Pathways Knowlegdes

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Pathway DOIs Note
ethene and chloroethene degradation

Accession ID: BioCyc:META_PWY-7776
  • 10.1007/s00203-004-0749-2
  • 10.1021/bi015523d
  • 10.1128/aem.00086-07
  • 10.1128/jb.185.18.5536-5545.2003
 Chuang AS, Mattes TE. Identification of polypeptides expressed in response to vinyl chloride, ethene, and epoxyethane in Nocardioides sp. strain JS614 by using peptide mass fingerprinting. Appl Environ Microbiol. 2007 Jul;73(13):4368–72. PMID: 17483267; PMCID: PMC1932774.; Mattes TE, Coleman NV, Spain JC, Gossett JM. Physiological and molecular genetic analyses of vinyl chloride and ethene biodegradation in Nocardioides sp. strain JS614. Arch Microbiol. 2005 Feb;183(2):95–106. doi: 10.1007/s00203-004-0749-2. PMID: 15599705.; Coleman NV, Spain JC. Epoxyalkane:Coenzyme M Transferase in the Ethene and Vinyl Chloride Biodegradation Pathways of Mycobacterium Strain JS60. J Bacteriol. 2003 Sep 15;185(18):5536–45. doi: 10.1128/jb.185.18.5536-5545.2003.; Ensign SA. Microbial metabolism of aliphatic alkenes. Biochemistry. 2001 May 22;40(20):5845–53. doi: 10.1021/bi015523d. PMID: 11352719.
CYP2E1 reactions

Accession ID: Reactome:R-CEL-211999
  • 10.1016/j.mrfmmm.2004.04.021
  • 10.1097/00000374-199906000-00006
  • 10.1146/annurev.pharmtox.44.101802.121704
 Gonzalez FJ. Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 2005 Jan;569(1-2):101–10. doi: 10.1016/j.mrfmmm.2004.04.021.; Caro AA, Cederbaum AI. Oxidative stress, toxicology, and pharmacology of CYP2E1. Annu Rev Pharmacol Toxicol. 2004;44():27–42. doi: 10.1146/annurev.pharmtox.44.101802.121704. PMID: 14744237.; Lieber CS. Microsomal Ethanol-Oxidizing System (MEOS): The First 30 Years (1968-1998)–A Review. Alcoholism Clin & Exp Res. 1999 Jun;23(6):991–1007. doi: 10.1111/j.1530-0277.1999.tb04217.x.
CYP2E1 reactions

Accession ID: Reactome:R-DDI-211999
  • 10.1016/j.mrfmmm.2004.04.021
  • 10.1097/00000374-199906000-00006
  • 10.1146/annurev.pharmtox.44.101802.121704
 Gonzalez FJ. Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 2005 Jan;569(1-2):101–10. doi: 10.1016/j.mrfmmm.2004.04.021.; Caro AA, Cederbaum AI. Oxidative stress, toxicology, and pharmacology of CYP2E1. Annu Rev Pharmacol Toxicol. 2004;44():27–42. doi: 10.1146/annurev.pharmtox.44.101802.121704. PMID: 14744237.; Lieber CS. Microsomal Ethanol-Oxidizing System (MEOS): The First 30 Years (1968-1998)–A Review. Alcoholism Clin & Exp Res. 1999 Jun;23(6):991–1007. doi: 10.1111/j.1530-0277.1999.tb04217.x.
Metabolism

Accession ID: Reactome:R-BTA-1430728		 -
Phase I - Functionalization of compounds

Accession ID: Reactome:R-BTA-211945
  • 10.1208/aapsj080112
  • 10.1517/17425255.2.6.895
  • 10.2174/1389200023337054
 Strolin Benedetti M, Whomsley R, Baltes E. Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics. Expert Opinion on Drug Metabolism & Toxicology. 2006 Nov 24;2(6):895–921. doi: 10.1517/17425255.2.6.895.; Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Xenobiotics

Accession ID: Reactome:R-BTA-211981
  • 10.1208/aapsj080112
  • 10.1517/phgs.5.3.305.29827
  • 10.2174/1389200023337054
 Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Lewis DF. 57 varieties: the human cytochromes P450. Pharmacogenomics. 2004 Apr;5(3):305–18. doi: 10.1517/phgs.5.3.305.29827. PMID: 15102545.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Biological oxidations

Accession ID: Reactome:R-CEL-211859		 -
Xenobiotics

Accession ID: Reactome:R-CEL-211981
  • 10.1208/aapsj080112
  • 10.1517/phgs.5.3.305.29827
  • 10.2174/1389200023337054
 Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Lewis DF. 57 varieties: the human cytochromes P450. Pharmacogenomics. 2004 Apr;5(3):305–18. doi: 10.1517/phgs.5.3.305.29827. PMID: 15102545.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Metabolism

