EC: 4.2.1.22

cystathionine beta-synthase (L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming))

enzyme lambda metabolic reaction experiment
uniprot:Q9YBL2 [cystathionine beta-synthase(Enzyme) wildtype]

L_Homocysteine + L_Serine -> H2O + L_Cystathionine		 (( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 0.2 mM pyridoxal 5'-phosphate, 100 mM sodium carbonate
PH: 8.3
Temperature: 85
uniprot:Q9YBL2 [cystathionine beta-synthase(Enzyme) wildtype]

L_Serine + L_Homocysteine -> H2O + L_Cystathionine		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.2 mM pyridoxal 5'-phosphate, 100 mM sodium carbonate
PH: 8.3
Temperature: 85
uniprot:Q9YBL2 [cystathionine beta-synthase(Enzyme) wildtype]

Sulfide + L_Serine -> H2O + L_Cysteine		 (( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 0.2 mM pyridoxal 5'-phosphate, 100 mM sodium carbonate, 1 mM EDTA
PH: 8.5
Temperature: 70
uniprot:Q9YBL2 [cystathionine beta-synthase(Enzyme) wildtype]

Sulfide + L_Serine -> H2O + L_Cysteine		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.2 mM pyridoxal 5'-phosphate, 100 mM sodium carbonate, 1 mM EDTA
PH: 8.5
Temperature: 70
uniprot:P35520 [S-Adenosyl-L-methionine]

L_Serine + L_Homocysteine -> H2O + L_Cystathionine		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 10 mM Tris/HCl
PH: 8.6
Temperature: 37
uniprot:P35520 [cystathionine beta-synthase(Enzyme) wildtype active core by trypsin cleavage]

L_Homocysteine + L_Serine -> H2O + L_Cystathionine		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 10 mM Tris/HCl
PH: 8.6
Temperature: 37
uniprot:P35520 [cystathionine beta-synthase(Enzyme) wildtype]

L_Serine + L_Homocysteine -> H2O + L_Cystathionine		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 10 mM Tris/HCl
PH: 8.6
Temperature: 37
uniprot:P35520 [cystathionine beta-synthase(Enzyme) wildtype]

L_Serine + L_Homocysteine -> L_Cystathionine + H2O		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 10 mM Tris/HCl
PH: 8.6
Temperature: 37
uniprot:P35520 [S-Adenosyl-L-methionine]

L_Serine + L_Homocysteine -> H2O + L_Cystathionine		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 10 mM Tris/HCl
PH: 8.6
Temperature: 37
uniprot:P35520 [cystathionine beta-synthase(Enzyme) wildtype active core by trypsin cleavage]

L_Homocysteine + L_Serine -> H2O + L_Cystathionine		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 10 mM Tris/HCl
PH: 8.6
Temperature: 37
uniprot:P32232 [cystathionine beta-synthase(Enzyme) wildtype]

L_Homocysteine + L_Serine -> L_Cystathionine + H2O		 (( (Vmax * A) ) / (Km + A)) buffer: 0.1 M Tris, 0.12 mM pyridoxalphosphate
PH: 8.3
Temperature: 37
uniprot:P32232 [cystathionine beta-synthase(Enzyme) wildtype]

L_Serine + L_Homocysteine -> H2O + L_Cystathionine		 (( (Vmax * A) ) / (Km + A)) buffer: 0.1 M Tris, 0.12 mM pyridoxalphosphate, 0.5 mM CuSO4
PH: 8.3
Temperature: 37
uniprot:P32232 [cystathionine beta-synthase(Enzyme) wildtype]

L_Homocysteine + L_Serine -> H2O + L_Cystathionine		 (( (Vmax * A) ) / (Km + A)) buffer: 0.1 M Tris, 0.12 mM pyridoxalphosphate
PH: 8.3
Temperature: 37
uniprot:P32232 [cystathionine beta-synthase(Enzyme) wildtype]

L_Homocysteine + L_Serine -> L_Cystathionine + H2O		 (( (Vmax * A) ) / (Km + A)) buffer: 0.1 M Tris, 0.12 mM pyridoxalphosphate, 0.5 mM CuSO4
PH: 8.3
Temperature: 37
uniprot:P35520 [Pyridoxal phosphate]

L_Homocysteine + L_Serine -> L_Cystathionine + H2O		 (( (Vmax * A) ) / (Km + A)) buffer: 100 mM Tris/HCl, 20 mM Dithiothreitol
PH: 8.6
Temperature: 37
uniprot:P35520 [Pyridoxal phosphate]

L_Serine + L_Homocysteine -> H2O + L_Cystathionine		 (( (Vmax * B) ) / (Km + B)) buffer: 100 mM Tris/HCl, 20 mM Dithiothreitol
PH: 8.6
Temperature: 37
uniprot:P32582 [cystathionine beta-synthase(Enzyme) mutant Q157A His-tagged]

H2O + L_Cystathionine -> Pyruvate + NH3 + L_Homocysteine		 (( (E * (( (kcatR / Km) ) * A)) ) / (1 + (A / Km))) buffer: 50 mM Tris, 20 µM PLP, 2 mM 5,5'-dithio-bis-(2-nitrobenzoic acid)
PH: 8.6
Temperature: 37
uniprot:P32582 [cystathionine beta-synthase(Enzyme) mutant S82A His-tagged]

L_Serine + L_Homocysteine -> L_Cystathionine + H2O		 (E * (( (( (kcatE * A) ) + (( (( (kcatF / Km_B) ) * A) ) * B)) ) / (( (( (KmE_A + A) ) + (( (( (Km_A / Km_B) ) * (1 + (B / KiF1_B))) ) * B)) ) + (( (( (( (1 / Km_B) ) * (1 + (B / KiF2_B))) ) * A) ) * B)))) buffer: 50 mM Tris, 20 µM PLP, 0.4 µM Cystathionine beta-lyase, 1.3 µM L-Lactate dehydrogenase, 150 µM NADH
PH: 8.6
Temperature: 37
uniprot:P32582 [cystathionine beta-synthase(Enzyme) mutant T81A His-tagged]

L_Serine + L_Homocysteine -> L_Cystathionine + H2O		 (E * (( (( (kcatE * A) ) + (( (( (kcatF / Km_B) ) * A) ) * B)) ) / (( (( (KmE_A + A) ) + (( (( (Km_A / Km_B) ) * (1 + (B / KiF1_B))) ) * B)) ) + (( (( (( (1 / Km_B) ) * (1 + (B / KiF2_B))) ) * A) ) * B)))) buffer: 50 mM Tris, 20 µM PLP, 0.4 µM Cystathionine beta-lyase, 1.3 µM L-Lactate dehydrogenase, 150 µM NADH
PH: 8.6
Temperature: 37
uniprot:P32582 [cystathionine beta-synthase(Enzyme) mutant T81A His-tagged]

L_Cystathionine + H2O -> L_Serine + L_Homocysteine		 (( (E * (( (kcatR / Km) ) * A)) ) / (1 + (A / Km))) buffer: 50 mM Tris, 20 µM PLP, 2 mM 5,5'-dithio-bis-(2-nitrobenzoic acid)
PH: 8.6
Temperature: 37
uniprot:P32582 [cystathionine beta-synthase(Enzyme) mutant T81A His-tagged]

L_Serine -> Pyruvate + NH3		 (( (E * (( (kcatR / Km) ) * A)) ) / (1 + (A / Km))) buffer: 50 mM Tris, 20 µM PLP, 0.4 µM Cystathionine beta-lyase, 1.3 µM L-Lactate dehydrogenase, 150 µM NADH
PH: 8.6
Temperature: 37
uniprot:P32582 [cystathionine beta-synthase(Enzyme) mutant S82A His-tagged]

L_Serine -> Pyruvate + NH3		 (( (E * (( (kcatR / Km) ) * A)) ) / (1 + (A / Km))) buffer: 50 mM Tris, 20 µM PLP, 0.4 µM Cystathionine beta-lyase, 1.3 µM L-Lactate dehydrogenase, 150 µM NADH
PH: 8.6
Temperature: 37
uniprot:P32582 [cystathionine beta-synthase(Enzyme) wildtype His-tagged]

