Pathways Knowlegdes
Necessitatibus eius consequatur ex aliquid fuga eum quidem sint consectetur velit
| Pathway | DOIs | Note |
|---|---|---|
| Phase II - Conjugation of compounds Accession ID: Reactome:R-XTR-156580 |
|
McCarver DG, Hines RN. The Ontogeny of Human Drug-Metabolizing Enzymes: Phase II Conjugation Enzymes and Regulatory Mechanisms. The Journal of Pharmacology and Experimental Therapeutics. 2002 Feb;300(2):361–6. doi: 10.1124/jpet.300.2.361. |
| Methylation Accession ID: Reactome:R-XTR-156581 |
|
Fontecave M, Atta M, Mulliez E. S-adenosylmethionine: nothing goes to waste. Trends Biochem Sci. 2004 May;29(5):243–9. doi: 10.1016/j.tibs.2004.03.007. PMID: 15130560.; Lu SC, Huang Z, Yang H, Mato JM, Avila MA, Tsukamoto H. Changes in methionine adenosyltransferase andS-adenosylmethionine homeostasis in alcoholic rat liver. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2000 Jul 01;279(1):G178–85. doi: 10.1152/ajpgi.2000.279.1.g178.; Weinshilboum RM, Otterness DM, Szumlanski CL. Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase. Annu Rev Pharmacol Toxicol. 1999;39():19–52. doi: 10.1146/annurev.pharmtox.39.1.19. PMID: 10331075. |
| Phase II - Conjugation of compounds Accession ID: Reactome:R-BTA-156580 |
|
McCarver DG, Hines RN. The Ontogeny of Human Drug-Metabolizing Enzymes: Phase II Conjugation Enzymes and Regulatory Mechanisms. The Journal of Pharmacology and Experimental Therapeutics. 2002 Feb;300(2):361–6. doi: 10.1124/jpet.300.2.361. |
| Metabolism Accession ID: Reactome:R-CEL-1430728 |
- | |
| Biological oxidations Accession ID: Reactome:R-DRE-211859 |
- | |
| Methylation Accession ID: Reactome:R-DRE-156581 |
|
Fontecave M, Atta M, Mulliez E. S-adenosylmethionine: nothing goes to waste. Trends Biochem Sci. 2004 May;29(5):243–9. doi: 10.1016/j.tibs.2004.03.007. PMID: 15130560.; Lu SC, Huang Z, Yang H, Mato JM, Avila MA, Tsukamoto H. Changes in methionine adenosyltransferase andS-adenosylmethionine homeostasis in alcoholic rat liver. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2000 Jul 01;279(1):G178–85. doi: 10.1152/ajpgi.2000.279.1.g178.; Weinshilboum RM, Otterness DM, Szumlanski CL. Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase. Annu Rev Pharmacol Toxicol. 1999;39():19–52. doi: 10.1146/annurev.pharmtox.39.1.19. PMID: 10331075. |
| Metabolism Accession ID: Reactome:R-DDI-1430728 |
- | |
| Biological oxidations Accession ID: Reactome:R-DME-211859 |
- | |
| Metabolism Accession ID: Reactome:R-HSA-1430728 |
|
Gao J, Shen W. Sirtuin-3-Mediated Cellular Metabolism Links Cardiovascular Remodeling with Hypertension. Biology (Basel). 2023 May 06;12(5). PMID: 37237500; PMCID: PMC10215109.; Chen D, Xia S, Zhang R, Li Y, Famulare CA, Fan H, Wu R, Wang M, Zhu AC, Elf SE, Su R, Dong L, Arellano M, Blum WG, Mao H, Lonial S, Stock W, Odenike O, Le Beau M, Boggon TJ, He C, Chen J, Gao X, Levine RL, Chen J. Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells. Molecular Cell. 2021 Sep;81(18):3833–3847.e11. doi: 10.1016/j.molcel.2021.06.027.; James MO, Jahn SC, Zhong G, Smeltz MG, Hu Z, Stacpoole PW. Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1. Pharmacology & Therapeutics. 2017 Feb;170():166–80. doi: 10.1016/j.pharmthera.2016.10.018.; Dalli J, Vlasakov I, Riley IR, Rodriguez AR, Spur BW, Petasis NA, Chiang N, Serhan CN. Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12232–7. PMID: 27791009; PMCID: PMC5087052.; Jahn SC, Solayman MHM, Lorenzo RJ, Langaee T, Stacpoole PW, James MO. GSTZ1 expression and chloride concentrations modulate sensitivity of cancer cells to dichloroacetate. Biochimica et Biophysica Acta (BBA) - General Subjects. 