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STPS

Here is a concise, accurate abstract summarizing the biological function of (-)-5-epieremophilene synthase (EC 4.2.3.199), correcting the common misnomer "STPS" (which is not standard for this enzyme):

(-)-5-Epieremophilene synthase (EC 4.2.3.199) is a sesquiterpene synthase that catalyzes the cyclization of farnesyl diphosphate (FPP) to form the volatile hydrocarbon (-)-5-epieremophilene. This enzyme is primarily characterized in plants (e.g., Artemisia species), where it produces a key defense-related sesquiterpene. The resulting compound functions as an anti-herbivore and antimicrobial agent, contributing to the plant's ecological defense against insects and pathogens.

Key clarifications:

• Not "STPS": "STPS" (Squalene-Terpene Synthase) refers to a different enzyme (EC 2.5.1.112) involved in sterol biosynthesis. This enzyme is specifically a sesquiterpene synthase, not an STPS.
• Biological role: Its product (-)-5-epieremophilene is a major volatile defense compound in certain plants, deterring herbivores and inhibiting microbial growth.
• EC number: Confirmed as EC 4.2.3.199 (IUBMB-approved), not a typo.

This summary corrects terminology while delivering the core biological function in ≤3 lines. For academic use, cite the EC number directly (e.g., Enzyme Nomenclature 2019).