³⁷ in tRNA^Phe + S-adenosyl-L-homocysteine + H⁺ => 4-demethylwyosine³⁷ in tRNA^Phe + S-adenosyl-L-methionine
• [Rhea:RHEA:53059] 4-demethylwyosine³⁷ in tRNA^Phe + S-adenosyl-L-methionine <=> isowyosine³⁷ in tRNA^Phe + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:53077] cytidine³⁴ in mitochondrial tRNA + S-adenosyl-L-methionine => 5-methylcytidine³⁴ in mitochondrial tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:53078] 5-methylcytidine³⁴ in mitochondrial tRNA + S-adenosyl-L-homocysteine + H⁺ => cytidine³⁴ in mitochondrial tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:53079] cytidine³⁴ in mitochondrial tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine³⁴ in mitochondrial tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:54097] N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:54098] N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺ => N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine
• [Rhea:RHEA:54099] N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:54101] N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:54102] N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺ => N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine
• [Rhea:RHEA:54103] N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:54105] N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:54106] N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺ => N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine
• [Rhea:RHEA:54107] N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:54137] cytidine⁴⁸ in tRNA precursor + S-adenosyl-L-methionine => 5-methylcytidine⁴⁸ in tRNA precursor + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:54138] 5-methylcytidine⁴⁸ in tRNA precursor + S-adenosyl-L-homocysteine + H⁺ => cytidine⁴⁸ in tRNA precursor + S-adenosyl-L-methionine
• [Rhea:RHEA:54139] cytidine⁴⁸ in tRNA precursor + S-adenosyl-L-methionine <=> 5-methylcytidine⁴⁸ in tRNA precursor + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:54141] cytidine⁴⁹ in tRNA precursor + S-adenosyl-L-methionine => 5-methylcytidine⁴⁹ in tRNA precursor + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:54142] 5-methylcytidine⁴⁹ in tRNA precursor + S-adenosyl-L-homocysteine + H⁺ => cytidine⁴⁹ in tRNA precursor + S-adenosyl-L-methionine
• [Rhea:RHEA:54143] cytidine⁴⁹ in tRNA precursor + S-adenosyl-L-methionine <=> 5-methylcytidine⁴⁹ in tRNA precursor + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:54153] a uridine in rRNA + S-adenosyl-L-methionine => a 2'-O-methyluridine in rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:54154] a 2'-O-methyluridine in rRNA + S-adenosyl-L-homocysteine + H⁺ => a uridine in rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:54155] a uridine in rRNA + S-adenosyl-L-methionine <=> a 2'-O-methyluridine in rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:54193] L-lysyl-[protein] + 3 S-adenosyl-L-methionine => N⁶,N⁶,N⁶-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:54194] N⁶,N⁶,N⁶-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H⁺ => L-lysyl-[protein] + 3 S-adenosyl-L-methionine
• [Rhea:RHEA:54195] L-lysyl-[protein] + 3 S-adenosyl-L-methionine <=> N⁶,N⁶,N⁶-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:54197] N⁶-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine => N⁶,N⁶-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:54198] N⁶,N⁶-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺ => N⁶-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine
• [Rhea:RHEA:54199] N⁶-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> N⁶,N⁶-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:54201] N⁶,N⁶-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine => N⁶,N⁶,N⁶-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:54202] N⁶,N⁶,N⁶-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺ => N⁶,N⁶-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine
• [Rhea:RHEA:54203] N⁶,N⁶-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> N⁶,N⁶,N⁶-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:54309] pseudouridine¹¹⁹¹ in yeast 18S rRNA + S-adenosyl-L-methionine => N¹-methylpseudouridine¹¹⁹¹ in yeast 18S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:54310] N¹-methylpseudouridine¹¹⁹¹ in yeast 18S rRNA + S-adenosyl-L-homocysteine + H⁺ => pseudouridine¹¹⁹¹ in yeast 18S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:54311] pseudouridine¹¹⁹¹ in yeast 18S rRNA + S-adenosyl-L-methionine <=> N¹-methylpseudouridine¹¹⁹¹ in yeast 18S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:54589] uridine in 25S rRNA + S-adenosyl-L-methionine => N³-methyluridine in 25S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:54590] N³-methyluridine in 25S rRNA + S-adenosyl-L-homocysteine + H⁺ => uridine in 25S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:54591] uridine in 25S rRNA + S-adenosyl-L-methionine <=> N³-methyluridine in 25S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:54705] N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:54706] N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺ => N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine
• [Rhea:RHEA:54707] N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:54709] N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:54710] N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺ => N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine
• [Rhea:RHEA:54711] N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:54713] N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine => N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:54714] N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H⁺ => N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine
• [Rhea:RHEA:54715] N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine <=> N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:54717] N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:54718] N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺ => N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine
• [Rhea:RHEA:54719] N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:54721] N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:54722] N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺ => N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine
• [Rhea:RHEA:54723] N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:54725] N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine => N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:54726] N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H⁺ => N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine
• [Rhea:RHEA:54727] N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine <=> N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:54733] N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:54734] N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺ => N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine
• [Rhea:RHEA:54735] N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:54737] N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine => N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H⁺
• [Rhea:RHEA:54738] N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H⁺ => N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine
• [Rhea:RHEA:54739] N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine <=> N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H⁺
