EC: 2.7.11.24

mitogen-activated protein kinase (ATP:protein phosphotransferase (MAPKK-activated))

enzyme lambda metabolic reaction experiment
uniprot:P47811 [mitogen-activated protein kinase(Enzyme) wildtype His-tagged T180 and Y182 phosphorylated]

ATP + Protein -> ADP + Phosphoprotein		 (( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 50 mM MOPS, 100 mM NaCl, 0.1 mM EDTA, 10 mM MgCl2, 0.2 mM NADH, 1 mM Phosphoenolpyruvate, 20 U/ml Lactate dehydrogenase, 15 U/ml Pyruvate kinase
PH: 7
Temperature: 25
uniprot:P47811 [mitogen-activated protein kinase(Enzyme) wildtype His-tagged T180 phosphorylated]

ATP + Protein -> ADP + Phosphoprotein		 (( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 50 mM MOPS, 100 mM NaCl, 0.1 mM EDTA, 10 mM MgCl2, 0.2 mM NADH, 1 mM Phosphoenolpyruvate, 20 U/ml Lactate dehydrogenase, 15 U/ml Pyruvate kinase
PH: 7
Temperature: 25
uniprot:P47811 [mitogen-activated protein kinase(Enzyme) wildtype His-tagged T180 and Y182 phosphorylated]

ATP + H2O -> Phosphate + ADP		 (( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 50 mM MOPS, 100 mM NaCl, 0.1 mM EDTA, 10 mM MgCl2, 0.2 mM NADH, 1 mM Phosphoenolpyruvate, 20 U/ml Lactate dehydrogenase, 15 U/ml Pyruvate kinase
PH: 7
Temperature: 25
uniprot:P47811 [mitogen-activated protein kinase(Enzyme) wildtype His-tagged T180 phosphorylated]

ATP + H2O -> Phosphate + ADP		 (( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 50 mM MOPS, 100 mM NaCl, 0.1 mM EDTA, 10 mM MgCl2, 0.2 mM NADH, 1 mM Phosphoenolpyruvate, 20 U/ml Lactate dehydrogenase, 15 U/ml Pyruvate kinase
PH: 7
Temperature: 25
uniprot:P47811 [mitogen-activated protein kinase(Enzyme) wildtype His-tagged T180 and Y182 phosphorylated]

ATP + Protein -> Phosphoprotein + ADP		 (( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 50 mM MOPS, 100 mM NaCl, 0.1 mM EDTA, 10 mM MgCl2, 0.2 mM NADH, 1 mM Phosphoenolpyruvate, 20 U/ml Lactate dehydrogenase, 15 U/ml Pyruvate kinase
PH: 7
Temperature: 25
uniprot:P47811 [mitogen-activated protein kinase(Enzyme) wildtype His-tagged T180 phosphorylated]

ATP + Protein -> Phosphoprotein + ADP		 (( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 50 mM MOPS, 100 mM NaCl, 0.1 mM EDTA, 10 mM MgCl2, 0.2 mM NADH, 1 mM Phosphoenolpyruvate, 20 U/ml Lactate dehydrogenase, 15 U/ml Pyruvate kinase
PH: 7
Temperature: 25
uniprot:P47811 [mitogen-activated protein kinase(Enzyme) wildtype mitogen-activated protein kinase p38 alpha (Mapk14)]

Protein + ATP -> Phosphoprotein + ADP		 (( (( (E * kcat) ) * B) ) / (Km + B)) buffer: 50 mM HEPES, 50 mM KCl, 10 mM MgCl2, 100 µM Na3VO4, 0.01 % CHAPS, 1 mM DTT, 10 µg/ml BSA
PH: 7.6
Temperature: 25
uniprot:P47811 [mitogen-activated protein kinase(Enzyme) wildtype mitogen-activated protein kinase p38 alpha (Mapk14)]

ATP + Protein -> ADP + Phosphoprotein		 (( (( (E * kcat) ) * B) ) / (Km + B)) buffer: 50 mM HEPES, 50 mM KCl, 10 mM MgCl2, 100 µM Na3VO4, 0.01 % CHAPS, 1 mM DTT, 10 µg/ml BSA
PH: 7.6
Temperature: 25
uniprot:P47811 [mitogen-activated protein kinase(Enzyme) wildtype mitogen-activated protein kinase p38 alpha (Mapk14)]

ATP + Protein -> Phosphoprotein + ADP		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 50 mM HEPES, 50 mM KCl, 10 mM MgCl2, 100 µM Na3VO4, 0.01 % CHAPS, 1 mM DTT, 10 µg/ml BSA
PH: 7.6
Temperature: 25

Pathways

pathway id name
Plant Reactome:R-OSA-9675508 Root elongation
Plant Reactome:R-OSA-9766881 TF network involved in salinity response
Plant Reactome:R-OSA-6788019 Salicylic acid signaling
Plant Reactome:R-OSA-9030769 Growth and developmental processes
Plant Reactome:R-OSA-9031670 Vegetative structure development
Plant Reactome:R-OSA-9623902 Seed development
Plant Reactome:R-OSA-9640032 Root structure development
Plant Reactome:R-OSA-8932729 Responses to stimuli: abiotic stimuli and stresses
Plant Reactome:R-OSA-2744345 Metabolism and regulation
Plant Reactome:R-OSA-2744341 Hormone signaling, transport, and metabolism
Plant Reactome:R-OSA-9031669 Reproductive structure development
Plant Reactome:R-OSA-9631623 Regulation of embryo development
Plant Reactome:R-OSA-9638808 Response to salinity
Reactome:R-HSA-9635486 Infection with Mycobacterium tuberculosis
Reactome:R-HSA-9637690 Response of Mtb to phagocytosis
Reactome:R-HSA-9635465 Suppression of apoptosis
Reactome:R-HSA-9664422 FCGR3A-mediated phagocytosis
Reactome:R-CEL-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Reactome:R-HSA-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Reactome:R-HSA-9700206 Signaling by ALK in cancer
Reactome:R-HSA-9824439 Bacterial Infection Pathways
Reactome:R-MMU-9732724 IFNG signaling activates MAPKs
Reactome:R-BTA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activity
Reactome:R-DME-9856651 MITF-M-dependent gene expression
Reactome:R-HSA-9856651 MITF-M-dependent gene expression
Reactome:R-MMU-9856649 Transcriptional and post-translational regulation of MITF-M expression and activity
Reactome:R-RNO-9856649 Transcriptional and post-translational regulation of MITF-M expression and activity
Reactome:R-CEL-9675108 Nervous system development
Reactome:R-MMU-9675108 Nervous system development
Reactome:R-HSA-9675108 Nervous system development
Reactome:R-HSA-9664417 Leishmania phagocytosis
Reactome:R-DME-9627069 Regulation of the apoptosome activity
Reactome:R-RNO-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Reactome:R-MMU-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Reactome:R-BTA-9732724 IFNG signaling activates MAPKs
Reactome:R-BTA-9730414 MITF-M-regulated melanocyte development
Reactome:R-CFA-9730414 MITF-M-regulated melanocyte development
Reactome:R-DME-9856649 Transcriptional and post-translational regulation of MITF-M expression and activity
Reactome:R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activity
Reactome:R-MMU-9730414 MITF-M-regulated melanocyte development
Reactome:R-RNO-9730414 MITF-M-regulated melanocyte development
Reactome:R-HSA-9658195 Leishmania infection
Reactome:R-HSA-9664420 Killing mechanisms
Reactome:R-SPO-198765 Signalling to ERK5
Reactome:R-DME-111461 Cytochrome c-mediated apoptotic response
Reactome:R-HSA-9725370 Signaling by ALK fusions and activated point mutants
Reactome:R-HSA-9732724 IFNG signaling activates MAPKs
Reactome:R-CEL-9730414 MITF-M-regulated melanocyte development
Reactome:R-CFA-9856651 MITF-M-dependent gene expression
Reactome:R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation
Reactome:R-MMU-9856651 MITF-M-dependent gene expression
Reactome:R-RNO-9675108 Nervous system development
Reactome:R-BTA-9675108 Nervous system development
Reactome:R-DME-9675108 Nervous system development
Reactome:R-HSA-9664407 Parasite infection
Reactome:R-HSA-9673324 WNT5:FZD7-mediated leishmania damping
Reactome:R-DME-111458 Formation of apoptosome
Reactome:R-SPO-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Reactome:R-BTA-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Reactome:R-DME-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Reactome:R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer
Reactome:R-HSA-9824443 Parasitic Infection Pathways
Reactome:R-RNO-9732724 IFNG signaling activates MAPKs
Reactome:R-CEL-9856649 Transcriptional and post-translational regulation of MITF-M expression and activity
Reactome:R-DME-9730414 MITF-M-regulated melanocyte development
Reactome:R-HSA-9730414 MITF-M-regulated melanocyte development
Reactome:R-CFA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation
Reactome:R-DME-9824585 Regulation of MITF-M-dependent genes involved in pigmentation
Reactome:R-MMU-9824585 Regulation of MITF-M-dependent genes involved in pigmentation
Reactome:R-CEL-5654726 Negative regulation of FGFR1 signaling
Reactome:R-CEL-5654733 Negative regulation of FGFR4 signaling
Reactome:R-CEL-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Reactome:R-RNO-9634635 Estrogen-stimulated signaling through PRKCZ
Reactome:R-RNO-9627069 Regulation of the apoptosome activity