2016 Jun;1860(6):1202–10. doi: 10.1016/j.bbagen.2016.01.024.; Dalli J, Ramon S, Norris PC, Colas RA, Serhan CN. Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways. The FASEB Journal. 2015 Feb 20;29(5):2120–36. doi: 10.1096/fj.14-268441.; Siiskonen H, Oikari S, Pasonen-Seppänen S, Rilla K. Hyaluronan Synthase 1: A Mysterious Enzyme with Unexpected Functions. Front. Immunol. 2015 Feb 05;6(). doi: 10.3389/fimmu.2015.00043.; Shroads AL, Coats BS, McDonough CW, Langaee T, Stacpoole PW. Haplotype variations in glutathione transferase zeta 1 influence the kinetics and dynamics of chronic dichloroacetate in children. The Journal of Clinical Pharma. 2014 Aug 06;55(1):50–5. doi: 10.1002/jcph.371.; Boone CD, Zhong G, Smeltz M, James MO, McKenna R. Preliminary X-ray crystallographic analysis of glutathione transferase zeta 1 (GSTZ1a-1a). Acta Crystallogr F Struct Biol Commun. 2014 Feb;70(Pt 2):187–9. PMID: 24637752; PMCID: PMC3936459.; Shah M, Baterina OY, Taupin V, Farquhar MG. ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression. J Cell Biol. 2013 Jul 08;202(1):113–27. PMID: 23836931; PMCID: PMC3704979.; Harada N, Fujimoto E, Okuyama M, Sakaue H, Nakaya Y. Identification and functional characterization of human glycerol-3-phosphate acyltransferase 1 gene promoters. Biochemical and Biophysical Research Communications. 2012 Jun;423(1):128–33. doi: 10.1016/j.bbrc.2012.05.094.; Shroads AL, Langaee T, Coats BS, Kurtz TL, Bullock JR, Weithorn D, Gong Y, Wagner DA, Ostrov DA, Johnson JA, Stacpoole PW. Human Polymorphisms in the Glutathione Transferase Zeta 1/Maleylacetoacetate Isomerase Gene Influence the Toxicokinetics of Dichloroacetate. The Journal of Clinical Pharma. 2012 Jun;52(6):837–49. doi: 10.1177/0091270011405664.; Yu W, Dittenhafer-Reed KE, Denu JM. SIRT3 Protein Deacetylates Isocitrate Dehydrogenase 2 (IDH2) and Regulates Mitochondrial Redox Status. Journal of Biological Chemistry. 2012 Apr;287(17):14078–86. doi: 10.1074/jbc.m112.355206.; Li W, James MO, McKenzie SC, Calcutt NA, Liu C, Stacpoole PW. Mitochondrion as a Novel Site of Dichloroacetate Biotransformation by Glutathione Transferase ?1. The Journal of Pharmacology and Experimental Therapeutics. 2011 Jan;336(1):87–94. doi: 10.1124/jpet.110.173195.; Bannenberg G, Serhan CN. Specialized pro-resolving lipid mediators in the inflammatory response: An update. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2010 Dec;1801(12):1260–73. doi: 10.1016/j.bbalip.2010.08.002.; Schiavoni G, Bennati AM, Castelli M, Fazia MAD, Beccari T, Servillo G, Roberti R. Activation of TM7SF2 promoter by SREBP-2 depends on a new sterol regulatory element, a GC-box, and an inverted CCAAT-box. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2010 May;1801(5):587–92. doi: 10.1016/j.bbalip.2010.01.013.; Serhan CN, Yang R, Martinod K, Kasuga K, Pillai PS, Porter TF, Oh SF, Spite M. Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions. J Exp Med. 2009 Jan 16;206(1):15–23. PMID: 19103881; PMCID: PMC2626672.; Stacpoole PW, Kurtz TL, Han Z, Langaee T. Role of dichloroacetate in the treatment of genetic mitochondrial diseases. Advanced Drug Delivery Reviews. 2008 Oct;60(13-14):1478–87. doi: 10.1016/j.addr.2008.02.014.; Rome S, Lecomte V, Meugnier E, Rieusset J, Debard C, Euthine V, Vidal H, Lefai E. Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle. Physiol Genomics. 