Pathways Knowlegdes

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Pathway DOIs Note
superpathway of inositol phosphate compounds

Accession ID: BioCyc:HUMAN_PWY-6371		 -
superpathway of 1D-myo-inositol hexakisphosphate biosynthesis (plants)

Accession ID: BioCyc:META_PWY-6555
  • 10.1016/s0031-9422(03)00446-1
 Raboy V. myo-Inositol-1,2,3,4,5,6-hexakisphosphate. Phytochemistry. 2003 Nov;64(6):1033–43. doi: 10.1016/s0031-9422(03)00446-1. PMID: 14568069.
D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis

Accession ID: BioCyc:META_PWY-6365		 -
1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)

Accession ID: BioCyc:YEAST_PWY-6361		 -
1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)

Accession ID: BioCyc:ARA_PWY-4661
  • 10.1016/s0031-9422(03)00446-1
  • 10.1038/346580a0
  • 10.1042/bj3140215
  • 10.1042/bj3140227
  • 10.1073/pnas.0504172102
 Stevenson-Paulik J, Bastidas RJ, Chiou S, Frye RA, York JD. Generation of phytate-free seeds in Arabidopsis through disruption of inositol polyphosphate kinases. Proc. Natl. Acad. Sci. U.S.A. 2005 Aug 17;102(35):12612–7. doi: 10.1073/pnas.0504172102.; Raboy V. myo-Inositol-1,2,3,4,5,6-hexakisphosphate. Phytochemistry. 2003 Nov;64(6):1033–43. doi: 10.1016/s0031-9422(03)00446-1. PMID: 14568069.; Brearley CA, Hanke DE. Inositol phosphates in the duckweed Spirodela polyrhiza L. Biochem J. 1996 Feb 15;314 ( Pt 1)():215–25. PMID: 8660286; PMCID: PMC1217028.; Brearley CA, Hanke DE. Metabolic evidence for the order of addition of individual phosphate esters in the myo-inositol moiety of inositol hexakisphosphate in the duckweed Spirodela polyrhiza L. Biochem J. 1996 Feb 15;314 ( Pt 1)():227–33. PMID: 8660287; PMCID: PMC1217029.; Stephens LR, Irvine RF. Stepwise phosphorylation of myo-inositol leading to myo-inositol hexakisphosphate in Dictyostelium. Nature. 1990 Aug 09;346(6284):580–3. doi: 10.1038/346580a0. PMID: 2198472.
Metabolism and regulation

Accession ID: Plant Reactome:R-OAU-2744345		 -
Secondary metabolism

Accession ID: Plant Reactome:R-TAE-2744344		 -
Metabolism and regulation

Accession ID: Plant Reactome:R-MES-2744345		 -
Lipid-independent phytate biosynthesis

Accession ID: Plant Reactome:R-MES-1119434
  • 10.1007/s00122-008-0818-z
  • 10.1007/s00122-008-0863-7
  • 10.1007/s10529-008-9730-5
  • 10.1007/s11103-011-9830-9
  • 10.1016/j.gene.2007.09.006
  • 10.1111/j.1467-7652.2008.00375.x
  • 10.1186/s12284-018-0200-y
 Perera I, Seneweera S, Hirotsu N. Manipulating the Phytic Acid Content of Rice Grain Toward Improving Micronutrient Bioavailability. Rice (N Y). 2018 Jan 11;11(1):4. PMID: 29327163; PMCID: PMC5764899.; Du H, Liu L, You L, Yang M, He Y, Li X, Xiong L. Characterization of an inositol 1,3,4-trisphosphate 5/6-kinase gene that is essential for drought and salt stress responses in rice. Plant Mol Biol. 2011 Dec;77(6):547–63. doi: 10.1007/s11103-011-9830-9. PMID: 22038091.; Kuwano M, Mimura T, Takaiwa F, Yoshida KT. Generation of stable ‘low phytic acid’ transgenic rice through antisense repression of the 1d-myo-inositol 3-phosphate synthase gene (RINO1) using the 18-kDa oleosin promoter. Plant Biotechnology Journal. 2008 Dec 12;7(1):96–105. doi: 10.1111/j.1467-7652.2008.00375.x.; Kim SI, Andaya CB, Newman JW, Goyal SS, Tai TH. Isolation and characterization of a low phytic acid rice mutant reveals a mutation in the rice orthologue of maize MIK. Theor Appl Genet. 2008 Nov;117(8):1291–301. doi: 10.1007/s00122-008-0863-7. PMID: 18726583.; Kim SI, Andaya CB, Goyal SS, Tai TH. The rice OsLpa1 gene encodes a novel protein involved in phytic acid metabolism. Theoretical and Applied Genetics. 2008 Jun 20;117(5):769–79. doi: 10.1007/s00122-008-0818-z.; Niu X, Chen Q, Wang X. OsITL1 gene encoding an inositol 1,3,4-trisphosphate 5/6-kinase is a negative regulator of osmotic stress signaling. Biotechnol Lett. 2008 Sep;30(9):1687–92. doi: 10.1007/s10529-008-9730-5. PMID: 18421420.; Suzuki M, Tanaka K, Kuwano M, Yoshida KT. Expression pattern of inositol phosphate-related enzymes in rice (Oryza sativa L.): implications for the phytic acid biosynthetic pathway. Gene. 2007 Dec 15;405(1-2):55–64. doi: 10.1016/j.gene.2007.09.006. PMID: 17961936.
Metabolism and regulation

