Pathways Knowlegdes

Necessitatibus eius consequatur ex aliquid fuga eum quidem sint consectetur velit

Pathway DOIs Note
biosynthesis of prostaglandins

Accession ID: BioCyc:MOUSE_PWY3DJ-35583
  • 10.1006/bbrc.1998.8715
  • 10.1126/science.294.5548.1871
  • 10.1126/science.7754369
  • 10.1152/ajpregu.1999.277.3.r734
 Funk CD. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science. 2001 Nov 30;294(5548):1871–5. doi: 10.1126/science.294.5548.1871. PMID: 11729303.; Pucci ML, Bao Y, Chan B, Itoh S, Lu R, Copeland NG, Gilbert DJ, Jenkins NA, Schuster VL. Cloning of mouse prostaglandin transporter PGT cDNA: species-specific substrate affinities. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 1999 Sep 01;277(3):R734–41. doi: 10.1152/ajpregu.1999.277.3.r734.; Lu R, Schuster VL. Molecular Cloning of the Gene for the Human Prostaglandin Transporter hPGT: Gene Organization, Promoter Activity, and Chromosomal Localization. Biochemical and Biophysical Research Communications. 1998 May;246(3):805–12. doi: 10.1006/bbrc.1998.8715.; Kanai N, Lu R, Satriano JA, Bao Y, Wolkoff AW, Schuster VL. Identification and characterization of a prostaglandin transporter. Science. 1995 May 12;268(5212):866–9. doi: 10.1126/science.7754369. PMID: 7754369.
triacylglycerol degradation

Accession ID: PlantCyc:MOSS_LIPAS-PWY		 -
phospholipases

Accession ID: PlantCyc:MOSS_LIPASYN-PWY		 -
fatty acid α-oxidation I (plants)

Accession ID: PlantCyc:MOSS_PWY-2501		 -
phosphatidylcholine acyl editing

Accession ID: PlantCyc:MOSS_PWY-6803		 -
ceramide degradation (generic)

Accession ID: PlantCyc:MOSS_PWY-6483		 -
Prostanoid ligand receptors

Accession ID: Reactome:R-DME-391908
  • 10.1016/s0031-6997(25)06784-5
 Coleman RA, Smith WL, Narumiya S. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacological Reviews. 1994 Jun;46(2):205–29. doi: 10.1016/s0031-6997(25)06784-5.
Eicosanoid ligand-binding receptors

Accession ID: Reactome:R-DME-391903
  • 10.1016/s0031-6997(25)06784-5
  • 10.1124/pr.55.1.8
  • 10.1124/pr.56.1.4
 Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Rovati GE, Serhan CN, Shimizu T, Yokomizo T. International Union of Pharmacology XLIV. Nomenclature for the oxoeicosanoid receptor. Pharmacol Rev. 2004 Mar;56(1):149–57. doi: 10.1124/pr.56.1.4. PMID: 15001665.; Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Nicosia S, Serhan CN, Shimizu T, Yokomizo T. International Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors. Pharmacol Rev. 2003 Mar;55(1):195–227. doi: 10.1124/pr.55.1.8. PMID: 12615958.; Coleman RA, Smith WL, Narumiya S. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacological Reviews. 1994 Jun;46(2):205–29. doi: 10.1016/s0031-6997(25)06784-5.
Metabolism

Accession ID: Reactome:R-BTA-1430728		 -
Metabolism of lipids

Accession ID: Reactome:R-BTA-556833		 -
GPCR ligand binding

Accession ID: Reactome:R-BTA-500792
  • 10.1016/j.pharmthera.2004.05.002
  • 10.1034/j.1600-0773.2002.910607.x
  • 10.1124/mol.63.6.1256
 Kristiansen K. Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis approaches to receptor structure and function. Pharmacol Ther. 2004 Jul;103(1):21–80. doi: 10.1016/j.pharmthera.2004.05.002. PMID: 15251227.; Fredriksson R, Lagerström MC, Lundin LG, Schiöth HB. The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Mol Pharmacol. 2003 Jun;63(6):1256–72. doi: 10.1124/mol.63.6.1256. PMID: 12761335.; Gether U, Asmar F, Meinild AK, Rasmussen SG. Structural basis for activation of G-protein-coupled receptors. Pharmacol Toxicol. 2002 Dec;91(6):304–12. doi: 10.1034/j.1600-0773.2002.910607.x. PMID: 12688373.
Prostanoid ligand receptors

