5-Formiminotetrahydrofolate (BioCAD00000004812)

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Metabolite Card

Formula: C20H24N8O6 (472.1819)
SMILES: NC1=NC2=C(N(C=N)C(CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)CN2)C(=O)N1

Synonyms [en]

5-formiminotetrahydrofolate; 5-formimidoyltetrahydrofolate; 5-formimidoyltetrahydrofolic acid; 5-Formiminotetrahydrofolic acid; (6R)-5-formiminotetrahydrofolate; N-[4-({[(6S)-2-amino-5-formimidoyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

5-Formiminotetrahydrofolate. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000004812). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

5-Formiminotetrahydrofolic acid is a substrate for Formimidoyltransferase-cyclodeaminase.

Cytoplasm
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 2311-81-1
  • PubChem: 135398659
  • PubChem: 135402017
  • PubChem: 530
  • ChEBI: ChEBI:15639
  • ChEBI: ChEBI:168563
  • HMDB: HMDB0001534
  • HMDB: HMDB01534
  • KEGG: C00664
  • BioCyc: CPD-671
  • Wikipedia: 5-Formiminotetrahydrofolate
  • RefMet: RM0009097
  • Metlin: METLIN_6305
  • Coconut NaturalProduct: CNP0083635.1

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R02287 2.1.2.5 5-formiminotetrahydrofolate:L-glutamate N-formiminotransferase
KEGG:R02302 4.3.1.4 5-formiminotetrahydrofolate ammonia-lyase (cyclizing)
KEGG:R02729 2.1.2.4 5-formiminotetrahydrofolate:glycine N-formiminotransferase
BioCyc:4.3.1.4-RXN 4.3.1.4 CPD-671 + 2 PROTON<=>AMMONIUM + 5-10-METHENYL-THF-GLU-N
BioCyc:GLUTAMATE-FORMIMINOTRANSFERASE-RXN 2.1.2.5 N-FORMIMINO-L-GLUTAMATE + THF-GLU-N --> CPD-671 + GLT
BioCyc:GLYCINE-FORMIMINOTRANSFERASE-RXN 2.1.2.4 CPD-671 + GLY<=>N-FORMIMINO-GLYCINE + THF-GLU-N
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Organism Source

Taxonomy Source

Pathway Synthetic

pathway id name
PathBank:SMP0120742 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)
PathBank:SMP0000432 Methotrexate Action Pathway
PathBank:SMP0087314 Histidine Metabolism
PathBank:SMP0120713 Histidinemia
PathBank:SMP0000543 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)
PathBank:SMP0087196 Folate Metabolism
PathBank:SMP0120656 Folate Malabsorption, Hereditary
PathBank:SMP0120493 Histidinemia
PathBank:SMP0000044 Histidine Metabolism
PathBank:SMP0000191 Histidinemia
PathBank:SMP0087219 Histidine Metabolism
PathBank:SMP0087380 Folate Metabolism
PathBank:SMP0063632 Histidine Metabolism
PathBank:SMP0120875 Folate Malabsorption, Hereditary
PathBank:SMP0120522 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)
PathBank:SMP0000053 Folate Metabolism
PathBank:SMP0000724 Folate Malabsorption, Hereditary
PathBank:SMP0000801 Folate Metabolism
PathBank:SMP0087295 Folate Metabolism
PathBank:SMP0087435 Folate Metabolism
View All Pathways