Pathways Knowlegdes

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Pathway DOIs Note
Biological oxidations

Accession ID: Reactome:R-SSC-211859		 -
FMO oxidises nucleophiles

Accession ID: Reactome:R-SSC-217271
  • 10.1016/j.pharmthera.2005.01.001
 Krueger SK, Williams DE. Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism. Pharmacology & Therapeutics. 2005 Jun;106(3):357–87. doi: 10.1016/j.pharmthera.2005.01.001.; Cashman JR. The role of flavin-containing monooxygenases in drug metabolism and development. Curr Opin Drug Discov Devel. 2003 Jul;6(4):486–93. PMID: 12951812.
Phase I - Functionalization of compounds

Accession ID: Reactome:R-XTR-211945
  • 10.1208/aapsj080112
  • 10.1517/17425255.2.6.895
  • 10.2174/1389200023337054
 Strolin Benedetti M, Whomsley R, Baltes E. Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics. Expert Opinion on Drug Metabolism & Toxicology. 2006 Nov 24;2(6):895–921. doi: 10.1517/17425255.2.6.895.; Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Phase I - Functionalization of compounds

Accession ID: Reactome:R-CEL-211945
  • 10.1208/aapsj080112
  • 10.1517/17425255.2.6.895
  • 10.2174/1389200023337054
 Strolin Benedetti M, Whomsley R, Baltes E. Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics. Expert Opinion on Drug Metabolism & Toxicology. 2006 Nov 24;2(6):895–921. doi: 10.1517/17425255.2.6.895.; Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Biological oxidations

Accession ID: Reactome:R-CFA-211859		 -
FMO oxidises nucleophiles

Accession ID: Reactome:R-CFA-217271
  • 10.1016/j.pharmthera.2005.01.001
 Krueger SK, Williams DE. Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism. Pharmacology & Therapeutics. 2005 Jun;106(3):357–87. doi: 10.1016/j.pharmthera.2005.01.001.; Cashman JR. The role of flavin-containing monooxygenases in drug metabolism and development. Curr Opin Drug Discov Devel. 2003 Jul;6(4):486–93. PMID: 12951812.
Metabolism

Accession ID: Reactome:R-DRE-1430728		 -
Metabolism

Accession ID: Reactome:R-GGA-1430728		 -
Biological oxidations

Accession ID: Reactome:R-GGA-211859		 -
FMO oxidises nucleophiles

Accession ID: Reactome:R-GGA-217271
  • 10.1016/j.pharmthera.2005.01.001
 Krueger SK, Williams DE. Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism. Pharmacology & Therapeutics. 2005 Jun;106(3):357–87. doi: 10.1016/j.pharmthera.2005.01.001.; Cashman JR. The role of flavin-containing monooxygenases in drug metabolism and development. Curr Opin Drug Discov Devel. 2003 Jul;6(4):486–93. PMID: 12951812.
Phase I - Functionalization of compounds

Accession ID: Reactome:R-HSA-211945
  • 10.1208/aapsj080112
  • 10.1517/17425255.2.6.895
  • 10.2174/1389200023337054
 Strolin Benedetti M, Whomsley R, Baltes E. Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics. Expert Opinion on Drug Metabolism & Toxicology. 2006 Nov 24;2(6):895–921. doi: 10.1517/17425255.2.6.895.; Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Diseases of metabolism

Accession ID: Reactome:R-HSA-5668914		 -
Metabolic disorders of biological oxidation enzymes