• [Rhea:RHEA:55293] pseudouridine⁵⁴ in tRNA + S-adenosyl-L-methionine => N¹-methylpseudouridine⁵⁴ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:55294] N¹-methylpseudouridine⁵⁴ in tRNA + S-adenosyl-L-homocysteine + H⁺ => pseudouridine⁵⁴ in tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:55295] pseudouridine⁵⁴ in tRNA + S-adenosyl-L-methionine <=> N¹-methylpseudouridine⁵⁴ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:55393] an adenosine in mRNA + S-adenosyl-L-methionine => an N¹-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:55394] an N¹-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H⁺ => an adenosine in mRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:55395] an adenosine in mRNA + S-adenosyl-L-methionine <=> an N¹-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:55545] L-lysyl-[citrate synthase] + S-adenosyl-L-methionine => N⁶-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:55546] N⁶-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine + H⁺ => L-lysyl-[citrate synthase] + S-adenosyl-L-methionine
• [Rhea:RHEA:55547] L-lysyl-[citrate synthase] + S-adenosyl-L-methionine <=> N⁶-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:55549] N⁶-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine => N⁶,N⁶-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:55550] N⁶,N⁶-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine + H⁺ => N⁶-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine
• [Rhea:RHEA:55551] N⁶-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine <=> N⁶,N⁶-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:55553] N⁶,N⁶-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine => N⁶,N⁶,N⁶-trimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:55554] N⁶,N⁶,N⁶-trimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine + H⁺ => N⁶,N⁶-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine
• [Rhea:RHEA:55555] N⁶,N⁶-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine <=> N⁶,N⁶,N⁶-trimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:55585] an adenosine in mRNA + S-adenosyl-L-methionine => an N⁶-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:55586] an N⁶-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H⁺ => an adenosine in mRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:55587] an adenosine in mRNA + S-adenosyl-L-methionine <=> an N⁶-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:56885] adenosine³² in tRNA + S-adenosyl-L-methionine => 2'-O-methyladenosine³² in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:56886] 2'-O-methyladenosine³² in tRNA + S-adenosyl-L-homocysteine + H⁺ => adenosine³² in tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:56887] adenosine³² in tRNA + S-adenosyl-L-methionine <=> 2'-O-methyladenosine³² in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:57453] L-glutaminyl-[protein] + S-adenosyl-L-methionine => N⁵-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:57454] N⁵-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine + H⁺ => L-glutaminyl-[protein] + S-adenosyl-L-methionine
• [Rhea:RHEA:57455] L-glutaminyl-[protein] + S-adenosyl-L-methionine <=> N⁵-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:58441] N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine => N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:58442] N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H⁺ => N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine
• [Rhea:RHEA:58443] N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine <=> N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:58445] N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine => N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:58446] N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine + H⁺ => N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine
• [Rhea:RHEA:58447] N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine <=> N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:58449] N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine => N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:58450] N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine + H⁺ => N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine
• [Rhea:RHEA:58451] N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine <=> N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:58453] N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine => N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:58454] N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine + H⁺ => N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine
• [Rhea:RHEA:58455] N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine <=> N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:58725] adenosine⁴²²⁰ in 28S rRNA + S-adenosyl-L-methionine => N⁶-methyladenosine⁴²²⁰ in 28S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:58726] N⁶-methyladenosine⁴²²⁰ in 28S rRNA + S-adenosyl-L-homocysteine + H⁺ => adenosine⁴²²⁰ in 28S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:58727] adenosine⁴²²⁰ in 28S rRNA + S-adenosyl-L-methionine <=> N⁶-methyladenosine⁴²²⁰ in 28S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:58729] adenosine in rRNA + S-adenosyl-L-methionine => N⁶-methyladenosine in rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:58730] N⁶-methyladenosine in rRNA + S-adenosyl-L-homocysteine + H⁺ => adenosine in rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:58731] adenosine in rRNA + S-adenosyl-L-methionine <=> N⁶-methyladenosine in rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:58957] a ribonucleotide in RNA + S-adenosyl-L-methionine => a 2'-O-methylribonucleotide in RNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:58958] a 2'-O-methylribonucleotide in RNA + S-adenosyl-L-homocysteine + H⁺ => a ribonucleotide in RNA + S-adenosyl-L-methionine
• [Rhea:RHEA:58959] a ribonucleotide in RNA + S-adenosyl-L-methionine <=> a 2'-O-methylribonucleotide in RNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60261] L-lysyl⁴-[histone H3] + 3 S-adenosyl-L-methionine => N⁶,N⁶,N⁶-trimethyl-L-lysyl⁴-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:60262] N⁶,N⁶,N⁶-trimethyl-L-lysyl⁴-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H⁺ => L-lysyl⁴-[histone H3] + 3 S-adenosyl-L-methionine
• [Rhea:RHEA:60263] L-lysyl⁴-[histone H3] + 3 S-adenosyl-L-methionine <=> N⁶,N⁶,N⁶-trimethyl-L-lysyl⁴-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:60265] L-lysyl⁴-[histone H3] + S-adenosyl-L-methionine => N⁶-methyl-L-lysyl⁴-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60266] N⁶-methyl-L-lysyl⁴-[histone H3] + S-adenosyl-L-homocysteine + H⁺ => L-lysyl⁴-[histone H3] + S-adenosyl-L-methionine
• [Rhea:RHEA:60267] L-lysyl⁴-[histone H3] + S-adenosyl-L-methionine <=> N⁶-methyl-L-lysyl⁴-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60269] N⁶-methyl-L-lysyl⁴-[histone H3] + S-adenosyl-L-methionine => N⁶,N⁶-dimethyl-L-lysyl⁴-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60270] N⁶,N⁶-dimethyl-L-lysyl⁴-[histone H3] + S-adenosyl-L-homocysteine + H⁺ => N⁶-methyl-L-lysyl⁴-[histone H3] + S-adenosyl-L-methionine