Reactome:R-SPO-418592 ADP signalling through P2Y purinoceptor 1
Reactome:R-SPO-881907 Gastrin-CREB signalling pathway via PKC and MAPK
Reactome:R-SPO-3858494 Beta-catenin independent WNT signaling
Reactome:R-DME-169893 Prolonged ERK activation events
Reactome:R-DME-9634635 Estrogen-stimulated signaling through PRKCZ
Reactome:R-MMU-111458 Formation of apoptosome
Reactome:R-MMU-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Reactome:R-CEL-5654743 Signaling by FGFR4
Reactome:R-CEL-9634635 Estrogen-stimulated signaling through PRKCZ
Reactome:R-RNO-9009391 Extra-nuclear estrogen signaling
Reactome:R-RNO-111458 Formation of apoptosome
Reactome:R-SPO-392518 Signal amplification
Reactome:R-SPO-2559582 Senescence-Associated Secretory Phenotype (SASP)
Reactome:R-BTA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Reactome:R-BTA-9627069 Regulation of the apoptosome activity
Reactome:R-DME-9009391 Extra-nuclear estrogen signaling
Reactome:R-DME-111471 Apoptotic factor-mediated response
Reactome:R-DDI-198765 Signalling to ERK5
Reactome:R-SCE-450341 Activation of the AP-1 family of transcription factors
Reactome:R-MMU-111461 Cytochrome c-mediated apoptotic response
Reactome:R-MMU-9634635 Estrogen-stimulated signaling through PRKCZ
Reactome:R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Reactome:R-CEL-169893 Prolonged ERK activation events
Reactome:R-CEL-1181150 Signaling by NODAL
Reactome:R-RNO-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Reactome:R-SPO-4086398 Ca2+ pathway
Reactome:R-BTA-9009391 Extra-nuclear estrogen signaling
Reactome:R-DME-170968 Frs2-mediated activation
Reactome:R-DME-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Reactome:R-MMU-9627069 Regulation of the apoptosome activity
Reactome:R-HSA-9009391 Extra-nuclear estrogen signaling
Reactome:R-CEL-170968 Frs2-mediated activation
Reactome:R-CEL-1502540 Signaling by Activin
Reactome:R-CEL-9009391 Extra-nuclear estrogen signaling
Reactome:R-CEL-450341 Activation of the AP-1 family of transcription factors
Reactome:R-RNO-111461 Cytochrome c-mediated apoptotic response
Reactome:R-SPO-432142 Platelet sensitization by LDL
Reactome:R-BTA-9634635 Estrogen-stimulated signaling through PRKCZ
Reactome:R-SCE-432142 Platelet sensitization by LDL
Reactome:R-MMU-9009391 Extra-nuclear estrogen signaling
Reactome:R-HSA-9634635 Estrogen-stimulated signaling through PRKCZ
Reactome:R-HSA-9627069 Regulation of the apoptosome activity
Reactome:R-BTA-74160 Gene expression (Transcription)
Reactome:R-BTA-73857 RNA Polymerase II Transcription
Reactome:R-BTA-1640170 Cell Cycle
Reactome:R-BTA-422475 Axon guidance
Reactome:R-BTA-375165 NCAM signaling for neurite out-growth
Reactome:R-BTA-437239 Recycling pathway of L1
Reactome:R-BTA-1181150 Signaling by NODAL
Reactome:R-BTA-168256 Immune System
Reactome:R-BTA-168898 Toll-like Receptor Cascades
Reactome:R-BTA-198753 ERK/MAPK targets
Reactome:R-BTA-168164 Toll Like Receptor 3 (TLR3) Cascade
Reactome:R-BTA-975155 MyD88 dependent cascade initiated on endosome
Reactome:R-BTA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Reactome:R-BTA-168179 Toll Like Receptor TLR1:TLR2 Cascade
Reactome:R-BTA-2029482 Regulation of actin dynamics for phagocytic cup formation
Reactome:R-BTA-2454202 Fc epsilon receptor (FCERI) signaling
Reactome:R-BTA-913531 Interferon Signaling
Reactome:R-BTA-449147 Signaling by Interleukins
Reactome:R-BTA-448424 Interleukin-17 signaling
Reactome:R-BTA-109606 Intrinsic Pathway for Apoptosis
Reactome:R-BTA-111458 Formation of apoptosome
Reactome:R-BTA-8953897 Cellular responses to stimuli
Reactome:R-BTA-2262752 Cellular responses to stress
Reactome:R-BTA-2559583 Cellular Senescence
Reactome:R-BTA-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-BTA-5654738 Signaling by FGFR2
Reactome:R-BTA-5654732 Negative regulation of FGFR3 signaling
Reactome:R-BTA-187687 Signalling to ERKs
Reactome:R-BTA-170968 Frs2-mediated activation
Reactome:R-BTA-170834 Signaling by TGF-beta Receptor Complex
Reactome:R-BTA-418594 G alpha (i) signalling events
Reactome:R-BTA-112043 PLC beta mediated events
Reactome:R-BTA-8939211 ESR-mediated signaling
Reactome:R-BTA-5673001 RAF/MAP kinase cascade
Reactome:R-BTA-5663213 RHO GTPases Activate WASPs and WAVEs
Reactome:R-CEL-68875 Mitotic Prophase
Reactome:R-CEL-432142 Platelet sensitization by LDL
Reactome:R-CEL-418592 ADP signalling through P2Y purinoceptor 1
Reactome:R-CEL-168142 Toll Like Receptor 10 (TLR10) Cascade
Reactome:R-CEL-975155 MyD88 dependent cascade initiated on endosome
Reactome:R-CEL-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Reactome:R-CEL-168179 Toll Like Receptor TLR1:TLR2 Cascade
Reactome:R-CEL-2029482 Regulation of actin dynamics for phagocytic cup formation
Reactome:R-CEL-2454202 Fc epsilon receptor (FCERI) signaling
Reactome:R-CEL-8953897 Cellular responses to stimuli
Reactome:R-CEL-3371556 Cellular response to heat stress
Reactome:R-CEL-3371453 Regulation of HSF1-mediated heat shock response
Reactome:R-CEL-5654736 Signaling by FGFR1
Reactome:R-CEL-5654727 Negative regulation of FGFR2 signaling
Reactome:R-CEL-187687 Signalling to ERKs
Reactome:R-CEL-9006936 Signaling by TGFB family members
Reactome:R-CEL-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Reactome:R-CEL-388396 GPCR downstream signalling
Reactome:R-CEL-5683057 MAPK family signaling cascades
Reactome:R-CEL-5674135 MAP2K and MAPK activation
Reactome:R-CEL-112409 RAF-independent MAPK1/3 activation
Reactome:R-CEL-422475 Axon guidance
Reactome:R-CFA-76002 Platelet activation, signaling and aggregation
Reactome:R-CFA-418592 ADP signalling through P2Y purinoceptor 1
Reactome:R-CFA-162582 Signaling Pathways
Reactome:R-DRE-5684996 ERK1/ERK2 pathway
Reactome:R-DRE-5675221 Negative regulation of MAPK pathway
Reactome:R-DRE-73887 Death Receptor Signaling
Reactome:R-DRE-1280215 Cytokine Signaling in Immune system
Reactome:R-DRE-449147 Signaling by Interleukins
Reactome:R-DDI-2559582 Senescence-Associated Secretory Phenotype (SASP)
Reactome:R-DDI-166520 Signaling by NTRKs
Reactome:R-DDI-202670 ERKs are inactivated
Reactome:R-DDI-416476 G alpha (q) signalling events
Reactome:R-DDI-168256 Immune System
Reactome:R-DDI-168898 Toll-like Receptor Cascades
Reactome:R-DDI-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
Reactome:R-DDI-166016 Toll Like Receptor 4 (TLR4) Cascade
Reactome:R-DDI-181438 Toll Like Receptor 2 (TLR2) Cascade
Reactome:R-DDI-448424 Interleukin-17 signaling
Reactome:R-DME-168256 Immune System
Reactome:R-DME-168898 Toll-like Receptor Cascades
Reactome:R-DME-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Reactome:R-DME-202670 ERKs are inactivated
Reactome:R-DME-168176 Toll Like Receptor 5 (TLR5) Cascade
Reactome:R-DME-166016 Toll Like Receptor 4 (TLR4) Cascade
Reactome:R-DME-181438 Toll Like Receptor 2 (TLR2) Cascade
Reactome:R-DME-2029482 Regulation of actin dynamics for phagocytic cup formation
Reactome:R-DME-2454202 Fc epsilon receptor (FCERI) signaling
Reactome:R-DME-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-DME-5654743 Signaling by FGFR4
Reactome:R-DME-166520 Signaling by NTRKs
Reactome:R-DME-74751 Insulin receptor signalling cascade
Reactome:R-DME-170834 Signaling by TGF-beta Receptor Complex
Reactome:R-DME-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Reactome:R-DME-1502540 Signaling by Activin
Reactome:R-DME-9006931 Signaling by Nuclear Receptors
Reactome:R-DME-194315 Signaling by Rho GTPases
Reactome:R-DME-5663213 RHO GTPases Activate WASPs and WAVEs
Reactome:R-DME-73887 Death Receptor Signaling
Reactome:R-DME-204998 Cell death signalling via NRAGE, NRIF and NADE
Reactome:R-DME-2559583 Cellular Senescence
Reactome:R-DME-2559582 Senescence-Associated Secretory Phenotype (SASP)
Reactome:R-DME-69278 Cell Cycle, Mitotic
Reactome:R-DME-68875 Mitotic Prophase
Reactome:R-DME-1266738 Developmental Biology
Reactome:R-DME-373760 L1CAM interactions
Reactome:R-DME-209425 Transcriptional activtion by AP-1 transcription factor
