Pathways Knowlegdes

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Pathway DOIs Note
superpathway of central carbon metabolism

Accession ID: BioCyc:LEISH_PWY3IU-99
  • 10.1073/pnas.0603539103
 Sernee MF, Ralton JE, Dinev Z, Khairallah GN, O’Hair RA, Williams SJ, McConville MJ. Leishmania ß-1,2-mannan is assembled on a mannose-cyclic phosphate primer. Proc. Natl. Acad. Sci. U.S.A. 2006 Jun 20;103(25):9458–63. doi: 10.1073/pnas.0603539103.
TCA cycle

Accession ID: BioCyc:LEISH_TCA
  • 10.1016/j.molbiopara.2006.04.010
  • 10.2307/3285729
 Leroux A, Fleming-Canepa X, Aranda A, Maugeri D, Cazzulo JJ, Sánchez MA, Nowicki C. Functional characterization and subcellular localization of the three malate dehydrogenase isozymes in Leishmania spp. Molecular and Biochemical Parasitology. 2006 Sep;149(1):74–85. doi: 10.1016/j.molbiopara.2006.04.010.; Louassini M, Foulquie M, Benitez R, Adroher J. Citric-Acid Cycle Key Enzyme Activities during In vitro Growth and Metacyclogenesis of Leishmania infantum Promastigotes. The Journal of Parasitology. 1999 Aug;85(4):595. doi: 10.2307/3285729.
superpathway of (R,R)-butanediol biosynthesis

Accession ID: BioCyc:LEISH_P125-PWY		 -
glycolysis I

Accession ID: BioCyc:LEISH_GLYCOLYSIS
  • 10.1016/j.bbamcr.2006.08.019
 Michels PAM, Bringaud F, Herman M, Hannaert V. Metabolic functions of glycosomes in trypanosomatids. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2006 Dec;1763(12):1463–77. doi: 10.1016/j.bbamcr.2006.08.019.
gluconeogenesis I

Accession ID: BioCyc:LEISH_GLUCONEO-PWY
  • 10.1073/pnas.0509196103
  • 10.1074/jbc.m603265200
 Rodríguez-Contreras D, Landfear SM. Metabolic Changes in Glucose Transporter-deficient Leishmania mexicana and Parasite Virulence. Journal of Biological Chemistry. 2006 Jul;281(29):20068–76. doi: 10.1074/jbc.m603265200.; Naderer T, Ellis MA, Sernee MF, De Souza DP, Curtis J, Handman E, McConville MJ. Virulence of Leishmania major in macrophages and mice requires the gluconeogenic enzyme fructose-1,6-bisphosphatase. Proc. Natl. Acad. Sci. U.S.A. 2006 Apr 04;103(14):5502–7. doi: 10.1073/pnas.0509196103.
folate metabolism

Accession ID: BioCyc:LEISH_PWY3IU-235
  • 10.1016/j.pt.2007.02.004
  • 10.1016/s0020-7519(01)00346-0
  • 10.1111/j.1365-2958.2009.06610.x
 Murta SMF, Vickers TJ, Scott DA, Beverley SM. Methylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential inLeishmania major. Molecular Microbiology. 2009 Mar;71(6):1386–401. doi: 10.1111/j.1365-2958.2009.06610.x.; Opperdoes FR, Coombs GH. Metabolism of Leishmania: proven and predicted. Trends Parasitol. 2007 Apr;23(4):149–58. doi: 10.1016/j.pt.2007.02.004. PMID: 17320480.; Ouellette M, Drummelsmith J, El Fadili A, Kündig C, Richard D, Roy G. Pterin transport and metabolism in Leishmania and related trypanosomatid parasites. International Journal for Parasitology. 2002 Apr;32(4):385–98. doi: 10.1016/s0020-7519(01)00346-0.
purine nucleotide metabolism (phosphotransfer and nucleotide modification)

Accession ID: BioCyc:LEISH_PWY3IU-445		 -
oxaloacetate degradation to pyruvate

Accession ID: BioCyc:LEISH_PWY3IU-39
  • 10.1016/j.molbiopara.2006.04.010
  • 10.1016/j.pt.2007.02.004
 Opperdoes FR, Coombs GH. Metabolism of Leishmania: proven and predicted. Trends Parasitol. 2007 Apr;23(4):149–58. doi: 10.1016/j.pt.2007.02.004. PMID: 17320480.; Leroux A, Fleming-Canepa X, Aranda A, Maugeri D, Cazzulo JJ, Sánchez MA, Nowicki C. Functional characterization and subcellular localization of the three malate dehydrogenase isozymes in Leishmania spp. Molecular and Biochemical Parasitology. 2006 Sep;149(1):74–85. doi: 10.1016/j.molbiopara.2006.04.010.
galactitol degradation

