Pathways Knowlegdes

Necessitatibus eius consequatur ex aliquid fuga eum quidem sint consectetur velit

Pathway DOIs Note
superpathway of pterocarpan biosynthesis (via formononetin)

Accession ID: PlantCyc:REDCLOVER_PWY-2229		 -
formononetin biosynthesis

Accession ID: PlantCyc:SOY_PWY-2321
  • 10.1016/0014-5793(94)01267-9
  • 10.1016/s0021-9258(17)31799-4
  • 10.1093/pcp/pcg034
  • 10.1093/pcp/pcm125
  • 10.1104/pp.104.056747
 Shimamura M, Akashi T, Sakurai N, Suzuki H, Saito K, Shibata D, Ayabe S, Aoki T. 2-Hydroxyisoflavanone dehydratase is a critical determinant of isoflavone productivity in hairy root cultures of Lotus japonicus. Plant Cell Physiol. 2007 Nov;48(11):1652–7. doi: 10.1093/pcp/pcm125. PMID: 17921150.; Akashi T, Aoki T, Ayabe S. Molecular and biochemical characterization of 2-hydroxyisoflavanone dehydratase. Involvement of carboxylesterase-like proteins in leguminous isoflavone biosynthesis. Plant Physiol. 2005 Mar;137(3):882–91. PMID: 15734910; PMCID: PMC1065389.; Akashi T, Sawada Y, Shimada N, Sakurai N, Aoki T, Ayabe S. cDNA cloning and biochemical characterization of S-adenosyl-L-methionine: 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase, a critical enzyme of the legume isoflavonoid phytoalexin pathway. Plant Cell Physiol. 2003 Feb;44(2):103–12. doi: 10.1093/pcp/pcg034. PMID: 12610212.; Guo L, Dixon RA, Paiva NL. The 'pterocarpan synthase' of alfalfa: association and co-induction of vestitone reductase and 7,2'-dihydroxy-4'-methoxy-isoflavanol (DMI) dehydratase, the two final enzymes in medicarpin biosynthesis. FEBS Lett. 1994 Dec 19;356(2-3):221–5. doi: 10.1016/0014-5793(94)01267-9. PMID: 7805842.; Guo L, Dixon RA, Paiva NL. Conversion of vestitone to medicarpin in alfalfa (Medicago sativa L.) is catalyzed by two independent enzymes. Identification, purification, and characterization of vestitone reductase and 7,2‘-dihydroxy-4‘-methoxyisoflavanol dehydratase. Journal of Biological Chemistry. 1994 Sep;269(35):22372–8. doi: 10.1016/s0021-9258(17)31799-4.
(-)-glycinol biosynthesis

Accession ID: PlantCyc:SOY_PWY-2761
  • 10.1016/0003-9861(89)90514-6
  • 10.1016/s0031-9422(02)00709-4
  • 10.1021/jf9912809
  • 10.1111/j.1432-1033.1984.tb08259.x
 Landini S, Graham MY, Graham TL. Lactofen induces isoflavone accumulation and glyceollin elicitation competency in soybean. Phytochemistry. 2003 Mar;62(6):865–74. doi: 10.1016/s0031-9422(02)00709-4. PMID: 12590114.; Boué SM, Carter CH, Ehrlich KC, Cleveland TE. Induction of the soybean phytoalexins coumestrol and glyceollin by Aspergillus. J Agric Food Chem. 2000 Jun;48(6):2167–72. doi: 10.1021/jf9912809. PMID: 10888516.; Kochs G, Grisebach H. Phytoalexin synthesis in soybean: Purification and reconstitution of cytochrome P450 3,9-dihydroxypterocarpan 6a-hydroxylase and separation from cytochrome P450 cinnamate 4-hydroxylase. Archives of Biochemistry and Biophysics. 1989 Sep;273(2):543–53. doi: 10.1016/0003-9861(89)90514-6.; HAGMANN M, HELLER W, GRISEBACH H. Induction of phytoalexin synthesis in soybean. Stereospecific 3,9-dihydroxypterocarpan 6a-hydroxylase from elicitor-induced soybean cell cultures. European Journal of Biochemistry. 1984 Jul;142(1):127–31. doi: 10.1111/j.1432-1033.1984.tb08259.x.
daidzein conjugates interconversion