Accession ID: Reactome:R-CFA-1430728		 -
CYP2E1 reactions

Accession ID: Reactome:R-CFA-211999
  • 10.1016/j.mrfmmm.2004.04.021
  • 10.1097/00000374-199906000-00006
  • 10.1146/annurev.pharmtox.44.101802.121704
 Gonzalez FJ. Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 2005 Jan;569(1-2):101–10. doi: 10.1016/j.mrfmmm.2004.04.021.; Caro AA, Cederbaum AI. Oxidative stress, toxicology, and pharmacology of CYP2E1. Annu Rev Pharmacol Toxicol. 2004;44():27–42. doi: 10.1146/annurev.pharmtox.44.101802.121704. PMID: 14744237.; Lieber CS. Microsomal Ethanol-Oxidizing System (MEOS): The First 30 Years (1968-1998)–A Review. Alcoholism Clin & Exp Res. 1999 Jun;23(6):991–1007. doi: 10.1111/j.1530-0277.1999.tb04217.x.
Cytochrome P450 - arranged by substrate type

Accession ID: Reactome:R-DRE-211897
  • 10.1097/00008571-200401000-00001
  • 10.1208/aapsj080112
  • 10.1517/phgs.5.3.305.29827
  • 10.2174/1389200023337054
 Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Lewis DF. 57 varieties: the human cytochromes P450. Pharmacogenomics. 2004 Apr;5(3):305–18. doi: 10.1517/phgs.5.3.305.29827. PMID: 15102545.; Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. Pharmacogenetics. 2004 Jan;14(1):1–18. doi: 10.1097/00008571-200401000-00001. PMID: 15128046.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Biological oxidations

Accession ID: Reactome:R-DDI-211859		 -
Xenobiotics

Accession ID: Reactome:R-DDI-211981
  • 10.1208/aapsj080112
  • 10.1517/phgs.5.3.305.29827
  • 10.2174/1389200023337054
 Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Lewis DF. 57 varieties: the human cytochromes P450. Pharmacogenomics. 2004 Apr;5(3):305–18. doi: 10.1517/phgs.5.3.305.29827. PMID: 15102545.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
CYP2E1 reactions

Accession ID: Reactome:R-GGA-211999
  • 10.1016/j.mrfmmm.2004.04.021
  • 10.1097/00000374-199906000-00006
  • 10.1146/annurev.pharmtox.44.101802.121704
 Gonzalez FJ. Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 2005 Jan;569(1-2):101–10. doi: 10.1016/j.mrfmmm.2004.04.021.; Caro AA, Cederbaum AI. Oxidative stress, toxicology, and pharmacology of CYP2E1. Annu Rev Pharmacol Toxicol. 2004;44():27–42. doi: 10.1146/annurev.pharmtox.44.101802.121704. PMID: 14744237.; Lieber CS. Microsomal Ethanol-Oxidizing System (MEOS): The First 30 Years (1968-1998)–A Review. Alcoholism Clin & Exp Res. 1999 Jun;23(6):991–1007. doi: 10.1111/j.1530-0277.1999.tb04217.x.
Biological oxidations

Accession ID: Reactome:R-HSA-211859		 -
Metabolism

Accession ID: Reactome:R-MMU-1430728		 -
Biological oxidations

Accession ID: Reactome:R-MMU-211859		 -
Phase I - Functionalization of compounds

Accession ID: Reactome:R-RNO-211945
  • 10.1208/aapsj080112
  • 10.1517/17425255.2.6.895
  • 10.2174/1389200023337054
 Strolin Benedetti M, Whomsley R, Baltes E. Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics. Expert Opinion on Drug Metabolism & Toxicology. 2006 Nov 24;2(6):895–921. doi: 10.1517/17425255.2.6.895.; Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Xenobiotics

Accession ID: Reactome:R-RNO-211981
  • 10.1208/aapsj080112
  • 10.1517/phgs.5.3.305.29827
  • 10.2174/1389200023337054
 Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Lewis DF. 57 varieties: the human cytochromes P450. Pharmacogenomics. 2004 Apr;5(3):305–18. doi: 10.1517/phgs.5.3.305.29827. PMID: 15102545.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Phase I - Functionalization of compounds

Accession ID: Reactome:R-SSC-211945
  • 10.1208/aapsj080112
  • 10.1517/17425255.2.6.895
  • 10.2174/1389200023337054
 Strolin Benedetti M, Whomsley R, Baltes E. Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics. Expert Opinion on Drug Metabolism & Toxicology. 2006 Nov 24;2(6):895–921. doi: 10.1517/17425255.2.6.895.; Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.