Accession ID: Reactome:R-HSA-5579029
  • 10.1002/ajmg.c.30293
  • 10.1016/j.pharmthera.2012.12.007
  • 10.1016/s0161-813x(03)00112-8
  • 10.1074/jbc.r112.431916
  • 10.1098/rstb.2012.0431
  • 10.1111/ced.12024
  • 10.3390/ijms141021021
  • 10.3748/wjg.v19.i38.6398
 Azimi F, Jafariyan M, Khatami S, Mortazavi Y, Azad M. Assessment of Thiopurine-based drugs according to Thiopurine S-methyltransferase genotype in patients with Acute Lymphoblastic Leukemia. Iran J Ped Hematol Oncol. 2014;4(1):32–8. PMID: 24734162; PMCID: PMC3980020.; Messenger J, Clark S, Massick S, Bechtel M. A review of trimethylaminuria: (fish odor syndrome). J Clin Aesthet Dermatol. 2013 Nov;6(11):45–8. PMID: 24307925; PMCID: PMC3848652.; Aoyama K, Nakaki T. Impaired glutathione synthesis in neurodegeneration. Int J Mol Sci. 2013 Oct 18;14(10):21021–44. PMID: 24145751; PMCID: PMC3821656.; Sticova E, Jirsa M. New insights in bilirubin metabolism and their clinical implications. World J Gastroenterol. 2013 Oct 14;19(38):6398–407. PMID: 24151358; PMCID: PMC3801310.; Pikuleva IA, Waterman MR. Cytochromes P450: Roles in Diseases. Journal of Biological Chemistry. 2013 Jun;288(24):17091–8. doi: 10.1074/jbc.r112.431916.; Zanger UM, Schwab M. Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol Ther. 2013 Apr;138(1):103–41. doi: 10.1016/j.pharmthera.2012.12.007. PMID: 23333322.; Nebert DW, Wikvall K, Miller WL. Human cytochromes P450 in health and disease. Philos Trans R Soc Lond B Biol Sci. 2013 Feb 19;368(1612):20120431. PMID: 23297354; PMCID: PMC3538421.; Millington GW. Obesity, genetics and the skin. Clin Exp Dermatol. 2013 Jan;38(1):50–6; quiz 56. doi: 10.1111/ced.12024. PMID: 23252752.; Mudd SH. Hypermethioninemias of genetic and non-genetic origin: A review. Am J Med Genet C Semin Med Genet. 2011 Feb 15;157C(1):3–32. doi: 10.1002/ajmg.c.30293. PMID: 21308989.; Shih JC. Cloning, after cloning, knock-out mice, and physiological functions of MAO A and B. Neurotoxicology. 2004 Jan;25(1-2):21–30. doi: 10.1016/s0161-813x(03)00112-8. PMID: 14697877.
Defective FMO3 causes TMAU

Accession ID: Reactome:R-HSA-5579019		 - Messenger J, Clark S, Massick S, Bechtel M. A review of trimethylaminuria: (fish odor syndrome). J Clin Aesthet Dermatol. 2013 Nov;6(11):45–8. PMID: 24307925; PMCID: PMC3848652.
Phase I - Functionalization of compounds

Accession ID: Reactome:R-MMU-211945
  • 10.1208/aapsj080112
  • 10.1517/17425255.2.6.895
  • 10.2174/1389200023337054
 Strolin Benedetti M, Whomsley R, Baltes E. Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics. Expert Opinion on Drug Metabolism & Toxicology. 2006 Nov 24;2(6):895–921. doi: 10.1517/17425255.2.6.895.; Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Metabolism

Accession ID: Reactome:R-RNO-1430728		 -
Metabolism

Accession ID: Reactome:R-XTR-1430728		 -
Metabolism

Accession ID: Reactome:R-CEL-1430728		 -
Phase I - Functionalization of compounds

Accession ID: Reactome:R-CFA-211945
  • 10.1208/aapsj080112
  • 10.1517/17425255.2.6.895
  • 10.2174/1389200023337054
 Strolin Benedetti M, Whomsley R, Baltes E. Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics. Expert Opinion on Drug Metabolism & Toxicology. 2006 Nov 24;2(6):895–921. doi: 10.1517/17425255.2.6.895.; Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Biological oxidations

Accession ID: Reactome:R-DRE-211859		 -