Accession ID: PlantCyc:SOY_PWY-2343
  • 10.1016/0003-9861(81)90347-7
  • 10.1016/0003-9861(83)90286-2
  • 10.1016/0003-9861(84)90298-4
  • 10.1016/0003-9861(86)90510-2
  • 10.1016/s0031-9422(01)00380-6
  • 10.1042/bj1290018pb
  • 10.1111/j.1432-1033.1975.tb02336.x
 Hsieh MC, Graham TL. Partial purification and characterization of a soybean beta-glucosidase with high specific activity towards isoflavone conjugates. Phytochemistry. 2001 Dec;58(7):995–1005. doi: 10.1016/s0031-9422(01)00380-6. PMID: 11730862.; Hinderer W, Köster J, Barz W. Purification and properties of a specific isoflavone 7-O-glucoside-6?-malonate malonylesterase from roots of chickpea (Cicer arietinum L.). Archives of Biochemistry and Biophysics. 1986 Aug;248(2):570–8. doi: 10.1016/0003-9861(86)90510-2.; Koester J, Bussmann R, Barz W. Malonyl-coenzyme A:Isoflavone 7-O-glucoside-6?-O-malonyltransferase from roots of chick pea (Cicer arietinum L.). Archives of Biochemistry and Biophysics. 1984 Nov;234(2):513–21. doi: 10.1016/0003-9861(84)90298-4.; Matern U, Feser C, Hammer D. Further characterization and regulation of malonyl-coenzyme A: Flavonoid glucoside malonyltransferases from parsley cell suspension cultures. Archives of Biochemistry and Biophysics. 1983 Oct;226(1):206–17. doi: 10.1016/0003-9861(83)90286-2.; Köster J, Barz W. UDP-glucose:Isoflavone 7-O-glucosyltransferase from roots of chick pea (Cicer arietinum L.). Archives of Biochemistry and Biophysics. 1981 Nov;212(1):98–104. doi: 10.1016/0003-9861(81)90347-7.; Hósel W, Barz W. Beta-Glucosidases from Cicer arietinum L. Purification and Properties of isoflavone-7-O-glucoside-specific beta-glucosidases. Eur J Biochem. 1975 Sep 15;57(2):607–16. doi: 10.1111/j.1432-1033.1975.tb02336.x. PMID: 240725.; Davenport HE, Dupont MS. The enzymic hydrolysis of malonated flavone glycosides. Biochem J. 1972 Sep;129(2):18P–19P. PMID: 4643301; PMCID: PMC1174128.
superpathway of pterocarpan biosynthesis (via daidzein)

Accession ID: PlantCyc:COMMONBEAN_PWY-2055
  • 10.1016/0003-9861(89)90514-6
  • 10.1016/s0031-9422(02)00709-4
  • 10.1021/jf9912809
  • 10.1111/j.1432-1033.1984.tb08259.x
 Landini S, Graham MY, Graham TL. Lactofen induces isoflavone accumulation and glyceollin elicitation competency in soybean. Phytochemistry. 2003 Mar;62(6):865–74. doi: 10.1016/s0031-9422(02)00709-4. PMID: 12590114.; Boué SM, Carter CH, Ehrlich KC, Cleveland TE. Induction of the soybean phytoalexins coumestrol and glyceollin by Aspergillus. J Agric Food Chem. 2000 Jun;48(6):2167–72. doi: 10.1021/jf9912809. PMID: 10888516.; Kochs G, Grisebach H. Phytoalexin synthesis in soybean: Purification and reconstitution of cytochrome P450 3,9-dihydroxypterocarpan 6a-hydroxylase and separation from cytochrome P450 cinnamate 4-hydroxylase. Archives of Biochemistry and Biophysics. 1989 Sep;273(2):543–53. doi: 10.1016/0003-9861(89)90514-6.; HAGMANN M, HELLER W, GRISEBACH H. Induction of phytoalexin synthesis in soybean. Stereospecific 3,9-dihydroxypterocarpan 6a-hydroxylase from elicitor-induced soybean cell cultures. European Journal of Biochemistry. 1984 Jul;142(1):127–31. doi: 10.1111/j.1432-1033.1984.tb08259.x.
isoflavonoid biosynthesis I