2008 Aug 15;34(3):327–37. doi: 10.1152/physiolgenomics.90211.2008. PMID: 18559965.; Reed BD, Charos AE, Szekely AM, Weissman SM, Snyder M. Genome-Wide Occupancy of SREBP1 and Its Partners NFY and SP1 Reveals Novel Functional Roles and Combinatorial Regulation of Distinct Classes of Genes. PLoS Genet. 2008 Jul 25;4(7):e1000133. doi: 10.1371/journal.pgen.1000133.; Shroads AL, Guo X, Dixit V, Liu H, James MO, Stacpoole PW. Age-Dependent Kinetics and Metabolism of Dichloroacetate: Possible Relevance to Toxicity. The Journal of Pharmacology and Experimental Therapeutics. 2008 Mar;324(3):1163–71. doi: 10.1124/jpet.107.134593.; Lombard DB, Alt FW, Cheng H, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV, Weissman S, Verdin E, Schwer B. Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation. Molecular and Cellular Biology. 2007 Dec 01;27(24):8807–14. doi: 10.1128/mcb.01636-07.; Schulz T, Schumacher U, Prehm P: Hyaluronan export by the ABC transporter MRP5 and its modulation by intracellular cGMP. J Biol Chem. 2007 Jul 20;282(29):20999-1004. doi: 10.1074/jbc.M700915200. Epub 2007 May 31.; Nagai M, Meerloo T, Takeda T, Farquhar MG. The adaptor protein ARH escorts megalin to and through endosomes. Mol Biol Cell. 2003 Dec;14(12):4984–96. PMID: 14528014; PMCID: PMC284800.; Nagai M, Sakakibara J, Nakamura Y, Gejyo F, Ono T. SREBP-2 and NF-Y are involved in the transcriptional regulation of squalene epoxidase. Biochemical and Biophysical Research Communications. 2002 Jul;295(1):74–80. doi: 10.1016/s0006-291x(02)00623-x.; Read J, Pearce J, Li X, Muirhead H, Chirgwin J, Davies C. The crystal structure of human phosphoglucose isomerase at 1.6 A resolution: implications for catalytic mechanism, cytokine activity and haemolytic anaemia. J Mol Biol. 2001 Jun 01;309(2):447–63. doi: 10.1006/jmbi.2001.4680. PMID: 11371164.; Polekhina G, Board PG, Blackburn AC, Parker MW. Crystal structure of maleylacetoacetate isomerase/glutathione transferase zeta reveals the molecular basis for its remarkable catalytic promiscuity. Biochemistry. 2001 Feb 13;40(6):1567–76. doi: 10.1021/bi002249z. PMID: 11327815.; Clish CB, Levy BD, Chiang N, Tai HH, Serhan CN. Oxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-onoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in inflammation. J Biol Chem. 2000 Aug 18;275(33):25372–80. doi: 10.1074/jbc.m002863200. PMID: 10837478.; Shiota C, Coffey J, Grimsby J, Grippo JF, Magnuson MA. Nuclear Import of Hepatic Glucokinase Depends upon Glucokinase Regulatory Protein, whereas Export Is Due to a Nuclear Export Signal Sequence in Glucokinase. Journal of Biological Chemistry. 1999 Dec;274(52):37125–30. doi: 10.1074/jbc.274.52.37125.; Gåfvels M, Olin M, Chowdhary BP, Raudsepp T, Andersson U, Persson B, Jansson M, Björkhem I, Eggertsen G. Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns. Genomics. 1999 Mar 01;56(2):184–96. doi: 10.1006/geno.1998.5606. PMID: 10051404.; Tong Z, Board PG, Anders MW. Glutathione transferase zeta-catalyzed biotransformation of dichloroacetic acid and other alpha-haloacids. Chem Res Toxicol. 1998 Nov;11(11):1332–8. doi: 10.1021/tx980144f. PMID: 9815194.; Pai J, Guryev O, Brown MS, Goldstein JL. Differential Stimulation of Cholesterol and Unsaturated Fatty Acid Biosynthesis in Cells Expressing Individual Nuclear Sterol Regulatory Element-binding Proteins. Journal of Biological Chemistry. 1998 Oct;273(40):26138–48. doi: 10.1074/jbc.273.40.26138.; Orho M, Bosshard NU, Buist NR, Gitzelmann R, Aynsley-Green A, Blümel P, Gannon MC, Nuttall FQ, Groop LC. Mutations in the liver glycogen synthase gene in children with hypoglycemia due to glycogen storage disease type 0. J Clin Invest. 