bioB
K01012 bioB; biotin synthase [EC:2.8.1.6]
Protein Function: biotin synthase [EC:2.8.1.6]
DBLinks
Proteins
| protein id | name | function | taxonomy source |
|---|
Reactions
| reaction id | name | note |
|---|---|---|
| KEGG:R01078 | dethiobiotin:sulfur sulfurtransferase | the reactant sulfur is not elemental sulfur, but it may be from the enzyme itself ([2Fe-2S] iron-sulfur centre) |
| BioCyc:2.8.1.6-RXN | 2 S-ADENOSYLMETHIONINE + Sulfurated-Sulfur-Acceptors + DETHIOBIOTIN + 2 Reduced-2Fe-2S-Ferredoxins --> Unsulfurated-Sulfur-Acceptors + BIOTIN + 2 CH33ADO + 2 MET + 2 Oxidized-2Fe-2S-Ferredoxins | The fourth and final step in the biosynthesis of biotin. |
| Rhea:RHEA:22061 | (4R,5S)-dethiobiotin + (sulfur carrier)-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => (sulfur carrier)-H + biotin + 2 5'-deoxyadenosine + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] | |
| Rhea:RHEA:22062 | (sulfur carrier)-H + biotin + 2 5'-deoxyadenosine + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] => (4R,5S)-dethiobiotin + (sulfur carrier)-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine | |
| Rhea:RHEA:22063 | (4R,5S)-dethiobiotin + (sulfur carrier)-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> (sulfur carrier)-H + biotin + 2 5'-deoxyadenosine + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] |