Accession ID: PlantCyc:PIGEONPEA_PWY-2002		 -
formononetin biosynthesis

Accession ID: PlantCyc:PIGEONPEA_PWY-2321		 -
(-)-glycinol biosynthesis

Accession ID: PlantCyc:PLANT_PWY-2761
  • 10.1016/0003-9861(89)90514-6
  • 10.1016/s0031-9422(02)00709-4
  • 10.1021/jf9912809
  • 10.1111/j.1432-1033.1984.tb08259.x
 Landini S, Graham MY, Graham TL. Lactofen induces isoflavone accumulation and glyceollin elicitation competency in soybean. Phytochemistry. 2003 Mar;62(6):865–74. doi: 10.1016/s0031-9422(02)00709-4. PMID: 12590114.; Boué SM, Carter CH, Ehrlich KC, Cleveland TE. Induction of the soybean phytoalexins coumestrol and glyceollin by Aspergillus. J Agric Food Chem. 2000 Jun;48(6):2167–72. doi: 10.1021/jf9912809. PMID: 10888516.; Kochs G, Grisebach H. Phytoalexin synthesis in soybean: Purification and reconstitution of cytochrome P450 3,9-dihydroxypterocarpan 6a-hydroxylase and separation from cytochrome P450 cinnamate 4-hydroxylase. Archives of Biochemistry and Biophysics. 1989 Sep;273(2):543–53. doi: 10.1016/0003-9861(89)90514-6.; HAGMANN M, HELLER W, GRISEBACH H. Induction of phytoalexin synthesis in soybean. Stereospecific 3,9-dihydroxypterocarpan 6a-hydroxylase from elicitor-induced soybean cell cultures. European Journal of Biochemistry. 1984 Jul;142(1):127–31. doi: 10.1111/j.1432-1033.1984.tb08259.x.
daidzein conjugates interconversion

Accession ID: PlantCyc:PLANT_PWY-2343
  • 10.1016/0003-9861(81)90347-7
  • 10.1016/0003-9861(83)90286-2
  • 10.1016/0003-9861(84)90298-4
  • 10.1016/0003-9861(86)90510-2
  • 10.1016/s0031-9422(01)00380-6
  • 10.1042/bj1290018pb
  • 10.1111/j.1432-1033.1975.tb02336.x
 Hsieh MC, Graham TL. Partial purification and characterization of a soybean beta-glucosidase with high specific activity towards isoflavone conjugates. Phytochemistry. 2001 Dec;58(7):995–1005. doi: 10.1016/s0031-9422(01)00380-6. PMID: 11730862.; Hinderer W, Köster J, Barz W. Purification and properties of a specific isoflavone 7-O-glucoside-6?-malonate malonylesterase from roots of chickpea (Cicer arietinum L.). Archives of Biochemistry and Biophysics. 1986 Aug;248(2):570–8. doi: 10.1016/0003-9861(86)90510-2.; Koester J, Bussmann R, Barz W. Malonyl-coenzyme A:Isoflavone 7-O-glucoside-6?-O-malonyltransferase from roots of chick pea (Cicer arietinum L.). Archives of Biochemistry and Biophysics. 1984 Nov;234(2):513–21. doi: 10.1016/0003-9861(84)90298-4.; Matern U, Feser C, Hammer D. Further characterization and regulation of malonyl-coenzyme A: Flavonoid glucoside malonyltransferases from parsley cell suspension cultures. Archives of Biochemistry and Biophysics. 1983 Oct;226(1):206–17. doi: 10.1016/0003-9861(83)90286-2.; Köster J, Barz W. UDP-glucose:Isoflavone 7-O-glucosyltransferase from roots of chick pea (Cicer arietinum L.). Archives of Biochemistry and Biophysics. 1981 Nov;212(1):98–104. doi: 10.1016/0003-9861(81)90347-7.; Hósel W, Barz W. Beta-Glucosidases from Cicer arietinum L. Purification and Properties of isoflavone-7-O-glucoside-specific beta-glucosidases. Eur J Biochem. 1975 Sep 15;57(2):607–16. doi: 10.1111/j.1432-1033.1975.tb02336.x. PMID: 240725.; Davenport HE, Dupont MS. The enzymic hydrolysis of malonated flavone glycosides. Biochem J. 1972 Sep;129(2):18P–19P. PMID: 4643301; PMCID: PMC1174128.
formononetin biosynthesis

Accession ID: PlantCyc:REDCLOVER_PWY-2321		 -
isoflavonoid biosynthesis I

Accession ID: PlantCyc:APPLERINGACACIA_PWY-2002		 -
isoflavonoid biosynthesis I

Accession ID: PlantCyc:BAMBARABEAN_PWY-2002		 -
superpathway of pterocarpan biosynthesis (via formononetin)