L_Homocysteine + L_Serine -> H2O + L_Cystathionine		 (E * (( (( (kcatF * A) ) * B) ) / (( (( (( (Km_B * (1 + (B / KiF1_B))) ) * A) ) + (Km_A * B)) ) + (( (( (1 + (B / KiF2_B)) ) * A) ) * B)))) buffer: 50 mM Tris, 20 µM PLP, 0.4 µM Cystathionine beta-lyase, 1.3 µM L-Lactate dehydrogenase, 150 µM NADH
PH: 8.6
Temperature: 37
uniprot:P32582 [cystathionine beta-synthase(Enzyme) mutant Y158F His-tagged]

L_Homocysteine + L_Serine -> H2O + L_Cystathionine		 (E * (( (( (kcatE * A) ) + (( (( (kcatF / Km_B) ) * A) ) * B)) ) / (( (( (KmE_A + A) ) + (( (( (Km_A / Km_B) ) * (1 + (B / KiF1_B))) ) * B)) ) + (( (( (( (1 / Km_B) ) * (1 + (B / KiF2_B))) ) * A) ) * B)))) buffer: 50 mM Tris, 20 µM PLP, 0.4 µM Cystathionine beta-lyase, 1.3 µM L-Lactate dehydrogenase, 150 µM NADH
PH: 8.6
Temperature: 37
uniprot:P32582 [cystathionine beta-synthase(Enzyme) mutant Y158F His-tagged]

L_Cystathionine + H2O -> L_Homocysteine + NH3 + Pyruvate		 (( (E * (( (kcatR / Km) ) * A)) ) / (1 + (A / Km))) buffer: 50 mM Tris, 20 µM PLP, 2 mM 5,5'-dithio-bis-(2-nitrobenzoic acid)
PH: 8.6
Temperature: 37
uniprot:P32582 [cystathionine beta-synthase(Enzyme) mutant Y158F His-tagged]

L_Cystathionine + H2O -> L_Homocysteine + L_Serine		 (( (E * (( (kcatR / Km) ) * A)) ) / (1 + (A / Km))) buffer: 50 mM Tris, 20 µM PLP, 2 mM 5,5'-dithio-bis-(2-nitrobenzoic acid)
PH: 8.6
Temperature: 37
uniprot:P32582 [cystathionine beta-synthase(Enzyme) wildtype His-tagged]

L_Cystathionine + H2O -> L_Serine + L_Homocysteine		 (( (E * (( (kcatR / Km) ) * A)) ) / (1 + (A / Km))) buffer: 50 mM Tris, 20 µM PLP, 2 mM 5,5'-dithio-bis-(2-nitrobenzoic acid)
PH: 8.6
Temperature: 37
uniprot:P32582 [cystathionine beta-synthase(Enzyme) mutant Q157A His-tagged]

L_Cystathionine + H2O -> L_Homocysteine + L_Serine		 (( (E * (( (kcatR / Km) ) * A)) ) / (1 + (A / Km))) buffer: 50 mM Tris, 20 µM PLP, 2 mM 5,5'-dithio-bis-(2-nitrobenzoic acid)
PH: 8.6
Temperature: 37
uniprot:P32582 [cystathionine beta-synthase(Enzyme) mutant Q157H His-tagged]

L_Serine -> Pyruvate + NH3		 (( (E * (( (kcatR / Km) ) * A)) ) / (1 + (A / Km))) buffer: 50 mM Tris, 20 µM PLP, 0.4 µM Cystathionine beta-lyase, 1.3 µM L-Lactate dehydrogenase, 150 µM NADH
PH: 8.6
Temperature: 37
uniprot:P32582 [cystathionine beta-synthase(Enzyme) mutant Q157A His-tagged]

L_Serine -> Pyruvate + NH3		 (( (E * (( (kcatR / Km) ) * A)) ) / (1 + (A / Km))) buffer: 50 mM Tris, 20 µM PLP, 0.4 µM Cystathionine beta-lyase, 1.3 µM L-Lactate dehydrogenase, 150 µM NADH
PH: 8.6
Temperature: 37
uniprot:P32582 [cystathionine beta-synthase(Enzyme) mutant Y158F His-tagged]

