E1.1.1.243
Abstract: (-)-trans-Carveol dehydrogenase (EC 1.1.1.243) is a NAD⁺-dependent oxidoreductase that catalyzes the stereospecific conversion of (-)-trans-carveol to carvone, a pivotal step in the biosynthesis of minty monoterpenes. This enzyme is primarily active in Mentha species (e.g., spearmint), where it enables the production of carvone—the major contributor to the characteristic aroma and flavor of spearmint oil. By facilitating this oxidation, E1.1.1.243 directly links monoterpene metabolism to plant secondary metabolite pathways, underpinning ecological roles (e.g., herbivore deterrence) and industrial applications in natural flavor/fragrance production.
(Note: EC 1.1.1.243 is the accepted Enzyme Commission number; the enzyme is also known as (-)-carveol dehydrogenase or carveol dehydrogenase in literature.)
Protein Function: (-)-trans-carveol dehydrogenase [EC:1.1.1.243]
DBLinks
Proteins
| protein id | name | function | taxonomy source |
|---|
Reactions
| reaction id | name | note |
|---|---|---|
| KEGG:R03114 | (-)-trans-carveol:NADP+ oxidoreductase | (-)-trans-Carveol + NADP+ <=> (-)-Carvone + NADPH + H+ |
| Rhea:RHEA:13630 | (1S,5R)-carveol + NADP+ => (R)-carvone + NADPH + H+ | |
| Rhea:RHEA:13631 | (R)-carvone + NADPH + H+ => (1S,5R)-carveol + NADP+ | |
| Rhea:RHEA:13632 | (1S,5R)-carveol + NADP+ <=> (R)-carvone + NADPH + H+ | |
| BioCyc:CARVEOL-DEHYDROGENASE-RXN | CPD-10051 + NADP --> CPD-1089 + NADPH + PROTON |