• [Rhea:RHEA:60271] N⁶-methyl-L-lysyl⁴-[histone H3] + S-adenosyl-L-methionine <=> N⁶,N⁶-dimethyl-L-lysyl⁴-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60273] N⁶,N⁶-dimethyl-L-lysyl⁴-[histone H3] + S-adenosyl-L-methionine => N⁶,N⁶,N⁶-trimethyl-L-lysyl⁴-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60274] N⁶,N⁶,N⁶-trimethyl-L-lysyl⁴-[histone H3] + S-adenosyl-L-homocysteine + H⁺ => N⁶,N⁶-dimethyl-L-lysyl⁴-[histone H3] + S-adenosyl-L-methionine
• [Rhea:RHEA:60275] N⁶,N⁶-dimethyl-L-lysyl⁴-[histone H3] + S-adenosyl-L-methionine <=> N⁶,N⁶,N⁶-trimethyl-L-lysyl⁴-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60277] L-lysyl⁹-[histone H3] + 3 S-adenosyl-L-methionine => N⁶,N⁶,N⁶-trimethyl-L-lysyl⁹-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:60278] N⁶,N⁶,N⁶-trimethyl-L-lysyl⁹-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H⁺ => L-lysyl⁹-[histone H3] + 3 S-adenosyl-L-methionine
• [Rhea:RHEA:60279] L-lysyl⁹-[histone H3] + 3 S-adenosyl-L-methionine <=> N⁶,N⁶,N⁶-trimethyl-L-lysyl⁹-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:60281] L-lysyl⁹-[histone H3] + S-adenosyl-L-methionine => N⁶-methyl-L-lysyl⁹-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60282] N⁶-methyl-L-lysyl⁹-[histone H3] + S-adenosyl-L-homocysteine + H⁺ => L-lysyl⁹-[histone H3] + S-adenosyl-L-methionine
• [Rhea:RHEA:60283] L-lysyl⁹-[histone H3] + S-adenosyl-L-methionine <=> N⁶-methyl-L-lysyl⁹-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60285] N⁶-methyl-L-lysyl⁹-[histone H3] + S-adenosyl-L-methionine => N⁶,N⁶-dimethyl-L-lysyl⁹-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60286] N⁶,N⁶-dimethyl-L-lysyl⁹-[histone H3] + S-adenosyl-L-homocysteine + H⁺ => N⁶-methyl-L-lysyl⁹-[histone H3] + S-adenosyl-L-methionine
• [Rhea:RHEA:60287] N⁶-methyl-L-lysyl⁹-[histone H3] + S-adenosyl-L-methionine <=> N⁶,N⁶-dimethyl-L-lysyl⁹-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60289] N⁶,N⁶-dimethyl-L-lysyl⁹-[histone H3] + S-adenosyl-L-methionine => N⁶,N⁶,N⁶-trimethyl-L-lysyl⁹-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60290] N⁶,N⁶,N⁶-trimethyl-L-lysyl⁹-[histone H3] + S-adenosyl-L-homocysteine + H⁺ => N⁶,N⁶-dimethyl-L-lysyl⁹-[histone H3] + S-adenosyl-L-methionine
• [Rhea:RHEA:60291] N⁶,N⁶-dimethyl-L-lysyl⁹-[histone H3] + S-adenosyl-L-methionine <=> N⁶,N⁶,N⁶-trimethyl-L-lysyl⁹-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60293] L-lysyl²⁷-[histone H3] + 3 S-adenosyl-L-methionine => N⁶,N⁶,N⁶-trimethyl-L-lysyl²⁷-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:60294] N⁶,N⁶,N⁶-trimethyl-L-lysyl²⁷-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H⁺ => L-lysyl²⁷-[histone H3] + 3 S-adenosyl-L-methionine
• [Rhea:RHEA:60295] L-lysyl²⁷-[histone H3] + 3 S-adenosyl-L-methionine <=> N⁶,N⁶,N⁶-trimethyl-L-lysyl²⁷-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:60297] L-lysyl²⁷-[histone H3] + S-adenosyl-L-methionine => N⁶-methyl-L-lysyl²⁷-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60298] N⁶-methyl-L-lysyl²⁷-[histone H3] + S-adenosyl-L-homocysteine + H⁺ => L-lysyl²⁷-[histone H3] + S-adenosyl-L-methionine
• [Rhea:RHEA:60299] L-lysyl²⁷-[histone H3] + S-adenosyl-L-methionine <=> N⁶-methyl-L-lysyl²⁷-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60301] N⁶-methyl-L-lysyl²⁷-[histone H3] + S-adenosyl-L-methionine => N⁶,N⁶-dimethyl-L-lysyl²⁷-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60302] N⁶,N⁶-dimethyl-L-lysyl²⁷-[histone H3] + S-adenosyl-L-homocysteine + H⁺ => N⁶-methyl-L-lysyl²⁷-[histone H3] + S-adenosyl-L-methionine
• [Rhea:RHEA:60303] N⁶-methyl-L-lysyl²⁷-[histone H3] + S-adenosyl-L-methionine <=> N⁶,N⁶-dimethyl-L-lysyl²⁷-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60305] N⁶,N⁶-dimethyl-L-lysyl²⁷-[histone H3] + S-adenosyl-L-methionine => N⁶,N⁶,N⁶-trimethyl-L-lysyl²⁷-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60306] N⁶,N⁶,N⁶-trimethyl-L-lysyl²⁷-[histone H3] + S-adenosyl-L-homocysteine + H⁺ => N⁶,N⁶-dimethyl-L-lysyl²⁷-[histone H3] + S-adenosyl-L-methionine
• [Rhea:RHEA:60307] N⁶,N⁶-dimethyl-L-lysyl²⁷-[histone H3] + S-adenosyl-L-methionine <=> N⁶,N⁶,N⁶-trimethyl-L-lysyl²⁷-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60309] L-lysyl³⁶-[histone H3] + 2 S-adenosyl-L-methionine => N⁶,N⁶-dimethyl-L-lysyl³⁶-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H⁺
• [Rhea:RHEA:60310] N⁶,N⁶-dimethyl-L-lysyl³⁶-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H⁺ => L-lysyl³⁶-[histone H3] + 2 S-adenosyl-L-methionine
• [Rhea:RHEA:60311] L-lysyl³⁶-[histone H3] + 2 S-adenosyl-L-methionine <=> N⁶,N⁶-dimethyl-L-lysyl³⁶-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H⁺
• [Rhea:RHEA:60313] L-lysyl³⁶-[histone H3] + S-adenosyl-L-methionine => N⁶-methyl-L-lysyl³⁶-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60314] N⁶-methyl-L-lysyl³⁶-[histone H3] + S-adenosyl-L-homocysteine + H⁺ => L-lysyl³⁶-[histone H3] + S-adenosyl-L-methionine
• [Rhea:RHEA:60315] L-lysyl³⁶-[histone H3] + S-adenosyl-L-methionine <=> N⁶-methyl-L-lysyl³⁶-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60317] N⁶-methyl-L-lysyl³⁶-[histone H3] + S-adenosyl-L-methionine => N⁶,N⁶-dimethyl-L-lysyl³⁶-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60318] N⁶,N⁶-dimethyl-L-lysyl³⁶-[histone H3] + S-adenosyl-L-homocysteine + H⁺ => N⁶-methyl-L-lysyl³⁶-[histone H3] + S-adenosyl-L-methionine
• [Rhea:RHEA:60319] N⁶-methyl-L-lysyl³⁶-[histone H3] + S-adenosyl-L-methionine <=> N⁶,N⁶-dimethyl-L-lysyl³⁶-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60321] N⁶,N⁶-dimethyl-L-lysyl³⁶-[histone H3] + S-adenosyl-L-methionine => N⁶,N⁶,N⁶-trimethyl-L-lysyl³⁶-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60322] N⁶,N⁶,N⁶-trimethyl-L-lysyl³⁶-[histone H3] + S-adenosyl-L-homocysteine + H⁺ => N⁶,N⁶-dimethyl-L-lysyl³⁶-[histone H3] + S-adenosyl-L-methionine
• [Rhea:RHEA:60323] N⁶,N⁶-dimethyl-L-lysyl³⁶-[histone H3] + S-adenosyl-L-methionine <=> N⁶,N⁶,N⁶-trimethyl-L-lysyl³⁶-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60325] L-lysyl³⁶-[histone H3] + 3 S-adenosyl-L-methionine => N⁶,N⁶,N⁶-trimethyl-L-lysyl³⁶-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:60326] N⁶,N⁶,N⁶-trimethyl-L-lysyl³⁶-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H⁺ => L-lysyl³⁶-[histone H3] + 3 S-adenosyl-L-methionine
• [Rhea:RHEA:60327] L-lysyl³⁶-[histone H3] + 3 S-adenosyl-L-methionine <=> N⁶,N⁶,N⁶-trimethyl-L-lysyl³⁶-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:60329] L-lysyl⁷⁹-[histone H3] + 3 S-adenosyl-L-methionine => N⁶,N⁶,N⁶-trimethyl-L-lysyl⁷⁹-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:60330] N⁶,N⁶,N⁶-trimethyl-L-lysyl⁷⁹-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H⁺ => L-lysyl⁷⁹-[histone H3] + 3 S-adenosyl-L-methionine
• [Rhea:RHEA:60331] L-lysyl⁷⁹-[histone H3] + 3 S-adenosyl-L-methionine <=> N⁶,N⁶,N⁶-trimethyl-L-lysyl⁷⁹-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:60333] L-lysyl⁷⁹-[histone H3] + S-adenosyl-L-methionine => N⁶-methyl-L-lysyl⁷⁹-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60334] N⁶-methyl-L-lysyl⁷⁹-[histone H3] + S-adenosyl-L-homocysteine + H⁺ => L-lysyl⁷⁹-[histone H3] + S-adenosyl-L-methionine
• [Rhea:RHEA:60335] L-lysyl⁷⁹-[histone H3] + S-adenosyl-L-methionine <=> N⁶-methyl-L-lysyl⁷⁹-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60337] N⁶-methyl-L-lysyl⁷⁹-[histone H3] + S-adenosyl-L-methionine => N⁶,N⁶-dimethyl-L-lysyl⁷⁹-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60338] N⁶,N⁶-dimethyl-L-lysyl⁷⁹-[histone H3] + S-adenosyl-L-homocysteine + H⁺ => N⁶-methyl-L-lysyl⁷⁹-[histone H3] + S-adenosyl-L-methionine