Accession ID: PlantCyc:SOY_PWY-2229
  • 10.1016/0003-9861(95)90019-5
  • 10.1016/0014-5793(94)01267-9
  • 10.1016/j.phytochem.2005.12.027
  • 10.1016/j.phytochem.2006.09.010
  • 10.1016/j.phytochem.2013.10.017
  • 10.1016/s0021-9258(17)31799-4
  • 10.1023/a:1005836508844
  • 10.1093/pcp/pcg034
  • 10.1104/pp.91.2.559
  • 10.1105/tpc.106.041376
 Celoy RM, VanEtten HD. (+)-Pisatin biosynthesis: from (-) enantiomeric intermediates via an achiral 7,2'-dihydroxy-4',5'-methylenedioxyisoflav-3-ene. Phytochemistry. 2014 Feb;98():120–7. doi: 10.1016/j.phytochem.2013.10.017. PMID: 24332213.; Liu CJ, Deavours BE, Richard SB, Ferrer JL, Blount JW, Huhman D, Dixon RA, Noel JP. Structural basis for dual functionality of isoflavonoid O-methyltransferases in the evolution of plant defense responses. Plant Cell. 2006 Dec;18(12):3656–69. PMID: 17172354; PMCID: PMC1785397.; Akashi T, VanEtten HD, Sawada Y, Wasmann CC, Uchiyama H, Ayabe S. Catalytic specificity of pea O-methyltransferases suggests gene duplication for (+)-pisatin biosynthesis. Phytochemistry. 2006 Dec;67(23):2525–30. doi: 10.1016/j.phytochem.2006.09.010. PMID: 17067644.; DiCenzo GL, VanEtten HD. Studies on the late steps of (+) pisatin biosynthesis: evidence for (-) enantiomeric intermediates. Phytochemistry. 2006 Apr;67(7):675–83. doi: 10.1016/j.phytochem.2005.12.027. PMID: 16504226.; Akashi T, Sawada Y, Shimada N, Sakurai N, Aoki T, Ayabe S. cDNA cloning and biochemical characterization of S-adenosyl-L-methionine: 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase, a critical enzyme of the legume isoflavonoid phytoalexin pathway. Plant Cell Physiol. 2003 Feb;44(2):103–12. doi: 10.1093/pcp/pcg034. PMID: 12610212.; Wu Q, Preisig CL, VanEtten HD. Isolation of the cDNAs encoding (+)6a-hydroxymaackiain 3-O-methyltransferase, the terminal step for the synthesis of the phytoalexin pisatin in Pisum sativum. Plant Mol Biol. 1997 Nov;35(5):551–60. doi: 10.1023/a:1005836508844. PMID: 9349277.; Guo L, Paiva NL. Molecular cloning and expression of alfalfa (Medicago sativa L.) vestitone reductase, the penultimate enzyme in medicarpin biosynthesis. Archives of Biochemistry and Biophysics. 1995 Jul;320(2):353–60. doi: 10.1016/0003-9861(95)90019-5.; Guo L, Dixon RA, Paiva NL. The 'pterocarpan synthase' of alfalfa: association and co-induction of vestitone reductase and 7,2'-dihydroxy-4'-methoxy-isoflavanol (DMI) dehydratase, the two final enzymes in medicarpin biosynthesis. FEBS Lett. 1994 Dec 19;356(2-3):221–5. doi: 10.1016/0014-5793(94)01267-9. PMID: 7805842.; Guo L, Dixon RA, Paiva NL. Conversion of vestitone to medicarpin in alfalfa (Medicago sativa L.) is catalyzed by two independent enzymes. Identification, purification, and characterization of vestitone reductase and 7,2‘-dihydroxy-4‘-methoxyisoflavanol dehydratase. Journal of Biological Chemistry. 1994 Sep;269(35):22372–8. doi: 10.1016/s0021-9258(17)31799-4.; Preisig CL, Matthews DE, VanEtten HD. Purification and Characterization of S-Adenosyl-l-methionine:6a-Hydroxymaackiain 3-O-Methyltransferase from Pisum sativum. Plant Physiol. 1989 Oct 01;91(2):559–66. doi: 10.1104/pp.91.2.559.
isoflavonoid biosynthesis I

