nrdA - Escherichia coli K-12
Ribonucleoside-diphosphate reductase 1 subunit alpha
> nrdA - Escherichia coli K-12 [Ribonucleoside-diphosphate reductase 1 subunit alpha]
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统计信息
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Metadata
Organism Source: 83333 - Escherichia coli K-12
EC Number: 1.17.4.1
Cluster:
Registry Model:
Reactions
| reaction id | name | note |
|---|---|---|
| KEGG:R02017 | 2'-deoxyadenosine 5'-diphosphate:oxidized-thioredoxin 2'-oxidoreductase | dADP + Thioredoxin disulfide + H2O <=> Thioredoxin + ADP |
| KEGG:R02018 | 2'-deoxyuridine 5'-diphosphate:oxidized-thioredoxin 2'-oxidoreductase | dUDP + Thioredoxin disulfide + H2O <=> Thioredoxin + UDP |
| KEGG:R02019 | 2'-deoxyguanosine 5'-diphosphate:oxidized-thioredoxin 2'-oxidoreductase | dGDP + Thioredoxin disulfide + H2O <=> GDP + Thioredoxin |
| KEGG:R02024 | 2'-deoxycytidine diphosphate:oxidized-thioredoxin 2'-oxidoreductase | dCDP + Thioredoxin disulfide + H2O <=> Thioredoxin + CDP |
| KEGG:R04294 | 2'-deoxyribonucleoside diphosphate:oxidized-thioredoxin 2'-oxidoreductase | general reaction (see R02017, R02018, R02019 and R02024) |
| KEGG:R08363 | 2'-deoxyribonucleoside-diphosphate:tryparedoxin-disulfide 2'-oxidoreductase | 2'-Deoxyribonucleoside diphosphate + Tryparedoxin disulfide + H2O <=> Ribonucleoside diphosphate + Tryparedoxin |
| KEGG:R08364 | 2'-deoxyribonucleoside-diphosphate:trypanothione-disulfide 2'-oxidoreductase | intermediate (Tryparedoxin [CPD:C16663], see R08361+R08363) |
| KEGG:R11893 | 5-fluorodeoxyuridine-diphosphate:thioredoxin-disulfide 2'-oxidoreductase | 5-Fluorodeoxyuridine diphosphate + Thioredoxin disulfide + H2O <=> 5-Fluorouridine diphosphate + Thioredoxin |
| BioCyc:CDPREDUCT-RXN | CDP + Red-Thioredoxin --> DCDP + Ox-Thioredoxin + WATER | |
| BioCyc:UDPREDUCT-RXN | UDP + Red-Thioredoxin --> DUDP + Ox-Thioredoxin + WATER | |
| BioCyc:ADPREDUCT-RXN | ADP reductase | Necessary for DNA synthesis. |
| BioCyc:RXN0-722 | UDP + Reduced-NrdH-Proteins --> DUDP + Oxidized-NrdH-Proteins + WATER | |
| BioCyc:RXN0-748 | GDP + Reduced-NrdH-Proteins --> DGDP + Oxidized-NrdH-Proteins + WATER | |
| BioCyc:RXN0-747 | ADP + Reduced-NrdH-Proteins --> DADP + Oxidized-NrdH-Proteins + WATER | |
| BioCyc:RIBONUCLEOSIDE-DIP-REDUCTII-RXN | CDP + Reduced-NrdH-Proteins --> DCDP + Oxidized-NrdH-Proteins + WATER | This reaction synthesizes deoxynucleoside diphosphates.Reduced glutaredoxin is the reductant. |
| BioCyc:RIBONUCLEOSIDE-DIP-REDUCTI-RXN | Red-Thioredoxin + Ribonucleoside-Diphosphates --> Ox-Thioredoxin + WATER + Deoxy-Ribonucleoside-Diphosphates | This reaction synthesizes deoxynucleoside diphosphates.Thioredoxin is the reductant cofactor and NADPH is the ultimatehydrogen donor. |
| BioCyc:GDPREDUCT-RXN | GDP + Red-Thioredoxin --> DGDP + Ox-Thioredoxin + WATER | Necessary for DNA synthesis. |
| Rhea:RHEA:23253 | a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O => a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol | |
| Rhea:RHEA:23254 | a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol => a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O | |
| Rhea:RHEA:23255 | a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O <=> a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol | |
| Rhea:RHEA:28027 | dUDP + [thioredoxin]-disulfide + H2O => [thioredoxin]-dithiol + UDP | |
| Rhea:RHEA:28028 | [thioredoxin]-dithiol + UDP => dUDP + [thioredoxin]-disulfide + H2O | |
| Rhea:RHEA:28029 | dUDP + [thioredoxin]-disulfide + H2O <=> [thioredoxin]-dithiol + UDP | |
| Rhea:RHEA:28031 | dGDP + [thioredoxin]-disulfide + H2O => [thioredoxin]-dithiol + GDP | |
| Rhea:RHEA:28032 | [thioredoxin]-dithiol + GDP => dGDP + [thioredoxin]-disulfide + H2O | |
| Rhea:RHEA:28033 | dGDP + [thioredoxin]-disulfide + H2O <=> [thioredoxin]-dithiol + GDP | |
| Rhea:RHEA:28035 | dADP + [thioredoxin]-disulfide + H2O => [thioredoxin]-dithiol + ADP | |
| Rhea:RHEA:28036 | [thioredoxin]-dithiol + ADP => dADP + [thioredoxin]-disulfide + H2O | |
| Rhea:RHEA:28037 | dADP + [thioredoxin]-disulfide + H2O <=> [thioredoxin]-dithiol + ADP | |
| Rhea:RHEA:28039 | dCDP + [thioredoxin]-disulfide + H2O => CDP + [thioredoxin]-dithiol | |
| Rhea:RHEA:28040 | CDP + [thioredoxin]-dithiol => dCDP + [thioredoxin]-disulfide + H2O | |
| Rhea:RHEA:28041 | dCDP + [thioredoxin]-disulfide + H2O <=> CDP + [thioredoxin]-dithiol |
Pathways
| pathway id | name |
|---|---|
| BioCyc:META_PWY-7227 | adenosine deoxyribonucleotides de novo biosynthesis |
| BioCyc:META_PWY-7229 | superpathway of adenosine nucleotides de novo biosynthesis I |
| BioCyc:META_PWY-7211 | superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis |
| BioCyc:ECOL316407_PWY-7184 | pyrimidine deoxyribonucleotides de novo biosynthesis I |
| BioCyc:META_PWY-7228 | superpathway of guanosine nucleotides de novo biosynthesis I |
| BioCyc:META_PWY-7184 | pyrimidine deoxyribonucleotides de novo biosynthesis I |
| BioCyc:ECO_PWY-7184 | pyrimidine deoxyribonucleotides de novo biosynthesis I |
| BioCyc:META_PWY-7226 | guanosine deoxyribonucleotides de novo biosynthesis I |
| BioCyc:ECO_PWY-7211 | superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis |
| PathBank:SMP0000959 | Pyrimidine Metabolism |