Pathways Knowlegdes
Necessitatibus eius consequatur ex aliquid fuga eum quidem sint consectetur velit
| Pathway | DOIs | Note |
|---|---|---|
| Metabolism Accession ID: Reactome:R-BTA-1430728 |
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| Metabolism of lipids Accession ID: Reactome:R-BTA-556833 |
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| Bile acid and bile salt metabolism Accession ID: Reactome:R-BTA-194068 |
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Kullak-Ublick GA, Stieger B, Meier PJ. Enterohepatic bile salt transporters in normal physiology and liver disease. Gastroenterology. 2004 Jan;126(1):322–42. doi: 10.1053/j.gastro.2003.06.005. PMID: 14699511.; Russell DW. The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem. 2003;72():137–74. doi: 10.1146/annurev.biochem.72.121801.161712. PMID: 12543708.; Trauner M, Boyer JL. Bile salt transporters: molecular characterization, function, and regulation. Physiol Rev. 2003 Apr;83(2):633–71. doi: 10.1152/physrev.00027.2002. PMID: 12663868.; Javitt NB. Cholesterol, Hydroxycholesterols, and Bile Acids. Biochemical and Biophysical Research Communications. 2002 Apr;292(5):1147–53. doi: 10.1006/bbrc.2001.2013. |
| Bile acid and bile salt metabolism Accession ID: Reactome:R-CEL-194068 |
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Kullak-Ublick GA, Stieger B, Meier PJ. Enterohepatic bile salt transporters in normal physiology and liver disease. Gastroenterology. 2004 Jan;126(1):322–42. doi: 10.1053/j.gastro.2003.06.005. PMID: 14699511.; Russell DW. The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem. 2003;72():137–74. doi: 10.1146/annurev.biochem.72.121801.161712. PMID: 12543708.; Trauner M, Boyer JL. Bile salt transporters: molecular characterization, function, and regulation. Physiol Rev. 2003 Apr;83(2):633–71. doi: 10.1152/physrev.00027.2002. PMID: 12663868.; Javitt NB. Cholesterol, Hydroxycholesterols, and Bile Acids. Biochemical and Biophysical Research Communications. 2002 Apr;292(5):1147–53. doi: 10.1006/bbrc.2001.2013. |
| Metabolism Accession ID: Reactome:R-CFA-1430728 |
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| Metabolism of lipids Accession ID: Reactome:R-CFA-556833 |
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| Bile acid and bile salt metabolism Accession ID: Reactome:R-CFA-194068 |
|
Kullak-Ublick GA, Stieger B, Meier PJ. Enterohepatic bile salt transporters in normal physiology and liver disease. Gastroenterology. 2004 Jan;126(1):322–42. doi: 10.1053/j.gastro.2003.06.005. PMID: 14699511.; Russell DW. The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem. 2003;72():137–74. doi: 10.1146/annurev.biochem.72.121801.161712. PMID: 12543708.; Trauner M, Boyer JL. Bile salt transporters: molecular characterization, function, and regulation. Physiol Rev. 2003 Apr;83(2):633–71. doi: 10.1152/physrev.00027.2002. PMID: 12663868.; Javitt NB. Cholesterol, Hydroxycholesterols, and Bile Acids. Biochemical and Biophysical Research Communications. 2002 Apr;292(5):1147–53. doi: 10.1006/bbrc.2001.2013. |
| Endogenous sterols Accession ID: Reactome:R-CFA-211976 |
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Pikuleva IA. Cytochrome P450s and cholesterol homeostasis. Pharmacol Ther. 2006 Dec;112(3):761–73. doi: 10.1016/j.pharmthera.2006.05.014. PMID: 16872679.; Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Lewis DF. 57 varieties: the human cytochromes P450. Pharmacogenomics. 2004 Apr;5(3):305–18. doi: 10.1517/phgs.5.3.305.29827. PMID: 15102545. |
| Cytochrome P450 - arranged by substrate type Accession ID: Reactome:R-DRE-211897 |
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Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Lewis DF. 57 varieties: the human cytochromes P450. Pharmacogenomics. 2004 Apr;5(3):305–18. doi: 10.1517/phgs.5.3.305.29827. PMID: 15102545.; Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. Pharmacogenetics. 2004 Jan;14(1):1–18. doi: 10.1097/00008571-200401000-00001. PMID: 15128046.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887. |
| Synthesis of bile acids and bile salts Accession ID: Reactome:R-DDI-192105 |
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Russell DW. The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem. 2003;72():137–74. doi: 10.1146/annurev.biochem.72.121801.161712. PMID: 12543708.; Javitt NB. Cholesterol, Hydroxycholesterols, and Bile Acids. Biochemical and Biophysical Research Communications. 2002 Apr;292(5):1147–53. doi: 10.1006/bbrc.2001.2013. |
| Bile acid and bile salt metabolism Accession ID: Reactome:R-DME-194068 |
|
Kullak-Ublick GA, Stieger B, Meier PJ. Enterohepatic bile salt transporters in normal physiology and liver disease. Gastroenterology. 2004 Jan;126(1):322–42. doi: 10.1053/j.gastro.2003.06.005. PMID: 14699511.; Russell DW. The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem. 2003;72():137–74. doi: 10.1146/annurev.biochem.72.121801.161712. PMID: 12543708.; Trauner M, Boyer JL. Bile salt transporters: molecular characterization, function, and regulation. Physiol Rev. 2003 Apr;83(2):633–71. doi: 10.1152/physrev.00027.2002. PMID: 12663868.; Javitt NB. Cholesterol, Hydroxycholesterols, and Bile Acids. Biochemical and Biophysical Research Communications. 2002 Apr;292(5):1147–53. doi: 10.1006/bbrc.2001.2013. |
| Bile acid and bile salt metabolism Accession ID: Reactome:R-GGA-194068 |
|
Kullak-Ublick GA, Stieger B, Meier PJ. Enterohepatic bile salt transporters in normal physiology and liver disease. Gastroenterology. 2004 Jan;126(1):322–42. doi: 10.1053/j.gastro.2003.06.005. PMID: 14699511.; Russell DW. The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem. 2003;72():137–74. doi: 10.1146/annurev.biochem.72.121801.161712. PMID: 12543708.; Trauner M, Boyer JL. Bile salt transporters: molecular characterization, function, and regulation. Physiol Rev. 2003 Apr;83(2):633–71. doi: 10.1152/physrev.00027.2002. PMID: 12663868.; Javitt NB. Cholesterol, Hydroxycholesterols, and Bile Acids. Biochemical and Biophysical Research Communications. 2002 Apr;292(5):1147–53. doi: 10.1006/bbrc.2001.2013. |
| Endogenous sterols Accession ID: Reactome:R-GGA-211976 |
|
Pikuleva IA. Cytochrome P450s and cholesterol homeostasis. Pharmacol Ther. 2006 Dec;112(3):761–73. doi: 10.1016/j.pharmthera.2006.05.014. PMID: 16872679.; Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Lewis DF. 57 varieties: the human cytochromes P450. Pharmacogenomics. 2004 Apr;5(3):305–18. doi: 10.1517/phgs.5.3.305.29827. PMID: 15102545. |
| Bile acid and bile salt metabolism Accession ID: Reactome:R-HSA-194068 |
|
Kullak-Ublick GA, Stieger B, Meier PJ. Enterohepatic bile salt transporters in normal physiology and liver disease. Gastroenterology. 2004 Jan;126(1):322–42. doi: 10.1053/j.gastro.2003.06.005. PMID: 14699511.; Russell DW. The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem. 2003;72():137–74. doi: 10.1146/annurev.biochem.72.121801.161712. PMID: 12543708.; Trauner M, Boyer JL. Bile salt transporters: molecular characterization, function, and regulation. Physiol Rev. 2003 Apr;83(2):633–71. doi: 10.1152/physrev.00027.2002. PMID: 12663868.; Javitt NB. Cholesterol, Hydroxycholesterols, and Bile Acids. Biochemical and Biophysical Research Communications. 2002 Apr;292(5):1147–53. doi: 10.1006/bbrc.2001.2013. |
| Biological oxidations Accession ID: Reactome:R-HSA-211859 |
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| Sterols are 12-hydroxylated by CYP8B1 Accession ID: Reactome:R-HSA-211994 |
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Gåfvels M, Olin M, Chowdhary BP, Raudsepp T, Andersson U, Persson B, Jansson M, Björkhem I, Eggertsen G. Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns. Genomics. 1999 Mar 01;56(2):184–96. doi: 10.1006/geno.1998.5606. PMID: 10051404. |
| Metabolism Accession ID: Reactome:R-MMU-1430728 |
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| Metabolism of lipids Accession ID: Reactome:R-MMU-556833 |
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| Metabolism of steroids Accession ID: Reactome:R-MMU-8957322 |
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Brown MS, Goldstein JL. Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL. Journal of Lipid Research. 2009 Apr;50():S15–27. doi: 10.1194/jlr.r800054-jlr200.; Dusso AS, Brown AJ, Slatopolsky E. Vitamin D. American Journal of Physiology-Renal Physiology. 2005 Jul;289(1):F8–F28. doi: 10.1152/ajprenal.00336.2004.; Payne AH, Hales DB. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocr Rev. 2004 Dec;25(6):947–70. doi: 10.1210/er.2003-0030. PMID: 15583024.; Russell DW. The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem. 2003;72():137–74. doi: 10.1146/annurev.biochem.72.121801.161712. PMID: 12543708.; Russell DW. Cholesterol biosynthesis and metabolism. Cardiovasc Drugs Ther. 1992 Apr;6(2):103–10. doi: 10.1007/bf00054556. PMID: 1390320. |
| Synthesis of bile acids and bile salts via 24-hydroxycholesterol Accession ID: Reactome:R-MMU-193775 |
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Russell DW. The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem. 2003;72():137–74. doi: 10.1146/annurev.biochem.72.121801.161712. PMID: 12543708.; Javitt NB. Cholesterol, Hydroxycholesterols, and Bile Acids. Biochemical and Biophysical Research Communications. 2002 Apr;292(5):1147–53. doi: 10.1006/bbrc.2001.2013.; Björkhem I, Lütjohann D, Diczfalusy U, Ståhle L, Ahlborg G, Wahren J. Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation. Journal of Lipid Research. 1998 Aug;39(8):1594–600. doi: 10.1016/s0022-2275(20)32188-x. |