Accession ID: BioCyc:LEISH_GALACTITOLCAT-PWY		 -
glycerol metabolism

Accession ID: BioCyc:LEISH_PWY3IU-106
  • 10.1016/j.molbiopara.2006.05.006
 Guerra DG, Decottignies A, Bakker BM, Michels PAM. The mitochondrial FAD-dependent glycerol-3-phosphate dehydrogenase of Trypanosomatidae and the glycosomal redox balance of insect stages of Trypanosoma brucei and Leishmania spp. Molecular and Biochemical Parasitology. 2006 Oct;149(2):155–69. doi: 10.1016/j.molbiopara.2006.05.006.
valine degradation I

Accession ID: BioCyc:LEISH_VALDEG-PWY
  • 10.1126/science.1112642
 Berriman M, Ghedin E, Hertz-Fowler C, Blandin G, Renauld H, Bartholomeu DC, Lennard NJ, Caler E, Hamlin NE, Haas B, Böhme U, Hannick L, Aslett MA, Shallom J, Marcello L, Hou L, Wickstead B, Alsmark UC, Arrowsmith C, Atkin RJ, Barron AJ, Bringaud F, Brooks K, Carrington M, Cherevach I, Chillingworth TJ, Churcher C, Clark LN, Corton CH, Cronin A, Davies RM, Doggett J, Djikeng A, Feldblyum T, Field MC, Fraser A, Goodhead I, Hance Z, Harper D, Harris BR, Hauser H, Hostetler J, Ivens A, Jagels K, Johnson D, Johnson J, Jones K, Kerhornou AX, Koo H, Larke N, Landfear S, Larkin C, Leech V, Line A, Lord A, Macleod A, Mooney PJ, Moule S, Martin DM, Morgan GW, Mungall K, Norbertczak H, Ormond D, Pai G, Peacock CS, Peterson J, Quail MA, Rabbinowitsch E, Rajandream MA, Reitter C, Salzberg SL, Sanders M, Schobel S, Sharp S, Simmonds M, Simpson AJ, Tallon L, Turner CM, Tait A, Tivey AR, Van Aken S, Walker D, Wanless D, Wang S, White B, White O, Whitehead S, Woodward J, Wortman J, Adams MD, Embley TM, Gull K, Ullu E, Barry JD, Fairlamb AH, Opperdoes F, Barrell BG, Donelson JE, Hall N, Fraser CM, Melville SE, El-Sayed NM. The genome of the African trypanosome Trypanosoma brucei. Science. 2005 Jul 15;309(5733):416–22. doi: 10.1126/science.1112642. PMID: 16020726.
glycine cleavage complex

Accession ID: BioCyc:LEISH_GLYCLEAV-PWY
  • 10.1074/jbc.m708014200
 Scott DA, Hickerson SM, Vickers TJ, Beverley SM. The Role of the Mitochondrial Glycine Cleavage Complex in the Metabolism and Virulence of the Protozoan Parasite Leishmania major. Journal of Biological Chemistry. 2008 Jan;283(1):155–65. doi: 10.1074/jbc.m708014200.
benzenesulfonate degradation

Accession ID: BioCyc:TRYPANO_DESULFONATION-PWY		 -
fatty acid α-oxidation

Accession ID: BioCyc:TRYPANO_PWY-2501		 -
superpathway of ornithine degradation

Accession ID: BioCyc:TRYPANO_ORNDEG-PWY		 -
4-aminobutyrate degradation I

Accession ID: BioCyc:TRYPANO_PWY-6535		 -
putrescine degradation I

Accession ID: BioCyc:TRYPANO_PUTDEG-PWY		 -
isoleucine degradation I

Accession ID: BioCyc:TRYPANO_ILEUDEG-PWY		 -
threonine degradation IV

Accession ID: BioCyc:TRYPANO_PWY-5436		 -
threonine degradation II

Accession ID: BioCyc:TRYPANO_THREONINE-DEG2-PWY		 -