Succinyl-CoA (BioCAD00000018053)
Metabolite Card
Formula: C25H40N7O19P3S (867.1312)
SMILES: CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O
Synonyms [en]
succinyl-CoA; S-(3-carboxy-propionyl)-CoA; Succinyl coenzyme A; S-(hydrogen succinyl)-CoA; S-(Hydrogen succinyl)coenzyme A; succinyl-coenzyme A
Last reviewed on 2024-06-28.
Cite this Page
Succinyl-CoA. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China.
https://biocad_registry.innovation.ac.cn/s/(-)-arctiin
(retrieved
2026-01-03) (CAD Registry RN: BioCAD00000018053). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Note
Succinyl-CoA is an important intermediate in the citric acid cycle, where it is synthesized from α-Ketoglutarate by α-ketoglutarate dehydrogenase (EC 1.2.4.2) through decarboxylation, and is converted into succinate through the hydrolytic release of coenzyme A by succinyl-CoA synthetase (EC 6.2.1.5). Succinyl-CoA may be an end product of peroxisomal beta-oxidation of dicarboxylic fatty acids; the identification of an apparently specific succinyl-CoA thioesterase (ACOT4, EC 3.1.2.3, hydrolyzes succinyl-CoA) in peroxisomes strongly suggests that succinyl-CoA is formed in peroxisomes. Acyl-CoA thioesterases (ACOTs) are a family of enzymes that catalyze the hydrolysis of the CoA esters of various lipids to the free acids and coenzyme A, thereby regulating levels of these compounds. (PMID: 16141203).
DBLinks
- CAS Registry Number: 604-98-8
- PubChem CID: 92133
- ChEBI: 15380
- HMDB: HMDB0001022
- LipidMaps: LMFA07050370
- KEGG: C00091
- BioCyc:
- NCBI MeSH: succinyl-coenzyme A
- Wikipedia: Succinyl-CoA
Other DBLinks
- CAS Registry Number: 604-98-8
- PubChem: 439161
- PubChem: 92133
- ChEBI: ChEBI:15380
- HMDB: HMDB0001022
- HMDB: HMDB01022
- LipidMaps: LMFA07050370
- KEGG: C00091
- NCBI MeSH: succinyl-coenzyme A
- Wikipedia: Succinyl-CoA
- DrugBank: DB03699
- RefMet: RM0152810
- MoNA: EMBL_MCF_2_0_HRMS_Library000516
- Metlin: METLIN_444
- Coconut NaturalProduct: CNP0127001.1
- Coconut NaturalProduct: CNP0127001.2
- Coconut NaturalProduct: CNP0127001.3
- Coconut NaturalProduct: CNP0127001.4
Class / Ontology
- WishartLab ClassyFire: [Fatty acyl thioesters] Fatty acyl thioesters
- RefMet: [Acyl CoAs] Acyl CoAs
- LipidMaps: [Fatty acyl CoAs [FA0705]] Fatty acyl CoAs [FA0705]
- ChEBI: [CHEBI:15380] succinyl-CoA
- Coconut NaturalProduct: [Fatty acyl CoAs] Fatty acyl CoAs
| ID | EC Number | Name |
|---|---|---|
| KEGG:R00265 | 1.2.1.52 | 2-oxoglutarate:NADP+ 2-oxidoreductase (CoA-succinylating) |
| KEGG:R00405 | 6.2.1.5 | succinate:CoA ligase (ADP-forming) |
| KEGG:R00406 | 2.8.3.22 | succinyl-CoA:(S)-malate CoA-transferase |
| KEGG:R00407 | 3.1.2.3 | succinyl-CoA hydrolase |
| KEGG:R00410 | 2.8.3.5 | succinyl-CoA:acetoacetate CoA-transferase |
| KEGG:R00432 | 6.2.1.4 | succinate:CoA ligase (GDP-forming) |
| KEGG:R00727 | 6.2.1.4 | succinate:CoA ligase (IDP-forming) |
| KEGG:R00829 | 2.3.1.16 | succinyl-CoA:acetyl-CoA C-acyltransferase; |
| KEGG:R00830 | 2.3.1.37 | succinyl-CoA:glycine C-succinyltransferase (decarboxylating) |
| KEGG:R00832 | 2.3.1.109 | succinyl-CoA:L-arginine N2-succinyltransferase |
| KEGG:R00833 | 5.4.99.2 | (R)-methylmalonyl-CoA CoA-carbonylmutase |
| KEGG:R01197 | 1.2.7.3 | 2-oxoglutarate:ferredoxin oxidoreductase (decarboxylating) |
| KEGG:R01559 | 2.8.3.2 | succinyl-CoA:oxalate CoA-transferase |
| KEGG:R01777 | 2.3.1.46 | succinyl-CoA:L-homoserine O-succinyltransferase |
| KEGG:R01780 | 2.8.3.5 | succinyl-CoA:3-oxo-acid CoA-transferase |
| KEGG:R02084 | 2.8.3.13 | succinyl-CoA:3-hydroxy-3-methylglutarate CoA-transferase |
| KEGG:R02407 | 2.8.3.- | succinyl-CoA:itaconate CoA-transferase |
| KEGG:R02570 | 2.3.1.61 | succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase |
| KEGG:R02990 | 2.8.3.6 | succinyl-CoA:3-oxoadipate CoA-transferase |
| KEGG:R03154 | 2.8.3.22 | succinyl-CoA:(S)-citramalate CoA-transferase |
Taxonomy Source
Pathway Synthetic
| pathway id | name |
|---|---|
| BioCyc:LEISH_PWY3IU-99 | superpathway of central carbon metabolism |
| BioCyc:LEISH_TCA | TCA cycle |
| BioCyc:LEISH_PROPIONMET-PWY | methylmalonyl pathway |
| BioCyc:TRYPANO_GLYCOLYSIS-TCA-GLYOX-BYPASS | superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass |
| BioCyc:TRYPANO_PWY0-781 | aspartate superpathway |
| BioCyc:LEISH_PWY3IU-61 | superpathway of glycolysis, pyruvate dehydrogenase and TCA cycle |
| BioCyc:TRYPANO_TCA | TCA cycle |
| BioCyc:TRYPANO_P4-PWY | superpathway of lysine, threonine and methionine biosynthesis I |
| BioCyc:TRYPANO_PWY0-321 | phenylacetate degradation I (aerobic) |
| BioCyc:TRYPANO_DAPLYSINESYN-PWY | lysine biosynthesis I |
| BioCyc:LEISH_PWY3IU-16 | acetyl-CoA degradation to acetate |
| BioCyc:TRYPANO_PWY-2361 | 3-oxoadipate degradation |
| BioCyc:TRYPANO_PWY-1361 | benzoyl-CoA degradation I (aerobic) |
| BioCyc:TRYPANO_P108-PWY | pyruvate fermentation to propionate I |
| BioCyc:TRYPANO_TCA-GLYOX-BYPASS | superpathway of glyoxylate bypass and TCA |
| BioCyc:TRYPANO_HOMOSER-METSYN-PWY | methionine biosynthesis I |
| WikiPathways:WP3583 | Central carbon metabolism |
| Plant Reactome:R-OGU-1119533 | TCA cycle (plant) |
| Plant Reactome:R-CCA-1119533 | TCA cycle (plant) |
| Plant Reactome:R-JCU-1119533 | TCA cycle (plant) |