数据之源，洞见之始

3-O-{α-D-GlcNAc-[(1→4)-β-D-GlcA-(1→4)-α-D-GlcNAc]_(n)-(1→4)-β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl}-L-seryl-[protein] + UDP-α-D-glucuronate => 3-O-{[(1→4)-β-D-GlcA-(1→4)-α-D-GlcNAc]_(n+1)-(1→4)-β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl}-L-seryl-[protein] + UDP + H⁺

= [] + UDP-alpha-D-glucuronate(3-)[C15H19N2O18P2] + [] + UDP(3-)[C9H11N2O12P2] + H+[H]

DB Links

• BioCyc: 2.4.1.225-RXN
• EC Number: 2.4.1.225
• Rhea: RHEA:20909

Alias

• [Rhea:RHEA:12529] N-acetyl-β-D-glucosaminyl-(1→4)-[hyaluronan]_(n) + UDP-α-D-glucuronate => [hyaluronan]_(n+1) + UDP + H⁺
• [Rhea:RHEA:12530] [hyaluronan]_(n+1) + UDP + H⁺ => N-acetyl-β-D-glucosaminyl-(1→4)-[hyaluronan]_(n) + UDP-α-D-glucuronate
• [Rhea:RHEA:12531] N-acetyl-β-D-glucosaminyl-(1→4)-[hyaluronan]_(n) + UDP-α-D-glucuronate <=> [hyaluronan]_(n+1) + UDP + H⁺
• [Rhea:RHEA:20909] 3-O-{α-D-GlcNAc-[(1→4)-β-D-GlcA-(1→4)-α-D-GlcNAc]_(n)-(1→4)-β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl}-L-seryl-[protein] + UDP-α-D-glucuronate => 3-O-{[(1→4)-β-D-GlcA-(1→4)-α-D-GlcNAc]_(n+1)-(1→4)-β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl}-L-seryl-[protein] + UDP + H⁺
• [Rhea:RHEA:20910] 3-O-{[(1→4)-β-D-GlcA-(1→4)-α-D-GlcNAc]_(n+1)-(1→4)-β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl}-L-seryl-[protein] + UDP + H⁺ => 3-O-{α-D-GlcNAc-[(1→4)-β-D-GlcA-(1→4)-α-D-GlcNAc]_(n)-(1→4)-β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl}-L-seryl-[protein] + UDP-α-D-glucuronate
• [Rhea:RHEA:20911] 3-O-{α-D-GlcNAc-[(1→4)-β-D-GlcA-(1→4)-α-D-GlcNAc]_(n)-(1→4)-β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl}-L-seryl-[protein] + UDP-α-D-glucuronate <=> 3-O-{[(1→4)-β-D-GlcA-(1→4)-α-D-GlcNAc]_(n+1)-(1→4)-β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl}-L-seryl-[protein] + UDP + H⁺
• [Rhea:RHEA:23429] 3-O-(β-D-GalNAc-(1→4)-β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl)-L-seryl-[protein] + UDP-α-D-glucuronate => 3-O-(β-D-GlcA-(1→3)-β-D-GalNAc-(1→4)-β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl)-L-seryl-[protein] + UDP + H⁺
• [Rhea:RHEA:23430] 3-O-(β-D-GlcA-(1→3)-β-D-GalNAc-(1→4)-β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl)-L-seryl-[protein] + UDP + H⁺ => 3-O-(β-D-GalNAc-(1→4)-β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl)-L-seryl-[protein] + UDP-α-D-glucuronate
• [Rhea:RHEA:23431] 3-O-(β-D-GalNAc-(1→4)-β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl)-L-seryl-[protein] + UDP-α-D-glucuronate <=> 3-O-(β-D-GlcA-(1→3)-β-D-GalNAc-(1→4)-β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl)-L-seryl-[protein] + UDP + H⁺
• [Rhea:RHEA:24169] 3-O-(β-D-galactosyl-(1→3)-β-D-galactosyl-(1→4)-β-D-xylosyl)-L-seryl-[protein] + UDP-α-D-glucuronate => 3-O-(β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl)-L-seryl-[protein] + UDP + H⁺
• [Rhea:RHEA:24170] 3-O-(β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl)-L-seryl-[protein] + UDP + H⁺ => 3-O-(β-D-galactosyl-(1→3)-β-D-galactosyl-(1→4)-β-D-xylosyl)-L-seryl-[protein] + UDP-α-D-glucuronate
• [Rhea:RHEA:24171] 3-O-(β-D-galactosyl-(1→3)-β-D-galactosyl-(1→4)-β-D-xylosyl)-L-seryl-[protein] + UDP-α-D-glucuronate <=> 3-O-(β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl)-L-seryl-[protein] + UDP + H⁺
• [Rhea:RHEA:46861] 3-O-[β-D-Xyl-(1→4)-Rib-ol-P-Rib-ol-P-3-β-D-GalNAc-(1→3)-β-D-GlcNAc-(1→4)-(O-6-P-α-D-Man)]-Thr-[protein] + UDP-α-D-glucuronate => 3-O-[β-D-GlcA-(1→3)-β-D-Xyl-(1→4)-Rib-ol-P-Rib-ol-P-3-β-D-GalNAc-(1→3)-β-D-GlcNAc-(1→4)-(O-6-P-α-D-Man)]-Thr-[protein] + UDP + H⁺
• [Rhea:RHEA:46862] 3-O-[β-D-GlcA-(1→3)-β-D-Xyl-(1→4)-Rib-ol-P-Rib-ol-P-3-β-D-GalNAc-(1→3)-β-D-GlcNAc-(1→4)-(O-6-P-α-D-Man)]-Thr-[protein] + UDP + H⁺ => 3-O-[β-D-Xyl-(1→4)-Rib-ol-P-Rib-ol-P-3-β-D-GalNAc-(1→3)-β-D-GlcNAc-(1→4)-(O-6-P-α-D-Man)]-Thr-[protein] + UDP-α-D-glucuronate
• [Rhea:RHEA:46863] 3-O-[β-D-Xyl-(1→4)-Rib-ol-P-Rib-ol-P-3-β-D-GalNAc-(1→3)-β-D-GlcNAc-(1→4)-(O-6-P-α-D-Man)]-Thr-[protein] + UDP-α-D-glucuronate <=> 3-O-[β-D-GlcA-(1→3)-β-D-Xyl-(1→4)-Rib-ol-P-Rib-ol-P-3-β-D-GalNAc-(1→3)-β-D-GlcNAc-(1→4)-(O-6-P-α-D-Man)]-Thr-[protein] + UDP + H⁺
• [Rhea:RHEA:54997] 3-O-{[β-D-GalNAc-(1→4)-β-D-GlcA-(1→3)]_(n)-β-D-GalNAc-(1→4)-β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl}-L-seryl-[protein] + UDP-α-D-glucuronate => 3-O-{β-D-GlcA-(1→3)-[β-D-GalNAc-(1→4)-β-D-GlcA-(1→3)]_(n)-β-D-GalNAc-(1→4)-β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl}-L-seryl-[protein] + UDP + H⁺
• [Rhea:RHEA:54998] 3-O-{β-D-GlcA-(1→3)-[β-D-GalNAc-(1→4)-β-D-GlcA-(1→3)]_(n)-β-D-GalNAc-(1→4)-β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl}-L-seryl-[protein] + UDP + H⁺ => 3-O-{[β-D-GalNAc-(1→4)-β-D-GlcA-(1→3)]_(n)-β-D-GalNAc-(1→4)-β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl}-L-seryl-[protein] + UDP-α-D-glucuronate
• [Rhea:RHEA:54999] 3-O-{[β-D-GalNAc-(1→4)-β-D-GlcA-(1→3)]_(n)-β-D-GalNAc-(1→4)-β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl}-L-seryl-[protein] + UDP-α-D-glucuronate <=> 3-O-{β-D-GlcA-(1→3)-[β-D-GalNAc-(1→4)-β-D-GlcA-(1→3)]_(n)-β-D-GalNAc-(1→4)-β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl}-L-seryl-[protein] + UDP + H⁺