Reactome:R-GGA-5683057 MAPK family signaling cascades
Reactome:R-HSA-422475 Axon guidance
Reactome:R-HSA-445144 Signal transduction by L1
Reactome:R-HSA-109606 Intrinsic Pathway for Apoptosis
Reactome:R-HSA-111471 Apoptotic factor-mediated response
Reactome:R-HSA-5693532 DNA Double-Strand Break Repair
Reactome:R-HSA-5654738 Signaling by FGFR2
Reactome:R-HSA-5654732 Negative regulation of FGFR3 signaling
Reactome:R-HSA-9006936 Signaling by TGFB family members
Reactome:R-HSA-112040 G-protein mediated events
Reactome:R-HSA-4086398 Ca2+ pathway
Reactome:R-HSA-5683057 MAPK family signaling cascades
Reactome:R-HSA-112409 RAF-independent MAPK1/3 activation
Reactome:R-HSA-9006925 Intracellular signaling by second messengers
Reactome:R-HSA-199418 Negative regulation of the PI3K/AKT network
Reactome:R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs
Reactome:R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE
Reactome:R-HSA-2559585 Oncogene Induced Senescence
Reactome:R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
Reactome:R-HSA-112315 Transmission across Chemical Synapses
Reactome:R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
Reactome:R-HSA-442755 Activation of NMDA receptors and postsynaptic events
Reactome:R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization
Reactome:R-HSA-1643685 Disease
Reactome:R-HSA-74160 Gene expression (Transcription)
Reactome:R-HSA-73857 RNA Polymerase II Transcription
Reactome:R-HSA-8941326 RUNX2 regulates bone development
Reactome:R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade
Reactome:R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
Reactome:R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
Reactome:R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling
Reactome:R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
Reactome:R-HSA-446652 Interleukin-1 family signaling
Reactome:R-HSA-448424 Interleukin-17 signaling
Reactome:R-MMU-1640170 Cell Cycle
Reactome:R-MMU-168256 Immune System
Reactome:R-MMU-168249 Innate Immune System
Reactome:R-MMU-975871 MyD88 cascade initiated on plasma membrane
Reactome:R-MMU-450294 MAP kinase activation
Reactome:R-MMU-450282 MAPK targets/ Nuclear events mediated by MAP kinases
Reactome:R-MMU-450341 Activation of the AP-1 family of transcription factors
Reactome:R-MMU-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
Reactome:R-MMU-181438 Toll Like Receptor 2 (TLR2) Cascade
Reactome:R-MMU-913531 Interferon Signaling
Reactome:R-MMU-449147 Signaling by Interleukins
Reactome:R-MMU-9007892 Interleukin-38 signaling
Reactome:R-MMU-448424 Interleukin-17 signaling
Reactome:R-MMU-76002 Platelet activation, signaling and aggregation
Reactome:R-MMU-418592 ADP signalling through P2Y purinoceptor 1
Reactome:R-MMU-5357801 Programmed Cell Death
Reactome:R-MMU-111446 Activation of BIM and translocation to mitochondria
Reactome:R-MMU-2559580 Oxidative Stress Induced Senescence
Reactome:R-MMU-74160 Gene expression (Transcription)
Reactome:R-MMU-73857 RNA Polymerase II Transcription
Reactome:R-MMU-162582 Signaling Pathways
Reactome:R-MMU-190236 Signaling by FGFR
Reactome:R-MMU-5654726 Negative regulation of FGFR1 signaling
Reactome:R-MMU-5654727 Negative regulation of FGFR2 signaling
Reactome:R-MMU-166520 Signaling by NTRKs
Reactome:R-MMU-388396 GPCR downstream signalling
Reactome:R-MMU-111885 Opioid Signalling
Reactome:R-MMU-111996 Ca-dependent events
Reactome:R-MMU-4086398 Ca2+ pathway
Reactome:R-MMU-8939211 ESR-mediated signaling
Reactome:R-MMU-5673001 RAF/MAP kinase cascade
Reactome:R-MMU-112411 MAPK1 (ERK2) activation
Reactome:R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs
Reactome:R-MMU-193648 NRAGE signals death through JNK
Reactome:R-RNO-68886 M Phase
Reactome:R-RNO-73728 RNA Polymerase I Promoter Opening
Reactome:R-RNO-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
Reactome:R-RNO-2559585 Oncogene Induced Senescence
Reactome:R-RNO-2559582 Senescence-Associated Secretory Phenotype (SASP)
Reactome:R-RNO-162582 Signaling Pathways
Reactome:R-RNO-190236 Signaling by FGFR
Reactome:R-RNO-5654726 Negative regulation of FGFR1 signaling
Reactome:R-RNO-5654727 Negative regulation of FGFR2 signaling
Reactome:R-RNO-166520 Signaling by NTRKs
Reactome:R-RNO-198753 ERK/MAPK targets
Reactome:R-RNO-9006936 Signaling by TGFB family members
Reactome:R-RNO-372790 Signaling by GPCR
Reactome:R-RNO-111995 phospho-PLA2 pathway
Reactome:R-RNO-416476 G alpha (q) signalling events
Reactome:R-RNO-4086398 Ca2+ pathway
Reactome:R-RNO-9006931 Signaling by Nuclear Receptors
Reactome:R-RNO-5687128 MAPK6/MAPK4 signaling
Reactome:R-RNO-194315 Signaling by Rho GTPases
Reactome:R-RNO-73887 Death Receptor Signaling
Reactome:R-RNO-193704 p75 NTR receptor-mediated signalling
Reactome:R-RNO-73894 DNA Repair
Reactome:R-RNO-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Reactome:R-RNO-109582 Hemostasis
Reactome:R-RNO-432142 Platelet sensitization by LDL
Reactome:R-RNO-392518 Signal amplification
Reactome:R-RNO-109606 Intrinsic Pathway for Apoptosis
Reactome:R-RNO-168898 Toll-like Receptor Cascades
Reactome:R-RNO-450341 Activation of the AP-1 family of transcription factors
Reactome:R-RNO-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
Reactome:R-RNO-168188 Toll Like Receptor TLR6:TLR2 Cascade
Reactome:R-RNO-2871796 FCERI mediated MAPK activation
Reactome:R-RNO-446652 Interleukin-1 family signaling
Reactome:R-RNO-1266738 Developmental Biology
Reactome:R-RNO-445144 Signal transduction by L1
Reactome:R-SCE-418346 Platelet homeostasis
Reactome:R-SCE-76002 Platelet activation, signaling and aggregation
Reactome:R-SCE-8953897 Cellular responses to stimuli
Reactome:R-SCE-2559582 Senescence-Associated Secretory Phenotype (SASP)
Reactome:R-SCE-975871 MyD88 cascade initiated on plasma membrane
Reactome:R-SCE-450282 MAPK targets/ Nuclear events mediated by MAP kinases
Reactome:R-SCE-168176 Toll Like Receptor 5 (TLR5) Cascade
Reactome:R-SCE-168138 Toll Like Receptor 9 (TLR9) Cascade
Reactome:R-SCE-937061 TRIF (TICAM1)-mediated TLR4 signaling
Reactome:R-SCE-448424 Interleukin-17 signaling
Reactome:R-SCE-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-SCE-198725 Nuclear Events (kinase and transcription factor activation)
Reactome:R-SCE-1640170 Cell Cycle
Reactome:R-SPO-168142 Toll Like Receptor 10 (TLR10) Cascade
Reactome:R-SPO-450341 Activation of the AP-1 family of transcription factors
Reactome:R-SPO-975155 MyD88 dependent cascade initiated on endosome
Reactome:R-SPO-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Reactome:R-SPO-168179 Toll Like Receptor TLR1:TLR2 Cascade
Reactome:R-SPO-69620 Cell Cycle Checkpoints
Reactome:R-SPO-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Reactome:R-SPO-187037 Signaling by NTRK1 (TRKA)
Reactome:R-SPO-388396 GPCR downstream signalling
Reactome:R-SPO-416476 G alpha (q) signalling events
Reactome:R-SPO-195721 Signaling by WNT
Reactome:R-SPO-194315 Signaling by Rho GTPases
Reactome:R-SPO-5668599 RHO GTPases Activate NADPH Oxidases
Reactome:R-BTA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
Reactome:R-BTA-162658 Golgi Cisternae Pericentriolar Stack Reorganization
Reactome:R-BTA-1266738 Developmental Biology
Reactome:R-BTA-373760 L1CAM interactions
Reactome:R-BTA-168249 Innate Immune System
Reactome:R-BTA-975871 MyD88 cascade initiated on plasma membrane
Reactome:R-BTA-450294 MAP kinase activation
Reactome:R-BTA-450282 MAPK targets/ Nuclear events mediated by MAP kinases
Reactome:R-BTA-450341 Activation of the AP-1 family of transcription factors
Reactome:R-BTA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
Reactome:R-BTA-181438 Toll Like Receptor 2 (TLR2) Cascade
Reactome:R-BTA-1280215 Cytokine Signaling in Immune system
Reactome:R-BTA-877300 Interferon gamma signaling
Reactome:R-BTA-109581 Apoptosis
Reactome:R-BTA-111461 Cytochrome c-mediated apoptotic response
Reactome:R-BTA-3371556 Cellular response to heat stress