Accession ID: Reactome:R-BTA-391908
  • 10.1016/s0031-6997(25)06784-5
 Coleman RA, Smith WL, Narumiya S. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacological Reviews. 1994 Jun;46(2):205–29. doi: 10.1016/s0031-6997(25)06784-5.
Arachidonate metabolism

Accession ID: Reactome:R-CEL-2142753
  • 10.1194/jlr.r900004-jlr200
 Buczynski MW, Dumlao DS, Dennis EA. Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology. Journal of Lipid Research. 2009 Jun;50(6):1015–38. doi: 10.1194/jlr.r900004-jlr200.
Signaling Pathways

Accession ID: Reactome:R-CFA-162582
  • 10.1016/j.bbcan.2006.09.001
  • 10.1016/j.cell.2007.06.009
  • 10.1016/j.cell.2009.03.045
  • 10.1016/j.cytogfr.2004.04.003
  • 10.1016/j.cytogfr.2005.01.001
  • 10.1016/j.devcel.2009.06.016
  • 10.1016/j.tcb.2009.05.008
  • 10.1016/j.tibs.2005.10.005
  • 10.1038/414799a
  • 10.1038/nature08144
  • 10.1038/nrm1498
  • 10.1038/nrm2299
  • 10.1038/nrm2717
  • 10.1038/nrm2803
  • 10.1038/nrm3048
  • 10.1038/sj.onc.1210394
  • 10.1093/jb/mvp148
  • 10.1098/rstb.2006.1894
  • 10.1101/gad.1653708
  • 10.3109/09687688.2011.603101
 Avraham R, Yarden Y. Feedback regulation of EGFR signalling: decision making by early and delayed loops. Nature Reviews Molecular Cell Biology. 2011 Jan 21;12(2):104–17. doi: 10.1038/nrm3048.; Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P. Regulation of small GTPases at epithelial cell-cell junctions. Mol Membr Biol. 2011 Oct;28(7-8):427–44. doi: 10.3109/09687688.2011.603101. PMID: 21781017.; Ritter SL, Hall RA. Fine-tuning of GPCR activity by receptor-interacting proteins. Nature Reviews Molecular Cell Biology. 2009 Dec;10(12):819–30. doi: 10.1038/nrm2803.; Miyazono K, Kamiya Y, Morikawa M. Bone morphogenetic protein receptors and signal transduction. Journal of Biochemistry. 2009 Sep 17;147(1):35–51. doi: 10.1093/jb/mvp148.; Kang JS, Liu C, Derynck R. New regulatory mechanisms of TGF-beta receptor function. Trends Cell Biol. 2009 Aug;19(8):385–94. doi: 10.1016/j.tcb.2009.05.008. PMID: 19648010.; MacDonald BT, Tamai K, He X. Wnt/ß-Catenin Signaling: Components, Mechanisms, and Diseases. Developmental Cell. 2009 Jul;17(1):9–26. doi: 10.1016/j.devcel.2009.06.016.; Angers S, Moon RT. Proximal events in Wnt signal transduction. Nature Reviews Molecular Cell Biology. 2009 Jun 17;10(7):468–77. doi: 10.1038/nrm2717.; Rosenbaum DM, Rasmussen SG, Kobilka BK. The structure and function of G-protein-coupled receptors. Nature. 2009 May 21;459(7245):356–63. PMID: 19458711; PMCID: PMC3967846.; Kopan R, Ilagan MX. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell. 2009 Apr 17;137(2):216–33. PMID: 19379690; PMCID: PMC2827930.; Andrae J, Gallini R, Betsholtz C. Role of platelet-derived growth factors in physiology and medicine. Genes Dev. 2008 May 15;22(10):1276–312. PMID: 18483217; PMCID: PMC2732412.; Oldham WM, Hamm HE. Heterotrimeric G protein activation by G-protein-coupled receptors. Nature Reviews Molecular Cell Biology. 2008 Jan;9(1):60–71. doi: 10.1038/nrm2299.; Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell. 2007 Jun 29;129(7):1261–74. PMID: 17604717; PMCID: PMC2756685.; McKay MM, Morrison DK. Integrating signals from RTKs to ERK/MAPK. Oncogene. 2007 May 14;26(22):3113–21. doi: 10.1038/sj.onc.1210394. PMID: 17496910.; Hehlgans S, Haase M, Cordes N. Signalling via integrins: Implications for cell survival and anticancer strategies. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 2007 Jan;1775(1):163–80. doi: 10.1016/j.bbcan.2006.09.001.; Reichardt LF. Neurotrophin-regulated signalling pathways. Philos Trans R Soc Lond B Biol Sci. 2006 Sep 29;361(1473):1545–64. PMID: 16939974; PMCID: PMC1664664.; Patterson RL, van Rossum DB, Nikolaidis N, Gill DL, Snyder SH. Phospholipase C-gamma: diverse roles in receptor-mediated calcium signaling. Trends Biochem Sci. 2005 Dec;30(12):688–97. doi: 10.1016/j.tibs.2005.10.005. PMID: 16260143.; Eswarakumar VP, Lax I, Schlessinger J. Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev. 2005 Apr;16(2):139–49. doi: 10.1016/j.cytogfr.2005.01.001. PMID: 15863030.; Wellbrock C, Karasarides M, Marais R. The RAF proteins take centre stage. Nature Reviews Molecular Cell Biology. 2004 Nov;5(11):875–85. doi: 10.1038/nrm1498.; Xie K, Wei D, Shi Q, Huang S. Constitutive and inducible expression and regulation of vascular endothelial growth factor. Cytokine Growth Factor Rev. 2004 Oct;15(5):297–324. doi: 10.1016/j.cytogfr.2004.04.003. PMID: 15450248.; Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 2001 Dec 13;414(6865):799–806. doi: 10.1038/414799a. PMID: 11742412.
Class A/1 (Rhodopsin-like receptors)

