superpathway of L-methionine biosynthesis (by sulfhydrylation)

Vermeij P, Kertesz MA. Pathways of Assimilative Sulfur Metabolism in Pseudomonas putida. J Bacteriol. 1999 Sep 15;181(18):5833–7. doi: 10.1128/jb.181.18.5833-5837.1999.

Metabolites

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydrogen sulfide

Formula: H2S (33.9877212)

CAS ID: 7783-06-4

Hydroxylamine

Formula: NH3O (33.0214628)

CAS ID: 7803-49-8

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Phenylhydrazine

Formula: C6H8N2 (108.06874479999999)

CAS ID: 100-63-0

Potassium cation

Formula: K (38.963708)

CAS ID: 24203-36-9

Semicarbazide

Formula: CH5N3O (75.04326)

CAS ID: 57-56-7

Sulfate

Formula: H2SO4 (97.9673812)

CAS ID: 7664-93-9

oxaloacetate(2-)

Formula: C4H2O5 (129.9902242)

CAS ID: 149-63-3

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

acetate

Formula: C2H3O2 (59.0133038)

CAS ID: 71-50-1

sulfite

Formula: O3S (79.956817)

CAS ID: 14265-45-3

siroheme(8-)

Formula: C42H36FeN4O16 (908.1475605999999)

CAS ID: 52553-42-1

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8

L-lysinium(1+)

Formula: C6H15N2O2 (147.113347)

CAS ID: 56-87-1



Enzyme

EC Number name full name note
2.5.1.-
1.2.1.11 aspartate-semialdehyde dehydrogenase L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating)
1.8.1.2 assimilatory sulfite reductase (NADPH) hydrogen-sulfide:NADP+ oxidoreductase
1.8.4.8 phosphoadenylyl-sulfate reductase (thioredoxin) adenosine 3',5'-bisphosphate,sulfite:thioredoxin-disulfide oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)
2.1.1.14 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase 5-methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase
2.3.1.31 homoserine O-acetyltransferase acetyl-CoA:L-homoserine O-acetyltransferase
2.5.1.47 cysteine synthase O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase
2.5.1.49 O-acetylhomoserine aminocarboxypropyltransferase O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase
2.6.1.1 aspartate transaminase L-aspartate:2-oxoglutarate aminotransferase
2.7.1.25 adenylyl-sulfate kinase ATP:adenylyl-sulfate 3'-phosphotransferase
2.7.2.4 aspartate kinase ATP:L-aspartate 4-phosphotransferase
2.7.7.4 sulfate adenylyltransferase ATP:sulfate adenylyltransferase


Proteins

Protein ID name full name
O68640 metX Homoserine O-Acetyltransferase
P05694 MET6 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
P06106 MET17 Homocysteine/cysteine synthase
P08465 MET2 Homoserine O-acetyltransferase
P08495 lysC Aspartokinase 2
P08536 MET3 Sulfate adenylyltransferase
P18408 MET16 Phosphoadenosine phosphosulfate reductase
P23542 AAT2 Aspartate aminotransferase, cytoplasmic
P26512 lysC ASPARTOKINASE LYSC ALPHA and beta SUBUNITs
P39692 MET10 Sulfite reductase [NADPH] flavoprotein component
P80877 metE 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
P94417 yclM Aspartokinase 3
P94890 metY O-acetyl-L-homoserine sulfhydrylase
P94891 metXA Homoserine O-acetyltransferase
Q02196 MET14 Adenylyl-sulfate kinase
Q04797 asd Aspartate-semialdehyde dehydrogenase
Q79VI4 metY O-acetyl-L-homoserine sulfhydrylase
Q8NRB3 metE Homocysteine methyltransferase