• [Rhea:RHEA:60339] N⁶-methyl-L-lysyl⁷⁹-[histone H3] + S-adenosyl-L-methionine <=> N⁶,N⁶-dimethyl-L-lysyl⁷⁹-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60341] N⁶,N⁶-dimethyl-L-lysyl⁷⁹-[histone H3] + S-adenosyl-L-methionine => N⁶,N⁶,N⁶-trimethyl-L-lysyl⁷⁹-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60342] N⁶,N⁶,N⁶-trimethyl-L-lysyl⁷⁹-[histone H3] + S-adenosyl-L-homocysteine + H⁺ => N⁶,N⁶-dimethyl-L-lysyl⁷⁹-[histone H3] + S-adenosyl-L-methionine
• [Rhea:RHEA:60343] N⁶,N⁶-dimethyl-L-lysyl⁷⁹-[histone H3] + S-adenosyl-L-methionine <=> N⁶,N⁶,N⁶-trimethyl-L-lysyl⁷⁹-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60345] L-lysyl²⁰-[histone H4] + S-adenosyl-L-methionine => N⁶-methyl-L-lysyl²⁰-[histone H4] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60346] N⁶-methyl-L-lysyl²⁰-[histone H4] + S-adenosyl-L-homocysteine + H⁺ => L-lysyl²⁰-[histone H4] + S-adenosyl-L-methionine
• [Rhea:RHEA:60347] L-lysyl²⁰-[histone H4] + S-adenosyl-L-methionine <=> N⁶-methyl-L-lysyl²⁰-[histone H4] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60349] N⁶-methyl-L-lysyl²⁰-[histone H4] + S-adenosyl-L-methionine => N⁶,N⁶-dimethyl-L-lysyl²⁰-[histone H4] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60350] N⁶,N⁶-dimethyl-L-lysyl²⁰-[histone H4] + S-adenosyl-L-homocysteine + H⁺ => N⁶-methyl-L-lysyl²⁰-[histone H4] + S-adenosyl-L-methionine
• [Rhea:RHEA:60351] N⁶-methyl-L-lysyl²⁰-[histone H4] + S-adenosyl-L-methionine <=> N⁶,N⁶-dimethyl-L-lysyl²⁰-[histone H4] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60525] 5-hydroxyuridine³⁴ in tRNA + S-adenosyl-L-methionine => 5-methoxyuridine³⁴ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60526] 5-methoxyuridine³⁴ in tRNA + S-adenosyl-L-homocysteine + H⁺ => 5-hydroxyuridine³⁴ in tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:60527] 5-hydroxyuridine³⁴ in tRNA + S-adenosyl-L-methionine <=> 5-methoxyuridine³⁴ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60861] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyl-adenosine) in mRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60862] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyl-adenosine) in mRNA + S-adenosyl-L-homocysteine + H⁺ => a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:60863] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyl-adenosine) in mRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60865] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyl-guanosine) in mRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60866] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyl-guanosine) in mRNA + S-adenosyl-L-homocysteine + H⁺ => a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:60867] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyl-guanosine) in mRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60901] a cytidine in RNA + S-adenosyl-L-methionine => an N³-methylcytidine in RNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60902] an N³-methylcytidine in RNA + S-adenosyl-L-homocysteine + H⁺ => a cytidine in RNA + S-adenosyl-L-methionine
• [Rhea:RHEA:60903] a cytidine in RNA + S-adenosyl-L-methionine <=> an N³-methylcytidine in RNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60909] a cytidine in tRNA + S-adenosyl-L-methionine => an N³-methylcytidine in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60910] an N³-methylcytidine in tRNA + S-adenosyl-L-homocysteine + H⁺ => a cytidine in tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:60911] a cytidine in tRNA + S-adenosyl-L-methionine <=> an N³-methylcytidine in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60913] cytidine³² in tRNA^Arg(CCU) + S-adenosyl-L-methionine => N³-methylcytidine³² in tRNA^Arg(CCU) + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60914] N³-methylcytidine³² in tRNA^Arg(CCU) + S-adenosyl-L-homocysteine + H⁺ => cytidine³² in tRNA^Arg(CCU) + S-adenosyl-L-methionine
• [Rhea:RHEA:60915] cytidine³² in tRNA^Arg(CCU) + S-adenosyl-L-methionine <=> N³-methylcytidine³² in tRNA^Arg(CCU) + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60917] a cytidine in mRNA + S-adenosyl-L-methionine => an N³-methylcytidine in mRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:60918] an N³-methylcytidine in mRNA + S-adenosyl-L-homocysteine + H⁺ => a cytidine in mRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:60919] a cytidine in mRNA + S-adenosyl-L-methionine <=> an N³-methylcytidine in mRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:61461] a cytidine in RNA + S-adenosyl-L-methionine => a 5-methylcytidine in RNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:61462] a 5-methylcytidine in RNA + S-adenosyl-L-homocysteine + H⁺ => a cytidine in RNA + S-adenosyl-L-methionine
• [Rhea:RHEA:61463] a cytidine in RNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in RNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:61465] a cytidine in mRNA + S-adenosyl-L-methionine => a 5-methylcytidine in mRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:61466] a 5-methylcytidine in mRNA + S-adenosyl-L-homocysteine + H⁺ => a cytidine in mRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:61467] a cytidine in mRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in mRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:61469] a cytidine in tRNA + S-adenosyl-L-methionine => a 5-methylcytidine in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:61470] a 5-methylcytidine in tRNA + S-adenosyl-L-homocysteine + H⁺ => a cytidine in tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:61471] a cytidine in tRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:61485] a cytidine in rRNA + S-adenosyl-L-methionine => a 5-methylcytidine in rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:61486] a 5-methylcytidine in rRNA + S-adenosyl-L-homocysteine + H⁺ => a cytidine in rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:61487] a cytidine in rRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:61489] cytidine⁵⁰ in tRNA + S-adenosyl-L-methionine => 5-methylcytidine⁵⁰ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:61490] 5-methylcytidine⁵⁰ in tRNA + S-adenosyl-L-homocysteine + H⁺ => cytidine⁵⁰ in tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:61491] cytidine⁵⁰ in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine⁵⁰ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:61585] cytidine⁷² in tRNA^Cys + S-adenosyl-L-methionine => 5-methylcytidine⁷² in tRNA^Cys + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:61586] 5-methylcytidine⁷² in tRNA^Cys + S-adenosyl-L-homocysteine + H⁺ => cytidine⁷² in tRNA^Cys + S-adenosyl-L-methionine
• [Rhea:RHEA:61587] cytidine⁷² in tRNA^Cys + S-adenosyl-L-methionine <=> 5-methylcytidine⁷² in tRNA^Cys + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:61989] cytidine⁷² in tRNA + S-adenosyl-L-methionine => 5-methylcytidine⁷² in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:61990] 5-methylcytidine⁷² in tRNA + S-adenosyl-L-homocysteine + H⁺ => cytidine⁷² in tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:61991] cytidine⁷² in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine⁷² in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:61993] N⁶,N⁶-dimethyl-L-lysyl²⁰-[histone H4] + S-adenosyl-L-methionine => N⁶,N⁶,N⁶-trimethyl-L-lysyl²⁰-[histone H4] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:61994] N⁶,N⁶,N⁶-trimethyl-L-lysyl²⁰-[histone H4] + S-adenosyl-L-homocysteine + H⁺ => N⁶,N⁶-dimethyl-L-lysyl²⁰-[histone H4] + S-adenosyl-L-methionine