Accession ID: PlantCyc:SOY_PWY-2002
  • 10.1006/abbi.1996.0539
  • 10.1006/abbi.1999.1238
  • 10.1016/s0021-9258(19)81556-9
  • 10.1016/s1360-1385(00)01680-0
  • 10.1073/pnas.212522099
  • 10.1093/pcp/pcg034
  • 10.1105/tpc.12.9.1689
  • 10.1146/annurev.arplant.55.031903.141729
 Dixon RA. Phytoestrogens. Annu Rev Plant Biol. 2004;55():225–61. doi: 10.1146/annurev.arplant.55.031903.141729. PMID: 15377220.; Akashi T, Sawada Y, Shimada N, Sakurai N, Aoki T, Ayabe S. cDNA cloning and biochemical characterization of S-adenosyl-L-methionine: 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase, a critical enzyme of the legume isoflavonoid phytoalexin pathway. Plant Cell Physiol. 2003 Feb;44(2):103–12. doi: 10.1093/pcp/pcg034. PMID: 12610212.; Liu C, Blount JW, Steele CL, Dixon RA. Bottlenecks for metabolic engineering of isoflavone glycoconjugates inArabidopsis. Proc. Natl. Acad. Sci. U.S.A. 2002 Oct 16;99(22):14578–83. doi: 10.1073/pnas.212522099.; He X, Dixon RA. Genetic Manipulation of Isoflavone 7-O-Methyltransferase Enhances Biosynthesis of 4'-O-Methylated Isoflavonoid Phytoalexins and Disease Resistance in Alfalfa. Plant Cell. 2000 Sep;12(9):1689–702. doi: 10.1105/tpc.12.9.1689.; Humphreys JM, Chapple C. Molecular 'pharming' with plant P450s. Trends Plant Sci. 2000 Jul;5(7):271–2. doi: 10.1016/s1360-1385(00)01680-0. PMID: 10871897.; Steele CL, Gijzen M, Qutob D, Dixon RA. Molecular Characterization of the Enzyme Catalyzing the Aryl Migration Reaction of Isoflavonoid Biosynthesis in Soybean. Archives of Biochemistry and Biophysics. 1999 Jul;367(1):146–50. doi: 10.1006/abbi.1999.1238.; He XZ, Dixon RA. Affinity chromatography, substrate/product specificity, and amino acid sequence analysis of an isoflavone O-methyltransferase from alfalfa (Medicago sativa L.). Arch Biochem Biophys. 1996 Dec 01;336(1):121–9. doi: 10.1006/abbi.1996.0539. PMID: 8951042.; Bednar RA, Hadcock JR. Purification and characterization of chalcone isomerase from soybeans. Journal of Biological Chemistry. 1988 Jul;263(20):9582–8. doi: 10.1016/s0021-9258(19)81556-9.
superpathway of pterocarpan biosynthesis (via formononetin)

Accession ID: PlantCyc:CARIETINUM_ICC4958_PWY-2229
  • 10.1016/0003-9861(95)90019-5
  • 10.1016/0014-5793(94)01267-9
  • 10.1016/s0021-9258(17)31799-4
  • 10.1093/pcp/pcg034
 Akashi T, Sawada Y, Shimada N, Sakurai N, Aoki T, Ayabe S. cDNA cloning and biochemical characterization of S-adenosyl-L-methionine: 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase, a critical enzyme of the legume isoflavonoid phytoalexin pathway. Plant Cell Physiol. 2003 Feb;44(2):103–12. doi: 10.1093/pcp/pcg034. PMID: 12610212.; Guo L, Paiva NL. Molecular cloning and expression of alfalfa (Medicago sativa L.) vestitone reductase, the penultimate enzyme in medicarpin biosynthesis. Archives of Biochemistry and Biophysics. 1995 Jul;320(2):353–60. doi: 10.1016/0003-9861(95)90019-5.; Guo L, Dixon RA, Paiva NL. The 'pterocarpan synthase' of alfalfa: association and co-induction of vestitone reductase and 7,2'-dihydroxy-4'-methoxy-isoflavanol (DMI) dehydratase, the two final enzymes in medicarpin biosynthesis. FEBS Lett. 1994 Dec 19;356(2-3):221–5. doi: 10.1016/0014-5793(94)01267-9. PMID: 7805842.; Guo L, Dixon RA, Paiva NL. Conversion of vestitone to medicarpin in alfalfa (Medicago sativa L.) is catalyzed by two independent enzymes. Identification, purification, and characterization of vestitone reductase and 7,2‘-dihydroxy-4‘-methoxyisoflavanol dehydratase. Journal of Biological Chemistry. 1994 Sep;269(35):22372–8. doi: 10.1016/s0021-9258(17)31799-4.
superpathway of pterocarpan biosynthesis (via formononetin)

Accession ID: PlantCyc:PIGEONPEA_PWY-2229		 -
(-)-glycinol biosynthesis

Accession ID: PlantCyc:PIGEONPEA_PWY-2761		 -
superpathway of pterocarpan biosynthesis (via formononetin)