1998 Aug 01;102(3):507–15. PMID: 9691087; PMCID: PMC508911.; Stacpoole PW, Henderson GN, Yan Z, Cornett R, James MO. Pharmacokinetics, metabolism and toxicology of dichloroacetate. Drug Metab Rev. 1998 Aug;30(3):499–539. doi: 10.3109/03602539808996323. PMID: 9710704.; Moestrup SK, Birn H, Fischer PB, Petersen CM, Verroust PJ, Sim RB, Christensen EI, Nexø E. Megalin-mediated endocytosis of transcobalamin-vitamin-B12 complexes suggests a role of the receptor in vitamin-B12 homeostasis. Proc. Natl. Acad. Sci. U.S.A. 1996 Aug 06;93(16):8612–7. doi: 10.1073/pnas.93.16.8612.; Hjälm G, Murray E, Crumley G, Harazim W, Lundgren S, Onyango I, Ek B, Larsson M, Juhlin C, Hellman P, Davis H, Åkerström G, Rask L, Morse B. Cloning and Sequencing of Human gp330, a Ca2+-Binding Receptor with Potential Intracellular Signaling Properties. European Journal of Biochemistry. 1996 Jul;239(1):132–7. doi: 10.1111/j.1432-1033.1996.0132u.x.; Matsushima M, Inazawa J, Takahashi E, Suzumori K, Nakamura Y. Molecular cloning and mapping of a human cDNA (SC5DL) encoding a protein homologous to fungal sterol-C5-desaturase. Cytogenet Cell Genet. 1996;74(4):252–4. doi: 10.1159/000134427. PMID: 8976377.; Clària J, Serhan CN. Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions. Proc. Natl. Acad. Sci. U.S.A. 1995 Oct 10;92(21):9475–9. doi: 10.1073/pnas.92.21.9475.; Kounnas MZ, Loukinova EB, Stefansson S, Harmony JAK, Brewer BH, Strickland DK, Argraves WS. Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin. Journal of Biological Chemistry. 1995 Sep;270(39):23234a. doi: 10.1016/s0021-9258(18)90095-5.; Xu W, Beutler E. The characterization of gene mutations for human glucose phosphate isomerase deficiency associated with chronic hemolytic anemia. J Clin Invest. 1994 Dec;94(6):2326–9. PMID: 7989588; PMCID: PMC330061.; Ishida H, Noshiro M, Okuda K, Coon MJ. Purification and characterization of 7 alpha-hydroxy-4-cholesten-3-one 12 alpha-hydroxylase. Journal of Biological Chemistry. 1992 Oct;267(30):21319–23. doi: 10.1016/s0021-9258(19)36611-6.; Newgard CB, Hwang PK, Fletterick RJ. The Family of Glycogen Phosphorylases: Structure and Functio. Critical Reviews in Biochemistry and Molecular Biology. 1989 Jan;24(1):69–99. doi: 10.3109/10409238909082552.; Chen YT, He JK, Ding JH, Brown BI. Glycogen debranching enzyme: purification, antibody characterization, and immunoblot analyses of type III glycogen storage disease. Am J Hum Genet. 1987 Dec;41(6):1002–15. PMID: 2961257; PMCID: PMC1684360.; Furuya E, Yokoyama M, Uyeda K. Regulation of fructose-6-phosphate 2-kinase by phosphorylation and dephosphorylation: possible mechanism for coordinated control of glycolysis and glycogenolysis. Proc Natl Acad Sci U S A. 1982 Jan;79(2):325–9. PMID: 6281764; PMCID: PMC345719.; TSUBOI KK, ESTRADA J, HUDSON PB. Enzymes of the human erythrocyte. IV. Phosphoglucose isomerase, purification and properties. J Biol Chem. 1958 Mar;231(1):19–29. PMID: 13538944. |
| Biological oxidations Accession ID: Reactome:R-SCE-211859 |
- | |
| Phase II - Conjugation of compounds Accession ID: Reactome:R-SSC-156580 |
|
McCarver DG, Hines RN. The Ontogeny of Human Drug-Metabolizing Enzymes: Phase II Conjugation Enzymes and Regulatory Mechanisms. The Journal of Pharmacology and Experimental Therapeutics. 2002 Feb;300(2):361–6. doi: 10.1124/jpet.300.2.361. |
| Biological oxidations Accession ID: Reactome:R-XTR-211859 |
- | |
| Arsenate Detoxification Accession ID: PathBank:SMP0121123 |
- |