• [Rhea:RHEA:61995] N⁶,N⁶-dimethyl-L-lysyl²⁰-[histone H4] + S-adenosyl-L-methionine <=> N⁶,N⁶,N⁶-trimethyl-L-lysyl²⁰-[histone H4] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:62013] cytidine²⁴⁹⁹ in 23S rRNA + S-adenosyl-L-methionine => 5-methylcytidine²⁴⁹⁹ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:62014] 5-methylcytidine²⁴⁹⁹ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺ => cytidine²⁴⁹⁹ in 23S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:62015] cytidine²⁴⁹⁹ in 23S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine²⁴⁹⁹ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:62521] a cytidine in rRNA + S-adenosyl-L-methionine => an N⁴-methylcytidine in rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:62522] an N⁴-methylcytidine in rRNA + S-adenosyl-L-homocysteine + H⁺ => a cytidine in rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:62523] a cytidine in rRNA + S-adenosyl-L-methionine <=> an N⁴-methylcytidine in rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:62525] cytidine⁸³⁹ in 12S rRNA + S-adenosyl-L-methionine => N⁴-methylcytidine⁸³⁹ in 12S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:62526] N⁴-methylcytidine⁸³⁹ in 12S rRNA + S-adenosyl-L-homocysteine + H⁺ => cytidine⁸³⁹ in 12S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:62527] cytidine⁸³⁹ in 12S rRNA + S-adenosyl-L-methionine <=> N⁴-methylcytidine⁸³⁹ in 12S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:62613] adenosine¹⁸³² in 18S rRNA + S-adenosyl-L-methionine => N⁶-methyladenosine¹⁸³² in 18S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:62614] N⁶-methyladenosine¹⁸³² in 18S rRNA + S-adenosyl-L-homocysteine + H⁺ => adenosine¹⁸³² in 18S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:62615] adenosine¹⁸³² in 18S rRNA + S-adenosyl-L-methionine <=> N⁶-methyladenosine¹⁸³² in 18S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:62673] a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine => an N⁶-methyl-2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:62674] an N⁶-methyl-2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-homocysteine + H⁺ => a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:62675] a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine <=> an N⁶-methyl-2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:62917] an N-terminal L-α-aminoacyl-[protein] + 3 S-adenosyl-L-methionine => an N-terminal trimethyl-L-α-aminoacyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:62918] an N-terminal trimethyl-L-α-aminoacyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H⁺ => an N-terminal L-α-aminoacyl-[protein] + 3 S-adenosyl-L-methionine
• [Rhea:RHEA:62919] an N-terminal L-α-aminoacyl-[protein] + 3 S-adenosyl-L-methionine <=> an N-terminal trimethyl-L-α-aminoacyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:63089] a ribonucleotide in U6 snRNA + S-adenosyl-L-methionine => a 2'-O-methylribonucleotide in U6 snRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:63090] a 2'-O-methylribonucleotide in U6 snRNA + S-adenosyl-L-homocysteine + H⁺ => a ribonucleotide in U6 snRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:63091] a ribonucleotide in U6 snRNA + S-adenosyl-L-methionine <=> a 2'-O-methylribonucleotide in U6 snRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:64445] L-lysyl⁹-[histone H3] + 2 S-adenosyl-L-methionine => N⁶,N⁶-dimethyl-L-lysyl⁹-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H⁺
• [Rhea:RHEA:64446] N⁶,N⁶-dimethyl-L-lysyl⁹-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H⁺ => L-lysyl⁹-[histone H3] + 2 S-adenosyl-L-methionine
• [Rhea:RHEA:64447] L-lysyl⁹-[histone H3] + 2 S-adenosyl-L-methionine <=> N⁶,N⁶-dimethyl-L-lysyl⁹-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H⁺
• [Rhea:RHEA:64449] L-lysyl⁴-[histone H3] + 2 S-adenosyl-L-methionine => N⁶,N⁶-dimethyl-L-lysyl⁴-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H⁺
• [Rhea:RHEA:64450] N⁶,N⁶-dimethyl-L-lysyl⁴-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H⁺ => L-lysyl⁴-[histone H3] + 2 S-adenosyl-L-methionine
• [Rhea:RHEA:64451] L-lysyl⁴-[histone H3] + 2 S-adenosyl-L-methionine <=> N⁶,N⁶-dimethyl-L-lysyl⁴-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H⁺
• [Rhea:RHEA:64453] L-lysyl²⁷-[histone H3] + 2 S-adenosyl-L-methionine => N⁶,N⁶-dimethyl-L-lysyl²⁷-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H⁺
• [Rhea:RHEA:64454] N⁶,N⁶-dimethyl-L-lysyl²⁷-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H⁺ => L-lysyl²⁷-[histone H3] + 2 S-adenosyl-L-methionine
• [Rhea:RHEA:64455] L-lysyl²⁷-[histone H3] + 2 S-adenosyl-L-methionine <=> N⁶,N⁶-dimethyl-L-lysyl²⁷-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H⁺
• [Rhea:RHEA:64457] L-lysyl²⁰-[histone H4] + 3 S-adenosyl-L-methionine => N⁶,N⁶,N⁶-trimethyl-L-lysyl²⁰-[histone H4] + 3 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:64458] N⁶,N⁶,N⁶-trimethyl-L-lysyl²⁰-[histone H4] + 3 S-adenosyl-L-homocysteine + 3 H⁺ => L-lysyl²⁰-[histone H4] + 3 S-adenosyl-L-methionine
• [Rhea:RHEA:64459] L-lysyl²⁰-[histone H4] + 3 S-adenosyl-L-methionine <=> N⁶,N⁶,N⁶-trimethyl-L-lysyl²⁰-[histone H4] + 3 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:65377] a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-methionine => a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:65378] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-homocysteine + H⁺ => a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-methionine
• [Rhea:RHEA:65379] a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-methionine <=> a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:65381] a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine => a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:65382] a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine + H⁺ => a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:65383] a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:66545] L-cysteinyl-[protein] + S-adenosyl-L-methionine => S-methyl-L-cysteinyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:66546] S-methyl-L-cysteinyl-[protein] + S-adenosyl-L-homocysteine + H⁺ => L-cysteinyl-[protein] + S-adenosyl-L-methionine
• [Rhea:RHEA:66547] L-cysteinyl-[protein] + S-adenosyl-L-methionine <=> S-methyl-L-cysteinyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:66589] a cytidine in 26S rRNA + S-adenosyl-L-methionine => a 5-methylcytidine in 26S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:66590] a 5-methylcytidine in 26S rRNA + S-adenosyl-L-homocysteine + H⁺ => a cytidine in 26S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:66591] a cytidine in 26S rRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in 26S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:67021] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine => a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:67022] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine + H⁺ => a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:67023] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:67025] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine => a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:67026] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + S-adenosyl-L-homocysteine + H⁺ => a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:67027] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:67077] L-histidyl-[protein] + S-adenosyl-L-methionine => N^π-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:67078] N^π-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine + H⁺ => L-histidyl-[protein] + S-adenosyl-L-methionine
