Arbutin (BioCAD00000006743)

plant natural products microbial natural products

Metabolite Card

Formula: C12H16O7 (272.0896)
SMILES: OC[C@H]1O[C@@H](OC2=CC=C(O)C=C2)[C@H](O)[C@@H](O)[C@@H]1O

Synonyms [en]

arbutin; Uvasol; Ursin; Hydroquinone-O-beta-D-glucopyranoside; p-Hydroxyphenyl beta-D-glucoside; 4-Hydroxyphenyl beta-D-glucopyranoside

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

Arbutin. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000006743). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

Arbutin is found in apple. Glucoside in pear leaves (Pyrus communis

Cytoplasm Extracellular
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 2400-71-7
  • CAS Registry Number: 497-76-7
  • PubChem: 346
  • PubChem: 440936
  • ChEBI: ChEBI:18305
  • HMDB: HMDB0029943
  • KEGG: C06186
  • BioCyc: HYDROQUINONE-O-BETA-D-GLUCOPYRANOSIDE
  • NCBI MeSH: Arbutin
  • Wikipedia: Arbutin
  • DrugBank: DB11217
  • RefMet: RM0157154
  • MoNA: Bruker_HCD_library000953
  • MoNA: Bruker_HCD_library000954
  • MoNA: CCMSLIB00000424768
  • MoNA: FiehnHILIC001074
  • MoNA: FiehnHILIC002599
  • MoNA: FiehnLib000080
  • MoNA: LU133505
  • MoNA: LU133506
  • MoNA: LU133551
  • MoNA: LU133552
  • MoNA: LU133553
  • MoNA: LU133554
  • MoNA: LU133555
  • MoNA: LU133556
  • MoNA: MoNA_0007223
  • MoNA: MoNA_0007224
  • MoNA: MoNA_0007225
  • MoNA: MoNA_0007348
  • MoNA: MoNA_0007349
  • MoNA: MoNA_0008947
  • MoNA: MoNA_0008948
  • MoNA: MoNA_0009125
  • MoNA: MoNA_0009126
  • MoNA: MoNA_0009127
  • MoNA: MoNA_0009128
  • MoNA: MoNA_0009360
  • MoNA: MoNA_0009362
  • MoNA: MoNA_0009363
  • MoNA: MoNA_0009364
  • MoNA: MoNA_0009365
  • MoNA: MoNA_0009638
  • MoNA: MoNA_0009639
  • MoNA: MoNA_0009640
  • MoNA: MoNA_0009641
  • MoNA: MoNA_0009642
  • MoNA: MoNA_0009643
  • MoNA: MoNA_0009644
  • MoNA: PR308726
  • MoNA: PR308727
  • MoNA: RIKENPlaSMA007303
  • MoNA: RIKENPlaSMA007304
  • MoNA: RIKENPlaSMA007305
  • MoNA: RIKENPlaSMA007306
  • MoNA: RIKENPlaSMA007307
  • MoNA: RIKENPlaSMA007308
  • MoNA: RIKENPlaSMA007309
  • MoNA: RIKENPlaSMA007310
  • MoNA: RIKENPlaSMA007311
  • MoNA: RIKENPlaSMA007312
  • MoNA: RIKENPlaSMA007313
  • MoNA: RIKENPlaSMA007314
  • MoNA: RIKENPlaSMA007315
  • MoNA: RIKENPlaSMA007316
  • MoNA: RIKENPlaSMA007317
  • MoNA: RIKENPlaSMA007318
  • MoNA: RIKENPlaSMA007319
  • MoNA: RIKENPlaSMA007320
  • MoNA: RIKENPlaSMA007321
  • MoNA: RIKENPlaSMA007322
  • MoNA: RIKENPlaSMA007323
  • MoNA: RIKENPlaSMA007324
  • MoNA: RIKENPlaSMA007325
  • MoNA: RIKENPlaSMA007326
  • MoNA: VF-NPL-LTQ006612
  • MoNA: VF-NPL-QEHF004642
  • MoNA: VF-NPL-QEHF004643
  • MoNA: VF-NPL-QEHF004644
  • MoNA: VF-NPL-QEHF004645
  • MoNA: VF-NPL-QEHF004646
  • MoNA: VF-NPL-QEHF004647
  • MoNA: VF-NPL-QEHF004648
  • MoNA: VF-NPL-QEHF004649
  • MoNA: VF-NPL-QEHF004650
  • MoNA: VF-NPL-QEHF004651
  • MoNA: VF-NPL-QEHF004652
  • MoNA: VF-NPL-QEHF004653
  • MoNA: VF-NPL-QEHF004654
  • MoNA: VF-NPL-QEHF004655
  • MoNA: VF-NPL-QEHF004656
  • Metlin: METLIN_43989
  • Coconut NaturalProduct: CNP0054838.1
  • Coconut NaturalProduct: CNP0054838.2
  • Coconut NaturalProduct: CNP0054838.3
  • Coconut NaturalProduct: CNP0054838.4
  • Coconut NaturalProduct: CNP0060571.0
  • Coconut NaturalProduct: CNP0206604.1
  • Coconut NaturalProduct: CNP0370542.1
  • Coconut NaturalProduct: CNP0370542.5
  • Coconut NaturalProduct: CNP0520336.1
  • Coconut NaturalProduct: CNP0520336.2
  • Coconut NaturalProduct: CNP0520336.3
  • Coconut NaturalProduct: CNP0520336.4

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R05132 2.7.1.- protein-N(pi)-phosphohistidine:arbutin 6-phosphotransferase
KEGG:R05769 2.4.1.218 UDP-glucose:hydroquinone-O-b-D-glucosyltransferase
BioCyc:TRANS-RXN-153 2.7.1.- PTSH-PHOSPHORYLATED + HYDROQUINONE-O-BETA-D-GLUCOPYRANOSIDE + Hpr-pi-phospho-L-histidines<=>CPD-1162 + Hpr-Histidine
Rhea:RHEA:12561 2.4.1.218 hydroquinone + UDP-α-D-glucose => hydroquinone O-β-D-glucopyranoside + UDP + H+
Rhea:RHEA:12562 2.4.1.218 hydroquinone O-β-D-glucopyranoside + UDP + H+ => hydroquinone + UDP-α-D-glucose
Rhea:RHEA:12563 2.4.1.218 hydroquinone + UDP-α-D-glucose <=> hydroquinone O-β-D-glucopyranoside + UDP + H+
Rhea:RHEA:34944 hydroquinone O-β-D-glucopyranoside(out) + phosphoenolpyruvate(in) => arbutin 6-phosphate(in) + pyruvate(in)
Rhea:RHEA:34945 arbutin 6-phosphate(in) + pyruvate(in) => hydroquinone O-β-D-glucopyranoside(out) + phosphoenolpyruvate(in)
Rhea:RHEA:34946 hydroquinone O-β-D-glucopyranoside(out) + phosphoenolpyruvate(in) <=> arbutin 6-phosphate(in) + pyruvate(in)
Rhea:RHEA:35024 hydroquinone O-β-D-glucopyranoside(out) => hydroquinone O-β-D-glucopyranoside(in)
Rhea:RHEA:35025 hydroquinone O-β-D-glucopyranoside(in) => hydroquinone O-β-D-glucopyranoside(out)
Rhea:RHEA:35026 hydroquinone O-β-D-glucopyranoside(out) <=> hydroquinone O-β-D-glucopyranoside(in)
BioCyc:RXN-18846 3.2.1.21 HYDROQUINONE-O-BETA-D-GLUCOPYRANOSIDE + WATER --> Glucopyranose + HYDROQUINONE
BioCyc:TRANS-RXN-247 HYDROQUINONE-O-BETA-D-GLUCOPYRANOSIDE + PROTON --> HYDROQUINONE-O-BETA-D-GLUCOPYRANOSIDE + PROTON
BioCyc:2.4.1.218-RXN 2.4.1.218 CPD-12575 + HYDROQUINONE --> HYDROQUINONE-O-BETA-D-GLUCOPYRANOSIDE + UDP + PROTON
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Organism Source

Taxonomy Source

  1. Itoa orientalis [ncbi taxid: 179731]
  2. Achillea spinulifolia [ncbi taxid: ]
  3. Afrocarpus gracilior [ncbi taxid: 165205]
  4. Agave xylonacantha [ncbi taxid: 3450508]
  5. Albizia procera [ncbi taxid: 384949]
  6. Allium waldsteinii [ncbi taxid: ]
  7. Alnus incana [ncbi taxid: 3516]
  8. Amaroria soulameoides [ncbi taxid: 43721]
  9. Ambrosia hispida [ncbi taxid: 2067517]
  10. Anacardium occidentale [ncbi taxid: 171929]
  11. Angelica furcijuga KITAGAWA [ncbi taxid: ]
  12. Anthemis cretica [ncbi taxid: 127978]
  13. Antidesma pentandrum [ncbi taxid: 344423]
  14. Antiphiona pinnatisecta [ncbi taxid: 81504]
  15. Aplophyllum villosum [ncbi taxid: ]
  16. Archaster typicus [ncbi taxid: 136937]
  17. Arctostaphylos uva-ursi [ncbi taxid: 84009]
  18. Arctostaphylos uve-ursi (L.) Spreng. [ncbi taxid: ]
  19. Artocarpus altilis [ncbi taxid: 194251]
  20. Asparagus officinalis [ncbi taxid: 4686]
  21. Aspergillus caelatus [ncbi taxid: 61420]
  22. Aspergillus giganteus [ncbi taxid: 5060]
  23. Aster batangensis [ncbi taxid: 1196467]
  24. Astragalus dissectus [ncbi taxid: 3084101]
  25. Astragalus onobrychis [ncbi taxid: 1091133]
  26. atriplex littoralis [ncbi taxid: 543010]
  27. Baeckea crenulata [ncbi taxid: ]
  28. Beaucarnea recurvata [ncbi taxid: 39519]
  29. Bergenia crassifolia [ncbi taxid: 29762]
  30. Bergenia crassifolia var. cordifolia [ncbi taxid: 885526]
  31. Breynia officinalis [ncbi taxid: 886290]
  32. Burkholderia cepacia [ncbi taxid: 292]
  33. Byssochlamys fulva [ncbi taxid: ]
  34. Cacalia pilgeriana [ncbi taxid: ]
  35. Caccinia glauca [ncbi taxid: ]
  36. Calophyllum inophyllum [ncbi taxid: 158927]
  37. Casearia multinervosa [ncbi taxid: 1619378]
  38. Cathormion altissimum [ncbi taxid: ]
  39. Centaurea arenaria [ncbi taxid: 1486496]
  40. Centaurea corcubionensis [ncbi taxid: 1436089]
  41. Centaurea solstitialis [ncbi taxid: 347529]
  42. Centroceras clavulatum [ncbi taxid: 159503]
  43. Chara ceratophylla [ncbi taxid: ]
  44. Cladophora rupestris [ncbi taxid: ]
  45. Cleome chrysantha [ncbi taxid: ]
  46. Clitocybe subilludens [ncbi taxid: ]
  47. Cosmos diversifolius [ncbi taxid: 2732727]
  48. Cotoneaster simonsii [ncbi taxid: 1572675]
  49. Cotylelobium scabriusculum [ncbi taxid: 365534]
  50. Crambe kotschyana [ncbi taxid: ]
  51. Cratystylis conocephala [ncbi taxid: 125682]
  52. Crocus sativus [ncbi taxid: 82528]
  53. Cryptocarya oblata [ncbi taxid: 1312790]
  54. Curcuma caesia [ncbi taxid: 508682]
  55. Cydonia oblonga [ncbi taxid: 36610]
  56. Dendrophthoe falcata [ncbi taxid: 160049]
  57. Detarium microcarpum [ncbi taxid: 327901]
  58. Diacarnus levii [ncbi taxid: ]
  59. Diospyros abyssinica [ncbi taxid: 413718]
  60. Diospyros elliptifolia [ncbi taxid: 2945281]
  61. Diospyros peregrina [ncbi taxid: ]
  62. Dorstenia barteri [ncbi taxid: 2604977]
