EC: 5.3.99.2

Prostaglandin-D synthase ((5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase)

enzyme lambda metabolic reaction experiment
uniprot:O09114 [Reduced glutathione]

Prostaglandin_H2 -> Prostaglandin_D2		 (( (Vmax * S) ) / (Km + S)) buffer: 100 mM Tris-HCl, 0.1 mg/ml IgG, 10% DMSO
PH: 8
Temperature: 25
uniprot:P22057 [prostaglandin-D synthase(Enzyme) wildtype]

Prostaglandin_H2 -> Prostaglandin_D2		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 0.1 M Tris-HCl, 1 mM dithiothreitol
PH: 9.5
Temperature: 25

Pathways

pathway id name
BioCyc:META_PWY66-374 C20 prostanoid biosynthesis
BioCyc:HUMAN_PWY66-374 C20 prostanoid biosynthesis
BioCyc:MOUSE_PWY3DJ-35583 biosynthesis of prostaglandins
Reactome:R-HSA-9690406 Transcriptional regulation of testis differentiation
Reactome:R-BTA-1430728 Metabolism
Reactome:R-BTA-556833 Metabolism of lipids
Reactome:R-CFA-1430728 Metabolism
Reactome:R-CFA-556833 Metabolism of lipids
Reactome:R-GGA-8978868 Fatty acid metabolism
Reactome:R-GGA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Reactome:R-GGA-156580 Phase II - Conjugation of compounds
Reactome:R-HSA-211859 Biological oxidations
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-556833 Metabolism of lipids
Reactome:R-MMU-211859 Biological oxidations
Reactome:R-RNO-8978868 Fatty acid metabolism
Reactome:R-RNO-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Reactome:R-RNO-156590 Glutathione conjugation
Reactome:R-BTA-8978868 Fatty acid metabolism
Reactome:R-BTA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Reactome:R-CFA-8978868 Fatty acid metabolism
Reactome:R-CFA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Reactome:R-GGA-2142753 Arachidonate metabolism
Reactome:R-HSA-1266738 Developmental Biology
Reactome:R-HSA-556833 Metabolism of lipids
Reactome:R-HSA-8978868 Fatty acid metabolism
Reactome:R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Reactome:R-HSA-156580 Phase II - Conjugation of compounds
Reactome:R-MMU-8978868 Fatty acid metabolism
Reactome:R-MMU-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Reactome:R-MMU-156580 Phase II - Conjugation of compounds
Reactome:R-RNO-2142753 Arachidonate metabolism
Reactome:R-RNO-211859 Biological oxidations
Reactome:R-GGA-1430728 Metabolism
Reactome:R-GGA-556833 Metabolism of lipids
Reactome:R-GGA-211859 Biological oxidations
Reactome:R-HSA-156590 Glutathione conjugation
Reactome:R-MMU-156590 Glutathione conjugation
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-556833 Metabolism of lipids
Reactome:R-BTA-2142753 Arachidonate metabolism
Reactome:R-CFA-2142753 Arachidonate metabolism
Reactome:R-GGA-156590 Glutathione conjugation
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-2142753 Arachidonate metabolism
Reactome:R-MMU-2142753 Arachidonate metabolism
Reactome:R-RNO-156580 Phase II - Conjugation of compounds
WikiPathways:WP4335 Eicosanoid lipid synthesis map
PathBank:SMP0120730 Leukotriene C4 Synthesis Deficiency
PathBank:SMP0000083 Acetylsalicylic Acid Action Pathway
PathBank:SMP0000087 Rofecoxib Action Pathway
PathBank:SMP0000094 Sulindac Action Pathway
PathBank:SMP0000104 Indomethacin Action Pathway
PathBank:SMP0000120 Naproxen Action Pathway
PathBank:SMP0000106 Meloxicam Action Pathway
PathBank:SMP0000693 Antrafenine Action Pathway
PathBank:SMP0000697 Flurbiprofen Action Pathway
PathBank:SMP0000701 Phenylbutazone Action Pathway
PathBank:SMP0000705 Tiaprofenic Acid Action Pathway
PathBank:SMP0000709 Salicylic Acid Action Pathway
PathBank:SMP0000075 Arachidonic Acid Metabolism
PathBank:SMP0000086 Ibuprofen Action Pathway
PathBank:SMP0000093 Diclofenac Action Pathway
PathBank:SMP0000098 Ketorolac Action Pathway
PathBank:SMP0000102 Bromfenac Action Pathway
PathBank:SMP0000114 Nabumetone Action Pathway
PathBank:SMP0000692 Antipyrine Action Pathway
PathBank:SMP0000696 Fenoprofen Action Pathway
PathBank:SMP0000700 Lornoxicam Action Pathway
PathBank:SMP0000704 Tolmetin Action Pathway
PathBank:SMP0000708 Salicylate-Sodium Action Pathway
PathBank:SMP0063595 Arachidonic Acid Metabolism
PathBank:SMP0000077 Piroxicam Action Pathway
PathBank:SMP0000084 Etodolac Action Pathway
PathBank:SMP0000109 Mefenamic Acid Action Pathway
PathBank:SMP0000289 Diflunisal Action Pathway
PathBank:SMP0000116 Valdecoxib Action Pathway
PathBank:SMP0000694 Carprofen Action Pathway
PathBank:SMP0000698 Magnesium Salicylate Action Pathway
PathBank:SMP0000702 Nepafenac Action Pathway
PathBank:SMP0000706 Tenoxicam Action Pathway
PathBank:SMP0000710 Acetaminophen Action Pathway
PathBank:SMP0120510 Leukotriene C4 Synthesis Deficiency
PathBank:SMP0000353 Leukotriene C4 Synthesis Deficiency
PathBank:SMP0000085 Ketoprofen Action Pathway
PathBank:SMP0000096 Celecoxib Action Pathway
PathBank:SMP0000101 Suprofen Action Pathway
PathBank:SMP0000113 Oxaprozin Action Pathway
PathBank:SMP0000695 Etoricoxib Action Pathway
PathBank:SMP0000699 Lumiracoxib Action Pathway
PathBank:SMP0000703 Trisalicylate-Choline Action Pathway
PathBank:SMP0000707 Salsalate Action Pathway
PathBank:SMP0087315 Arachidonic Acid Metabolism