Accession ID: PlantCyc:LJAPONICUS_PWY-2229
  • 10.1016/0003-9861(95)90019-5
  • 10.1016/0014-5793(94)01267-9
  • 10.1016/j.phytochem.2005.12.027
  • 10.1016/j.phytochem.2006.09.010
  • 10.1016/j.phytochem.2013.10.017
  • 10.1016/s0021-9258(17)31799-4
  • 10.1023/a:1005836508844
  • 10.1093/pcp/pcg034
  • 10.1104/pp.91.2.559
  • 10.1105/tpc.106.041376
 Celoy RM, VanEtten HD. (+)-Pisatin biosynthesis: from (-) enantiomeric intermediates via an achiral 7,2'-dihydroxy-4',5'-methylenedioxyisoflav-3-ene. Phytochemistry. 2014 Feb;98():120–7. doi: 10.1016/j.phytochem.2013.10.017. PMID: 24332213.; Liu CJ, Deavours BE, Richard SB, Ferrer JL, Blount JW, Huhman D, Dixon RA, Noel JP. Structural basis for dual functionality of isoflavonoid O-methyltransferases in the evolution of plant defense responses. Plant Cell. 2006 Dec;18(12):3656–69. PMID: 17172354; PMCID: PMC1785397.; Akashi T, VanEtten HD, Sawada Y, Wasmann CC, Uchiyama H, Ayabe S. Catalytic specificity of pea O-methyltransferases suggests gene duplication for (+)-pisatin biosynthesis. Phytochemistry. 2006 Dec;67(23):2525–30. doi: 10.1016/j.phytochem.2006.09.010. PMID: 17067644.; DiCenzo GL, VanEtten HD. Studies on the late steps of (+) pisatin biosynthesis: evidence for (-) enantiomeric intermediates. Phytochemistry. 2006 Apr;67(7):675–83. doi: 10.1016/j.phytochem.2005.12.027. PMID: 16504226.; Akashi T, Sawada Y, Shimada N, Sakurai N, Aoki T, Ayabe S. cDNA cloning and biochemical characterization of S-adenosyl-L-methionine: 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase, a critical enzyme of the legume isoflavonoid phytoalexin pathway. Plant Cell Physiol. 2003 Feb;44(2):103–12. doi: 10.1093/pcp/pcg034. PMID: 12610212.; Wu Q, Preisig CL, VanEtten HD. Isolation of the cDNAs encoding (+)6a-hydroxymaackiain 3-O-methyltransferase, the terminal step for the synthesis of the phytoalexin pisatin in Pisum sativum. Plant Mol Biol. 1997 Nov;35(5):551–60. doi: 10.1023/a:1005836508844. PMID: 9349277.; Guo L, Paiva NL. Molecular cloning and expression of alfalfa (Medicago sativa L.) vestitone reductase, the penultimate enzyme in medicarpin biosynthesis. Archives of Biochemistry and Biophysics. 1995 Jul;320(2):353–60. doi: 10.1016/0003-9861(95)90019-5.; Guo L, Dixon RA, Paiva NL. The 'pterocarpan synthase' of alfalfa: association and co-induction of vestitone reductase and 7,2'-dihydroxy-4'-methoxy-isoflavanol (DMI) dehydratase, the two final enzymes in medicarpin biosynthesis. FEBS Lett. 1994 Dec 19;356(2-3):221–5. doi: 10.1016/0014-5793(94)01267-9. PMID: 7805842.; Guo L, Dixon RA, Paiva NL. Conversion of vestitone to medicarpin in alfalfa (Medicago sativa L.) is catalyzed by two independent enzymes. Identification, purification, and characterization of vestitone reductase and 7,2‘-dihydroxy-4‘-methoxyisoflavanol dehydratase. Journal of Biological Chemistry. 1994 Sep;269(35):22372–8. doi: 10.1016/s0021-9258(17)31799-4.; Preisig CL, Matthews DE, VanEtten HD. Purification and Characterization of S-Adenosyl-l-methionine:6a-Hydroxymaackiain 3-O-Methyltransferase from Pisum sativum. Plant Physiol. 1989 Oct 01;91(2):559–66. doi: 10.1104/pp.91.2.559.
(-)-glycinol biosynthesis

Accession ID: PlantCyc:LJAPONICUS_PWY-2761		 -
formononetin biosynthesis

Accession ID: PlantCyc:MTRUNCATULA_PWY-2321		 -