Reactome:R-BTA-3371453 Regulation of HSF1-mediated heat shock response
Reactome:R-BTA-162582 Signaling Pathways
Reactome:R-BTA-5654736 Signaling by FGFR1
Reactome:R-BTA-1295596 Spry regulation of FGF signaling
Reactome:R-BTA-5654741 Signaling by FGFR3
Reactome:R-BTA-169893 Prolonged ERK activation events
Reactome:R-BTA-198765 Signalling to ERK5
Reactome:R-BTA-9006936 Signaling by TGFB family members
Reactome:R-BTA-372790 Signaling by GPCR
Reactome:R-BTA-112040 G-protein mediated events
Reactome:R-BTA-881907 Gastrin-CREB signalling pathway via PKC and MAPK
Reactome:R-BTA-5684996 ERK1/ERK2 pathway
Reactome:R-BTA-5675221 Negative regulation of MAPK pathway
Reactome:R-BTA-1257604 PI3K/AKT Signaling
Reactome:R-BTA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Reactome:R-BTA-195258 RHO GTPase Effectors
Reactome:R-BTA-5668599 RHO GTPases Activate NADPH Oxidases
Reactome:R-CEL-69278 Cell Cycle, Mitotic
Reactome:R-CEL-68886 M Phase
Reactome:R-CEL-392518 Signal amplification
Reactome:R-CEL-168256 Immune System
Reactome:R-CEL-168898 Toll-like Receptor Cascades
Reactome:R-CEL-202670 ERKs are inactivated
Reactome:R-CEL-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
Reactome:R-CEL-166016 Toll Like Receptor 4 (TLR4) Cascade
Reactome:R-CEL-181438 Toll Like Receptor 2 (TLR2) Cascade
Reactome:R-CEL-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
Reactome:R-CEL-913531 Interferon Signaling
Reactome:R-CEL-448424 Interleukin-17 signaling
Reactome:R-CEL-2559582 Senescence-Associated Secretory Phenotype (SASP)
Reactome:R-CEL-190236 Signaling by FGFR
Reactome:R-CEL-5654738 Signaling by FGFR2
Reactome:R-CEL-187037 Signaling by NTRK1 (TRKA)
Reactome:R-CEL-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Reactome:R-CEL-881907 Gastrin-CREB signalling pathway via PKC and MAPK
Reactome:R-CEL-9006931 Signaling by Nuclear Receptors
Reactome:R-CEL-194315 Signaling by Rho GTPases
Reactome:R-CEL-5663213 RHO GTPases Activate WASPs and WAVEs
Reactome:R-CEL-1266738 Developmental Biology
Reactome:R-CEL-445144 Signal transduction by L1
Reactome:R-CEL-212436 Generic Transcription Pathway
Reactome:R-CFA-418346 Platelet homeostasis
Reactome:R-CFA-195721 Signaling by WNT
Reactome:R-DRE-162582 Signaling Pathways
Reactome:R-DRE-5683057 MAPK family signaling cascades
Reactome:R-DRE-193704 p75 NTR receptor-mediated signalling
Reactome:R-DRE-5693606 DNA Double Strand Break Response
Reactome:R-DRE-168256 Immune System
Reactome:R-DDI-2262752 Cellular responses to stress
Reactome:R-DDI-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-DDI-198753 ERK/MAPK targets
Reactome:R-DDI-372790 Signaling by GPCR
Reactome:R-DDI-168249 Innate Immune System
Reactome:R-DDI-450294 MAP kinase activation
Reactome:R-DDI-168176 Toll Like Receptor 5 (TLR5) Cascade
Reactome:R-DDI-168138 Toll Like Receptor 9 (TLR9) Cascade
Reactome:R-DDI-937061 TRIF (TICAM1)-mediated TLR4 signaling
Reactome:R-DME-168249 Innate Immune System
Reactome:R-DME-975871 MyD88 cascade initiated on plasma membrane
Reactome:R-DME-450294 MAP kinase activation
Reactome:R-DME-198753 ERK/MAPK targets
Reactome:R-DME-168164 Toll Like Receptor 3 (TLR3) Cascade
Reactome:R-DME-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Reactome:R-DME-168138 Toll Like Receptor 9 (TLR9) Cascade
Reactome:R-DME-937061 TRIF (TICAM1)-mediated TLR4 signaling
Reactome:R-DME-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
Reactome:R-DME-913531 Interferon Signaling
Reactome:R-DME-446652 Interleukin-1 family signaling
Reactome:R-DME-448424 Interleukin-17 signaling
Reactome:R-DME-162582 Signaling Pathways
Reactome:R-DME-5654736 Signaling by FGFR1
Reactome:R-DME-5654738 Signaling by FGFR2
Reactome:R-DME-5654732 Negative regulation of FGFR3 signaling
Reactome:R-DME-5654733 Negative regulation of FGFR4 signaling
Reactome:R-DME-74752 Signaling by Insulin receptor
Reactome:R-DME-9006936 Signaling by TGFB family members
Reactome:R-DME-388396 GPCR downstream signalling
Reactome:R-DME-416476 G alpha (q) signalling events
Reactome:R-DME-8939211 ESR-mediated signaling
Reactome:R-DME-5673001 RAF/MAP kinase cascade
Reactome:R-DME-112411 MAPK1 (ERK2) activation
Reactome:R-DME-193704 p75 NTR receptor-mediated signalling
Reactome:R-DME-8953897 Cellular responses to stimuli
Reactome:R-DME-3371556 Cellular response to heat stress
Reactome:R-DME-3371453 Regulation of HSF1-mediated heat shock response
Reactome:R-DME-68886 M Phase
Reactome:R-DME-375165 NCAM signaling for neurite out-growth
Reactome:R-DME-1181150 Signaling by NODAL
Reactome:R-DME-109582 Hemostasis
Reactome:R-DME-76002 Platelet activation, signaling and aggregation
Reactome:R-DME-209459 Imd pathway
Reactome:R-DME-209409 Formation of the nuclear AP-1 transcription factor 'scaffolding complex'
Reactome:R-DME-450724 JNK signalling
Reactome:R-GGA-5687128 MAPK6/MAPK4 signaling
Reactome:R-HSA-1266738 Developmental Biology
Reactome:R-HSA-1181150 Signaling by NODAL
Reactome:R-HSA-76002 Platelet activation, signaling and aggregation
Reactome:R-HSA-418592 ADP signalling through P2Y purinoceptor 1
Reactome:R-HSA-139910 Activation of BMF and translocation to mitochondria
Reactome:R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Reactome:R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-HSA-5654736 Signaling by FGFR1
Reactome:R-HSA-1295596 Spry regulation of FGF signaling
Reactome:R-HSA-5654741 Signaling by FGFR3
Reactome:R-HSA-198765 Signalling to ERK5
Reactome:R-HSA-202670 ERKs are inactivated
Reactome:R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
Reactome:R-HSA-372790 Signaling by GPCR
Reactome:R-HSA-111995 phospho-PLA2 pathway
Reactome:R-HSA-195721 Signaling by WNT
Reactome:R-HSA-3858494 Beta-catenin independent WNT signaling
Reactome:R-HSA-9006931 Signaling by Nuclear Receptors
Reactome:R-HSA-5687128 MAPK6/MAPK4 signaling
Reactome:R-HSA-8943724 Regulation of PTEN gene transcription
Reactome:R-HSA-195258 RHO GTPase Effectors
Reactome:R-HSA-5668599 RHO GTPases Activate NADPH Oxidases
Reactome:R-HSA-2262752 Cellular responses to stress
Reactome:R-HSA-2559583 Cellular Senescence
Reactome:R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Reactome:R-HSA-1640170 Cell Cycle
Reactome:R-HSA-68875 Mitotic Prophase
Reactome:R-HSA-73728 RNA Polymerase I Promoter Opening
Reactome:R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade
Reactome:R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Reactome:R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
Reactome:R-HSA-166166 MyD88-independent TLR4 cascade
Reactome:R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
Reactome:R-HSA-2871796 FCERI mediated MAPK activation
Reactome:R-HSA-913531 Interferon Signaling
Reactome:R-HSA-449147 Signaling by Interleukins
Reactome:R-HSA-9007892 Interleukin-38 signaling
Reactome:R-MMU-162658 Golgi Cisternae Pericentriolar Stack Reorganization
Reactome:R-MMU-168142 Toll Like Receptor 10 (TLR10) Cascade
Reactome:R-MMU-168176 Toll Like Receptor 5 (TLR5) Cascade
Reactome:R-MMU-166016 Toll Like Receptor 4 (TLR4) Cascade
Reactome:R-MMU-937061 TRIF (TICAM1)-mediated TLR4 signaling
Reactome:R-MMU-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
Reactome:R-MMU-1280215 Cytokine Signaling in Immune system
Reactome:R-MMU-877300 Interferon gamma signaling
Reactome:R-MMU-5693606 DNA Double Strand Break Response
Reactome:R-MMU-418346 Platelet homeostasis
Reactome:R-MMU-375165 NCAM signaling for neurite out-growth
Reactome:R-MMU-437239 Recycling pathway of L1
Reactome:R-MMU-1181150 Signaling by NODAL
Reactome:R-MMU-109606 Intrinsic Pathway for Apoptosis
Reactome:R-MMU-2559585 Oncogene Induced Senescence
Reactome:R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP)
Reactome:R-MMU-73728 RNA Polymerase I Promoter Opening
Reactome:R-MMU-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
Reactome:R-MMU-5654743 Signaling by FGFR4
Reactome:R-MMU-5654733 Negative regulation of FGFR4 signaling
Reactome:R-MMU-187037 Signaling by NTRK1 (TRKA)
