methylerythritol phosphate pathway I
Feurle J, Espinosa E, Eckstein S, Pont F, Kunzmann V, Fournié JJ, Herderich M, Wilhelm M. Escherichia coli produces phosphoantigens activating human gamma delta T cells. J Biol Chem. 2002 Jan 04;277(1):148–54. doi: 10.1074/jbc.m106443200. PMID: 11675382.; Hecht S, Eisenreich W, Adam P, Amslinger S, Kis K, Bacher A, Arigoni D, Rohdich F. Studies on the nonmevalonate pathway to terpenes: The role of the GcpE (IspG) protein. Proc. Natl. Acad. Sci. U.S.A. 2001 Dec 18;98(26):14837–42. doi: 10.1073/pnas.201399298.; Kim SW, Keasling JD. Metabolic engineering of the nonmevalonate isopentenyl diphosphate synthesis pathway in Escherichia coli enhances lycopene production. Biotechnol Bioeng. 2001 Feb 20;72(4):408–15. doi: 10.1002/1097-0290(20000220)72:4<408::aid-bit1003>3.0.co;2-h. PMID: 11180061.; Charon L, Hoeffler JF, Pale-Grosdemange C, Lois LM, Campos N, Boronat A, Rohmer M. Deuterium-labelled isotopomers of 2-C-methyl-D-erythritol as tools for the elucidation of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis. Biochem J. 2000 Mar 15;346 Pt 3():737–42. PMID: 10698701; PMCID: PMC1220907.; Lüttgen H, Rohdich F, Herz S, Wungsintaweekul J, Hecht S, Schuhr CA, Fellermeier M, Sagner S, Zenk MH, Bacher A, Eisenreich W. Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-
Metabolites
(3-Amino-1-hydroxy-1-phosphono-propyl)phosphonic acid
Formula: C3H10NO7P2- (233.99325100000001)
CAS ID:
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.1.1.267 | 1-deoxy-D-xylulose-5-phosphate reductoisomerase | 2-C-methyl-D-erythritol-4-phosphate:NADP+ oxidoreductase (isomerizing) | |
| 1.17.7.3 | (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin) | (E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:oxidized flavodoxin oxidoreductase | |
| 1.17.7.4 | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase | isopentenyl-diphosphate:ferredoxin oxidoreductase | |
| 2.2.1.7 | 1-deoxy-D-xylulose-5-phosphate synthase | pyruvate:D-glyceraldehyde-3-phosphate acetaldehydetransferase (decarboxylating) | |
| 2.7.1.148 | 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase | ATP:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 2-phosphotransferase | |
| 2.7.7.60 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase | CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase | |
| 4.6.1.12 | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate-forming) | |
| 5.3.3.2 | isopentenyl-diphosphate DELTA-isomerase | 3-methylbut-3-en-1-yl-diphosphate DELTA3-DELTA2-isomerase |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P45568 | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase |
| P62615 | ispE | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase |
| P62617 | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase |
| P62620 | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) |
| P62623 | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
| P77488 | dxs | 1-deoxy-D-xylulose-5-phosphate synthase |
| Q46822 | idi | Isopentenyl-diphosphate Delta-isomerase |
| Q46893 | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase |