6-(Hydroxymethyl)-7,8-dihydropterin (BioCAD00000005117)

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Metabolite Card

Formula: C7H9N5O2 (195.0756)
SMILES: NC1=NC2=C(N=C(CO)CN2)C(=O)N1

Synonyms [en]

6-HYDROXYMETHYL-7,8-DIHYDROPTERIN; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine; 2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4(3H)-one; 2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-one; 6-(Hydroxymethyl)-7,8-dihydropterin; 2-Amino-4-hydroxy-6-(hydroxymethyl)-7,8-dihydropteridine

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

6-(Hydroxymethyl)-7,8-dihydropterin. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000005117). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-ol, also known as hmdp cpd, belongs to pterins and derivatives class of compounds. Those are polycyclic aromatic compounds containing a pterin moiety, which consist of a pteridine ring bearing a ketone and an amine group to form 2-aminopteridin-4(3H)-one. 2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-ol is slightly soluble (in water) and a very weakly acidic compound (based on its pKa). 2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-ol can be found in a number of food items such as cardoon, sunburst squash (pattypan squash), climbing bean, and fenugreek, which makes 2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-ol a potential biomarker for the consumption of these food products. 2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-ol exists in E.coli (prokaryote) and yeast (eukaryote).

Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 3672-03-5
  • PubChem: 135398568
  • ChEBI: ChEBI:17083
  • ChEBI: ChEBI:44841
  • HMDB: HMDB0304227
  • KEGG: C01300
  • BioCyc: AMINO-OH-HYDROXYMETHYL-DIHYDROPTERIDINE
  • NCBI MeSH: 6-hydroxymethyl-7,8-dihydropterin
  • DrugBank: DB02119
  • Metlin: METLIN_3335
  • Coconut NaturalProduct: CNP0159535.0
  • Coconut NaturalProduct: CNP0511006.0
  • Coconut NaturalProduct: CNP0601316.0
  • Coconut NaturalProduct: CNP0606593.0

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R03066 2.5.1.15 6-(hydroxymethyl)-7,8-dihydropterin:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase
KEGG:R03503 2.7.6.3 ATP:6-hydroxymethyl-7,8-dihydropterin 6'-diphosphotransferase
KEGG:R03504 4.1.2.25 7,8-dihydroneopterin glycolaldehyde-lyase [6-(hydroxymethyl)-7,8-dihydropterin-forming]
KEGG:R11718 4.1.2.59 7,8-dihydroneopterin-3'-phosphate glycolaldehyde-phosphate-lyase [6-(hydroxymethyl)-7,8-dihydropterin-forming]
KEGG:R11719 4.1.2.60 7,8-dihydroneopterin-3'-triphosphate glycolaldehyde-phosphate-lyase [6-(hydroxymethyl)-7,8-dihydropterin-forming]
BioCyc:H2PTERIDINEPYROPHOSPHOKIN-RXN 2.7.6.3 AMINO-OH-HYDROXYMETHYL-DIHYDROPTERIDINE + ATP --> PROTON + DIHYDROPTERIN-CH2OH-PP + AMP
BioCyc:H2NEOPTERINALDOL-RXN 4.1.2.25 DIHYDRO-NEO-PTERIN --> GLYCOLALDEHYDE + AMINO-OH-HYDROXYMETHYL-DIHYDROPTERIDINE
Rhea:RHEA:10541 4.1.2.25 7,8-dihydroneopterin => 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde
Rhea:RHEA:10542 4.1.2.25 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde => 7,8-dihydroneopterin
Rhea:RHEA:10543 4.1.2.25 7,8-dihydroneopterin <=> 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde
Rhea:RHEA:11413 2.7.6.3 6-hydroxymethyl-7,8-dihydropterin + ATP => (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H+
Rhea:RHEA:11414 2.7.6.3 (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H+ => 6-hydroxymethyl-7,8-dihydropterin + ATP
Rhea:RHEA:11415 2.7.6.3 6-hydroxymethyl-7,8-dihydropterin + ATP <=> (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H+
Rhea:RHEA:30888 6-hydroxymethyl-7,8-dihydropterin + 4-aminobenzoate => 7,8-dihydropteroate + H2O
Rhea:RHEA:30889 7,8-dihydropteroate + H2O => 6-hydroxymethyl-7,8-dihydropterin + 4-aminobenzoate
Rhea:RHEA:30890 6-hydroxymethyl-7,8-dihydropterin + 4-aminobenzoate <=> 7,8-dihydropteroate + H2O
Rhea:RHEA:51017 4.1.2.59 7,8-dihydroneopterin 3'-phosphate => glycolaldehyde phosphate + 6-hydroxymethyl-7,8-dihydropterin
Rhea:RHEA:51018 4.1.2.59 glycolaldehyde phosphate + 6-hydroxymethyl-7,8-dihydropterin => 7,8-dihydroneopterin 3'-phosphate
Rhea:RHEA:51019 4.1.2.59 7,8-dihydroneopterin 3'-phosphate <=> glycolaldehyde phosphate + 6-hydroxymethyl-7,8-dihydropterin
Rhea:RHEA:52773 4.1.2.60 7,8-dihydroneopterin 3'-triphosphate => glycolaldehyde triphosphate + 6-hydroxymethyl-7,8-dihydropterin
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Organism Source

Taxonomy Source

  1. Saccharomyces cerevisiae [ncbi taxid: 4932]
  2. Arabidopsis thaliana [ncbi taxid: 3702]
  3. Citrullus lanatus [ncbi taxid: 3654]

Pathway Synthetic

pathway id name
PathBank:SMP0000925 Folate Biosynthesis
PathBank:SMP0001902 GTP Degradation and Molybdenum Cofactor Biosynthesis
PlantCyc:SORGHUMBICOLOR_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
PlantCyc:SUGARBEET_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
PlantCyc:ACOERULEA_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
PlantCyc:SUNFLOWER_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
PlantCyc:AHALLERI_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
PlantCyc:AHYPOCHONDRIACUS_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
PlantCyc:ALYRATA_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
PlantCyc:ARA_PWY-3742 tetrahydrofolate biosynthesis II
PlantCyc:ZMARINA_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
PlantCyc:CASSAVA_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
PlantCyc:POPLAR_PWY-3742 tetrahydrofolate biosynthesis II
PlantCyc:RMULTIFLORA_PWY-3742 tetrahydrofolate biosynthesis II
PlantCyc:RUBBERTREE_PWY-3742 tetrahydrofolate biosynthesis II
PlantCyc:RUBBERTREE_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
PlantCyc:SFALLAX_PWY-3742 tetrahydrofolate biosynthesis II
PlantCyc:CLEMENTINE_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
PlantCyc:SUGARBEET_PWY-3742 tetrahydrofolate biosynthesis II
PlantCyc:SWEETORANGE_PWY-3742 tetrahydrofolate biosynthesis II
View All Pathways