CCAAT/enhancer binding protein (C/EBP), other
C/EBP (CCAAT/enhancer binding protein) transcription factors are a family of pivotal regulators governing cell differentiation, metabolism, inflammation, and stress responses. Key isoforms—such as C/EBPα (essential for adipogenesis, granulopoiesis, and hepatocyte function), C/EBPβ/δ (critical in acute-phase inflammation and macrophage activation), and C/EBPγ (involved in metabolic homeostasis)—orchestrate lineage-specific gene expression by binding to CCAAT enhancer motifs. Their coordinated actions are indispensable for development, tissue homeostasis, and adaptive responses, with dysregulation implicated in metabolic disorders, cancer, and inflammatory diseases.
(Abstract: 98 words)
Protein Function:
DBLinks
- KEGG: K23479
Proteins
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Reactions
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