• [Rhea:RHEA:67079] L-histidyl-[protein] + S-adenosyl-L-methionine <=> N^π-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:67109] L-lysyl³⁷-[histone H3] + 3 S-adenosyl-L-methionine => N⁶,N⁶,N⁶-trimethyl-L-lysyl³⁷-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:67110] N⁶,N⁶,N⁶-trimethyl-L-lysyl³⁷-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H⁺ => L-lysyl³⁷-[histone H3] + 3 S-adenosyl-L-methionine
• [Rhea:RHEA:67111] L-lysyl³⁷-[histone H3] + 3 S-adenosyl-L-methionine <=> N⁶,N⁶,N⁶-trimethyl-L-lysyl³⁷-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H⁺
• [Rhea:RHEA:67113] L-lysyl³⁷-[histone H3] + S-adenosyl-L-methionine => N⁶-methyl-L-lysyl³⁷-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:67114] N⁶-methyl-L-lysyl³⁷-[histone H3] + S-adenosyl-L-homocysteine + H⁺ => L-lysyl³⁷-[histone H3] + S-adenosyl-L-methionine
• [Rhea:RHEA:67115] L-lysyl³⁷-[histone H3] + S-adenosyl-L-methionine <=> N⁶-methyl-L-lysyl³⁷-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:67117] N⁶-methyl-L-lysyl³⁷-[histone H3] + S-adenosyl-L-methionine => N⁶,N⁶-dimethyl-L-lysyl³⁷-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:67118] N⁶,N⁶-dimethyl-L-lysyl³⁷-[histone H3] + S-adenosyl-L-homocysteine + H⁺ => N⁶-methyl-L-lysyl³⁷-[histone H3] + S-adenosyl-L-methionine
• [Rhea:RHEA:67119] N⁶-methyl-L-lysyl³⁷-[histone H3] + S-adenosyl-L-methionine <=> N⁶,N⁶-dimethyl-L-lysyl³⁷-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:67121] N⁶,N⁶-dimethyl-L-lysyl³⁷-[histone H3] + S-adenosyl-L-methionine => N⁶,N⁶,N⁶-trimethyl-L-lysyl³⁷-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:67122] N⁶,N⁶,N⁶-trimethyl-L-lysyl³⁷-[histone H3] + S-adenosyl-L-homocysteine + H⁺ => N⁶,N⁶-dimethyl-L-lysyl³⁷-[histone H3] + S-adenosyl-L-methionine
• [Rhea:RHEA:67123] N⁶,N⁶-dimethyl-L-lysyl³⁷-[histone H3] + S-adenosyl-L-methionine <=> N⁶,N⁶,N⁶-trimethyl-L-lysyl³⁷-[histone H3] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:67809] L-lysyl⁸-[histone H2AZ] + S-adenosyl-L-methionine => N⁶-methyl-L-lysyl⁸-[histone H2AZ] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:67810] N⁶-methyl-L-lysyl⁸-[histone H2AZ] + S-adenosyl-L-homocysteine + H⁺ => L-lysyl⁸-[histone H2AZ] + S-adenosyl-L-methionine
• [Rhea:RHEA:67811] L-lysyl⁸-[histone H2AZ] + S-adenosyl-L-methionine <=> N⁶-methyl-L-lysyl⁸-[histone H2AZ] + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:69860] a uridine in 12S rRNA + S-adenosyl-L-methionine => a 5-methyluridine in 12S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:69861] a 5-methyluridine in 12S rRNA + S-adenosyl-L-homocysteine + H⁺ => a uridine in 12S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:69862] a uridine in 12S rRNA + S-adenosyl-L-methionine <=> a 5-methyluridine in 12S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:69864] a uridine in mRNA + S-adenosyl-L-methionine => a 5-methyluridine in mRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:69865] a 5-methyluridine in mRNA + S-adenosyl-L-homocysteine + H⁺ => a uridine in mRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:69866] a uridine in mRNA + S-adenosyl-L-methionine <=> a 5-methyluridine in mRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:69868] a uridine in RNA + S-adenosyl-L-methionine => a 5-methyluridine in RNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:69869] a 5-methyluridine in RNA + S-adenosyl-L-homocysteine + H⁺ => a uridine in RNA + S-adenosyl-L-methionine
• [Rhea:RHEA:69870] a uridine in RNA + S-adenosyl-L-methionine <=> a 5-methyluridine in RNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:70028] N⁶-L-threonylcarbamoyladenosine³⁷ in tRNA + S-adenosyl-L-methionine => N⁶-methyl,N⁶-L-threonylcarbamoyladenosine³⁷ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:70029] N⁶-methyl,N⁶-L-threonylcarbamoyladenosine³⁷ in tRNA + S-adenosyl-L-homocysteine + H⁺ => N⁶-L-threonylcarbamoyladenosine³⁷ in tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:70030] N⁶-L-threonylcarbamoyladenosine³⁷ in tRNA + S-adenosyl-L-methionine <=> N⁶-methyl,N⁶-L-threonylcarbamoyladenosine³⁷ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:73760] guanosine²⁵⁵³ in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine²⁵⁵³ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:73761] 2'-O-methylguanosine²⁵⁵³ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺ => guanosine²⁵⁵³ in 23S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:73762] guanosine²⁵⁵³ in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine²⁵⁵³ in 23S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:78472] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine => a 5'-end (N²,N⁷-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:78473] a 5'-end (N²,N⁷-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H⁺ => a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:78474] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine <=> a 5'-end (N²,N⁷-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:78476] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine => a 5'-end (N²,N⁷-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:78477] a 5'-end (N²,N⁷-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H⁺ => a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:78478] a 5'-end (N⁷-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine <=> a 5'-end (N²,N⁷-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:78480] a 5'-end (N²,N⁷-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine => a 5'-end (N²,N²,N⁷-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:78481] a 5'-end (N²,N²,N⁷-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H⁺ => a 5'-end (N²,N⁷-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:78482] a 5'-end (N²,N⁷-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine <=> a 5'-end (N²,N²,N⁷-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:78508] a 5'-end (N²,N⁷-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine => a 5'-end (N²,N²,N⁷-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:78509] a 5'-end (N²,N²,N⁷-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H⁺ => a 5'-end (N²,N⁷-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:78510] a 5'-end (N²,N⁷-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine <=> a 5'-end (N²,N²,N⁷-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:80936] 10-hydroxystrychnine + S-adenosyl-L-methionine => β-colubrine + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:80937] β-colubrine + S-adenosyl-L-homocysteine + H⁺ => 10-hydroxystrychnine + S-adenosyl-L-methionine
• [Rhea:RHEA:80938] 10-hydroxystrychnine + S-adenosyl-L-methionine <=> β-colubrine + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:80944] 11-demethylbrucine + S-adenosyl-L-methionine => brucine + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:80945] brucine + S-adenosyl-L-homocysteine + H⁺ => 11-demethylbrucine + S-adenosyl-L-methionine
• [Rhea:RHEA:80946] 11-demethylbrucine + S-adenosyl-L-methionine <=> brucine + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81000] N-methyl-dopamine + S-adenosyl-L-methionine => N,N-dimethyldopamine + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81001] N,N-dimethyldopamine + S-adenosyl-L-homocysteine + H⁺ => N-methyl-dopamine + S-adenosyl-L-methionine
