EC: 1.13.11.6

3-hydroxyanthranilate 3,4-dioxygenase (3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing))

enzyme lambda metabolic reaction experiment
uniprot:Q1LCS4 [Fe2+]

O2 + 3_Hydroxyanthranilate -> 2_Amino_3_carboxymuconate_semialdehyde		 (( (( (E * kcat) ) * A) ) / (( (Km + A) ) + (( (A ^ 2) ) / Ki))) buffer: 10 mM phosphate, 20 mM DTT
PH: 7.2
Temperature: 36
uniprot:Q1LCS4 [3-hydroxyanthranilate 3,4-dioxygenase(Enzyme) wildtype]

O2 + 3_Hydroxyanthranilate -> 2_Amino_3_carboxymuconate_semialdehyde		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 10 mM Phosphate
PH: 7.2
Temperature: 36
uniprot:Q1LCS4 [3-hydroxyanthranilate 3,4-dioxygenase(Enzyme) mutant R99A]

3_Hydroxyanthranilate + O2 -> 2_Amino_3_carboxymuconate_semialdehyde		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 10 mM Phosphate
PH: 7.2
Temperature: 36
uniprot:Q1LCS4 [3-hydroxyanthranilate 3,4-dioxygenase(Enzyme) mutant E110A]

O2 + 3_Hydroxyanthranilate -> 2_Amino_3_carboxymuconate_semialdehyde		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 10 mM Phosphate
PH: 7.2
Temperature: 36

Pathways

pathway id name
BioCyc:HUMAN_TRYPTOPHAN-DEGRADATION-1 tryptophan degradation
BioCyc:HUMAN_PWY66-401 superpathway of tryptophan utilization
BioCyc:META_PWY-3502 superpathway of NAD biosynthesis in eukaryotes
BioCyc:META_PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
BioCyc:YEAST_PWY-5651 tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
BioCyc:MOUSE_NADSYN-PWY NAD biosynthesis II (from tryptophan)
BioCyc:HUMAN_PWY-6309 L-kynurenine degradation
BioCyc:META_PWY-5647 2-nitrobenzoate degradation I
BioCyc:META_NADSYN-PWY NAD de novo biosynthesis II (from tryptophan)
BioCyc:YEAST_NADSYN-PWY NAD de novo biosynthesis
BioCyc:HUMAN_NADSYN-PWY NAD de novo biosynthesis
BioCyc:HUMAN_PWY-5651 tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
BioCyc:META_TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation III (eukaryotic)
BioCyc:META_PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine)
BioCyc:MOUSE_TRYPTOPHAN-DEGRADATION-1 tryptophan degradation III (eukaryotic)
BioCyc:MOUSE_PWY-5651 tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
Reactome:R-DRE-71291 Amino acid and derivative metabolism
Reactome:R-MMU-1430728 Metabolism
Reactome:R-SCE-71291 Amino acid and derivative metabolism
Reactome:R-CEL-71240 Tryptophan catabolism
Reactome:R-DDI-71291 Amino acid and derivative metabolism
Reactome:R-HSA-71240 Tryptophan catabolism
Reactome:R-MMU-71240 Tryptophan catabolism
Reactome:R-RNO-71240 Tryptophan catabolism
Reactome:R-SCE-1430728 Metabolism
Reactome:R-CEL-71291 Amino acid and derivative metabolism
Reactome:R-DRE-1430728 Metabolism
Reactome:R-DDI-71240 Tryptophan catabolism
Reactome:R-HSA-71291 Amino acid and derivative metabolism
Reactome:R-MMU-71291 Amino acid and derivative metabolism
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-71291 Amino acid and derivative metabolism
Reactome:R-CEL-1430728 Metabolism
Reactome:R-DRE-71240 Tryptophan catabolism
Reactome:R-DDI-1430728 Metabolism
Reactome:R-HSA-1430728 Metabolism
Reactome:R-SCE-71240 Tryptophan catabolism
WikiPathways:WP5044 Kynurenine pathway and links to cell senescence
PathBank:SMP0000190 Hawkinsinuria
PathBank:SMP0002353 Tryptophan Metabolism
PathBank:SMP0000169 Alkaptonuria
PathBank:SMP0000429 Disulfiram Action Pathway
PathBank:SMP0087237 Tryptophan Metabolism
PathBank:SMP0000063 Tryptophan Metabolism
PathBank:SMP0000218 Tyrosinemia Type I
PathBank:SMP0000533 Monoamine Oxidase-A Deficiency (MAO-A)
PathBank:SMP0002338 NAD Metabolism
PathBank:SMP0000006 Tyrosine Metabolism
PathBank:SMP0000494 Tyrosinemia, Transient, of the Newborn
PathBank:SMP0000498 Dopamine beta-Hydroxylase Deficiency
PathBank:SMP0087235 Tyrosine Metabolism