Reactome:R-MMU-198725 Nuclear Events (kinase and transcription factor activation)
Reactome:R-MMU-1502540 Signaling by Activin
Reactome:R-MMU-418594 G alpha (i) signalling events
Reactome:R-MMU-112043 PLC beta mediated events
Reactome:R-MMU-881907 Gastrin-CREB signalling pathway via PKC and MAPK
Reactome:R-MMU-3858494 Beta-catenin independent WNT signaling
Reactome:R-MMU-5684996 ERK1/ERK2 pathway
Reactome:R-MMU-5675221 Negative regulation of MAPK pathway
Reactome:R-MMU-110056 MAPK3 (ERK1) activation
Reactome:R-MMU-1257604 PI3K/AKT Signaling
Reactome:R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Reactome:R-MMU-195258 RHO GTPase Effectors
Reactome:R-MMU-5668599 RHO GTPases Activate NADPH Oxidases
Reactome:R-MMU-204998 Cell death signalling via NRAGE, NRIF and NADE
Reactome:R-RNO-1640170 Cell Cycle
Reactome:R-RNO-73854 RNA Polymerase I Promoter Clearance
Reactome:R-RNO-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Reactome:R-RNO-8953897 Cellular responses to stimuli
Reactome:R-RNO-2262752 Cellular responses to stress
Reactome:R-RNO-2559583 Cellular Senescence
Reactome:R-RNO-5654743 Signaling by FGFR4
Reactome:R-RNO-5654733 Negative regulation of FGFR4 signaling
Reactome:R-RNO-187037 Signaling by NTRK1 (TRKA)
Reactome:R-RNO-198725 Nuclear Events (kinase and transcription factor activation)
Reactome:R-RNO-388396 GPCR downstream signalling
Reactome:R-RNO-111885 Opioid Signalling
Reactome:R-RNO-111996 Ca-dependent events
Reactome:R-RNO-881907 Gastrin-CREB signalling pathway via PKC and MAPK
Reactome:R-RNO-3858494 Beta-catenin independent WNT signaling
Reactome:R-RNO-8939211 ESR-mediated signaling
Reactome:R-RNO-5673001 RAF/MAP kinase cascade
Reactome:R-RNO-112411 MAPK1 (ERK2) activation
Reactome:R-RNO-5663213 RHO GTPases Activate WASPs and WAVEs
Reactome:R-RNO-193648 NRAGE signals death through JNK
Reactome:R-RNO-111471 Apoptotic factor-mediated response
Reactome:R-RNO-168256 Immune System
Reactome:R-RNO-168249 Innate Immune System
Reactome:R-RNO-975871 MyD88 cascade initiated on plasma membrane
Reactome:R-RNO-450294 MAP kinase activation
Reactome:R-RNO-450282 MAPK targets/ Nuclear events mediated by MAP kinases
Reactome:R-RNO-168176 Toll Like Receptor 5 (TLR5) Cascade
Reactome:R-RNO-166016 Toll Like Receptor 4 (TLR4) Cascade
Reactome:R-RNO-937061 TRIF (TICAM1)-mediated TLR4 signaling
Reactome:R-RNO-168179 Toll Like Receptor TLR1:TLR2 Cascade
Reactome:R-RNO-2029482 Regulation of actin dynamics for phagocytic cup formation
Reactome:R-RNO-2454202 Fc epsilon receptor (FCERI) signaling
Reactome:R-RNO-913531 Interferon Signaling
Reactome:R-RNO-449147 Signaling by Interleukins
Reactome:R-RNO-9007892 Interleukin-38 signaling
Reactome:R-RNO-448424 Interleukin-17 signaling
Reactome:R-SCE-109582 Hemostasis
Reactome:R-SCE-168142 Toll Like Receptor 10 (TLR10) Cascade
Reactome:R-SCE-168164 Toll Like Receptor 3 (TLR3) Cascade
Reactome:R-SCE-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Reactome:R-SCE-166166 MyD88-independent TLR4 cascade
Reactome:R-SCE-168188 Toll Like Receptor TLR6:TLR2 Cascade
Reactome:R-SCE-449147 Signaling by Interleukins
Reactome:R-SCE-162582 Signaling Pathways
Reactome:R-SCE-198765 Signalling to ERK5
Reactome:R-SCE-388396 GPCR downstream signalling
Reactome:R-SCE-881907 Gastrin-CREB signalling pathway via PKC and MAPK
Reactome:R-SCE-69613 p53-Independent G1/S DNA Damage Checkpoint
Reactome:R-SPO-168898 Toll-like Receptor Cascades
Reactome:R-SPO-202670 ERKs are inactivated
Reactome:R-SPO-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
Reactome:R-SPO-166016 Toll Like Receptor 4 (TLR4) Cascade
Reactome:R-SPO-181438 Toll Like Receptor 2 (TLR2) Cascade
Reactome:R-SPO-449147 Signaling by Interleukins
Reactome:R-SPO-1640170 Cell Cycle
Reactome:R-SPO-2262752 Cellular responses to stress
Reactome:R-SPO-166520 Signaling by NTRKs
Reactome:R-SPO-372790 Signaling by GPCR
Reactome:R-SPO-5687128 MAPK6/MAPK4 signaling
Reactome:R-BTA-212436 Generic Transcription Pathway
Reactome:R-BTA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Reactome:R-BTA-68886 M Phase
Reactome:R-BTA-202670 ERKs are inactivated
Reactome:R-BTA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Reactome:R-BTA-168138 Toll Like Receptor 9 (TLR9) Cascade
Reactome:R-BTA-166166 MyD88-independent TLR4 cascade
Reactome:R-BTA-168188 Toll Like Receptor TLR6:TLR2 Cascade
Reactome:R-BTA-2871796 FCERI mediated MAPK activation
Reactome:R-BTA-2559585 Oncogene Induced Senescence
Reactome:R-BTA-2559582 Senescence-Associated Secretory Phenotype (SASP)
Reactome:R-BTA-5654743 Signaling by FGFR4
Reactome:R-BTA-5654733 Negative regulation of FGFR4 signaling
Reactome:R-BTA-187037 Signaling by NTRK1 (TRKA)
Reactome:R-BTA-198725 Nuclear Events (kinase and transcription factor activation)
Reactome:R-BTA-1502540 Signaling by Activin
Reactome:R-BTA-388396 GPCR downstream signalling
Reactome:R-BTA-111885 Opioid Signalling
Reactome:R-BTA-111996 Ca-dependent events
Reactome:R-BTA-9006931 Signaling by Nuclear Receptors
Reactome:R-BTA-194315 Signaling by Rho GTPases
Reactome:R-CEL-1640170 Cell Cycle
Reactome:R-CEL-162658 Golgi Cisternae Pericentriolar Stack Reorganization
Reactome:R-CEL-109582 Hemostasis
Reactome:R-CEL-76002 Platelet activation, signaling and aggregation
Reactome:R-CEL-456926 Thrombin signalling through proteinase activated receptors (PARs)
Reactome:R-CEL-975871 MyD88 cascade initiated on plasma membrane
Reactome:R-CEL-450282 MAPK targets/ Nuclear events mediated by MAP kinases
Reactome:R-CEL-168164 Toll Like Receptor 3 (TLR3) Cascade
Reactome:R-CEL-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Reactome:R-CEL-166166 MyD88-independent TLR4 cascade
Reactome:R-CEL-168188 Toll Like Receptor TLR6:TLR2 Cascade
Reactome:R-CEL-2871796 FCERI mediated MAPK activation
Reactome:R-CEL-877300 Interferon gamma signaling
Reactome:R-CEL-2559583 Cellular Senescence
Reactome:R-CEL-162582 Signaling Pathways
Reactome:R-CEL-5654741 Signaling by FGFR3
Reactome:R-CEL-5654732 Negative regulation of FGFR3 signaling
Reactome:R-CEL-198725 Nuclear Events (kinase and transcription factor activation)
Reactome:R-CEL-170834 Signaling by TGF-beta Receptor Complex
Reactome:R-CEL-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
Reactome:R-CEL-195721 Signaling by WNT
Reactome:R-CEL-5684996 ERK1/ERK2 pathway
Reactome:R-CEL-5675221 Negative regulation of MAPK pathway
Reactome:R-CEL-110056 MAPK3 (ERK1) activation
Reactome:R-CEL-195258 RHO GTPase Effectors
Reactome:R-CEL-375165 NCAM signaling for neurite out-growth
Reactome:R-CEL-373760 L1CAM interactions
Reactome:R-CEL-74160 Gene expression (Transcription)
Reactome:R-CFA-3858494 Beta-catenin independent WNT signaling
Reactome:R-DRE-5673001 RAF/MAP kinase cascade
Reactome:R-DRE-204998 Cell death signalling via NRAGE, NRIF and NADE
Reactome:R-DRE-73894 DNA Repair
Reactome:R-DRE-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Reactome:R-DRE-446652 Interleukin-1 family signaling
Reactome:R-DRE-9007892 Interleukin-38 signaling
Reactome:R-DDI-8953897 Cellular responses to stimuli
Reactome:R-DDI-187037 Signaling by NTRK1 (TRKA)
Reactome:R-DDI-881907 Gastrin-CREB signalling pathway via PKC and MAPK
Reactome:R-DDI-168142 Toll Like Receptor 10 (TLR10) Cascade
Reactome:R-DDI-450282 MAPK targets/ Nuclear events mediated by MAP kinases
Reactome:R-DDI-975155 MyD88 dependent cascade initiated on endosome
Reactome:R-DDI-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Reactome:R-DDI-168179 Toll Like Receptor TLR1:TLR2 Cascade
Reactome:R-DDI-1280215 Cytokine Signaling in Immune system
Reactome:R-DDI-449147 Signaling by Interleukins
Reactome:R-DME-5357801 Programmed Cell Death
Reactome:R-DME-109606 Intrinsic Pathway for Apoptosis
Reactome:R-DME-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
Reactome:R-DME-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Reactome:R-DME-168179 Toll Like Receptor TLR1:TLR2 Cascade
Reactome:R-DME-2871796 FCERI mediated MAPK activation
