Pathways Knowlegdes

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Pathway DOIs Note
superpathway of tryptophan utilization

Accession ID: BioCyc:HUMAN_PWY66-401		 -
superpathway of melatonin degradation

Accession ID: BioCyc:HUMAN_PWY-6402		 -
melatonin degradation I

Accession ID: BioCyc:HUMAN_PWY-6398
  • 10.1007/s00018-008-8001-x
  • 10.1016/j.tem.2007.10.007
  • 10.1111/j.1600-079x.2006.00407.x
  • 10.1111/j.1600-079x.2008.00630.x
  • 10.1124/dmd.104.002410
 Semak I, Korik E, Antonova M, Wortsman J, Slominski A. Metabolism of melatonin by cytochrome P450s in rat liver mitochondria and microsomes. Journal of Pineal Research. 2008 Oct 09;45(4):515–23. doi: 10.1111/j.1600-079x.2008.00630.x.; Hardeland R. Melatonin, hormone of darkness and more – occurrence, control mechanisms, actions and bioactive metabolites. Cellular and Molecular Life Sciences. 2008 Mar 17;65(13):2001–18. doi: 10.1007/s00018-008-8001-x.; Slominski A, Tobin DJ, Zmijewski MA, Wortsman J, Paus R. Melatonin in the skin: synthesis, metabolism and functions. Trends Endocrinol Metab. 2008 Jan;19(1):17–24. doi: 10.1016/j.tem.2007.10.007. PMID: 18155917.; Tan D, Manchester LC, Terron MP, Flores LJ, Reiter RJ. One molecule, many derivatives: A never-ending interaction of melatonin with reactive oxygen and nitrogen species? Journal of Pineal Research. 2006 Nov 29;42(1):28–42. doi: 10.1111/j.1600-079x.2006.00407.x.; Ma X, Idle JR, Krausz KW, Gonzalez FJ. Metabolism of melatonin by human cytochromes p450. Drug Metab Dispos. 2005 Apr;33(4):489–94. doi: 10.1124/dmd.104.002410. PMID: 15616152.
melatonin degradation I

Accession ID: BioCyc:META_PWY-6398
  • 10.1006/abio.2000.4709
  • 10.1007/s00018-008-8001-x
  • 10.1016/j.tem.2007.10.007
  • 10.1111/j.1600-079x.2006.00407.x
  • 10.1111/j.1600-079x.2008.00630.x
  • 10.1124/dmd.104.002410
 Semak I, Korik E, Antonova M, Wortsman J, Slominski A. Metabolism of melatonin by cytochrome P450s in rat liver mitochondria and microsomes. Journal of Pineal Research. 2008 Oct 09;45(4):515–23. doi: 10.1111/j.1600-079x.2008.00630.x.; Hardeland R. Melatonin, hormone of darkness and more – occurrence, control mechanisms, actions and bioactive metabolites. Cellular and Molecular Life Sciences. 2008 Mar 17;65(13):2001–18. doi: 10.1007/s00018-008-8001-x.; Slominski A, Tobin DJ, Zmijewski MA, Wortsman J, Paus R. Melatonin in the skin: synthesis, metabolism and functions. Trends Endocrinol Metab. 2008 Jan;19(1):17–24. doi: 10.1016/j.tem.2007.10.007. PMID: 18155917.; Tan D, Manchester LC, Terron MP, Flores LJ, Reiter RJ. One molecule, many derivatives: A never-ending interaction of melatonin with reactive oxygen and nitrogen species? Journal of Pineal Research. 2006 Nov 29;42(1):28–42. doi: 10.1111/j.1600-079x.2006.00407.x.; Ma X, Idle JR, Krausz KW, Gonzalez FJ. Metabolism of melatonin by human cytochromes p450. Drug Metab Dispos. 2005 Apr;33(4):489–94. doi: 10.1124/dmd.104.002410. PMID: 15616152.; Kobayashi K, Yamamoto T, Taguchi M, Chiba K. High-performance liquid chromatography determination of N- and O-demethylase activities of chemicals in human liver microsomes: application of postcolumn fluorescence derivatization using Nash reagent. Anal Biochem. 2000 Sep 10;284(2):342–7. doi: 10.1006/abio.2000.4709. PMID: 10964418.
superpathway of melatonin degradation

Accession ID: BioCyc:META_PWY-6402
  • 10.1006/abio.2000.4709
  • 10.1007/s00018-008-8001-x
  • 10.1016/j.tem.2007.10.007
  • 10.1111/j.1600-079x.2006.00407.x
  • 10.1111/j.1600-079x.2009.00701.x
 Hardeland R, Tan D, Reiter RJ. Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines. Journal of Pineal Research. 2009 Aug 02;47(2):109–26. doi: 10.1111/j.1600-079x.2009.00701.x.; Hardeland R. Melatonin, hormone of darkness and more – occurrence, control mechanisms, actions and bioactive metabolites. Cellular and Molecular Life Sciences. 2008 Mar 17;65(13):2001–18. doi: 10.1007/s00018-008-8001-x.; Slominski A, Tobin DJ, Zmijewski MA, Wortsman J, Paus R. Melatonin in the skin: synthesis, metabolism and functions. Trends Endocrinol Metab. 2008 Jan;19(1):17–24. doi: 10.1016/j.tem.2007.10.007. PMID: 18155917.; Tan D, Manchester LC, Terron MP, Flores LJ, Reiter RJ. One molecule, many derivatives: A never-ending interaction of melatonin with reactive oxygen and nitrogen species? Journal of Pineal Research. 2006 Nov 29;42(1):28–42. doi: 10.1111/j.1600-079x.2006.00407.x.; Kobayashi K, Yamamoto T, Taguchi M, Chiba K. High-performance liquid chromatography determination of N- and O-demethylase activities of chemicals in human liver microsomes: application of postcolumn fluorescence derivatization using Nash reagent. Anal Biochem. 2000 Sep 10;284(2):342–7. doi: 10.1006/abio.2000.4709. PMID: 10964418.
Melatonin metabolism and effects

Accession ID: WikiPathways:WP3298
  • 10.1007/s10803-014-2197-4
 Veatch OJ, Pendergast JS, Allen MJ, Leu RM, Johnson CH, Elsea SH, Malow BA. Genetic Variation in Melatonin Pathway Enzymes in Children with Autism Spectrum Disorder and Comorbid Sleep Onset Delay. Journal of Autism and Developmental Disorders. 2014 Jul 25;45(1):100–10. doi: 10.1007/s10803-014-2197-4.
Tryptophan metabolism

Accession ID: WikiPathways:WP79		 -
Tryptophan Metabolism

Accession ID: PathBank:SMP0087330		 -
Tryptophan Metabolism

Accession ID: PathBank:SMP0087237		 -
Tryptophan Metabolism

Accession ID: PathBank:SMP0063693		 -
Tryptophan Metabolism

Accession ID: PathBank:SMP0000063		 -
Tryptophan Metabolism

Accession ID: PathBank:SMP0087451		 -