Thiamin triphosphate (BioCAD00000018471)

{$topic}

Metabolite Card

Formula: C12H20N4O10P3S (505.0113)
SMILES: CC1=C(CCOP(O)(=O)OP(O)(=O)OP(O)(O)=O)SC=[N+]1CC1=C(N)N=C(C)N=C1

Synonyms [en]

Thiamin triphosphate; Thiamine triphosphate; thiamine(1+) triphosphate; ThTP; 3-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-5-{2-[(hydroxy{[hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl)oxy]ethyl}-4-methyl-1,3-thiazol-3-ium; Thiamin triphosphic acid

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

Thiamin triphosphate. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000018471). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

Thiamine triphosphate is the triphosphate ester of thiamine. Thiamine triphosphate (ThTP) was previously considered to be a specific neuroactive form of thiamine. However, it was recently shown that ThTP exists in bacteria, fungi, plants and animals suggesting a much more general cellular role. In particular, it seems to play a role in response to amino acid starvation. In mammals, ThTP is hydrolyzed by a specific thiamine triphosphatase. In Leigh's disease, this compound is present in decreased amounts in the brain due to a metabolic block in its formation.

Extracellular
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 15666-52-1
  • CAS Registry Number: 3475-65-8
  • CAS Registry Number: 50851-39-3
  • PubChem: 511
  • ChEBI: ChEBI:9534
  • HMDB: HMDB0001512
  • KEGG: C03028
  • NCBI MeSH: Thiamine Triphosphate
  • Wikipedia: Thiamine triphosphate
  • Wikipedia: Thiamine_triphosphate
  • Coconut NaturalProduct: CNP0573159.0

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R00616 2.7.4.15 ATP:thiamine-diphosphate phosphotransferase
KEGG:R00618 3.6.1.28 thiamin-triphosphate phosphohydrolase
KEGG:R11319 2.7.4.3 ADP:thiamin-diphosphate phosphotransferase
View More
Organism Source

Taxonomy Source

  1. Mus musculus [ncbi taxid: 10090]

Pathway Synthetic

pathway id name
Reactome:R-BTA-1430728 Metabolism
Reactome:R-CFA-1430728 Metabolism
Reactome:R-DRE-196849 Metabolism of water-soluble vitamins and cofactors
Reactome:R-HSA-196849 Metabolism of water-soluble vitamins and cofactors
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-196849 Metabolism of water-soluble vitamins and cofactors
Reactome:R-RNO-196849 Metabolism of water-soluble vitamins and cofactors
Reactome:R-SSC-196854 Metabolism of vitamins and cofactors
Reactome:R-XTR-196819 Vitamin B1 (thiamin) metabolism
Reactome:R-BTA-196849 Metabolism of water-soluble vitamins and cofactors
Reactome:R-CFA-196849 Metabolism of water-soluble vitamins and cofactors
Reactome:R-DRE-196854 Metabolism of vitamins and cofactors
Reactome:R-HSA-196854 Metabolism of vitamins and cofactors
Reactome:R-MMU-196854 Metabolism of vitamins and cofactors
Reactome:R-RNO-196854 Metabolism of vitamins and cofactors
Reactome:R-SSC-1430728 Metabolism
Reactome:R-SSC-196819 Vitamin B1 (thiamin) metabolism
Reactome:R-BTA-196819 Vitamin B1 (thiamin) metabolism
Reactome:R-CFA-196819 Vitamin B1 (thiamin) metabolism
Reactome:R-DRE-1430728 Metabolism
View All Pathways