Reactome:R-DME-877300 Interferon gamma signaling
Reactome:R-DME-5654726 Negative regulation of FGFR1 signaling
Reactome:R-DME-5654727 Negative regulation of FGFR2 signaling
Reactome:R-DME-187037 Signaling by NTRK1 (TRKA)
Reactome:R-DME-74749 Signal attenuation
Reactome:R-DME-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Reactome:R-DME-372790 Signaling by GPCR
Reactome:R-DME-5683057 MAPK family signaling cascades
Reactome:R-DME-5674135 MAP2K and MAPK activation
Reactome:R-DME-112409 RAF-independent MAPK1/3 activation
Reactome:R-DME-193648 NRAGE signals death through JNK
Reactome:R-DME-2262752 Cellular responses to stress
Reactome:R-DME-2559585 Oncogene Induced Senescence
Reactome:R-DME-162658 Golgi Cisternae Pericentriolar Stack Reorganization
Reactome:R-DME-422475 Axon guidance
Reactome:R-DME-437239 Recycling pathway of L1
Reactome:R-DME-74160 Gene expression (Transcription)
Reactome:R-DME-73857 RNA Polymerase II Transcription
Reactome:R-DME-392518 Signal amplification
Reactome:R-DME-5252538 Drosophila signaling pathways
Reactome:R-DME-350431 Planar Cell Polarity pathway
Reactome:R-DME-450736 Activation of Downstream Effectors
Reactome:R-HSA-375165 NCAM signaling for neurite out-growth
Reactome:R-HSA-373760 L1CAM interactions
Reactome:R-HSA-109582 Hemostasis
Reactome:R-HSA-432142 Platelet sensitization by LDL
Reactome:R-HSA-392518 Signal amplification
Reactome:R-HSA-5357801 Programmed Cell Death
Reactome:R-HSA-111461 Cytochrome c-mediated apoptotic response
Reactome:R-HSA-5693606 DNA Double Strand Break Response
Reactome:R-HSA-5654743 Signaling by FGFR4
Reactome:R-HSA-5654733 Negative regulation of FGFR4 signaling
Reactome:R-HSA-187037 Signaling by NTRK1 (TRKA)
Reactome:R-HSA-187687 Signalling to ERKs
Reactome:R-HSA-169893 Prolonged ERK activation events
Reactome:R-HSA-198725 Nuclear Events (kinase and transcription factor activation)
Reactome:R-HSA-170834 Signaling by TGF-beta Receptor Complex
Reactome:R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Reactome:R-HSA-1502540 Signaling by Activin
Reactome:R-HSA-418594 G alpha (i) signalling events
Reactome:R-HSA-112043 PLC beta mediated events
Reactome:R-HSA-416476 G alpha (q) signalling events
Reactome:R-HSA-5684996 ERK1/ERK2 pathway
Reactome:R-HSA-5675221 Negative regulation of MAPK pathway
Reactome:R-HSA-110056 MAPK3 (ERK1) activation
Reactome:R-HSA-1257604 PI3K/AKT Signaling
Reactome:R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Reactome:R-HSA-194315 Signaling by Rho GTPases
Reactome:R-HSA-193648 NRAGE signals death through JNK
Reactome:R-HSA-2559580 Oxidative Stress Induced Senescence
Reactome:R-HSA-112316 Neuronal System
Reactome:R-HSA-444257 RSK activation
Reactome:R-HSA-69278 Cell Cycle, Mitotic
Reactome:R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
Reactome:R-HSA-73864 RNA Polymerase I Transcription
Reactome:R-HSA-212436 Generic Transcription Pathway
Reactome:R-HSA-8940973 RUNX2 regulates osteoblast differentiation
Reactome:R-HSA-168256 Immune System
Reactome:R-HSA-168249 Innate Immune System
Reactome:R-HSA-975871 MyD88 cascade initiated on plasma membrane
Reactome:R-HSA-450294 MAP kinase activation
Reactome:R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases
Reactome:R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
Reactome:R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
Reactome:R-MMU-68886 M Phase
Reactome:R-MMU-168898 Toll-like Receptor Cascades
Reactome:R-MMU-198753 ERK/MAPK targets
Reactome:R-MMU-168164 Toll Like Receptor 3 (TLR3) Cascade
Reactome:R-MMU-975155 MyD88 dependent cascade initiated on endosome
Reactome:R-MMU-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Reactome:R-MMU-168179 Toll Like Receptor TLR1:TLR2 Cascade
Reactome:R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
Reactome:R-MMU-2454202 Fc epsilon receptor (FCERI) signaling
Reactome:R-MMU-446652 Interleukin-1 family signaling
Reactome:R-MMU-73894 DNA Repair
Reactome:R-MMU-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Reactome:R-MMU-1266738 Developmental Biology
Reactome:R-MMU-445144 Signal transduction by L1
Reactome:R-MMU-109581 Apoptosis
Reactome:R-MMU-114452 Activation of BH3-only proteins
Reactome:R-MMU-139910 Activation of BMF and translocation to mitochondria
Reactome:R-MMU-3371556 Cellular response to heat stress
Reactome:R-MMU-3371453 Regulation of HSF1-mediated heat shock response
Reactome:R-MMU-73864 RNA Polymerase I Transcription
Reactome:R-MMU-212436 Generic Transcription Pathway
Reactome:R-MMU-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Reactome:R-MMU-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-MMU-5654736 Signaling by FGFR1
Reactome:R-MMU-1295596 Spry regulation of FGF signaling
Reactome:R-MMU-5654741 Signaling by FGFR3
Reactome:R-MMU-169893 Prolonged ERK activation events
Reactome:R-MMU-198765 Signalling to ERK5
Reactome:R-MMU-9006936 Signaling by TGFB family members
Reactome:R-MMU-372790 Signaling by GPCR
Reactome:R-MMU-111995 phospho-PLA2 pathway
Reactome:R-MMU-195721 Signaling by WNT
Reactome:R-MMU-9006931 Signaling by Nuclear Receptors
Reactome:R-MMU-5687128 MAPK6/MAPK4 signaling
Reactome:R-MMU-194315 Signaling by Rho GTPases
Reactome:R-MMU-73887 Death Receptor Signaling
Reactome:R-MMU-193704 p75 NTR receptor-mediated signalling
Reactome:R-RNO-69278 Cell Cycle, Mitotic
Reactome:R-RNO-68875 Mitotic Prophase
Reactome:R-RNO-74160 Gene expression (Transcription)
Reactome:R-RNO-73857 RNA Polymerase II Transcription
Reactome:R-RNO-2559580 Oxidative Stress Induced Senescence
Reactome:R-RNO-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-RNO-5654736 Signaling by FGFR1
Reactome:R-RNO-1295596 Spry regulation of FGF signaling
Reactome:R-RNO-5654741 Signaling by FGFR3
Reactome:R-RNO-169893 Prolonged ERK activation events
Reactome:R-RNO-198765 Signalling to ERK5
Reactome:R-RNO-202670 ERKs are inactivated
Reactome:R-RNO-170834 Signaling by TGF-beta Receptor Complex
Reactome:R-RNO-112040 G-protein mediated events
Reactome:R-RNO-195721 Signaling by WNT
Reactome:R-RNO-5683057 MAPK family signaling cascades
Reactome:R-RNO-112409 RAF-independent MAPK1/3 activation
Reactome:R-RNO-9006925 Intracellular signaling by second messengers
Reactome:R-RNO-199418 Negative regulation of the PI3K/AKT network
Reactome:R-RNO-5693532 DNA Double-Strand Break Repair
Reactome:R-RNO-418346 Platelet homeostasis
Reactome:R-RNO-5357801 Programmed Cell Death
Reactome:R-RNO-111446 Activation of BIM and translocation to mitochondria
Reactome:R-RNO-168164 Toll Like Receptor 3 (TLR3) Cascade
Reactome:R-RNO-975155 MyD88 dependent cascade initiated on endosome
Reactome:R-RNO-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Reactome:R-RNO-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
Reactome:R-RNO-422475 Axon guidance
Reactome:R-RNO-373760 L1CAM interactions
Reactome:R-SCE-392518 Signal amplification
Reactome:R-SCE-2559583 Cellular Senescence
Reactome:R-SCE-168249 Innate Immune System
Reactome:R-SCE-450294 MAP kinase activation
Reactome:R-SCE-198753 ERK/MAPK targets
Reactome:R-SCE-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
Reactome:R-SCE-166016 Toll Like Receptor 4 (TLR4) Cascade
Reactome:R-SCE-181438 Toll Like Receptor 2 (TLR2) Cascade
Reactome:R-SCE-166520 Signaling by NTRKs
Reactome:R-SCE-69620 Cell Cycle Checkpoints
Reactome:R-SCE-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Reactome:R-SPO-109582 Hemostasis
Reactome:R-SPO-76002 Platelet activation, signaling and aggregation
Reactome:R-SPO-168256 Immune System
Reactome:R-SPO-975871 MyD88 cascade initiated on plasma membrane
Reactome:R-SPO-450282 MAPK targets/ Nuclear events mediated by MAP kinases
Reactome:R-SPO-168164 Toll Like Receptor 3 (TLR3) Cascade
Reactome:R-SPO-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Reactome:R-SPO-166166 MyD88-independent TLR4 cascade
Reactome:R-SPO-168188 Toll Like Receptor TLR6:TLR2 Cascade
Reactome:R-SPO-69615 G1/S DNA Damage Checkpoints