Accession ID: Plant Reactome:R-TDI-2744345		 -
Metabolism and regulation

Accession ID: Plant Reactome:R-DRO-2744345		 -
Lipid-independent phytate biosynthesis

Accession ID: Plant Reactome:R-OMI-1119434
  • 10.1007/s00122-008-0818-z
  • 10.1007/s00122-008-0863-7
  • 10.1007/s10529-008-9730-5
  • 10.1007/s11103-011-9830-9
  • 10.1016/j.gene.2007.09.006
  • 10.1111/j.1467-7652.2008.00375.x
  • 10.1186/s12284-018-0200-y
 Perera I, Seneweera S, Hirotsu N. Manipulating the Phytic Acid Content of Rice Grain Toward Improving Micronutrient Bioavailability. Rice (N Y). 2018 Jan 11;11(1):4. PMID: 29327163; PMCID: PMC5764899.; Du H, Liu L, You L, Yang M, He Y, Li X, Xiong L. Characterization of an inositol 1,3,4-trisphosphate 5/6-kinase gene that is essential for drought and salt stress responses in rice. Plant Mol Biol. 2011 Dec;77(6):547–63. doi: 10.1007/s11103-011-9830-9. PMID: 22038091.; Kuwano M, Mimura T, Takaiwa F, Yoshida KT. Generation of stable ‘low phytic acid’ transgenic rice through antisense repression of the 1d-myo-inositol 3-phosphate synthase gene (RINO1) using the 18-kDa oleosin promoter. Plant Biotechnology Journal. 2008 Dec 12;7(1):96–105. doi: 10.1111/j.1467-7652.2008.00375.x.; Kim SI, Andaya CB, Newman JW, Goyal SS, Tai TH. Isolation and characterization of a low phytic acid rice mutant reveals a mutation in the rice orthologue of maize MIK. Theor Appl Genet. 2008 Nov;117(8):1291–301. doi: 10.1007/s00122-008-0863-7. PMID: 18726583.; Kim SI, Andaya CB, Goyal SS, Tai TH. The rice OsLpa1 gene encodes a novel protein involved in phytic acid metabolism. Theoretical and Applied Genetics. 2008 Jun 20;117(5):769–79. doi: 10.1007/s00122-008-0818-z.; Niu X, Chen Q, Wang X. OsITL1 gene encoding an inositol 1,3,4-trisphosphate 5/6-kinase is a negative regulator of osmotic stress signaling. Biotechnol Lett. 2008 Sep;30(9):1687–92. doi: 10.1007/s10529-008-9730-5. PMID: 18421420.; Suzuki M, Tanaka K, Kuwano M, Yoshida KT. Expression pattern of inositol phosphate-related enzymes in rice (Oryza sativa L.): implications for the phytic acid biosynthetic pathway. Gene. 2007 Dec 15;405(1-2):55–64. doi: 10.1016/j.gene.2007.09.006. PMID: 17961936.
Metabolism and regulation

Accession ID: Plant Reactome:R-PTI-2744345		 -
Metabolism and regulation

Accession ID: Plant Reactome:R-GMA-2744345		 -
Secondary metabolism

Accession ID: Plant Reactome:R-GMA-2744344		 -
Metabolism and regulation

Accession ID: Plant Reactome:R-PDA-2744345		 -
Metabolism and regulation

Accession ID: Plant Reactome:R-PVU-2744345		 -
Lipid-independent phytate biosynthesis