  63. Echinocereus triglochidiatus [ncbi taxid: 336123]
  64. Elattostachys apetala [ncbi taxid: 556960]
  65. Enicosanthum cupulare [ncbi taxid: ]
  66. Eriostemon fitzgeraldii [ncbi taxid: ]
  67. Erythrina pallida [ncbi taxid: 2590713]
  68. Erythrophleum couminga [ncbi taxid: 3086805]
  69. Escherichia coli [ncbi taxid: 562]
  70. Eucalyptus australiana [ncbi taxid: ]
  71. Eusideroxylon zwageri [ncbi taxid: 128625]
  72. Fallopia multiflora [ncbi taxid: 76025]
  73. Fritillaria raddeana [ncbi taxid: 59071]
  74. Garcinia subelliptica [ncbi taxid: 212238]
  75. Geigeria plumosa [ncbi taxid: 1548582]
  76. Goniothalamus tamirensis [ncbi taxid: 553657]
  77. Gossypium indicum [ncbi taxid: ]
  78. Gutenbergia cordifolia [ncbi taxid: 1671336]
  79. Hamamelistes betulae [ncbi taxid: ]
  80. Helicoverpa armigera [ncbi taxid: 29058]
  81. Helicoverpa zea [ncbi taxid: 7113]
  82. Heterophyllaea pustulata [ncbi taxid: 60145]
  83. Inga velutina [ncbi taxid: 486091]
  84. Ircinia ramosa [ncbi taxid: 281041]
  85. Isertia haenkeana [ncbi taxid: 378937]
  86. Jacobaea aquatica [ncbi taxid: 189230]
  87. Lactuca serriola [ncbi taxid: 75943]
  88. Lagochilus leiacanthus [ncbi taxid: 2039844]
  89. Laurencia decumbens [ncbi taxid: 997938]
  90. Laurencia johnstonii [ncbi taxid: ]
  91. Lecanora nipponica [ncbi taxid: ]
  92. Lecidea kochiana [ncbi taxid: ]
  93. Lejeunea pallescens [ncbi taxid: 280556]
  94. Lepidophorum grisleyi [ncbi taxid: ]
  95. Lespedeza cyrtobotrya [ncbi taxid: 701533]
  96. Leuconostoc mesenteroides [ncbi taxid: 1245]
  97. Linaria maroccana [ncbi taxid: 237459]
  98. Lindera pipericarpa [ncbi taxid: ]
  99. Litsea lii [ncbi taxid: ]
  100. Lonicera tatarica var. morrowii [ncbi taxid: 255350]
  101. Lotus angustissimus [ncbi taxid: 181259]
  102. Lycium barbarum [ncbi taxid: 112863]
  103. Lycium chinense [ncbi taxid: 112883]
  104. Lycopodium japonicum [ncbi taxid: 672196]
  105. Maackia tashiroi [ncbi taxid: 256641]
  106. Mikania scandens [ncbi taxid: 102787]
  107. Mutisia orbignyana [ncbi taxid: 909280]
  108. Myroxylon peruiferum [ncbi taxid: 1231556]
  109. Nanodea muscosa [ncbi taxid: 463667]
  110. Navanax inermis [ncbi taxid: 259618]
  111. Nelumbo nucifera [ncbi taxid: 4432]
  112. Ocimum pilosum [ncbi taxid: ]
  113. Ocotea minarum [ncbi taxid: 881606]
  114. Onobrychis bobrovi [ncbi taxid: ]
  115. Onobrychis viciifolia [ncbi taxid: 3882]
  116. Ononis hircina [ncbi taxid: ]
  117. Origanum majorana [ncbi taxid: 268884]
  118. Ormosia nobilis [ncbi taxid: ]
  119. Paenibacillus macerans [ncbi taxid: 44252]
  120. Passiflora murucuja [ncbi taxid: 237869]
  121. Penstemon mucronatus [ncbi taxid: 1811924]
  122. Petasites hybridus [ncbi taxid: 278673]
  123. Petrosia volcano [ncbi taxid: ]
  124. Petrosia weinbergi [ncbi taxid: 1336823]
  125. Phaeotremella fagi [ncbi taxid: 334123]