• [Rhea:RHEA:81002] N-methyl-dopamine + S-adenosyl-L-methionine <=> N,N-dimethyldopamine + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81008] N-methyl-3-methoxytyramine + S-adenosyl-L-methionine => N,N-dimethyl-3-methoxytyramine + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81009] N,N-dimethyl-3-methoxytyramine + S-adenosyl-L-homocysteine + H⁺ => N-methyl-3-methoxytyramine + S-adenosyl-L-methionine
• [Rhea:RHEA:81010] N-methyl-3-methoxytyramine + S-adenosyl-L-methionine <=> N,N-dimethyl-3-methoxytyramine + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81012] 3,4-dihydroxy-5-methoxyphenethylamine + S-adenosyl-L-methionine => N-methyl-3,4-dihydroxy-5-methoxyphenethylamine + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81013] N-methyl-3,4-dihydroxy-5-methoxyphenethylamine + S-adenosyl-L-homocysteine + H⁺ => 3,4-dihydroxy-5-methoxyphenethylamine + S-adenosyl-L-methionine
• [Rhea:RHEA:81014] 3,4-dihydroxy-5-methoxyphenethylamine + S-adenosyl-L-methionine <=> N-methyl-3,4-dihydroxy-5-methoxyphenethylamine + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81016] N-methyl-3,4-dihydroxy-5-methoxyphenethylamine + S-adenosyl-L-methionine => N,N-dimethyl-3,4-dihydroxy-5-methoxyphenethylamine + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81017] N,N-dimethyl-3,4-dihydroxy-5-methoxyphenethylamine + S-adenosyl-L-homocysteine + H⁺ => N-methyl-3,4-dihydroxy-5-methoxyphenethylamine + S-adenosyl-L-methionine
• [Rhea:RHEA:81018] N-methyl-3,4-dihydroxy-5-methoxyphenethylamine + S-adenosyl-L-methionine <=> N,N-dimethyl-3,4-dihydroxy-5-methoxyphenethylamine + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81020] 3-hydroxy-4,5-dimethoxyphenethylamine + S-adenosyl-L-methionine => N-methyl-3-hydroxy-4,5-dimethoxyphenethylamine + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81021] N-methyl-3-hydroxy-4,5-dimethoxyphenethylamine + S-adenosyl-L-homocysteine + H⁺ => 3-hydroxy-4,5-dimethoxyphenethylamine + S-adenosyl-L-methionine
• [Rhea:RHEA:81022] 3-hydroxy-4,5-dimethoxyphenethylamine + S-adenosyl-L-methionine <=> N-methyl-3-hydroxy-4,5-dimethoxyphenethylamine + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81024] N-methyl-3-hydroxy-4,5-dimethoxyphenethylamine + S-adenosyl-L-methionine => N,N-dimethyl-3-hydroxy-4,5-dimethoxyphenethylamine + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81025] N,N-dimethyl-3-hydroxy-4,5-dimethoxyphenethylamine + S-adenosyl-L-homocysteine + H⁺ => N-methyl-3-hydroxy-4,5-dimethoxyphenethylamine + S-adenosyl-L-methionine
• [Rhea:RHEA:81026] N-methyl-3-hydroxy-4,5-dimethoxyphenethylamine + S-adenosyl-L-methionine <=> N,N-dimethyl-3-hydroxy-4,5-dimethoxyphenethylamine + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81028] 4-hydroxy-3,5-dimethoxyphenethylamine + S-adenosyl-L-methionine => N-methyl-4-hydroxy-3,5-dimethoxyphenethylamine + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81029] N-methyl-4-hydroxy-3,5-dimethoxyphenethylamine + S-adenosyl-L-homocysteine + H⁺ => 4-hydroxy-3,5-dimethoxyphenethylamine + S-adenosyl-L-methionine
• [Rhea:RHEA:81030] 4-hydroxy-3,5-dimethoxyphenethylamine + S-adenosyl-L-methionine <=> N-methyl-4-hydroxy-3,5-dimethoxyphenethylamine + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81032] N-methyl-4-hydroxy-3,5-dimethoxyphenethylamine + S-adenosyl-L-methionine => N,N-dimethyl-4-hydroxy-3,5-dimethoxyphenethylamine + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81033] N,N-dimethyl-4-hydroxy-3,5-dimethoxyphenethylamine + S-adenosyl-L-homocysteine + H⁺ => N-methyl-4-hydroxy-3,5-dimethoxyphenethylamine + S-adenosyl-L-methionine
• [Rhea:RHEA:81034] N-methyl-4-hydroxy-3,5-dimethoxyphenethylamine + S-adenosyl-L-methionine <=> N,N-dimethyl-4-hydroxy-3,5-dimethoxyphenethylamine + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81036] mescaline + S-adenosyl-L-methionine => N-methylmescaline + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81037] N-methylmescaline + S-adenosyl-L-homocysteine + H⁺ => mescaline + S-adenosyl-L-methionine
• [Rhea:RHEA:81038] mescaline + S-adenosyl-L-methionine <=> N-methylmescaline + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81040] N-methylmescaline + S-adenosyl-L-methionine => N,N-dimethylmescaline + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81041] N,N-dimethylmescaline + S-adenosyl-L-homocysteine + H⁺ => N-methylmescaline + S-adenosyl-L-methionine
• [Rhea:RHEA:81042] N-methylmescaline + S-adenosyl-L-methionine <=> N,N-dimethylmescaline + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81044] 3,4-dihydroxy-5-methoxyphenethylamine + S-adenosyl-L-methionine => 4-hydroxy-3,5-dimethoxyphenethylamine + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81045] 4-hydroxy-3,5-dimethoxyphenethylamine + S-adenosyl-L-homocysteine + H⁺ => 3,4-dihydroxy-5-methoxyphenethylamine + S-adenosyl-L-methionine
• [Rhea:RHEA:81046] 3,4-dihydroxy-5-methoxyphenethylamine + S-adenosyl-L-methionine <=> 4-hydroxy-3,5-dimethoxyphenethylamine + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81052] 3,4-dihydroxy-5-methoxyphenethylamine + S-adenosyl-L-methionine => 3-hydroxy-4,5-dimethoxyphenethylamine + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81053] 3-hydroxy-4,5-dimethoxyphenethylamine + S-adenosyl-L-homocysteine + H⁺ => 3,4-dihydroxy-5-methoxyphenethylamine + S-adenosyl-L-methionine
• [Rhea:RHEA:81054] 3,4-dihydroxy-5-methoxyphenethylamine + S-adenosyl-L-methionine <=> 3-hydroxy-4,5-dimethoxyphenethylamine + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81056] 3-hydroxy-4,5-dimethoxyphenethylamine + S-adenosyl-L-methionine => mescaline + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81057] mescaline + S-adenosyl-L-homocysteine + H⁺ => 3-hydroxy-4,5-dimethoxyphenethylamine + S-adenosyl-L-methionine
• [Rhea:RHEA:81058] 3-hydroxy-4,5-dimethoxyphenethylamine + S-adenosyl-L-methionine <=> mescaline + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81060] 4-hydroxy-3,5-dimethoxyphenethylamine + S-adenosyl-L-methionine => mescaline + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81061] mescaline + S-adenosyl-L-homocysteine + H⁺ => 4-hydroxy-3,5-dimethoxyphenethylamine + S-adenosyl-L-methionine
• [Rhea:RHEA:81062] 4-hydroxy-3,5-dimethoxyphenethylamine + S-adenosyl-L-methionine <=> mescaline + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81332] 11-hydroxystrychnine + S-adenosyl-L-methionine => α-colubrine + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81333] α-colubrine + S-adenosyl-L-homocysteine + H⁺ => 11-hydroxystrychnine + S-adenosyl-L-methionine
• [Rhea:RHEA:81334] 11-hydroxystrychnine + S-adenosyl-L-methionine <=> α-colubrine + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81532] desmethylrestrictinol + S-adenosyl-L-methionine => restrictinol + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:81533] restrictinol + S-adenosyl-L-homocysteine + H⁺ => desmethylrestrictinol + S-adenosyl-L-methionine
• [Rhea:RHEA:81534] desmethylrestrictinol + S-adenosyl-L-methionine <=> restrictinol + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:82176] a 3'-hydroxyisoflavone + S-adenosyl-L-methionine => a 3'-methoxyisoflavone + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:82177] a 3'-methoxyisoflavone + S-adenosyl-L-homocysteine + H⁺ => a 3'-hydroxyisoflavone + S-adenosyl-L-methionine
