Pathways Knowlegdes

Necessitatibus eius consequatur ex aliquid fuga eum quidem sint consectetur velit

Pathway DOIs Note
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde

Accession ID: BioCyc:LEISH_PWY-5651		 -
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde

Accession ID: BioCyc:TRYPANO_PWY-5651		 -
tryptophan degradation via kynurenine

Accession ID: BioCyc:CALBI_TRYPTOPHAN-DEGRADATION-1
  • 10.1002/jobm.19740140508
  • 10.1016/s0014-5793(02)02585-1
  • 10.1271/bbb.69.2358
 TSAI S, TSAI L, LI Y. An IsolatedCandida albicansTL3 Capable of Degrading Phenol at Large Concentration. Bioscience, Biotechnology, and Biochemistry. 2005 Jan;69(12):2358–67. doi: 10.1271/bbb.69.2358.; Panozzo C, Nawara M, Suski C, Kucharczyk R, Skoneczny M, Bécam A, Rytka J, Herbert CJ. Aerobic and anaerobic NAD+ metabolism in Saccharomyces cerevisiae. FEBS Letters. 2002 Mar 22;517(1-3):97–102. doi: 10.1016/s0014-5793(02)02585-1.; Teuscher G, Karczewski P, Weide H. [Catabolism of tryptophan by Candida guilliermondii, strain H17]. Z Allg Mikrobiol. 1974;14(5):429–33. doi: 10.1002/jobm.3630140508. PMID: 4408763.
NAD biosynthesis II (from tryptophan)

Accession ID: BioCyc:TRYPANO_NADSYN-PWY		 -
NAD biosynthesis (from tryptophan)

Accession ID: BioCyc:CALBI_NADSYN-PWY
  • 10.1016/j.tibs.2006.11.006
  • 10.1111/j.1567-1364.2007.00231.x
  • 10.1128/jb.139.3.883-888.1979
 Li YF, Bao WG. Why do some yeast species require niacin for growth? Different modes of NAD synthesis. FEMS Yeast Res. 2007 Aug;7(5):657–64. doi: 10.1111/j.1567-1364.2007.00231.x. PMID: 17425674.; Belenky P, Bogan KL, Brenner C. NAD+ metabolism in health and disease. Trends Biochem Sci. 2007 Jan;32(1):12–9. doi: 10.1016/j.tibs.2006.11.006. PMID: 17161604.; Chaffin WL, Barton RA, Jacobson EL, Jacobson MK. Nicotinamide adenine dinucleotide metabolism in Candida albicans. J Bacteriol. 1979 Sep;139(3):883–8. doi: 10.1128/jb.139.3.883-888.1979.
tryptophan degradation I (via anthranilate)

Accession ID: BioCyc:TRYPANO_TRPCAT-PWY		 -
NAD biosynthesis II (from tryptophan)

Accession ID: BioCyc:LEISH_NADSYN-PWY		 -
tryptophan degradation I (via anthranilate)

Accession ID: BioCyc:LEISH_TRPCAT-PWY		 -
Pleural mesothelioma

Accession ID: WikiPathways:WP5087
  • 10.1016/j.canlet.2005.08.010
 Whitson BA, Kratzke RA. Molecular pathways in malignant pleural mesothelioma. Cancer Lett. 2006 Aug 08;239(2):183–9. doi: 10.1016/j.canlet.2005.08.010. PMID: 16216411.
T cell modulation in pancreatic cancer

Accession ID: WikiPathways:WP5078
  • 10.3390/cancers12082274
 Saka D, Gökalp M, Piyade B, Cevik NC, Arik Sever E, Unutmaz D, Ceyhan GO, Demir IE, Asimgil H. Mechanisms of T-Cell Exhaustion in Pancreatic Cancer. Cancers (Basel). 2020 Aug 14;12(8). PMID: 32823814; PMCID: PMC7464444.
Kynurenine pathway and links to cell senescence

Accession ID: WikiPathways:WP5044
  • 10.1038/s41380-019-0414-4
 Savitz J. The kynurenine pathway: a finger in every pie. Molecular Psychiatry. 2019 Apr 12;25(1):131–47. doi: 10.1038/s41380-019-0414-4.