superpathway of N-acetylglucosamine, N-acetylmannosamine and N-acetylneuraminate degradation
Walters DM, Stirewalt VL, Melville SB. Cloning, Sequence, and Transcriptional Regulation of the Operon Encoding a Putative N -Acetylmannosamine-6-Phosphate Epimerase ( nanE ) and Sialic Acid Lyase ( nanA ) in Clostridium perfringens. J Bacteriol. 1999 Aug;181(15):4526–32. doi: 10.1128/jb.181.15.4526-4532.1999.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 2.7.1.60 | N-acylmannosamine kinase | ATP:N-acyl-D-mannosamine 6-phosphotransferase | |
| 3.5.1.25 | N-acetylglucosamine-6-phosphate deacetylase | N-acetyl-D-glucosamine-6-phosphate amidohydrolase | |
| 3.5.99.6 | glucosamine-6-phosphate deaminase | 2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing) | |
| 4.1.3.3 | N-acetylneuraminate lyase | aceneuramate pyruvate-lyase (N-acetyl-D-mannosamine-forming) | |
| 5.1.3.9 | N-acylglucosamine-6-phosphate 2-epimerase | N-acyl-D-glucosamine-6-phosphate 2-epimerase |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P0A6L4 | nanA | N-acetylneuraminate lyase |
| P0A759 | nagB | Glucosamine-6-phosphate deaminase |
| P0A761 | nanE | Putative N-acetylmannosamine-6-phosphate 2-epimerase |
| P0AF18 | nagA | N-acetylglucosamine-6-phosphate deacetylase |
| P45425 | nanK | N-acetylmannosamine kinase |
| Q8XNZ3 | nanE | Putative N-acetylmannosamine-6-phosphate 2-epimerase |
| Q9S4K9 | nanA | N-acetylneuraminate lyase |