ilvI - Escherichia coli K-12
Acetolactate synthase isozyme 3 large subunit
> ilvI - Escherichia coli K-12 [Acetolactate synthase isozyme 3 large subunit]
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Metadata
Organism Source: 83333 - Escherichia coli K-12
EC Number: 2.2.1.6
Cluster:
Registry Model:
Reactions
| reaction id | name | note |
|---|---|---|
| KEGG:R00006 | pyruvate:pyruvate acetaldehydetransferase (decarboxylating); | TPP-dependent enzymatic reaction (R00014+R03050) |
| KEGG:R00014 | pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating) | 2-oxoglutarate dehydrogenase complex: pyruvate dehydrogenase (see R01699), subsequently R03270 |
| KEGG:R00226 | pyruvate:pyruvate acetaldehydetransferase (decarboxylating); | TPP-dependent enzymatic reaction (R00014+R04672) |
| KEGG:R03050 | 2-acetolactate pyruvate-lyase (carboxylating) | TPP-dependent enzymatic reaction (see R00006), following after R00014 |
| KEGG:R04672 | (S)-2-acetolactate pyruvate-lyase (carboxylating) | TPP-dependent enzymatic reaction (see R00226), following after R00014 |
| KEGG:R04673 | (S)-2-aceto-2-hydroxybutanoate pyruvate-lyase (carboxylating) | TPP-dependent enzymatic reaction (see R08648), following after R00014 |
| KEGG:R08648 | pyruvate:2-oxobutanoate acetaldehydetransferase (decarboxylating) | TPP-dependent enzymatic reaction (R00014+R04673) |
| BioCyc:ACETOOHBUTSYN-RXN | 2-aceto-2-hydroxy-butyrate synthase | |
| BioCyc:ACETOLACTSYN-RXN | PROTON + 2 PYRUVATE --> 2-ACETO-LACTATE + CARBON-DIOXIDE | |
| Rhea:RHEA:25250 | 2 pyruvate + H+ => (2S)-2-acetolactate + CO2 | |
| Rhea:RHEA:25251 | (2S)-2-acetolactate + CO2 => 2 pyruvate + H+ | |
| Rhea:RHEA:25252 | 2 pyruvate + H+ <=> (2S)-2-acetolactate + CO2 | |
| Rhea:RHEA:27655 | 2-oxobutanoate + pyruvate + H+ => (S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2 | |
| Rhea:RHEA:27656 | (S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2 => 2-oxobutanoate + pyruvate + H+ | |
| Rhea:RHEA:27657 | 2-oxobutanoate + pyruvate + H+ <=> (S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2 | |
| Manual Audit:BIOCAD_RXN-85537 | Acetolactate Synthesis | Condensation of two molecules of pyruvate to form (S)-2-Acetolactate, releasing carbon dioxide. This is the first committed step in the pathway towards branched-chain amino acids and TMP precursors. |
| Manual Audit:BIOCAD_RXN-85541 | α-Acetolactate Synthesis | Condensation of two pyruvate molecules to form α-acetolactate, a key intermediate in the branched-chain amino acid and 2,3-butanediol pathways. |
Pathways
| pathway id | name |
|---|---|
| BioCyc:ECO_ILEUSYN-PWY | L-isoleucine biosynthesis I (from threonine) |
| BioCyc:ECOL316407_VALSYN-PWY | valine biosynthesis |
| BioCyc:META_THREOCAT-PWY | superpathway of L-threonine metabolism |
| BioCyc:META_ILEUSYN-PWY | L-isoleucine biosynthesis I (from threonine) |
| BioCyc:ECO_BRANCHED-CHAIN-AA-SYN-PWY | superpathway of branched chain amino acid biosynthesis |
| BioCyc:ECO_THREOCAT-PWY | superpathway of L-threonine metabolism |
| BioCyc:META_VALSYN-PWY | L-valine biosynthesis |
| BioCyc:META_BRANCHED-CHAIN-AA-SYN-PWY | superpathway of branched chain amino acid biosynthesis |
| BioCyc:ECO_VALSYN-PWY | L-valine biosynthesis |
| BioCyc:ECOL316407_ILEUSYN-PWY | isoleucine biosynthesis I (from threonine) |
| BioCyc:ECOL316407_BRANCHED-CHAIN-AA-SYN-PWY | superpathway of leucine, valine, and isoleucine biosynthesis |
| BioCyc:META_PWY-7111 | pyruvate fermentation to isobutanol (engineered) |
| BioCyc:META_PWY-3001 | superpathway of L-isoleucine biosynthesis I |
| BioCyc:ECOL316407_THREOCAT-PWY | superpathway of threonine metabolism |
| PathBank:SMP0000832 | Valine Biosynthesis |
| PathBank:SMP0000838 | Isoleucine Biosynthesis |
| PathBank:SMP0000994 | Secondary Metabolites: Valine and L-Leucine Biosynthesis from Pyruvate |
| PathBank:SMP0001904 | 2-Oxopent-4-enoate Metabolism |
| PathBank:SMP0002049 | 2-Oxopent-4-enoate Metabolism 2 |