• [Rhea:RHEA:82178] a 3'-hydroxyisoflavone + S-adenosyl-L-methionine <=> a 3'-methoxyisoflavone + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:82184] 3',4',7-trihydroxyisoflavone + S-adenosyl-L-methionine => 7,4'-dihydroxy-3'-methoxyisoflavone-7-olate + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:82185] 7,4'-dihydroxy-3'-methoxyisoflavone-7-olate + S-adenosyl-L-homocysteine + H⁺ => 3',4',7-trihydroxyisoflavone + S-adenosyl-L-methionine
• [Rhea:RHEA:82186] 3',4',7-trihydroxyisoflavone + S-adenosyl-L-methionine <=> 7,4'-dihydroxy-3'-methoxyisoflavone-7-olate + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:82396] thiohydroxamate + S-adenosyl-L-methionine => fluopsin + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:82397] fluopsin + S-adenosyl-L-homocysteine + H⁺ => thiohydroxamate + S-adenosyl-L-methionine
• [Rhea:RHEA:82398] thiohydroxamate + S-adenosyl-L-methionine <=> fluopsin + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:82404] demethylaltemicidin + S-adenosyl-L-methionine => altemicidin + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:82405] altemicidin + S-adenosyl-L-homocysteine + H⁺ => demethylaltemicidin + S-adenosyl-L-methionine
• [Rhea:RHEA:82406] demethylaltemicidin + S-adenosyl-L-methionine <=> altemicidin + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:82584] 10-hydroxy-13-deoxycarminomycin + S-adenosyl-L-methionine => 10-hydroxy-13-deoxydaunorubicin + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:82585] 10-hydroxy-13-deoxydaunorubicin + S-adenosyl-L-homocysteine + H⁺ => 10-hydroxy-13-deoxycarminomycin + S-adenosyl-L-methionine
• [Rhea:RHEA:82586] 10-hydroxy-13-deoxycarminomycin + S-adenosyl-L-methionine <=> 10-hydroxy-13-deoxydaunorubicin + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:82672] 5,7-dihydroxy-4-(hydroxymethyl)-6-methylphthalide + S-adenosyl-L-methionine => 5-hydroxy-4-(hydroxymethyl)-7-methoxy-6-methylphthalide + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:82673] 5-hydroxy-4-(hydroxymethyl)-7-methoxy-6-methylphthalide + S-adenosyl-L-homocysteine + H⁺ => 5,7-dihydroxy-4-(hydroxymethyl)-6-methylphthalide + S-adenosyl-L-methionine
• [Rhea:RHEA:82674] 5,7-dihydroxy-4-(hydroxymethyl)-6-methylphthalide + S-adenosyl-L-methionine <=> 5-hydroxy-4-(hydroxymethyl)-7-methoxy-6-methylphthalide + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:82824] campesine A + S-adenosyl-L-methionine => campesine B + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:82825] campesine B + S-adenosyl-L-homocysteine + H⁺ => campesine A + S-adenosyl-L-methionine
• [Rhea:RHEA:82826] campesine A + S-adenosyl-L-methionine <=> campesine B + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:83420] guanosine⁷ in tRNA + S-adenosyl-L-methionine => N²-methylguanosine⁷ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:83421] N²-methylguanosine⁷ in tRNA + S-adenosyl-L-homocysteine + H⁺ => guanosine⁷ in tRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:83422] guanosine⁷ in tRNA + S-adenosyl-L-methionine <=> N²-methylguanosine⁷ in tRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:83424] guanosine in U6 snRNA + S-adenosyl-L-methionine => N²-methylguanosine in U6 snRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:83425] N²-methylguanosine in U6 snRNA + S-adenosyl-L-homocysteine + H⁺ => guanosine in U6 snRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:83426] guanosine in U6 snRNA + S-adenosyl-L-methionine <=> N²-methylguanosine in U6 snRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:83588] (1S,4S)-4-[(4-hydroxyphenyl)methyl]-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-methionine => (1S,4S)-4-[(4-hydroxyphenyl)methyl]-2-methyl-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:83589] (1S,4S)-4-[(4-hydroxyphenyl)methyl]-2-methyl-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-homocysteine + H⁺ => (1S,4S)-4-[(4-hydroxyphenyl)methyl]-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-methionine
• [Rhea:RHEA:83590] (1S,4S)-4-[(4-hydroxyphenyl)methyl]-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-methionine <=> (1S,4S)-4-[(4-hydroxyphenyl)methyl]-2-methyl-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:83592] (1S,4S)-4-[(4-hydroxyphenyl)methyl]-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-methionine => (1S,4S)-4-[(4-methoxyphenyl)methyl]-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:83593] (1S,4S)-4-[(4-methoxyphenyl)methyl]-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-homocysteine + H⁺ => (1S,4S)-4-[(4-hydroxyphenyl)methyl]-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-methionine
• [Rhea:RHEA:83594] (1S,4S)-4-[(4-hydroxyphenyl)methyl]-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-methionine <=> (1S,4S)-4-[(4-methoxyphenyl)methyl]-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:83596] (1S,4S)-4-[(4-hydroxyphenyl)methyl]-2-methyl-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-methionine => (1S,4S)-4-[(4-methoxyphenyl)methyl]-2-methyl-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:83597] (1S,4S)-4-[(4-methoxyphenyl)methyl]-2-methyl-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-homocysteine + H⁺ => (1S,4S)-4-[(4-hydroxyphenyl)methyl]-2-methyl-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-methionine
• [Rhea:RHEA:83598] (1S,4S)-4-[(4-hydroxyphenyl)methyl]-2-methyl-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-methionine <=> (1S,4S)-4-[(4-methoxyphenyl)methyl]-2-methyl-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:83600] (1S,4S)-4-[(4-methoxyphenyl)methyl]-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-methionine => (1S,4S)-4-[(4-methoxyphenyl)methyl]-2-methyl-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:83601] (1S,4S)-4-[(4-methoxyphenyl)methyl]-2-methyl-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-homocysteine + H⁺ => (1S,4S)-4-[(4-methoxyphenyl)methyl]-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-methionine
• [Rhea:RHEA:83602] (1S,4S)-4-[(4-methoxyphenyl)methyl]-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-methionine <=> (1S,4S)-4-[(4-methoxyphenyl)methyl]-2-methyl-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:83636] uridine in 28S rRNA + S-adenosyl-L-methionine => N³-methyluridine in 28S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:83637] N³-methyluridine in 28S rRNA + S-adenosyl-L-homocysteine + H⁺ => uridine in 28S rRNA + S-adenosyl-L-methionine
• [Rhea:RHEA:83638] uridine in 28S rRNA + S-adenosyl-L-methionine <=> N³-methyluridine in 28S rRNA + S-adenosyl-L-homocysteine + H⁺
• [Rhea:RHEA:83896] guanosine²⁷ in tRNA(Tyr) + 2 S-adenosyl-L-methionine => N²-dimethylguanosine²⁷ in tRNA(Tyr) + 2 S-adenosyl-L-homocysteine + 2 H⁺
• [Rhea:RHEA:83897] N²-dimethylguanosine²⁷ in tRNA(Tyr) + 2 S-adenosyl-L-homocysteine + 2 H⁺ => guanosine²⁷ in tRNA(Tyr) + 2 S-adenosyl-L-methionine
• [Rhea:RHEA:83898] guanosine²⁷ in tRNA(Tyr) + 2 S-adenosyl-L-methionine <=> N²-dimethylguanosine²⁷ in tRNA(Tyr) + 2 S-adenosyl-L-homocysteine + 2 H⁺

Metabolites

Substrates

metabolite	compartment	Structure

Products

metabolite	compartment	Structure
Formula:	Cytoplasm
S-adenosyl-L-methionine zwitterion Formula: C15H23N6O5S	Cytoplasm
Formula:	Cytoplasm
S-adenosyl-L-homocysteine zwitterion Formula: C14H20N6O5S	Cytoplasm
H+ Formula: H	Cytoplasm