succinate fermentation to butanoate

Söhling B, Gottschalk G. Molecular analysis of the anaerobic succinate degradation pathway in Clostridium kluyveri. J Bacteriol. 1996 Feb;178(3):871–80. doi: 10.1128/jb.178.3.871-880.1996.; Thorpe C, Kim JP. Structure and mechanism of action of the Acyl-CoA dehydrogenases 1. The FASEB Journal. 1995 Jun;9(9):718–25. doi: 10.1096/fasebj.9.9.7601336.; Hauge JG, Crane FL, Beinert H. ON THE MECHANISM OF DEHYDROGENATION OF FATTY ACYL DERIVATIVES OF COENZYME A. Journal of Biological Chemistry. 1956 Apr;219(2):727–33. doi: 10.1016/s0021-9258(18)65732-1.; Green DE, Mii S, Mahler HR, Bock RM. STUDIES ON THE FATTY ACID OXIDIZING SYSTEM OF ANIMAL TISSUES. Journal of Biological Chemistry. 1954 Jan;206(1):1–12. doi: 10.1016/s0021-9258(18)71290-8.; MAHLER HR. Studies on the fatty acid oxidizing system of animal tissues. IV. The prosthetic group of butyryl coenzyme A dehydrogenase. J Biol Chem. 1954 Jan;206(1):13–26. PMID: 13130522.

Metabolites

Copper

Formula: Cu (62.929599)

CAS ID: 7440-50-8

Fe3+

Formula: Fe (55.934939)

CAS ID: 7439-89-6

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

succinate(2-)

Formula: C4H4O4 (116.01095839999999)

CAS ID: 56-14-4

acetate

Formula: C2H3O2 (59.0133038)

CAS ID: 71-50-1

4-oxobutanoate

Formula: C4H5O3 (101.02386800000001)

CAS ID:

4-hydroxybutyrate

Formula: C4H7O3 (103.0395172)

CAS ID: 1320-61-2

butyrate

Formula: C4H7O2 (87.0446022)

CAS ID: 461-55-2

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
2.8.3.-
1.1.1.61 4-hydroxybutyrate dehydrogenase 4-hydroxybutanoate:NAD+ oxidoreductase
1.2.1.76 succinate-semialdehyde dehydrogenase (acylating) succinate semialdehyde:NADP+ oxidoreductase (CoA-acylating)
2.8.3.18 succinyl-CoA:acetate CoA-transferase succinyl-CoA:acetate CoA-transferase


Proteins

Protein ID name full name
P38942 cat2 Cat2
P38945 4hbD 4hbD
P38946 cat1 Cat1
P38947 sucD SucD