Reactome:R-SPO-8953897 Cellular responses to stimuli
Reactome:R-SPO-2559583 Cellular Senescence
Reactome:R-SPO-162582 Signaling Pathways
Reactome:R-BTA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Reactome:R-BTA-69278 Cell Cycle, Mitotic
Reactome:R-BTA-68875 Mitotic Prophase
Reactome:R-BTA-168142 Toll Like Receptor 10 (TLR10) Cascade
Reactome:R-BTA-168176 Toll Like Receptor 5 (TLR5) Cascade
Reactome:R-BTA-166016 Toll Like Receptor 4 (TLR4) Cascade
Reactome:R-BTA-937061 TRIF (TICAM1)-mediated TLR4 signaling
Reactome:R-BTA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
Reactome:R-BTA-5357801 Programmed Cell Death
Reactome:R-BTA-111471 Apoptotic factor-mediated response
Reactome:R-BTA-2559580 Oxidative Stress Induced Senescence
Reactome:R-BTA-190236 Signaling by FGFR
Reactome:R-BTA-5654726 Negative regulation of FGFR1 signaling
Reactome:R-BTA-5654727 Negative regulation of FGFR2 signaling
Reactome:R-BTA-166520 Signaling by NTRKs
Reactome:R-BTA-111995 phospho-PLA2 pathway
Reactome:R-BTA-416476 G alpha (q) signalling events
Reactome:R-BTA-5683057 MAPK family signaling cascades
Reactome:R-BTA-112409 RAF-independent MAPK1/3 activation
Reactome:R-BTA-9006925 Intracellular signaling by second messengers
Reactome:R-BTA-199418 Negative regulation of the PI3K/AKT network
Reactome:R-CEL-418346 Platelet homeostasis
Reactome:R-CEL-168249 Innate Immune System
Reactome:R-CEL-450294 MAP kinase activation
Reactome:R-CEL-198753 ERK/MAPK targets
Reactome:R-CEL-168176 Toll Like Receptor 5 (TLR5) Cascade
Reactome:R-CEL-168138 Toll Like Receptor 9 (TLR9) Cascade
Reactome:R-CEL-937061 TRIF (TICAM1)-mediated TLR4 signaling
Reactome:R-CEL-1280215 Cytokine Signaling in Immune system
Reactome:R-CEL-449147 Signaling by Interleukins
Reactome:R-CEL-2262752 Cellular responses to stress
Reactome:R-CEL-2559580 Oxidative Stress Induced Senescence
Reactome:R-CEL-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-CEL-166520 Signaling by NTRKs
Reactome:R-CEL-372790 Signaling by GPCR
Reactome:R-CEL-416476 G alpha (q) signalling events
Reactome:R-CEL-3858494 Beta-catenin independent WNT signaling
Reactome:R-CEL-4086398 Ca2+ pathway
Reactome:R-CEL-8939211 ESR-mediated signaling
Reactome:R-CEL-5673001 RAF/MAP kinase cascade
Reactome:R-CEL-112411 MAPK1 (ERK2) activation
Reactome:R-CEL-437239 Recycling pathway of L1
Reactome:R-CEL-73857 RNA Polymerase II Transcription
Reactome:R-CFA-109582 Hemostasis
Reactome:R-CFA-432142 Platelet sensitization by LDL
Reactome:R-CFA-392518 Signal amplification
Reactome:R-CFA-4086398 Ca2+ pathway
Reactome:R-CFA-1266738 Developmental Biology
Reactome:R-DRE-193648 NRAGE signals death through JNK
Reactome:R-DRE-5693532 DNA Double-Strand Break Repair
Reactome:R-DDI-2559583 Cellular Senescence
Reactome:R-DDI-162582 Signaling Pathways
Reactome:R-DDI-198725 Nuclear Events (kinase and transcription factor activation)
Reactome:R-DDI-388396 GPCR downstream signalling
Reactome:R-DDI-975871 MyD88 cascade initiated on plasma membrane
Reactome:R-DDI-168164 Toll Like Receptor 3 (TLR3) Cascade
Reactome:R-DDI-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Reactome:R-DDI-166166 MyD88-independent TLR4 cascade
Reactome:R-DDI-168188 Toll Like Receptor TLR6:TLR2 Cascade
Reactome:R-DME-109581 Apoptosis
Reactome:R-DME-168142 Toll Like Receptor 10 (TLR10) Cascade
Reactome:R-DME-450282 MAPK targets/ Nuclear events mediated by MAP kinases
Reactome:R-DME-450341 Activation of the AP-1 family of transcription factors
Reactome:R-DME-975155 MyD88 dependent cascade initiated on endosome
Reactome:R-DME-166166 MyD88-independent TLR4 cascade
Reactome:R-DME-168188 Toll Like Receptor TLR6:TLR2 Cascade
Reactome:R-DME-1280215 Cytokine Signaling in Immune system
Reactome:R-DME-449147 Signaling by Interleukins
Reactome:R-DME-9007892 Interleukin-38 signaling
Reactome:R-DME-190236 Signaling by FGFR
Reactome:R-DME-1295596 Spry regulation of FGF signaling
Reactome:R-DME-5654741 Signaling by FGFR3
Reactome:R-DME-187687 Signalling to ERKs
Reactome:R-DME-198725 Nuclear Events (kinase and transcription factor activation)
Reactome:R-DME-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
Reactome:R-DME-881907 Gastrin-CREB signalling pathway via PKC and MAPK
Reactome:R-DME-5684996 ERK1/ERK2 pathway
Reactome:R-DME-5675221 Negative regulation of MAPK pathway
Reactome:R-DME-110056 MAPK3 (ERK1) activation
Reactome:R-DME-195258 RHO GTPase Effectors
Reactome:R-DME-2559580 Oxidative Stress Induced Senescence
Reactome:R-DME-1640170 Cell Cycle
Reactome:R-DME-445144 Signal transduction by L1
Reactome:R-DME-212436 Generic Transcription Pathway
Reactome:R-DME-418592 ADP signalling through P2Y purinoceptor 1
Reactome:R-DME-209397 Formation of the cytosolic BSK 'scaffolding complex'
Reactome:R-GGA-162582 Signaling Pathways
Reactome:R-HSA-437239 Recycling pathway of L1
Reactome:R-HSA-418346 Platelet homeostasis
Reactome:R-HSA-109581 Apoptosis
Reactome:R-HSA-114452 Activation of BH3-only proteins
Reactome:R-HSA-111446 Activation of BIM and translocation to mitochondria
Reactome:R-HSA-111458 Formation of apoptosome
Reactome:R-HSA-73894 DNA Repair
Reactome:R-HSA-162582 Signaling Pathways
Reactome:R-HSA-190236 Signaling by FGFR
Reactome:R-HSA-5654726 Negative regulation of FGFR1 signaling
Reactome:R-HSA-5654727 Negative regulation of FGFR2 signaling
Reactome:R-HSA-166520 Signaling by NTRKs
Reactome:R-HSA-170968 Frs2-mediated activation
Reactome:R-HSA-198753 ERK/MAPK targets
Reactome:R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Reactome:R-HSA-388396 GPCR downstream signalling
Reactome:R-HSA-111885 Opioid Signalling
Reactome:R-HSA-111996 Ca-dependent events
Reactome:R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK
Reactome:R-HSA-8939211 ESR-mediated signaling
Reactome:R-HSA-5673001 RAF/MAP kinase cascade
Reactome:R-HSA-112411 MAPK1 (ERK2) activation
Reactome:R-HSA-6807070 PTEN Regulation
Reactome:R-HSA-73887 Death Receptor Signaling
Reactome:R-HSA-193704 p75 NTR receptor-mediated signalling
Reactome:R-HSA-205043 NRIF signals cell death from the nucleus
Reactome:R-HSA-8953897 Cellular responses to stimuli
Reactome:R-HSA-3371556 Cellular response to heat stress
Reactome:R-HSA-3371453 Regulation of HSF1-mediated heat shock response
Reactome:R-HSA-438064 Post NMDA receptor activation events
Reactome:R-HSA-68886 M Phase
Reactome:R-HSA-5663205 Infectious disease
Reactome:R-HSA-73854 RNA Polymerase I Promoter Clearance
Reactome:R-HSA-8878166 Transcriptional regulation by RUNX2
Reactome:R-HSA-168898 Toll-like Receptor Cascades
Reactome:R-HSA-450341 Activation of the AP-1 family of transcription factors
Reactome:R-HSA-975155 MyD88 dependent cascade initiated on endosome
Reactome:R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Reactome:R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
Reactome:R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
Reactome:R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
Reactome:R-HSA-1280215 Cytokine Signaling in Immune system
Reactome:R-HSA-877300 Interferon gamma signaling
Reactome:R-MMU-69278 Cell Cycle, Mitotic
Reactome:R-MMU-68875 Mitotic Prophase
Reactome:R-MMU-202670 ERKs are inactivated
Reactome:R-MMU-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Reactome:R-MMU-168138 Toll Like Receptor 9 (TLR9) Cascade
Reactome:R-MMU-166166 MyD88-independent TLR4 cascade
Reactome:R-MMU-168188 Toll Like Receptor TLR6:TLR2 Cascade
Reactome:R-MMU-2871796 FCERI mediated MAPK activation
Reactome:R-MMU-5693532 DNA Double-Strand Break Repair
Reactome:R-MMU-109582 Hemostasis
Reactome:R-MMU-432142 Platelet sensitization by LDL
Reactome:R-MMU-392518 Signal amplification
Reactome:R-MMU-422475 Axon guidance
Reactome:R-MMU-373760 L1CAM interactions
Reactome:R-MMU-111471 Apoptotic factor-mediated response
Reactome:R-MMU-8953897 Cellular responses to stimuli
Reactome:R-MMU-2262752 Cellular responses to stress
Reactome:R-MMU-2559583 Cellular Senescence
Reactome:R-MMU-73854 RNA Polymerase I Promoter Clearance
