Triiodothyronine sulfate (BioCAD00000020253)

blood urine kidney liver

Metabolite Card

Formula: C15H12I3NO7S (730.7469)
SMILES: N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(OS(O)(=O)=O)C=C2)C(I)=C1)C(O)=O

Synonyms [en]

triiodothyronine sulfate; Triiodothyronine sulfuric ester; Triiodothyronine sulphate; XBQYQXVJBNDCGY-LBPRGKRZSA-N; 3,5,3'-triiodo-L-Thyronine 4-O-sulphate; 3,5,3'-triiodo-L-thyronine 4'-O-sulfate

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

Triiodothyronine sulfate. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000020253). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

Triiodothyronine sulfate (T3S), also known as 3,5,3‘-triiodothyronine sulfate, is the sulfated conjugate of the thyroid hormone triiodothyronine (T3). T3, along with thyroxine (T4) are tyrosine-based hormones that are primarily responsible for regulation of metabolism. Both hormones are produced by the follicular cells of the thyroid gland and are regulated by TSH (thyroid-stimulating hormone) made by the thyrotropes of the anterior pituitary gland. The major form of thyroid hormone in the blood is thyroxine (T4), which has a longer half-life than T3. T4 is converted into the active T3 (three to four times more potent than T4) within cells by deiodinases (5'-iodinase) (Wikipedia). Triiodothyronine sulfate is the dominant nondeiodinative product of T3 metabolism and its formation from T3 is catalyzed by phenolsulfotransferases primarily located in the liver and kidney (PMID: 8126143).

Cytoplasm Extracellular Membrane
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 31135-55-4
  • PubChem: 122196
  • ChEBI: ChEBI:35432
  • HMDB: HMDB0003036
  • NCBI MeSH: triiodothyronine sulfate
  • Metlin: METLIN_1006
  • Coconut NaturalProduct: CNP0348850.1

Class / Ontology

Metabolic Network
ID EC Number Name
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Organism Source

Taxonomy Source

Pathway Synthetic

pathway id name
Reactome:R-BTA-1430728 Metabolism
Reactome:R-CEL-211859 Biological oxidations
Reactome:R-CEL-156584 Cytosolic sulfonation of small molecules
Reactome:R-CFA-1430728 Metabolism
Reactome:R-CFA-156580 Phase II - Conjugation of compounds
Reactome:R-DRE-156584 Cytosolic sulfonation of small molecules
Reactome:R-DME-156584 Cytosolic sulfonation of small molecules
Reactome:R-GGA-156580 Phase II - Conjugation of compounds
Reactome:R-HSA-211859 Biological oxidations
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-211859 Biological oxidations
Reactome:R-XTR-156584 Cytosolic sulfonation of small molecules
Reactome:R-BTA-211859 Biological oxidations
Reactome:R-CFA-156584 Cytosolic sulfonation of small molecules
Reactome:R-DME-1430728 Metabolism
Reactome:R-GGA-156584 Cytosolic sulfonation of small molecules
Reactome:R-HSA-156580 Phase II - Conjugation of compounds
Reactome:R-MMU-156580 Phase II - Conjugation of compounds
Reactome:R-RNO-211859 Biological oxidations
Reactome:R-SSC-1430728 Metabolism
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