Mycophenolic acid O-acyl-glucuronide (BioCAD00000014323)

blood urine kidney liver

Metabolite Card

Formula: C23H28O12 (496.1581)
SMILES: COC1=C(C)C2=C(C(=O)OC2)C(O)=C1C\C=C(/C)CCC(=O)O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O

Synonyms [en]

Mycophenolic acid O-acyl-glucuronide; AcMPAG; Mycophenolic acid-O-acyl-beta-D-glucopyranuronoside; Mycophenolic acid acyl glucuronide; DTXSID501343826; 1-O-(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

Mycophenolic acid O-acyl-glucuronide. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000014323). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

Mycophenolic acid O-acyl-glucuronide is a metabolite of mycophenolate mofetil. Mycophenolate mofetil (MMF) (brand names CellCept, Myfortic) is an immunosuppressant and prodrug of mycophenolic acid, used extensively in transplant medicine. It is a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH) in purine biosynthesis which is necessary for the growth of T cells and B cells. Other cells are able to recover purines via a separate, scavenger, pathway and are, thus, able to escape the effect. MMF is a less toxic alternative to azathioprine. (Wikipedia)

Cytoplasm
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 99043-04-6
  • PubChem: 10028772
  • ChEBI: ChEBI:64689
  • HMDB: HMDB0060491
  • KEGG: C20383
  • Coconut NaturalProduct: CNP0463090.1

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R10134 3.1.1.93 mycophenolic acid O-acyl-glucuronide-ester hydrolase
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Organism Source

Taxonomy Source

  1. Streptomyces sp. SANK 60895 [ncbi taxid: ]

Pathway Synthetic

pathway id name
Reactome:R-BTA-1430728 Metabolism
Reactome:R-CFA-1430728 Metabolism
Reactome:R-CFA-156580 Phase II - Conjugation of compounds
Reactome:R-GGA-156580 Phase II - Conjugation of compounds
Reactome:R-HSA-211859 Biological oxidations
Reactome:R-HSA-156588 Glucuronidation
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-211859 Biological oxidations
Reactome:R-MMU-156588 Glucuronidation
Reactome:R-BTA-211859 Biological oxidations
Reactome:R-BTA-156588 Glucuronidation
Reactome:R-HSA-156580 Phase II - Conjugation of compounds
Reactome:R-MMU-156580 Phase II - Conjugation of compounds
Reactome:R-RNO-211859 Biological oxidations
Reactome:R-RNO-156588 Glucuronidation
Reactome:R-SSC-1430728 Metabolism
Reactome:R-SSC-211859 Biological oxidations
Reactome:R-SSC-156588 Glucuronidation
Reactome:R-CFA-211859 Biological oxidations
Reactome:R-CFA-156588 Glucuronidation
View All Pathways