L_Serine -> Pyruvate + NH3		 (( (E * (( (kcatR / Km) ) * A)) ) / (1 + (A / Km))) buffer: 50 mM Tris, 20 µM PLP, 0.4 µM Cystathionine beta-lyase, 1.3 µM L-Lactate dehydrogenase, 150 µM NADH
PH: 8.6
Temperature: 37
uniprot:P32582 [cystathionine beta-synthase(Enzyme) mutant T85A His-tagged]

L_Homocysteine + L_Serine -> L_Cystathionine + H2O		 (E * (( (( (kcatE * A) ) + (( (( (kcatF / Km_B) ) * A) ) * B)) ) / (( (( (KmE_A + A) ) + (( (( (Km_A / Km_B) ) * (1 + (B / KiF1_B))) ) * B)) ) + (( (( (( (1 / Km_B) ) * (1 + (B / KiF2_B))) ) * A) ) * B)))) buffer: 50 mM Tris, 20 µM PLP, 0.4 µM Cystathionine beta-lyase, 1.3 µM L-Lactate dehydrogenase, 150 µM NADH
PH: 8.6
Temperature: 37
uniprot:P32582 [cystathionine beta-synthase(Enzyme) mutant Q157H His-tagged]

L_Homocysteine + L_Serine -> H2O + L_Cystathionine		 (E * (( (( (kcatE * A) ) + (( (( (kcatF / Km_B) ) * A) ) * B)) ) / (( (( (KmE_A + A) ) + (( (( (Km_A / Km_B) ) * (1 + (B / KiF1_B))) ) * B)) ) + (( (( (( (1 / Km_B) ) * (1 + (B / KiF2_B))) ) * A) ) * B)))) buffer: 50 mM Tris, 20 µM PLP, 0.4 µM Cystathionine beta-lyase, 1.3 µM L-Lactate dehydrogenase, 150 µM NADH
PH: 8.6
Temperature: 37
uniprot:P32582 [cystathionine beta-synthase(Enzyme) mutant T85A His-tagged]

L_Cystathionine + H2O -> Pyruvate + NH3 + L_Homocysteine		 (( (E * (( (kcatR / Km) ) * A)) ) / (1 + (A / Km))) buffer: 50 mM Tris, 20 µM PLP, 2 mM 5,5'-dithio-bis-(2-nitrobenzoic acid)
PH: 8.6
Temperature: 37
uniprot:P32582 [cystathionine beta-synthase(Enzyme) mutant Q157E His-tagged]

H2O + L_Cystathionine -> L_Homocysteine + Pyruvate + NH3		 (( (E * (( (kcatR / Km) ) * A)) ) / (1 + (A / Km))) buffer: 50 mM Tris, 20 µM PLP, 2 mM 5,5'-dithio-bis-(2-nitrobenzoic acid)
PH: 8.6
Temperature: 37
uniprot:P32582 [cystathionine beta-synthase(Enzyme) mutant S82A His-tagged]

L_Cystathionine + H2O -> L_Serine + L_Homocysteine		 (( (E * (( (kcatR / Km) ) * A)) ) / (1 + (A / Km))) buffer: 50 mM Tris, 20 µM PLP, 2 mM 5,5'-dithio-bis-(2-nitrobenzoic acid)
PH: 8.6
Temperature: 37
uniprot:P32582 [cystathionine beta-synthase(Enzyme) mutant T85A His-tagged]

L_Cystathionine + H2O -> L_Serine + L_Homocysteine		 (( (E * (( (kcatR / Km) ) * A)) ) / (1 + (A / Km))) buffer: 50 mM Tris, 20 µM PLP, 2 mM 5,5'-dithio-bis-(2-nitrobenzoic acid)
PH: 8.6
Temperature: 37
uniprot:P32582 [cystathionine beta-synthase(Enzyme) mutant Q157E His-tagged]

L_Cystathionine + H2O -> L_Homocysteine + L_Serine		 (( (E * (( (kcatR / Km) ) * A)) ) / (1 + (A / Km))) buffer: 50 mM Tris, 20 µM PLP, 2 mM 5,5'-dithio-bis-(2-nitrobenzoic acid)
PH: 8.6
Temperature: 37
uniprot:P32582 [cystathionine beta-synthase(Enzyme) mutant Q157E His-tagged]

