(2<i>R</i>,3<i>S</i>)-3-isopropylmalate + NAD<small><sup>+</sup></small> <=> 4-methyl-2-oxopentanoate + CO<small><sub>2</sub></small> + NADH - 数据之源，洞见之始

Rhea:RHEA:32274

Multi-step reaction: RHEA:10892 and RHEA:25078

(2R,3S)-3-isopropylmalate + NAD⁺ <=> 4-methyl-2-oxopentanoate + CO₂ + NADH

= (2R,3S)-3-Isopropylmalate[C7H12O5] + NAD(1-)[C21H26N7O14P2] + 4-Methyl-2-oxopentanoate[C6H10O3] + CO2[CO2] + NADH(2-)[C21H27N7O14P2]

DB Links

KEGG: R10052
EC Number: 1.1.1.85
Rhea: RHEA:32274

Alias

[Rhea:RHEA:32272] (2R,3S)-3-isopropylmalate + NAD⁺ => 4-methyl-2-oxopentanoate + CO₂ + NADH
[Rhea:RHEA:32273] 4-methyl-2-oxopentanoate + CO₂ + NADH => (2R,3S)-3-isopropylmalate + NAD⁺
[Rhea:RHEA:32274] (2R,3S)-3-isopropylmalate + NAD⁺ <=> 4-methyl-2-oxopentanoate + CO₂ + NADH

Metabolites

Substrates

metabolite	compartment	Structure

Products

metabolite	compartment	Structure
(2R,3S)-3-Isopropylmalate Formula: C7H12O5	Cytoplasm
NAD(1-) Formula: C21H26N7O14P2	Cytoplasm
4-Methyl-2-oxopentanoate Formula: C6H10O3	Cytoplasm
CO2 Formula: CO2	Cytoplasm
NADH(2-) Formula: C21H27N7O14P2	Cytoplasm