Accession ID: Reactome:R-CFA-373076
  • 10.1002/cmdc.200600134
  • 10.1186/gb-2002-3-11-research0063
 Jacoby E, Bouhelal R, Gerspacher M, Seuwen K. The 7 TM G-protein-coupled receptor target family. ChemMedChem. 2006 Aug;1(8):761–82. doi: 10.1002/cmdc.200600134. PMID: 16902930.; Joost P, Methner A. Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands. Genome Biology. 2002 Oct 17;3(11):research0063.1. doi: 10.1186/gb-2002-3-11-research0063.
Prostanoid ligand receptors

Accession ID: Reactome:R-CFA-391908
  • 10.1016/s0031-6997(25)06784-5
 Coleman RA, Smith WL, Narumiya S. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacological Reviews. 1994 Jun;46(2):205–29. doi: 10.1016/s0031-6997(25)06784-5.
G alpha (q) signalling events

Accession ID: Reactome:R-CFA-416476
  • 10.1038/38284
  • 10.1073/pnas.0801508105
  • 10.1073/pnas.95.21.12197
  • 10.1111/j.1538-7836.2005.01377.x
  • 10.1159/000186689
 Mizuno N, Itoh H. Functions and regulatory mechanisms of Gq-signaling pathways. Neurosignals. 2009;17(1):42–54. doi: 10.1159/000186689. PMID: 19212139.; Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundström M, Doyle DA, Siderovski DP. Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6457–62. PMID: 18434541; PMCID: PMC2359823.; COUGHLIN SR. Protease-activated receptors in hemostasis, thrombosis and vascular biology. Journal of Thrombosis and Haemostasis. 2005 Aug;3(8):1800–14. doi: 10.1111/j.1538-7836.2005.01377.x.; Ma YC, Huang XY. Identification of the binding site for Gqalpha on its effector Bruton's tyrosine kinase. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12197–201. PMID: 9770463; PMCID: PMC22808.; Offermanns S, Toombs CF, Hu YH, Simon MI. Defective platelet activation in G alpha(q)-deficient mice. Nature. 1997 Sep 11;389(6647):183–6. doi: 10.1038/38284. PMID: 9296496.
Metabolism

Accession ID: Reactome:R-CFA-1430728		 -
Metabolism of lipids

Accession ID: Reactome:R-CFA-556833		 -
Signaling by GPCR

Accession ID: Reactome:R-DRE-372790
  • 10.1002/cmdc.200600134
  • 10.1038/nrm2299
  • 10.1093/emboj/18.7.1723
 Oldham WM, Hamm HE. Heterotrimeric G protein activation by G-protein-coupled receptors. Nature Reviews Molecular Cell Biology. 2008 Jan;9(1):60–71. doi: 10.1038/nrm2299.; Jacoby E, Bouhelal R, Gerspacher M, Seuwen K. The 7 TM G-protein-coupled receptor target family. ChemMedChem. 2006 Aug;1(8):761–82. doi: 10.1002/cmdc.200600134. PMID: 16902930.; Bockaert J, Pin JP. Molecular tinkering of G protein-coupled receptors: an evolutionary success. EMBO J. 1999 Apr 01;18(7):1723–9. PMID: 10202136; PMCID: PMC1171258.