L_Serine -> Pyruvate + NH3		 (( (E * (( (kcatR / Km) ) * A)) ) / (1 + (A / Km))) buffer: 50 mM Tris, 20 µM PLP, 0.4 µM Cystathionine beta-lyase, 1.3 µM L-Lactate dehydrogenase, 150 µM NADH
PH: 8.6
Temperature: 37
uniprot:P32582 [cystathionine beta-synthase(Enzyme) mutant T85A His-tagged]

L_Serine -> Pyruvate + NH3		 (( (E * (( (kcatR / Km) ) * A)) ) / (1 + (A / Km))) buffer: 50 mM Tris, 20 µM PLP, 0.4 µM Cystathionine beta-lyase, 1.3 µM L-Lactate dehydrogenase, 150 µM NADH
PH: 8.6
Temperature: 37

Pathways

pathway id name
BioCyc:HUMAN_PWY-6292 cysteine biosynthesis
BioCyc:HUMAN_PWY-5328 superpathway of methionine degradation
BioCyc:META_PWY-801 homocysteine and cysteine interconversion
BioCyc:META_PWY-5328 superpathway of L-methionine salvage and degradation
BioCyc:META_PWY66-426 hydrogen sulfide biosynthesis II (mammalian)
BioCyc:META_PWY-8010 L-cysteine biosynthesis IX (Trichomonas vaginalis)
BioCyc:META_PWY-6293 superpathway of L-cysteine biosynthesis (fungi)
BioCyc:META_PWY-821 superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae)
BioCyc:MTBCDC1551_SULFATE-CYS-PWY superpathway of sulfate assimilation and cysteine biosynthesis
BioCyc:MOUSE_PWY-5328 superpathway of methionine degradation
BioCyc:MOUSE_PWY-6292 cysteine biosynthesis III (mammalia)
BioCyc:HUMAN_PWY66-426 hydrogen sulfide biosynthesis II (mammalian)
BioCyc:META_PWY-6292 superpathway of L-cysteine biosynthesis (mammalian)
BioCyc:YEAST_PWY-821 superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae)
BioCyc:MTBH37RV_PWY-I9 L-cysteine biosynthesis VI (from L-methionine)
BioCyc:MTBCDC1551_PWY-6292 superpathway of L-cysteine biosynthesis (mammalian)
BioCyc:MTBCDC1551_HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine)
BioCyc:MOUSE_HOMOCYSDEGR-PWY cysteine biosynthesis/homocysteine degradation
BioCyc:HUMAN_HOMOCYSDEGR-PWY cysteine biosynthesis/homocysteine degradation (trans-sulfuration)
BioCyc:META_HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine)
BioCyc:YEAST_PWY-801 homocysteine and cysteine interconversion
BioCyc:YEAST_PWY-6293 cysteine biosynthesis IV (fungi)
BioCyc:MTBCDC1551_CYSTSYN-PWY L-cysteine biosynthesis I
BioCyc:MOUSE_CYSTEINE-SYN2-PWY cysteine biosynthesis II
Reactome:R-CEL-1614635 Sulfur amino acid metabolism
Reactome:R-MMU-1430728 Metabolism
Reactome:R-SCE-71291 Amino acid and derivative metabolism
Reactome:R-SCE-1614603 Cysteine formation from homocysteine
Reactome:R-DDI-71291 Amino acid and derivative metabolism
Reactome:R-HSA-1614603 Cysteine formation from homocysteine
Reactome:R-HSA-2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se
Reactome:R-MMU-1614603 Cysteine formation from homocysteine
Reactome:R-RNO-1614603 Cysteine formation from homocysteine
Reactome:R-SCE-1430728 Metabolism
Reactome:R-SCE-1614635 Sulfur amino acid metabolism
Reactome:R-CEL-71291 Amino acid and derivative metabolism
Reactome:R-CEL-1614603 Cysteine formation from homocysteine
Reactome:R-DDI-1614635 Sulfur amino acid metabolism
Reactome:R-HSA-71291 Amino acid and derivative metabolism
Reactome:R-MMU-71291 Amino acid and derivative metabolism
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-71291 Amino acid and derivative metabolism
Reactome:R-CEL-1430728 Metabolism
Reactome:R-DDI-1430728 Metabolism