Reactome:R-MMU-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Reactome:R-MMU-5654738 Signaling by FGFR2
Reactome:R-MMU-5654732 Negative regulation of FGFR3 signaling
Reactome:R-MMU-187687 Signalling to ERKs
Reactome:R-MMU-170968 Frs2-mediated activation
Reactome:R-MMU-170834 Signaling by TGF-beta Receptor Complex
Reactome:R-MMU-112040 G-protein mediated events
Reactome:R-MMU-416476 G alpha (q) signalling events
Reactome:R-MMU-5683057 MAPK family signaling cascades
Reactome:R-MMU-112409 RAF-independent MAPK1/3 activation
Reactome:R-MMU-9006925 Intracellular signaling by second messengers
Reactome:R-MMU-199418 Negative regulation of the PI3K/AKT network
Reactome:R-RNO-162658 Golgi Cisternae Pericentriolar Stack Reorganization
Reactome:R-RNO-73864 RNA Polymerase I Transcription
Reactome:R-RNO-212436 Generic Transcription Pathway
Reactome:R-RNO-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Reactome:R-RNO-3371556 Cellular response to heat stress
Reactome:R-RNO-3371453 Regulation of HSF1-mediated heat shock response
Reactome:R-RNO-5654738 Signaling by FGFR2
Reactome:R-RNO-5654732 Negative regulation of FGFR3 signaling
Reactome:R-RNO-187687 Signalling to ERKs
Reactome:R-RNO-170968 Frs2-mediated activation
Reactome:R-RNO-1502540 Signaling by Activin
Reactome:R-RNO-418594 G alpha (i) signalling events
Reactome:R-RNO-112043 PLC beta mediated events
Reactome:R-RNO-5684996 ERK1/ERK2 pathway
Reactome:R-RNO-5675221 Negative regulation of MAPK pathway
Reactome:R-RNO-110056 MAPK3 (ERK1) activation
Reactome:R-RNO-1257604 PI3K/AKT Signaling
Reactome:R-RNO-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Reactome:R-RNO-195258 RHO GTPase Effectors
Reactome:R-RNO-5668599 RHO GTPases Activate NADPH Oxidases
Reactome:R-RNO-204998 Cell death signalling via NRAGE, NRIF and NADE
Reactome:R-RNO-5693606 DNA Double Strand Break Response
Reactome:R-RNO-76002 Platelet activation, signaling and aggregation
Reactome:R-RNO-418592 ADP signalling through P2Y purinoceptor 1
Reactome:R-RNO-109581 Apoptosis
Reactome:R-RNO-114452 Activation of BH3-only proteins
Reactome:R-RNO-139910 Activation of BMF and translocation to mitochondria
Reactome:R-RNO-168142 Toll Like Receptor 10 (TLR10) Cascade
Reactome:R-RNO-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Reactome:R-RNO-168138 Toll Like Receptor 9 (TLR9) Cascade
Reactome:R-RNO-166166 MyD88-independent TLR4 cascade
Reactome:R-RNO-181438 Toll Like Receptor 2 (TLR2) Cascade
Reactome:R-RNO-1280215 Cytokine Signaling in Immune system
Reactome:R-RNO-877300 Interferon gamma signaling
Reactome:R-RNO-375165 NCAM signaling for neurite out-growth
Reactome:R-RNO-437239 Recycling pathway of L1
Reactome:R-RNO-1181150 Signaling by NODAL
Reactome:R-SCE-418592 ADP signalling through P2Y purinoceptor 1
Reactome:R-SCE-2262752 Cellular responses to stress
Reactome:R-SCE-168256 Immune System
Reactome:R-SCE-168898 Toll-like Receptor Cascades
Reactome:R-SCE-202670 ERKs are inactivated
Reactome:R-SCE-975155 MyD88 dependent cascade initiated on endosome
Reactome:R-SCE-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Reactome:R-SCE-168179 Toll Like Receptor TLR1:TLR2 Cascade
Reactome:R-SCE-1280215 Cytokine Signaling in Immune system
Reactome:R-SCE-187037 Signaling by NTRK1 (TRKA)
Reactome:R-SCE-372790 Signaling by GPCR
Reactome:R-SCE-416476 G alpha (q) signalling events
Reactome:R-SCE-69615 G1/S DNA Damage Checkpoints
Reactome:R-SPO-418346 Platelet homeostasis
Reactome:R-SPO-168249 Innate Immune System
Reactome:R-SPO-450294 MAP kinase activation
Reactome:R-SPO-198753 ERK/MAPK targets
Reactome:R-SPO-168176 Toll Like Receptor 5 (TLR5) Cascade
Reactome:R-SPO-168138 Toll Like Receptor 9 (TLR9) Cascade
Reactome:R-SPO-937061 TRIF (TICAM1)-mediated TLR4 signaling
Reactome:R-SPO-1280215 Cytokine Signaling in Immune system
Reactome:R-SPO-448424 Interleukin-17 signaling
Reactome:R-SPO-69613 p53-Independent G1/S DNA Damage Checkpoint
Reactome:R-SPO-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-SPO-198725 Nuclear Events (kinase and transcription factor activation)
Reactome:R-SPO-5683057 MAPK family signaling cascades
Reactome:R-SPO-195258 RHO GTPase Effectors
WikiPathways:WP4861 Endoplasmic reticulum stress response in coronavirus infection
WikiPathways:WP5144 NRP1-triggered signaling pathways in pancreatic cancer
WikiPathways:WP5298 Dravet syndrome: Scn1a-A1783V point mutation model
WikiPathways:WP2643 Nanoparticle-mediated activation of receptor signaling
WikiPathways:WP4746 Thyroid hormones production and peripheral downstream signaling effects
WikiPathways:WP4838 Regucalcin in proximal tubule epithelial kidney cells
WikiPathways:WP5200 Dravet syndrome
WikiPathways:WP4873 Peroxiredoxin 2 induced ovarian failure
WikiPathways:WP5098 T-cell activation SARS-CoV-2
WikiPathways:WP5272 LDL- influence on CD14 and TLR4
WikiPathways:WP5322 CKAP4 signaling pathway map
WikiPathways:WP5158 Urotensin-II-mediated signaling pathway
WikiPathways:WP5242 Comprehensive IL-17A signaling
WikiPathways:WP3830 Toll, IMD, JAK/STAT pathways for immune response to pathogens
PathBank:SMP0108225 Insulin Signalling
PathBank:SMP0120931 Toll-Like Receptor Pathway 1
PathBank:SMP0120935 T Cell Receptor Signaling Pathway
PathBank:SMP0120939 FAS signaling pathway ( CD95 )
PathBank:SMP0120947 Growth Hormone Signaling Pathway
PathBank:SMP0120955 Toll-Like Receptor Pathway 1
PathBank:SMP0120959 T Cell Receptor Signaling Pathway
PathBank:SMP0120963 FAS signaling pathway ( CD95 )
PathBank:SMP0089759 CD40L Signalling Pathway
PathBank:SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages
PathBank:SMP0063810 EGF Signalling Pathway
PathBank:SMP0063899 Toll-Like Receptor Pathway 1
PathBank:SMP0066977 T Cell Receptor Signaling Pathway
PathBank:SMP0067587 Stat3 Signaling Pathway
PathBank:SMP0108220 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
PathBank:SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells
PathBank:SMP0108240 Cadmium Induces DNA Synthesis and Proliferation in Macrophages
PathBank:SMP0069695 FAS signaling pathway ( CD95 )
PathBank:SMP0120888 Succinate Signalling During Inflammation
PathBank:SMP0120938 EPO Signaling Pathway
PathBank:SMP0120942 CD40L Signalling Pathway
PathBank:SMP0120962 EPO Signaling Pathway
PathBank:SMP0002411 Stress-Activated Signalling Pathways: High Osmolarity
PathBank:SMP0100483 TNF/Stress Related Signaling
PathBank:SMP0100498 TNF/Stress Related Signaling
PathBank:SMP0108174 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
PathBank:SMP0108178 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
PathBank:SMP0108186 Fc Epsilon Receptor I Signaling in Mast Cells
PathBank:SMP0069678 EPO Signaling Pathway
PathBank:SMP0069871 BCR Signaling Pathway
PathBank:SMP0120886 Succinate Signalling During Inflammation
PathBank:SMP0120924 EGF Signalling Pathway
PathBank:SMP0120940 BCR Signaling Pathway
PathBank:SMP0120948 EGF Signalling Pathway
PathBank:SMP0120960 Stat3 Signaling Pathway
PathBank:SMP0120964 BCR Signaling Pathway
PathBank:SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
PathBank:SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells
PathBank:SMP0063792 TNF/Stress Related Signaling
PathBank:SMP0108219 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
PathBank:SMP0069593 Toll-Like Receptor Pathway 2
PathBank:SMP0120925 GnRH Signaling Pathway
PathBank:SMP0120937 Toll-Like Receptor Pathway 2
PathBank:SMP0120949 GnRH Signaling Pathway
PathBank:SMP0120957 CXCR4 Signaling Pathway
PathBank:SMP0120961 Toll-Like Receptor Pathway 2
PathBank:SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
PathBank:SMP0000391 Insulin Signalling
PathBank:SMP0002410 Stress-Activated Signalling Pathways: Low Osmolarity
PathBank:SMP0084634 Succinate Signalling During Inflammation
PathBank:SMP0063784 Ras Signaling Pathway
PathBank:SMP0063807 Growth Hormone Signaling Pathway
PathBank:SMP0063811 GnRH Signaling Pathway
PathBank:SMP0064625 CXCR4 Signaling Pathway