  126. Phelline lucida [ncbi taxid: 92224]
  127. Phyllodium pulchellum [ncbi taxid: 406422]
  128. Piptostigma fugax [ncbi taxid: 2986207]
  129. Pithecellobium albicans [ncbi taxid: ]
  130. Preussia australis [ncbi taxid: 55178]
  131. Pseudocyclosorus subochthodes [ncbi taxid: 1132564]
  132. Psora corallina [ncbi taxid: ]
  133. Pyrus communis [ncbi taxid: 23211]
  134. Pythium ultimum [ncbi taxid: ]
  135. Quercus glauca [ncbi taxid: 103489]
  136. Rhodiola coccinea [ncbi taxid: 1442767]
  137. Rhododendron dauricum [ncbi taxid: 880079]
  138. Rhododendron groenlandicum [ncbi taxid: 49605]
  139. Rhododendron mucronatum [ncbi taxid: 401655]
  140. Rhododendron ungerni [ncbi taxid: ]
  141. Russula japonica [ncbi taxid: 258984]
  142. Saccharopolyspora hirsuta [ncbi taxid: 1837]
  143. Salvia bicolor [ncbi taxid: ]
  144. Salvia cyanescens [ncbi taxid: 1933716]
  145. Salvia paramiltiorrhiza [ncbi taxid: 587676]
  146. Salvia rhyacophila [ncbi taxid: 2026527]
  147. Scorzonera hispanica [ncbi taxid: ]
  148. Scutellaria racemosa [ncbi taxid: 1620191]
  149. Sedum takesimense Nakai [ncbi taxid: ]
  150. Selaginella pulvinata [ncbi taxid: 672198]
  151. Selaginella tamariscina [ncbi taxid: 137178]
  152. Senecio callosus [ncbi taxid: 462508]
  153. Sideritis kuegleriana [ncbi taxid: 403023]
  154. Solanum mauritianum [ncbi taxid: 205564]
  155. Solanum meridense [ncbi taxid: ]
  156. Solanum unguiculatum [ncbi taxid: ]
  157. Solenopsis punctaticeps [ncbi taxid: 625246]
  158. Sphagnum rubellum [ncbi taxid: 128231]
  159. Stemona saxorum [ncbi taxid: ]
  160. Stephania hernandifolia [ncbi taxid: ]
  161. Streptomyces actuosus [ncbi taxid: 1885]
  162. Streptomyces alboverticillatus [ncbi taxid: 173770]
  163. Streptomyces bobili [ncbi taxid: 67280]
  164. Streptomyces viridogenes [ncbi taxid: 68283]
  165. Strychnos tricalysioides [ncbi taxid: 1040936]
  166. Thalassotalea sp. PP2-459 [ncbi taxid: 1742724]
  167. Thymelaea hirsuta [ncbi taxid: 69845]
  168. Toronia toru [ncbi taxid: ]
  169. Trapa japonica [ncbi taxid: 363523]
  170. Trichodesma incanum [ncbi taxid: 1421769]
  171. Turnera diffusa [ncbi taxid: 329212]
  172. Ulva conglobata [ncbi taxid: 2772500]
  173. Umbraculum mediterraneum [ncbi taxid: 195874]
  174. Urochloa decumbens [ncbi taxid: 240449]
  175. Vaccinium vitis-idaea [ncbi taxid: 180772]
  176. Ventilago goughii [ncbi taxid: ]
  177. Veronica turrilliana [ncbi taxid: 189994]
  178. Viburnum lantanoides [ncbi taxid: 237946]
  179. Vicia hirsuta [ncbi taxid: 3910]
  180. Xanthorrhoea resinosa [ncbi taxid: 49740]
  181. Xenia florida [ncbi taxid: ]
  182. Xenia obscuronata [ncbi taxid: ]
  183. Zanthoxylum piperitum [ncbi taxid: 354529]
  184. Arbutus unedo [ncbi taxid: 84005]

Pathway Synthetic

pathway id name
BioCyc:META_PWY-7913 firefly bioluminescence
View All Pathways