Reactome:R-DDI-1614603 Cysteine formation from homocysteine
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-1614635 Sulfur amino acid metabolism
Reactome:R-HSA-2408522 Selenoamino acid metabolism
Reactome:R-MMU-1614635 Sulfur amino acid metabolism
Reactome:R-RNO-1614635 Sulfur amino acid metabolism
WikiPathways:WP5355 Metabolic Epileptic Disorders
WikiPathways:WP4504 Cysteine and methionine catabolism
PathBank:SMP0120694 Dihydropyrimidine Dehydrogenase Deficiency (DHPD)
PathBank:SMP0120718 Hypermethioninemia
PathBank:SMP0120754 Non-Ketotic Hyperglycinemia
PathBank:SMP0120770 Hyperglycinemia, Non-Ketotic
PathBank:SMP0120798 gamma-Cystathionase Deficiency (CTH)
PathBank:SMP0000177 Cystathionine beta-Synthase Deficiency
PathBank:SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)
PathBank:SMP0002382 Sulfur Metabolism
PathBank:SMP0087298 Homocysteine Degradation
PathBank:SMP0087338 Glycine and Serine Metabolism
PathBank:SMP0087342 Methionine Metabolism
PathBank:SMP0120653 3-Phosphoglycerate Dehydrogenase Deficiency
PathBank:SMP0120741 Sarcosinemia
PathBank:SMP0120853 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type
PathBank:SMP0120471 Cystathionine beta-Synthase Deficiency
PathBank:SMP0120475 Dimethylglycine Dehydrogenase Deficiency
PathBank:SMP0120487 Glycine N-Methyltransferase Deficiency
PathBank:SMP0120519 Methionine Adenosyltransferase Deficiency
PathBank:SMP0120527 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency
PathBank:SMP0120580 Homocystinuria, Cystathionine beta-Synthase Deficiency
PathBank:SMP0000033 Methionine Metabolism
PathBank:SMP0000455 Homocysteine Degradation
PathBank:SMP0000222 Glycine N-Methyltransferase Deficiency
PathBank:SMP0000515 Homocystinuria, Cystathionine beta-Synthase Deficiency
PathBank:SMP0087273 Selenoamino Acid Metabolism
PathBank:SMP0063587 Selenoamino Acid Metabolism
PathBank:SMP0063637 Methionine Metabolism
PathBank:SMP0120872 3-Phosphoglycerate Dehydrogenase Deficiency
PathBank:SMP0120521 Sarcosinemia
PathBank:SMP0120634 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type
PathBank:SMP0000341 Hypermethioninemia
PathBank:SMP0000221 Methionine Adenosyltransferase Deficiency
PathBank:SMP0002309 Cysteine Metabolism
PathBank:SMP0063628 Homocysteine Degradation
PathBank:SMP0120691 Cystathionine beta-Synthase Deficiency
PathBank:SMP0120695 Dimethylglycine Dehydrogenase Deficiency
PathBank:SMP0120707 Glycine N-Methyltransferase Deficiency
PathBank:SMP0120739 Methionine Adenosyltransferase Deficiency
PathBank:SMP0120747 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency
PathBank:SMP0120799 Homocystinuria, Cystathionine beta-Synthase Deficiency
PathBank:SMP0120474 Dihydropyrimidine Dehydrogenase Deficiency (DHPD)
PathBank:SMP0120498 Hypermethioninemia
PathBank:SMP0120534 Non-Ketotic Hyperglycinemia
PathBank:SMP0120550 Hyperglycinemia, Non-Ketotic
PathBank:SMP0120579 gamma-Cystathionase Deficiency (CTH)
PathBank:SMP0000029 Selenoamino Acid Metabolism
PathBank:SMP0000214 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency
PathBank:SMP0000514 gamma-Cystathionase Deficiency (CTH)
PathBank:SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type
PathBank:SMP0063626 Glycine and Serine Metabolism