• [Rhea:RHEA:56161] an archaeal dolichyl α-D-glucosyl phosphate + UDP-α-D-glucuronate => an archaeal dolichyl β-D-glucuronosyl-(1→4)-α-D-glucosyl phosphate + UDP + H⁺
• [Rhea:RHEA:56162] an archaeal dolichyl β-D-glucuronosyl-(1→4)-α-D-glucosyl phosphate + UDP + H⁺ => an archaeal dolichyl α-D-glucosyl phosphate + UDP-α-D-glucuronate
• [Rhea:RHEA:56163] an archaeal dolichyl α-D-glucosyl phosphate + UDP-α-D-glucuronate <=> an archaeal dolichyl β-D-glucuronosyl-(1→4)-α-D-glucosyl phosphate + UDP + H⁺
• [Rhea:RHEA:56509] 3-O-(β-D-galactosyl-(1→3)-β-D-galactosyl-(1→4)-β-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-α-D-glucuronate => 3-O-[β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-2-O-P-Xyl]-L-seryl-[protein] + UDP + H⁺
• [Rhea:RHEA:56510] 3-O-[β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-2-O-P-Xyl]-L-seryl-[protein] + UDP + H⁺ => 3-O-(β-D-galactosyl-(1→3)-β-D-galactosyl-(1→4)-β-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-α-D-glucuronate
• [Rhea:RHEA:56511] 3-O-(β-D-galactosyl-(1→3)-β-D-galactosyl-(1→4)-β-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-α-D-glucuronate <=> 3-O-[β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-2-O-P-Xyl]-L-seryl-[protein] + UDP + H⁺
• [Rhea:RHEA:67925] 3-O-{(1→[3)-α-D-Xyl-(1→3)-β-D-GlcA-(1→]_(n)-4)-β-D-Xyl-(1→4)-Rib-ol-P-Rib-ol-P-3-β-D-GalNAc-(1→3)-β-D-GlcNAc-(1→4)-O-6-P-α-D-Man}-L-Thr-[protein] + UDP-α-D-glucuronate => 3-O-{β-D-GlcA-(1→[3)-α-D-Xyl-(1→3)-β-D-GlcA-(1→]_(n)-4)-β-D-Xyl-(1→4)-Rib-ol-P-Rib-ol-P-3-β-D-GalNAc-(1→3)-β-D-GlcNAc-(1→4)-O-6-P-α-D-Man}-L-Thr-[protein] + UDP + H⁺
• [Rhea:RHEA:67926] 3-O-{β-D-GlcA-(1→[3)-α-D-Xyl-(1→3)-β-D-GlcA-(1→]_(n)-4)-β-D-Xyl-(1→4)-Rib-ol-P-Rib-ol-P-3-β-D-GalNAc-(1→3)-β-D-GlcNAc-(1→4)-O-6-P-α-D-Man}-L-Thr-[protein] + UDP + H⁺ => 3-O-{(1→[3)-α-D-Xyl-(1→3)-β-D-GlcA-(1→]_(n)-4)-β-D-Xyl-(1→4)-Rib-ol-P-Rib-ol-P-3-β-D-GalNAc-(1→3)-β-D-GlcNAc-(1→4)-O-6-P-α-D-Man}-L-Thr-[protein] + UDP-α-D-glucuronate
• [Rhea:RHEA:67927] 3-O-{(1→[3)-α-D-Xyl-(1→3)-β-D-GlcA-(1→]_(n)-4)-β-D-Xyl-(1→4)-Rib-ol-P-Rib-ol-P-3-β-D-GalNAc-(1→3)-β-D-GlcNAc-(1→4)-O-6-P-α-D-Man}-L-Thr-[protein] + UDP-α-D-glucuronate <=> 3-O-{β-D-GlcA-(1→[3)-α-D-Xyl-(1→3)-β-D-GlcA-(1→]_(n)-4)-β-D-Xyl-(1→4)-Rib-ol-P-Rib-ol-P-3-β-D-GalNAc-(1→3)-β-D-GlcNAc-(1→4)-O-6-P-α-D-Man}-L-Thr-[protein] + UDP + H⁺

Metabolites

Substrates

metabolite	compartment	Structure

Products

metabolite	compartment	Structure
Formula:	Cytoplasm
UDP-alpha-D-glucuronate(3-) Formula: C15H19N2O18P2	Cytoplasm
Formula:	Cytoplasm
UDP(3-) Formula: C9H11N2O12P2	Cytoplasm
H+ Formula: H	Cytoplasm