Pathways Knowlegdes

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Pathway DOIs Note
phosphatidylcholine biosynthesis I

Accession ID: BioCyc:TRYPANO_PWY3O-450		 -
superpathway of phospholipid biosynthesis

Accession ID: BioCyc:LEISH_PWY3IU-205		 -
phosphatidylcholine biosynthesis II

Accession ID: BioCyc:TRYPANO_PWY4FS-2		 -
ester phospholipid biosynthesis

Accession ID: BioCyc:LEISH_PWY3IU-157
  • 10.1007/bf02534216
  • 10.1016/s0166-6851(02)00220-7
  • 10.1038/sj.emboj.7601565
  • 10.1111/j.1365-2958.2005.04579.x
 Zhang K, Pompey JM, Hsu FF, Key P, Bandhuvula P, Saba JD, Turk J, Beverley SM. Redirection of sphingolipid metabolism toward de novo synthesis of ethanolamine in Leishmania. EMBO J. 2007 Feb 21;26(4):1094–104. PMID: 17290222; PMCID: PMC1852826.; Zufferey R, Mamoun CB. The initial step of glycerolipid metabolism in Leishmania major promastigotes involves a single glycerol-3-phosphate acyltransferase enzyme important for the synthesis of triacylglycerol but not essential for virulence. Molecular Microbiology. 2005 Mar 15;56(3):800–10. doi: 10.1111/j.1365-2958.2005.04579.x.; Zufferey R, Mamoun CB. Choline transport in Leishmania major promastigotes and its inhibition by choline and phosphocholine analogs. Molecular and Biochemical Parasitology. 2002 Nov;125(1-2):127–34. doi: 10.1016/s0166-6851(02)00220-7.; Wassef MK, Fioretti TB, Dwyer DM. Lipid analyses of isolated surface membranes of Leishmania donovani promastigotes. Lipids. 1985 Feb;20(2):108–15. doi: 10.1007/bf02534216. PMID: 3982233.
choline biosynthesis III

Accession ID: BioCyc:TRYPANO_PWY-3561		 -
Metabolism and regulation

Accession ID: Plant Reactome:R-OAU-2744345		 -
Choline biosynthesis III

Accession ID: Plant Reactome:R-OAU-1119276
  • 10.1016/s0021-9258(17)31993-2
  • 10.1073/pnas.171228998
  • 10.1104/pp.103.4.1269
  • 10.1105/tpc.15.00207
 Lin YC, Liu YC, Nakamura Y. The Choline/Ethanolamine Kinase Family in Arabidopsis: Essential Role of CEK4 in Phospholipid Biosynthesis and Embryo Development. Plant Cell. 2015 May;27(5):1497–511. PMID: 25966764; PMCID: PMC4456650.; McNeil SD, Nuccio ML, Ziemak MJ, Hanson AD. Enhanced synthesis of choline and glycine betaine in transgenic tobacco plants that overexpress phosphoethanolamine N -methyltransferase. Proc. Natl. Acad. Sci. U.S.A. 2001 Jul 31;98(17):10001–5. doi: 10.1073/pnas.171228998.; Wang X, Xu L, Zheng L. Cloning and expression of phosphatidylcholine-hydrolyzing phospholipase D from Ricinus communis L. Journal of Biological Chemistry. 1994 Aug;269(32):20312–7. doi: 10.1016/s0021-9258(17)31993-2.; Summers PS, Weretilnyk EA. Choline Synthesis in Spinach in Relation to Salt Stress. Plant Physiol. 1993 Dec;103(4):1269–76. PMID: 12232019; PMCID: PMC159115.
Choline biosynthesis III

Accession ID: Plant Reactome:R-FVE-1119276
  • 10.1016/s0021-9258(17)31993-2
  • 10.1073/pnas.171228998
  • 10.1104/pp.103.4.1269
  • 10.1105/tpc.15.00207
 Lin YC, Liu YC, Nakamura Y. The Choline/Ethanolamine Kinase Family in Arabidopsis: Essential Role of CEK4 in Phospholipid Biosynthesis and Embryo Development. Plant Cell. 2015 May;27(5):1497–511. PMID: 25966764; PMCID: PMC4456650.; McNeil SD, Nuccio ML, Ziemak MJ, Hanson AD. Enhanced synthesis of choline and glycine betaine in transgenic tobacco plants that overexpress phosphoethanolamine N -methyltransferase. Proc. Natl. Acad. Sci. U.S.A. 2001 Jul 31;98(17):10001–5. doi: 10.1073/pnas.171228998.; Wang X, Xu L, Zheng L. Cloning and expression of phosphatidylcholine-hydrolyzing phospholipase D from Ricinus communis L. Journal of Biological Chemistry. 1994 Aug;269(32):20312–7. doi: 10.1016/s0021-9258(17)31993-2.; Summers PS, Weretilnyk EA. Choline Synthesis in Spinach in Relation to Salt Stress. Plant Physiol. 1993 Dec;103(4):1269–76. PMID: 12232019; PMCID: PMC159115.
Metabolism and regulation

Accession ID: Plant Reactome:R-MES-2744345		 -
Metabolism and regulation

Accession ID: Plant Reactome:R-TDI-2744345		 -
Fatty acid and lipid metabolism

Accession ID: Plant Reactome:R-TDI-3906998		 -
Metabolism and regulation

Accession ID: Plant Reactome:R-DRO-2744345		 -
Fatty acid and lipid metabolism

Accession ID: Plant Reactome:R-OGU-3906998		 -
Metabolism and regulation

Accession ID: Plant Reactome:R-PTI-2744345		 -
Metabolism and regulation

Accession ID: Plant Reactome:R-GMA-2744345		 -
Metabolism and regulation

Accession ID: Plant Reactome:R-PDA-2744345		 -
Metabolism and regulation

Accession ID: Plant Reactome:R-PVU-2744345		 -
Fatty acid and lipid metabolism

Accession ID: Plant Reactome:R-PVU-3906998		 -
Fatty acid and lipid metabolism

Accession ID: Plant Reactome:R-BNA-3906998		 -
Choline biosynthesis III

Accession ID: Plant Reactome:R-CCA-1119276
  • 10.1016/s0021-9258(17)31993-2
  • 10.1073/pnas.171228998
  • 10.1104/pp.103.4.1269
  • 10.1105/tpc.15.00207
 Lin YC, Liu YC, Nakamura Y. The Choline/Ethanolamine Kinase Family in Arabidopsis: Essential Role of CEK4 in Phospholipid Biosynthesis and Embryo Development. Plant Cell. 2015 May;27(5):1497–511. PMID: 25966764; PMCID: PMC4456650.; McNeil SD, Nuccio ML, Ziemak MJ, Hanson AD. Enhanced synthesis of choline and glycine betaine in transgenic tobacco plants that overexpress phosphoethanolamine N -methyltransferase. Proc. Natl. Acad. Sci. U.S.A. 2001 Jul 31;98(17):10001–5. doi: 10.1073/pnas.171228998.; Wang X, Xu L, Zheng L. Cloning and expression of phosphatidylcholine-hydrolyzing phospholipase D from Ricinus communis L. Journal of Biological Chemistry. 1994 Aug;269(32):20312–7. doi: 10.1016/s0021-9258(17)31993-2.; Summers PS, Weretilnyk EA. Choline Synthesis in Spinach in Relation to Salt Stress. Plant Physiol. 1993 Dec;103(4):1269–76. PMID: 12232019; PMCID: PMC159115.