Accession ID: Plant Reactome:R-DCA-1119434
  • 10.1007/s00122-008-0818-z
  • 10.1007/s00122-008-0863-7
  • 10.1007/s10529-008-9730-5
  • 10.1007/s11103-011-9830-9
  • 10.1016/j.gene.2007.09.006
  • 10.1111/j.1467-7652.2008.00375.x
  • 10.1186/s12284-018-0200-y
 Perera I, Seneweera S, Hirotsu N. Manipulating the Phytic Acid Content of Rice Grain Toward Improving Micronutrient Bioavailability. Rice (N Y). 2018 Jan 11;11(1):4. PMID: 29327163; PMCID: PMC5764899.; Du H, Liu L, You L, Yang M, He Y, Li X, Xiong L. Characterization of an inositol 1,3,4-trisphosphate 5/6-kinase gene that is essential for drought and salt stress responses in rice. Plant Mol Biol. 2011 Dec;77(6):547–63. doi: 10.1007/s11103-011-9830-9. PMID: 22038091.; Kuwano M, Mimura T, Takaiwa F, Yoshida KT. Generation of stable ‘low phytic acid’ transgenic rice through antisense repression of the 1d-myo-inositol 3-phosphate synthase gene (RINO1) using the 18-kDa oleosin promoter. Plant Biotechnology Journal. 2008 Dec 12;7(1):96–105. doi: 10.1111/j.1467-7652.2008.00375.x.; Kim SI, Andaya CB, Newman JW, Goyal SS, Tai TH. Isolation and characterization of a low phytic acid rice mutant reveals a mutation in the rice orthologue of maize MIK. Theor Appl Genet. 2008 Nov;117(8):1291–301. doi: 10.1007/s00122-008-0863-7. PMID: 18726583.; Kim SI, Andaya CB, Goyal SS, Tai TH. The rice OsLpa1 gene encodes a novel protein involved in phytic acid metabolism. Theoretical and Applied Genetics. 2008 Jun 20;117(5):769–79. doi: 10.1007/s00122-008-0818-z.; Niu X, Chen Q, Wang X. OsITL1 gene encoding an inositol 1,3,4-trisphosphate 5/6-kinase is a negative regulator of osmotic stress signaling. Biotechnol Lett. 2008 Sep;30(9):1687–92. doi: 10.1007/s10529-008-9730-5. PMID: 18421420.; Suzuki M, Tanaka K, Kuwano M, Yoshida KT. Expression pattern of inositol phosphate-related enzymes in rice (Oryza sativa L.): implications for the phytic acid biosynthetic pathway. Gene. 2007 Dec 15;405(1-2):55–64. doi: 10.1016/j.gene.2007.09.006. PMID: 17961936.
Lipid-independent phytate biosynthesis

Accession ID: Plant Reactome:R-CCA-1119434
  • 10.1007/s00122-008-0818-z
  • 10.1007/s00122-008-0863-7
  • 10.1007/s10529-008-9730-5
  • 10.1007/s11103-011-9830-9
  • 10.1016/j.gene.2007.09.006
  • 10.1111/j.1467-7652.2008.00375.x
  • 10.1186/s12284-018-0200-y
 Perera I, Seneweera S, Hirotsu N. Manipulating the Phytic Acid Content of Rice Grain Toward Improving Micronutrient Bioavailability. Rice (N Y). 2018 Jan 11;11(1):4. PMID: 29327163; PMCID: PMC5764899.; Du H, Liu L, You L, Yang M, He Y, Li X, Xiong L. Characterization of an inositol 1,3,4-trisphosphate 5/6-kinase gene that is essential for drought and salt stress responses in rice. Plant Mol Biol. 2011 Dec;77(6):547–63. doi: 10.1007/s11103-011-9830-9. PMID: 22038091.; Kuwano M, Mimura T, Takaiwa F, Yoshida KT. Generation of stable ‘low phytic acid’ transgenic rice through antisense repression of the 1d-myo-inositol 3-phosphate synthase gene (RINO1) using the 18-kDa oleosin promoter. Plant Biotechnology Journal. 2008 Dec 12;7(1):96–105. doi: 10.1111/j.1467-7652.2008.00375.x.; Kim SI, Andaya CB, Newman JW, Goyal SS, Tai TH. Isolation and characterization of a low phytic acid rice mutant reveals a mutation in the rice orthologue of maize MIK. Theor Appl Genet. 2008 Nov;117(8):1291–301. doi: 10.1007/s00122-008-0863-7. PMID: 18726583.; Kim SI, Andaya CB, Goyal SS, Tai TH. The rice OsLpa1 gene encodes a novel protein involved in phytic acid metabolism. Theoretical and Applied Genetics. 2008 Jun 20;117(5):769–79. doi: 10.1007/s00122-008-0818-z.; Niu X, Chen Q, Wang X. OsITL1 gene encoding an inositol 1,3,4-trisphosphate 5/6-kinase is a negative regulator of osmotic stress signaling. Biotechnol Lett. 2008 Sep;30(9):1687–92. doi: 10.1007/s10529-008-9730-5. PMID: 18421420.; Suzuki M, Tanaka K, Kuwano M, Yoshida KT. Expression pattern of inositol phosphate-related enzymes in rice (Oryza sativa L.): implications for the phytic acid biosynthetic pathway. Gene. 2007 Dec 15;405(1-2):55–64. doi: 10.1016/j.gene.2007.09.006. PMID: 17961936.
Metabolism and regulation

Accession ID: Plant Reactome:R-CSI-2744345		 -