Estradiol-17beta 3-sulfate (BioCAD00000010732)

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Metabolite Card

Formula: C18H24O5S (352.1344)
SMILES: [H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])C3=CC=C(OS(O)(=O)=O)C=C3CC[C@@]21[H]

Synonyms [en]

Estradiol-17beta 3-sulfate; (17beta)-17-hydroxyestra-1(10),2,4-trien-3-yl hydrogen sulfate; estradiol 3-sulphate; beta-estradiol 3-sulfate; 17beta-hydroxyestra-1,3,5(10)-trien-3-yl hydrogen sulfate; estradiol-3-sulfate

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

Estradiol-17beta 3-sulfate. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000010732). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

17beta-Estradiol 3-sulfate, also known as estradiol 3-sulfuric acid or estradiol-17beta 3-sulfate, belongs to the class of organic compounds known as sulfated steroids. These are sterol lipids containing a sulfate group attached to the steroid skeleton. 17beta-Estradiol 3-sulfate is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. The estrogen patch is a delivery system for estradiol used as hormone replacement therapy to treat the symptoms of menopause, such as hot flashes and vaginal dryness, and to prevent osteoporosis. Originally marketed as Vivelle(Novartis), it was discontinued in 2003 and reintroduced in a smaller form as Vivelle-Dot. Although estrogen is given transdermally rather than in the standard oral tablets, the estrogen patch carries similar risks and benefits as more conventional forms of estrogen-only hormone replacement therapy.

Cytoplasm Extracellular Membrane
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 481-96-9
  • PubChem: 66416
  • ChEBI: ChEBI:166844
  • ChEBI: ChEBI:4866
  • HMDB: HMDB0004448
  • HMDB: HMDB04448
  • LipidMaps: LMST05020005
  • KEGG: C08357
  • NCBI MeSH: estradiol-3-sulfate
  • Wikipedia: Estradiol_sulfate
  • RefMet: RM0126011
  • Metlin: METLIN_43185
  • Coconut NaturalProduct: CNP0085741.6

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R00535 2.8.2.15 3'-phosphoadenylylsulfate:17beta-estradiol 3-sulfotransferase
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Organism Source

Taxonomy Source

  1. Penis cervi [ncbi taxid: ]

Pathway Synthetic

pathway id name
Reactome:R-BTA-1430728 Metabolism
Reactome:R-CFA-1430728 Metabolism
Reactome:R-CFA-156580 Phase II - Conjugation of compounds
Reactome:R-DRE-156584 Cytosolic sulfonation of small molecules
Reactome:R-GGA-156580 Phase II - Conjugation of compounds
Reactome:R-HSA-211859 Biological oxidations
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-211859 Biological oxidations
Reactome:R-XTR-156584 Cytosolic sulfonation of small molecules
Reactome:R-BTA-211859 Biological oxidations
Reactome:R-CFA-156584 Cytosolic sulfonation of small molecules
Reactome:R-GGA-156584 Cytosolic sulfonation of small molecules
Reactome:R-HSA-156580 Phase II - Conjugation of compounds
Reactome:R-MMU-156580 Phase II - Conjugation of compounds
Reactome:R-RNO-211859 Biological oxidations
Reactome:R-SSC-1430728 Metabolism
Reactome:R-SSC-211859 Biological oxidations
Reactome:R-BTA-156584 Cytosolic sulfonation of small molecules
Reactome:R-CFA-211859 Biological oxidations
Reactome:R-DRE-1430728 Metabolism
View All Pathways